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Items: 1 to 50 of 75

1.

Correction: The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation (doi:10.1242/jcs.229500).

Bissig C, Croisé P, Heiligenstein X, Hurbain I, Lenk GM, Kaufman E, Sannerud R, Annaert W, Meisler MH, Weisman LS, Raposo G, van Niel G.

J Cell Sci. 2019 Mar 28;132(6). pii: jcs231746. doi: 10.1242/jcs.231746. No abstract available.

PMID:
30923131
2.

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation.

Bissig C, Croisé P, Heiligenstein X, Hurbain I, Lenk GM, Kaufman E, Sannerud R, Annaert W, Meisler MH, Weisman LS, Raposo G, van Niel G.

J Cell Sci. 2019 Feb 28;132(5). pii: jcs229500. doi: 10.1242/jcs.229500. Erratum in: J Cell Sci. 2019 Mar 28;132(6):.

3.

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.

4.

Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress.

Takeda E, Jin N, Itakura E, Kira S, Kamada Y, Weisman LS, Noda T, Matsuura A.

Mol Biol Cell. 2018 Feb 15;29(4):510-522. doi: 10.1091/mbc.E17-09-0553. Epub 2017 Dec 13.

5.

Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome.

Jin N, Jin Y, Weisman LS.

J Cell Biol. 2017 Jul 3;216(7):2075-2090. doi: 10.1083/jcb.201611144. Epub 2017 Jun 21.

6.

Spatial regulation of organelle release from myosin V transport by p21-activated kinases.

Yau RG, Wong S, Weisman LS.

J Cell Biol. 2017 Jun 5;216(6):1557-1566. doi: 10.1083/jcb.201607020. Epub 2017 May 11.

7.

PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.

Hasegawa J, Strunk BS, Weisman LS.

Cell Struct Funct. 2017 May 3;42(1):49-60. doi: 10.1247/csf.17003. Epub 2017 Mar 7. Review.

8.

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Pappas SS, Bonifacino J, Danek A, Dauer WT, De M, De Franceschi L, DiPaolo G, Fuller R, Haucke V, Hermann A, Kornmann B, Landwehrmeyer B, Levin J, Neiman AM, Rudnicki DD, Sibon O, Velayos-Baeza A, Vonk JJ, Walker RH, Weisman LS, Albin RL.

Tremor Other Hyperkinet Mov (N Y). 2017 Feb 15;7:428. doi: 10.7916/D8XD127W. eCollection 2017.

9.

An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.

Lang MJ, Strunk BS, Azad N, Petersen JL, Weisman LS.

Mol Biol Cell. 2017 Apr 1;28(7):858-864. doi: 10.1091/mbc.E16-06-0390. Epub 2017 Feb 1.

10.

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.

Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL.

J Clin Invest. 2016 Nov 1;126(11):4088-4102. doi: 10.1172/JCI87148. Epub 2016 Sep 26.

11.

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.

Jin N, Lang MJ, Weisman LS.

Biochem Soc Trans. 2016 Feb;44(1):177-84. doi: 10.1042/BST20150174. Review.

12.

The vacuole/lysosome is required for cell-cycle progression.

Jin Y, Weisman LS.

Elife. 2015 Aug 31;4. doi: 10.7554/eLife.08160.

13.

Close encounters of the lysosome-peroxisome kind.

Jin Y, Strunk BS, Weisman LS.

Cell. 2015 Apr 9;161(2):197-8. doi: 10.1016/j.cell.2015.03.046.

14.

Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.

McCartney AJ, Zolov SN, Kauffman EJ, Zhang Y, Strunk BS, Weisman LS, Sutton MA.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4896-905. doi: 10.1073/pnas.1411117111. Epub 2014 Oct 29.

15.

Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization.

Yau RG, Peng Y, Valiathan RR, Birkeland SR, Wilson TE, Weisman LS.

Dev Cell. 2014 Mar 10;28(5):520-33. doi: 10.1016/j.devcel.2014.02.001.

16.

The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase.

Li SC, Diakov TT, Xu T, Tarsio M, Zhu W, Couoh-Cardel S, Weisman LS, Kane PM.

Mol Biol Cell. 2014 Apr;25(8):1251-62. doi: 10.1091/mbc.E13-10-0563. Epub 2014 Feb 12.

17.

Roles for PI(3,5)P2 in nutrient sensing through TORC1.

Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS.

Mol Biol Cell. 2014 Apr;25(7):1171-85. doi: 10.1091/mbc.E14-01-0021. Epub 2014 Jan 29.

18.

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.

Li X, Wang X, Zhang X, Zhao M, Tsang WL, Zhang Y, Yau RG, Weisman LS, Xu H.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21165-70. doi: 10.1073/pnas.1311864110. Epub 2013 Dec 9.

19.

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.

McCartney AJ, Zhang Y, Weisman LS.

Bioessays. 2014 Jan;36(1):52-64. doi: 10.1002/bies.201300012. Epub 2013 Oct 28. Review.

20.

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.

Samie M, Wang X, Zhang X, Goschka A, Li X, Cheng X, Gregg E, Azar M, Zhuo Y, Garrity AG, Gao Q, Slaugenhaupt S, Pickel J, Zolov SN, Weisman LS, Lenk GM, Titus S, Bryant-Genevier M, Southall N, Juan M, Ferrer M, Xu H.

Dev Cell. 2013 Sep 16;26(5):511-24. doi: 10.1016/j.devcel.2013.08.003. Epub 2013 Aug 29.

21.

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17472-7. doi: 10.1073/pnas.1203106109. Epub 2012 Oct 9.

22.

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P.

Zhang Y, McCartney AJ, Zolov SN, Ferguson CJ, Meisler MH, Sutton MA, Weisman LS.

