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Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells.

Kim JT, Li C, Weiss HL, Zhou Y, Liu C, Wang Q, Evers BM.

Cells. 2019 Sep 19;8(9). pii: E1106. doi: 10.3390/cells8091106.


Pharmacogenomic potential in advanced cancer patients.

Nichols D, Arnold S, Weiss HL, Wu J, Durbin EB, Miller R, Kolesar J.

Am J Health Syst Pharm. 2019 Mar 19;76(7):415-423. doi: 10.1093/ajhp/zxy079.


Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling.

Rock S, Li X, Song J, Townsend CM Jr, Weiss HL, Rychahou P, Gao T, Li J, Evers BM.

PLoS One. 2019 Mar 27;14(3):e0211134. doi: 10.1371/journal.pone.0211134. eCollection 2019.


S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.

Liu L, Qi L, Knifley T, Piecoro DW, Rychahou P, Liu J, Mitov MI, Martin J, Wang C, Wu J, Weiss HL, Butterfield DA, Evers BM, O'Connor KL, Chen M.

J Biol Chem. 2019 May 3;294(18):7516-7527. doi: 10.1074/jbc.RA118.004365. Epub 2019 Mar 18.


Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.

Johnson J, Rychahou P, Sviripa VM, Weiss HL, Liu C, Watt DS, Evers BM.

PLoS One. 2019 Mar 15;14(3):e0209392. doi: 10.1371/journal.pone.0209392. eCollection 2019.


The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer.

Wen YA, Xiong X, Scott T, Li AT, Wang C, Weiss HL, Tan L, Bradford E, Fan TWM, Chandel NS, Barrett TA, Gao T.

Cell Death Differ. 2019 Oct;26(10):1955-1969. doi: 10.1038/s41418-018-0265-6. Epub 2019 Jan 18.


Neoadjuvant administration of hydroxychloroquine in a phase 1 clinical trial induced plasma Par-4 levels and apoptosis in diverse tumors.

Wang P, Burikhanov R, Jayswal R, Weiss HL, Arnold SM, Villano JL, Rangnekar VM.

Genes Cancer. 2018 May;9(5-6):190-197. doi: 10.18632/genesandcancer.181.


Characterization of Squamous Cell Lung Cancers from Appalachian Kentucky.

Liu J, Murali T, Yu T, Liu C, Sivakumaran TA, Moseley HNB, Zhulin IB, Weiss HL, Durbin EB, Ellingson SR, Liu J, Huang B, Hallahan BJ, Horbinski CM, Hodges K, Napier DL, Bocklage T, Mueller J, Vanderford NL, Fardo DW, Wang C, Arnold SM.

Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):348-356. doi: 10.1158/1055-9965.EPI-17-0984. Epub 2018 Oct 30.


De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer.

Jafari N, Drury J, Morris AJ, Onono FO, Stevens PD, Gao T, Liu J, Wang C, Lee EY, Weiss HL, Evers BM, Zaytseva YY.

Mol Cancer Res. 2019 Jan;17(1):140-152. doi: 10.1158/1541-7786.MCR-18-0199. Epub 2018 Aug 28.


Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.

Stevens PD, Wen YA, Xiong X, Zaytseva YY, Li AT, Wang C, Stevens AT, Farmer TN, Gan T, Weiss HL, Inagaki M, Marchetto S, Borg JP, Gao T.

Cancer Res. 2018 Sep 1;78(17):4839-4852. doi: 10.1158/0008-5472.CAN-17-3629. Epub 2018 Jul 6.


Profiles of Radioresistance Mechanisms in Prostate Cancer.

Chaiswing L, Weiss HL, Jayswal RD, Clair DKS, Kyprianou N.

Crit Rev Oncog. 2018;23(1-2):39-67. doi: 10.1615/CritRevOncog.2018025946. Review.


Polypharmacology Within the Full Kinome: a Machine Learning Approach.

Jones D, Bopaiah J, Alghamedy F, Jacobs N, Weiss HL, de Jong WA, Ellingson SR.

AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:98-107. eCollection 2018.


Incorporating Protein Dynamics Through Ensemble Docking in Machine Learning Models to Predict Drug Binding.

Alghamedy F, Bopaiah J, Jones D, Zhang X, Weiss HL, Ellingson SR.

AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:26-34. eCollection 2018.


Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.

Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers M.

Oncotarget. 2018 May 15;9(37):24787-24800. doi: 10.18632/oncotarget.25361. eCollection 2018 May 15.


Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary.

Chauhan A, Farooqui Z, Murray LA, Weiss HL, War Myint Z, Raajasekar AKA, Evers BM, Arnold S, Anthony L.

