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Items: 1 to 50 of 78


Modeling Human Cancer-induced Cachexia.

Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC.

Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016.


Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium.

Chung JH, Milani-Nejad N, Davis JP, Weisleder N, Whitson BA, Mohler PJ, Janssen PML.

Am J Physiol Heart Circ Physiol. 2019 Jul 26. doi: 10.1152/ajpheart.00163.2019. [Epub ahead of print]


Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.

Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S.

Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x.


Mineralocorticoid receptor antagonists improve membrane integrity independent of muscle force in muscular dystrophy.

Hauck JS, Lowe J, Rastogi N, McElhanon KE, Petrosino JM, Peczkowski KK, Chadwick AN, Zins JG, Accornero F, Janssen PML, Weisleder NL, Rafael-Fortney JA.

Hum Mol Genet. 2019 Jun 15;28(12):2030-2045. doi: 10.1093/hmg/ddz039.


A Murine Model of Myocardial Ischemia-Reperfusion Injury.

Xu Z, McElhanon KE, Beck EX, Weisleder N.

Methods Mol Biol. 2018;1717:145-153. doi: 10.1007/978-1-4939-7526-6_12.


Non-contrast estimation of diffuse myocardial fibrosis with dual energy CT: A phantom study.

Kumar V, McElhanon KE, Min JK, He X, Xu Z, Beck EX, Simonetti OP, Weisleder N, Raman SV.

J Cardiovasc Comput Tomogr. 2018 Jan - Feb;12(1):74-80. doi: 10.1016/j.jcct.2017.12.002. Epub 2017 Dec 5.


Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases.

Gushchina LV, Kwiatkowski TA, Bhattacharya S, Weisleder NL.

Pharmacol Ther. 2018 May;185:12-25. doi: 10.1016/j.pharmthera.2017.10.020. Epub 2017 Oct 31. Review.


High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and Repair.

Pathak-Sharma S, Zhang X, Lam JGT, Weisleder N, Seveau SM.

Front Cell Infect Microbiol. 2017 Jul 14;7:305. doi: 10.3389/fcimb.2017.00305. eCollection 2017.


Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B.

Gushchina LV, Bhattacharya S, McElhanon KE, Choi JH, Manring H, Beck EX, Alloush J, Weisleder N.

Mol Ther. 2017 Oct 4;25(10):2360-2371. doi: 10.1016/j.ymthe.2017.06.025. Epub 2017 Jul 3.


Targeted deletion of Kcne3 impairs skeletal muscle function in mice.

King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW.

FASEB J. 2017 Jul;31(7):2937-2947. doi: 10.1096/fj.201600965RR. Epub 2017 Mar 29.


Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.

Chadwick JA, Bhattacharya S, Lowe J, Weisleder N, Rafael-Fortney JA.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C155-C168. doi: 10.1152/ajpcell.00269.2016. Epub 2016 Nov 23.


Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction.

Zhao S, Xu Z, Wang H, Reese BE, Gushchina LV, Jiang M, Agarwal P, Xu J, Zhang M, Shen R, Liu Z, Weisleder N, He X.

Nat Commun. 2016 Oct 27;7:13306. doi: 10.1038/ncomms13306.


Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking.

Bhattacharya S, McElhanon KE, Gushchina LV, Weisleder N.

Life Sci. 2016 Dec 15;167:39-45. doi: 10.1016/j.lfs.2016.10.018. Epub 2016 Oct 17. Review.


Exercise-driven metabolic pathways in healthy cartilage.

Blazek AD, Nam J, Gupta R, Pradhan M, Perera P, Weisleder NL, Hewett TE, Chaudhari AM, Lee BS, Leblebicioglu B, Butterfield TA, Agarwal S.

Osteoarthritis Cartilage. 2016 Jul;24(7):1210-22. doi: 10.1016/j.joca.2016.02.004. Epub 2016 Feb 27.


Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.

Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP.

Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794.


Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis.

Blazek AD, Paleo BJ, Weisleder N.

Physiology (Bethesda). 2015 Nov;30(6):438-48. doi: 10.1152/physiol.00019.2015. Review.


Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.


Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.

Nam J, Perera P, Gordon R, Jeong YH, Blazek AD, Kim DG, Tee BC, Sun Z, Eubank TD, Zhao Y, Lablebecioglu B, Liu S, Litsky A, Weisleder NL, Lee BS, Butterfield T, Schneyer AL, Agarwal S.