EMBO J. 2012 Aug 15;31(16):3442-56. doi: 10.1038/emboj.2012.200. Epub 2012 Jul 27.

23.

Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes.

Eves PT, Jin Y, Brunner M, Weisman LS.

J Cell Biol. 2012 Jul 9;198(1):69-85. doi: 10.1083/jcb.201201024. Epub 2012 Jul 2.

24.

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR.

Mol Biol Cell. 2012 Aug;23(15):2955-62. doi: 10.1091/mbc.E11-12-1034. Epub 2012 Jun 13.

25.

Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR.

J Biol Chem. 2012 Jun 15;287(25):20913-21. doi: 10.1074/jbc.M111.334060. Epub 2012 Apr 30.

26.

Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.

Jin Y, Sultana A, Gandhi P, Franklin E, Hamamoto S, Khan AR, Munson M, Schekman R, Weisman LS.

Dev Cell. 2011 Dec 13;21(6):1156-70. doi: 10.1016/j.devcel.2011.10.009.

27.

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A.

PLoS Genet. 2011 Oct;7(10):e1002319. doi: 10.1371/journal.pgen.1002319. Epub 2011 Oct 20.

28.

The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding.

Sultana A, Jin Y, Dregger C, Franklin E, Weisman LS, Khan AR.

FEBS Lett. 2011 Nov 16;585(22):3520-7. doi: 10.1016/j.febslet.2011.10.013. Epub 2011 Oct 20.

29.

Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.

Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH.

PLoS Genet. 2011 Jun;7(6):e1002104. doi: 10.1371/journal.pgen.1002104. Epub 2011 Jun 2.

30.

Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing.

Birkeland SR, Jin N, Ozdemir AC, Lyons RH Jr, Weisman LS, Wilson TE.

Genetics. 2010 Dec;186(4):1127-37. doi: 10.1534/genetics.110.123232. Epub 2010 Oct 5.

31.

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H.

Nat Commun. 2010 Jul 13;1:38. doi: 10.1038/ncomms1037.

32.

Myosin-driven peroxisome partitioning in S. cerevisiae.

Fagarasanu A, Mast FD, Knoblach B, Jin Y, Brunner MJ, Logan MR, Glover JN, Eitzen GA, Aitchison JD, Weisman LS, Rachubinski RA.

J Cell Biol. 2009 Aug 24;186(4):541-54. doi: 10.1083/jcb.200904050. Epub 2009 Aug 17.

33.

Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH.

Am J Hum Genet. 2009 Jan;84(1):85-8. doi: 10.1016/j.ajhg.2008.12.010.

34.

PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex.

Jin Y, Taylor Eves P, Tang F, Weisman LS.

Mol Biol Cell. 2009 Mar;20(5):1312-23. doi: 10.1091/mbc.E08-09-0954. Epub 2008 Dec 30.

35.

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.

EMBO J. 2008 Dec 17;27(24):3221-34. doi: 10.1038/emboj.2008.248. Epub 2008 Nov 27.

36.

The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance.

Peng Y, Weisman LS.

Dev Cell. 2008 Sep;15(3):478-85. doi: 10.1016/j.devcel.2008.07.007.

37.

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.

Lipatova Z, Tokarev AA, Jin Y, Mulholland J, Weisman LS, Segev N.

Mol Biol Cell. 2008 Oct;19(10):4177-87. doi: 10.1091/mbc.E08-02-0220. Epub 2008 Jul 23.

38.

Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.

Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR.

Mol Biol Cell. 2008 Jul;19(7):2718-28. doi: 10.1091/mbc.E08-01-0105. Epub 2008 Apr 23.

39.

Pushing for answers: is myosin V directly involved in moving mitochondria?

Valiathan RR, Weisman LS.

J Cell Biol. 2008 Apr 7;181(1):15-8. doi: 10.1083/jcb.200803064.

40.

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23. Epub 2007 Oct 23.

41.

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.

Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH.

Nature. 2007 Jul 5;448(7149):68-72. Epub 2007 Jun 17.

42.

Palmitoylation plays a role in targeting Vac8p to specific membrane subdomains.

Peng Y, Tang F, Weisman LS.

Traffic. 2006 Oct;7(10):1378-87.

43.

Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes.

Tang F, Peng Y, Nau JJ, Kauffman EJ, Weisman LS.

Traffic. 2006 Oct;7(10):1368-77. Epub 2006 Jul 5.

44.

Organelles on the move: insights from yeast vacuole inheritance.

Weisman LS.

Nat Rev Mol Cell Biol. 2006 Apr;7(4):243-52. Review.

PMID:
16607287
46.

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover.

Duex JE, Tang F, Weisman LS.

J Cell Biol. 2006 Feb 27;172(5):693-704. Epub 2006 Feb 21.

47.

Structural basis for myosin V discrimination between distinct cargoes.

Pashkova N, Jin Y, Ramaswamy S, Weisman LS.

EMBO J. 2006 Feb 22;25(4):693-700. Epub 2006 Jan 26.

48.

A point mutation in the cargo-binding domain of myosin V affects its interaction with multiple cargoes.

Pashkova N, Catlett NL, Novak JL, Weisman LS.

Eukaryot Cell. 2005 Apr;4(4):787-98.

49.

Myosin V attachment to cargo requires the tight association of two functional subdomains.

Pashkova N, Catlett NL, Novak JL, Wu G, Lu R, Cohen RE, Weisman LS.

J Cell Biol. 2005 Jan 31;168(3):359-64.

50.

Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage.

Wang CW, Stromhaug PE, Kauffman EJ, Weisman LS, Klionsky DJ.

J Cell Biol. 2003 Dec 8;163(5):973-85.

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