J Oncol. 2018 May 7;2018:3519247. doi: 10.1155/2018/3519247. eCollection 2018.


FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice.

Li J, Song J, Li X, Rock SB, Sinner HF, Weiss HL, Weiss T, Townsend CM Jr, Gao T, Evers BM.

Endocrinology. 2018 Aug 1;159(8):2939-2952. doi: 10.1210/en.2018-00284.


Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.

Wang Q, Zhou Y, Rychahou P, Harris JW, Zaytseva YY, Liu J, Wang C, Weiss HL, Liu C, Lee EY, Evers BM.

Cancer Res. 2018 Jun 15;78(12):3163-3175. doi: 10.1158/0008-5472.CAN-17-3107. Epub 2018 Apr 17.


Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer.

Wen YA, Xiong X, Zaytseva YY, Napier DL, Vallee E, Li AT, Wang C, Weiss HL, Evers BM, Gao T.

Cell Death Dis. 2018 Feb 15;9(3):265. doi: 10.1038/s41419-018-0330-6.


Colorectal cancer lung metastasis treatment with polymer-drug nanoparticles.

Rychahou P, Bae Y, Reichel D, Zaytseva YY, Lee EY, Napier D, Weiss HL, Roller N, Frohman H, Le AT, Mark Evers B.

J Control Release. 2018 Apr 10;275:85-91. doi: 10.1016/j.jconrel.2018.02.008. Epub 2018 Feb 6.


Extracellular redox state shift: A novel approach to target prostate cancer invasion.

Zhong W, Weiss HL, Jayswal RD, Hensley PJ, Downes LM, St Clair DK, Chaiswing L.

Free Radic Biol Med. 2018 Mar;117:99-109. doi: 10.1016/j.freeradbiomed.2018.01.023. Epub 2018 Feb 2.


Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration.

Kim JT, Napier DL, Weiss HL, Lee EY, Townsend CM Jr, Evers BM.

Neoplasia. 2018 Feb;20(2):175-181. doi: 10.1016/j.neo.2017.11.012. Epub 2017 Dec 19.


Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.

Kim JT, Weiss HL, Evers BM.

Int J Oncol. 2017 Jun;50(6):2200-2206. doi: 10.3892/ijo.2017.3990. Epub 2017 May 9.


Fluorinated N,N'-Diarylureas As Novel Therapeutic Agents Against Cancer Stem Cells.

Kenlan DE, Rychahou P, Sviripa VM, Weiss HL, Liu C, Watt DS, Evers BM.

Mol Cancer Ther. 2017 May;16(5):831-837. doi: 10.1158/1535-7163.MCT-15-0634. Epub 2017 Mar 3.


Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer.

Wen YA, Xing X, Harris JW, Zaytseva YY, Mitov MI, Napier DL, Weiss HL, Mark Evers B, Gao T.

Cell Death Dis. 2017 Feb 2;8(2):e2593. doi: 10.1038/cddis.2017.21.


Ketogenesis contributes to intestinal cell differentiation.

Wang Q, Zhou Y, Rychahou P, Fan TW, Lane AN, Weiss HL, Evers BM.

Cell Death Differ. 2017 Mar;24(3):458-468. doi: 10.1038/cdd.2016.142. Epub 2016 Dec 9.


Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer.

Upreti M, Jyoti A, Johnson SE, Swindell EP, Napier D, Sethi P, Chan R, Feddock JM, Weiss HL, O'Halloran TV, Evers BM.

Oncotarget. 2016 Jul 5;7(27):41559-41574. doi: 10.18632/oncotarget.9490.


An obligatory role for neurotensin in high-fat-diet-induced obesity.

Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM.

Nature. 2016 May 19;533(7603):411-5. doi: 10.1038/nature17662. Epub 2016 May 11.


S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide.

Stewart RL, Carpenter BL, West DS, Knifley T, Liu L, Wang C, Weiss HL, Gal TS, Durbin EB, Arnold SM, O'Connor KL, Chen M.

Oncotarget. 2016 Jun 7;7(23):34630-42. doi: 10.18632/oncotarget.8969.


Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer.

Stewart RL, West D, Wang C, Weiss HL, Gal T, Durbin EB, O'Connor W, Chen M, O'Connor KL.

Hum Pathol. 2016 Aug;54:174-83. doi: 10.1016/j.humpath.2016.04.003. Epub 2016 Apr 20.


Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells.

Li J, Song J, Weiss HL, Weiss T, Townsend CM Jr, Evers BM.

Mol Endocrinol. 2016 Jan;30(1):26-36. doi: 10.1210/me.2015-1094. Epub 2015 Nov 3.


Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.

Kim JT, Li J, Song J, Lee EY, Weiss HL, Townsend CM Jr, Evers BM.

Oncotarget. 2015 Sep 29;6(29):26960-70. doi: 10.18632/oncotarget.4745.


Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.

Wen YA, Li X, Goretsky T, Weiss HL, Barrett TA, Gao T.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2013-23. doi: 10.1016/j.bbadis.2015.07.012. Epub 2015 Jul 15.


Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration.

Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T, Evers BM.

Oncotarget. 2015 Aug 7;6(22):18891-904.


Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer.

Granados-Principal S, Liu Y, Guevara ML, Blanco E, Choi DS, Qian W, Patel T, Rodriguez AA, Cusimano J, Weiss HL, Zhao H, Landis MD, Dave B, Gross SS, Chang JC.

Breast Cancer Res. 2015 Feb 22;17:25. doi: 10.1186/s13058-015-0527-x.


TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.

Zhou Y, Rychahou P, Wang Q, Weiss HL, Evers BM.

Cell Death Dis. 2015 Feb 5;6:e1631. doi: 10.1038/cddis.2014.588.


Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration.

Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee EY, Mustain W, Valentino J, Guo P, Evers BM.

ACS Nano. 2015 Feb 24;9(2):1108-16. doi: 10.1021/acsnano.5b00067. Epub 2015 Feb 10.


Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.

Kim JT, Liu C, Zaytseva YY, Weiss HL, Townsend CM Jr, Evers BM.

Int J Cancer. 2015 Mar 15;136(6):1475-81. doi: 10.1002/ijc.29123. Epub 2014 Aug 14.


Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ.

J Biol Chem. 2014 Sep 19;289(38):26021-37. doi: 10.1074/jbc.M114.561134. Epub 2014 Aug 1.


Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.

Zhou Y, Wang Q, Weiss HL, Evers BM.

Mol Biol Cell. 2014 Sep 15;25(18):2882-90. doi: 10.1091/mbc.E14-05-0998. Epub 2014 Jul 23.


Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.

Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM.

Carcinogenesis. 2014 Jun;35(6):1341-51. doi: 10.1093/carcin/bgu042. Epub 2014 Feb 7.


A survey of the barriers associated with academic-based cancer research commercialization.

Vanderford NL, Weiss LT, Weiss HL.

PLoS One. 2013 Aug 21;8(8):e72268. doi: 10.1371/journal.pone.0072268. eCollection 2013.


Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery.

Hollis CP, Weiss HL, Leggas M, Evers BM, Gemeinhart RA, Li T.

J Control Release. 2013 Nov 28;172(1):12-21. doi: 10.1016/j.jconrel.2013.06.039. Epub 2013 Aug 3.


NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation.

Wang Q, Zhou Y, Rychahou P, Liu C, Weiss HL, Evers BM.

Cell Death Dis. 2013 Jun 13;4:e671. doi: 10.1038/cddis.2013.202.


Mechanical clot damage from cavitation during sonothrombolysis.

Weiss HL, Selvaraj P, Okita K, Matsumoto Y, Voie A, Hoelscher T, Szeri AJ.

J Acoust Soc Am. 2013 May;133(5):3159-75. doi: 10.1121/1.4795774.


In vivo investigation of hybrid Paclitaxel nanocrystals with dual fluorescent probes for cancer theranostics.

Hollis CP, Weiss HL, Evers BM, Gemeinhart RA, Li T.

Pharm Res. 2014 Jun;31(6):1450-9. doi: 10.1007/s11095-013-1048-x. Epub 2013 Apr 26.


Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors.

Kim JT, Li J, Jang ER, Gulhati P, Rychahou PG, Napier DL, Wang C, Weiss HL, Lee EY, Anthony L, Townsend CM Jr, Liu C, Evers BM.

Carcinogenesis. 2013 May;34(5):953-61. doi: 10.1093/carcin/bgt018. Epub 2013 Jan 25.


PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.

Li J, Song J, Cassidy MG, Rychahou P, Starr ME, Liu J, Li X, Epperly G, Weiss HL, Townsend CM Jr, Gao T, Evers BM.

Mol Endocrinol. 2012 Aug;26(8):1380-93. doi: 10.1210/me.2012-1024. Epub 2012 Jun 14.


Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA.

Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T, Evers BM.

Carcinogenesis. 2012 Sep;33(9):1782-90. doi: 10.1093/carcin/bgs203. Epub 2012 Jun 13.


Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.

Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM.

Cancer Res. 2012 Mar 15;72(6):1504-17. doi: 10.1158/0008-5472.CAN-11-4057. Epub 2012 Jan 19.

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