Bone. 2015 Sep;78:62-70. doi: 10.1016/j.bone.2015.04.038. Epub 2015 Apr 30.


Sarcolipin overexpression improves muscle energetics and reduces fatigue.

Sopariwala DH, Pant M, Shaikh SA, Goonasekera SA, Molkentin JD, Weisleder N, Ma J, Pan Z, Periasamy M.

J Appl Physiol (1985). 2015 Apr 15;118(8):1050-8. doi: 10.1152/japplphysiol.01066.2014. Epub 2015 Feb 19.


Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury.

Liu J, Zhu H, Zheng Y, Xu Z, Li L, Tan T, Park KH, Hou J, Zhang C, Li D, Li R, Liu Z, Weisleder N, Zhu D, Lin P, Ma J.

J Mol Cell Cardiol. 2015 Mar;80:10-19. doi: 10.1016/j.yjmcc.2014.12.010. Epub 2014 Dec 20.


Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells.

Zhao S, Agarwal P, Rao W, Huang H, Zhang R, Liu Z, Yu J, Weisleder N, Zhang W, He X.

Integr Biol (Camb). 2014 Sep;6(9):874-84. doi: 10.1039/c4ib00100a.


Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.

Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, Wang Z, Yao Y, Li Y, Whitson BA, Duann P, Li H, Zhou X, Zhu H, Takeshima H, Hunter JC, McLeod RL, Weisleder N, Zeng C, Ma J.

Nat Commun. 2014 Jul 18;5:4387. doi: 10.1038/ncomms5387.


Expression levels of sarcolemmal membrane repair proteins following prolonged exercise training in mice.

Alloush J, Roof SR, Beck EX, Ziolo MT, Weisleder N.

Indian J Biochem Biophys. 2013 Oct;50(5):428-35.


Analysis of osmotic stress induced Ca2+ spark termination in mammalian skeletal muscle.

Ferrante C, Szappanos H, Csernoch L, Weisleder N.

Indian J Biochem Biophys. 2013 Oct;50(5):411-8.


A murine model of myocardial ischemia-reperfusion injury through ligation of the left anterior descending artery.

Xu Z, Alloush J, Beck E, Weisleder N.

J Vis Exp. 2014 Apr 10;(86). doi: 10.3791/51329.


Assessment of calcium sparks in intact skeletal muscle fibers.

Park KH, Weisleder N, Zhou J, Gumpper K, Zhou X, Duann P, Ma J, Lin PH.

J Vis Exp. 2014 Feb 24;(84):e50898. doi: 10.3791/50898.


Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.

Manring H, Abreu E, Brotto L, Weisleder N, Brotto M.

Front Physiol. 2014 Feb 18;5:37. doi: 10.3389/fphys.2014.00037. eCollection 2014. Review.


TRIM proteins in therapeutic membrane repair of muscular dystrophy.

Alloush J, Weisleder N.

JAMA Neurol. 2013 Jul;70(7):928-31. doi: 10.1001/jamaneurol.2013.469. Review.


A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.

Leon-Salas WD, Rizk H, Mo C, Weisleder N, Brotto L, Abreu E, Brotto M.

Recent Pat Biotechnol. 2013 Apr;7(1):71-81. Review.


Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

Tjondrokoesoemo A, Li N, Lin PH, Pan Z, Ferrante CJ, Shirokova N, Brotto M, Weisleder N, Ma J.

J Biol Chem. 2013 Jan 25;288(4):2103-9. doi: 10.1074/jbc.M112.425975. Epub 2012 Dec 5.


Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle.

Zhao X, Moloughney JG, Zhang S, Komazaki S, Weisleder N.

PLoS One. 2012;7(11):e49862. doi: 10.1371/journal.pone.0049862. Epub 2012 Nov 19.


Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications.

Moloughney JG, Weisleder N.

Recent Pat Biotechnol. 2012 Dec;6(3):200-11. Review.


Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.

Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J.

Sci Transl Med. 2012 Jun 20;4(139):139ra85. doi: 10.1126/scitranslmed.3003921.


Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters.

He B, Tang RH, Weisleder N, Xiao B, Yuan Z, Cai C, Zhu H, Lin P, Qiao C, Li J, Mayer C, Li J, Ma J, Xiao X.

Mol Ther. 2012 Apr;20(4):727-35. doi: 10.1038/mt.2012.5. Epub 2012 Feb 7.


Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair.

Lin P, Zhu H, Cai C, Wang X, Cao C, Xiao R, Pan Z, Weisleder N, Takeshima H, Ma J.

FASEB J. 2012 May;26(5):1875-83. doi: 10.1096/fj.11-188599. Epub 2012 Jan 17.


Detection of calcium sparks in intact and permeabilized skeletal muscle fibers.

Weisleder N, Zhou J, Ma J.

Methods Mol Biol. 2012;798:395-410. doi: 10.1007/978-1-61779-343-1_23.


Store-operated calcium entry is present in HL-1 cardiomyocytes and contributes to resting calcium.

Touchberry CD, Elmore CJ, Nguyen TM, Andresen JJ, Zhao X, Orange M, Weisleder N, Brotto M, Claycomb WC, Wacker MJ.

Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):45-50. doi: 10.1016/j.bbrc.2011.10.133. Epub 2011 Nov 6.


Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.

Tjondrokoesoemo A, Park KH, Ferrante C, Komazaki S, Lesniak S, Brotto M, Ko JK, Zhou J, Weisleder N, Ma J.

PLoS One. 2011;6(9):e25740. doi: 10.1371/journal.pone.0025740. Epub 2011 Sep 30.


Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling.

Yi J, Ma C, Li Y, Weisleder N, Ríos E, Ma J, Zhou J.

J Biol Chem. 2011 Sep 16;286(37):32436-43. doi: 10.1074/jbc.M110.217711. Epub 2011 Jul 27.


Visualization of MG53-mediated cell membrane repair using in vivo and in vitro systems.

Weisleder N, Lin P, Zhao X, Orange M, Zhu H, Ma J.

J Vis Exp. 2011 Jun 30;(52). pii: 2717. doi: 10.3791/2717.


Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

Thornton AM, Zhao X, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M.

Aging (Albany NY). 2011 Jun;3(6):621-34.


Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.

Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H.

Cell Res. 2011 Sep;21(9):1295-304. doi: 10.1038/cr.2011.81. Epub 2011 May 10.


Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.

Hwang M, Ko JK, Weisleder N, Takeshima H, Ma J.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C106-14. doi: 10.1152/ajpcell.00382.2010. Epub 2011 Apr 27.


A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice.

Ko JK, Choi KH, Zhao X, Komazaki S, Pan Z, Weisleder N, Ma J.

FASEB J. 2011 Aug;25(8):2638-49. doi: 10.1096/fj.11-181560. Epub 2011 Apr 25.


Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.

Waddell LB, Lemckert FA, Zheng XF, Tran J, Evesson FJ, Hawkes JM, Lek A, Street NE, Lin P, Clarke NF, Landstrom AP, Ackerman MJ, Weisleder N, Ma J, North KN, Cooper ST.

J Neuropathol Exp Neurol. 2011 Apr;70(4):302-13. doi: 10.1097/NEN.0b013e31821350b0.


Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair.

Zhu H, Lin P, De G, Choi KH, Takeshima H, Weisleder N, Ma J.

J Biol Chem. 2011 Apr 15;286(15):12820-4. doi: 10.1074/jbc.C111.221440. Epub 2011 Feb 22.


Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.

Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ.

Circ Heart Fail. 2011 Mar;4(2):214-23. doi: 10.1161/CIRCHEARTFAILURE.110.958694. Epub 2011 Jan 7.


Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms.

Ko JK, Choi KH, Peng J, He F, Zhang Z, Weisleder N, Lin J, Ma J.

J Biol Chem. 2011 Mar 18;286(11):9038-48. doi: 10.1074/jbc.M110.198457. Epub 2010 Dec 28.


Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression.

Zhao X, Min CK, Ko JK, Parness J, Kim DH, Weisleder N, Ma J.

Biophys J. 2010 Sep 8;99(5):1556-64. doi: 10.1016/j.bpj.2010.06.050.


MG53 constitutes a primary determinant of cardiac ischemic preconditioning.

Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP.

Circulation. 2010 Jun 15;121(23):2565-74. doi: 10.1161/CIRCULATIONAHA.110.954628. Epub 2010 Jun 1.


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