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Technical and diagnostic performance of a new fully automated immunoassay for the determination of intact fibroblast growth factor 23 (FGF23).

van Helden J, Weiskirchen R.

Scand J Clin Lab Invest. 2018 Oct 31:1-7. doi: 10.1080/00365513.2018.1526411. [Epub ahead of print]


An update on the recent advances in antifibrotic therapy.

Tacke F, Weiskirchen R.

Expert Rev Gastroenterol Hepatol. 2018 Sep 27:1-10. doi: 10.1080/17474124.2018.1530110. [Epub ahead of print]


Cross-method comparison of serum androstenedione measurement with respect to the validation of a new fully automated chemiluminescence immunoassay.

van Helden J, Weiskirchen R.

Clin Biochem. 2018 Sep 24. pii: S0009-9120(18)30456-9. doi: 10.1016/j.clinbiochem.2018.09.009. [Epub ahead of print]


Visfatin Serum Levels Predict Mortality in Critically Ill Patients.

Koch A, Weiskirchen R, Krusch A, Bruensing J, Buendgens L, Herbers U, Yagmur E, Koek GH, Trautwein C, Tacke F.

Dis Markers. 2018 Aug 26;2018:7315356. doi: 10.1155/2018/7315356. eCollection 2018.


Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.

Sonntag R, Giebeler N, Nevzorova YA, Bangen JM, Fahrenkamp D, Lambertz D, Haas U, Hu W, Gassler N, Cubero FJ, Müller-Newen G, Abdallah AT, Weiskirchen R, Ticconi F, Costa IG, Barbacid M, Trautwein C, Liedtke C.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9282-9287. doi: 10.1073/pnas.1807155115. Epub 2018 Aug 27.


Mining the Age-Dependent Reference Intervals of B Vitamins from Routine Laboratory Test Results.

Evliyaoglu O, van Helden J, Imöhl M, Weiskirchen R.

Lab Med. 2018 Aug 1. doi: 10.1093/labmed/lmy045. [Epub ahead of print]


High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients.

Koch A, Yagmur E, Linka J, Schumacher F, Bruensing J, Buendgens L, Herbers U, Koek GH, Weiskirchen R, Trautwein C, Tacke F.

Dis Markers. 2018 Jul 8;2018:8583121. doi: 10.1155/2018/8583121. eCollection 2018.


Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes.

Roderfeld M, Padem S, Lichtenberger J, Quack T, Weiskirchen R, Longerich T, Schramm G, Churin Y, Irungbam K, Tschuschner A, Windhorst A, Grevelding CG, Roeb E.

Hepatology. 2018 Jul 27. doi: 10.1002/hep.30192. [Epub ahead of print]


Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis.

Borkham-Kamphorst E, Steffen BT, van de Leur E, Haas U, Weiskirchen R.

Cell Signal. 2018 Nov;51:72-85. doi: 10.1016/j.cellsig.2018.07.005. Epub 2018 Jul 22.


Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts.

Weiskirchen R, Weiskirchen S, Tacke F.

F1000Res. 2018 Jun 27;7. pii: F1000 Faculty Rev-921. doi: 10.12688/f1000research.14841.1. eCollection 2018. Review.


Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients.

Koch A, Yagmur E, Hoss A, Buendgens L, Herbers U, Weiskirchen R, Koek GH, Trautwein C, Tacke F.

J Clin Lab Anal. 2018 Nov;32(9):e22614. doi: 10.1002/jcla.22614. Epub 2018 Jul 5.


Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications.

Weiskirchen R, Weiskirchen S, Tacke F.

Mol Aspects Med. 2018 Jun 26. pii: S0098-2997(18)30038-4. doi: 10.1016/j.mam.2018.06.003. [Epub ahead of print] Review.


High mobility group box 1 as a biomarker in critically ill patients.

Yagmur E, Buendgens L, Herbers U, Beeretz A, Weiskirchen R, Koek GH, Trautwein C, Tacke F, Koch A.

J Clin Lab Anal. 2018 Oct;32(8):e22584. doi: 10.1002/jcla.22584. Epub 2018 Jun 3.


Brain copper storage after genetic long-term correction in a mouse model of Wilson disease.

Uerlings R, Moreno D, Murillo O, Gazquez C, Hernández-Alcoceba R, González-Aseguinolaza G, Weiskirchen R.

Neurol Genet. 2018 May 18;4(3):e243. doi: 10.1212/NXG.0000000000000243. eCollection 2018 Jun. No abstract available.


N-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting.

Borkham-Kamphorst E, Van de Leur E, Meurer SK, Buhl EM, Weiskirchen R.

Front Pharmacol. 2018 Apr 25;9:426. doi: 10.3389/fphar.2018.00426. eCollection 2018.


The miR-371∼373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis.

Ullmann P, Rodriguez F, Schmitz M, Meurer SK, Qureshi-Baig K, Felten P, Ginolhac A, Antunes L, Frasquilho S, Zügel N, Weiskirchen R, Haan S, Letellier E.

Cancer Res. 2018 Jul 15;78(14):3793-3808. doi: 10.1158/0008-5472.CAN-17-3003. Epub 2018 May 10.


Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing.

Gauthier A, Fisch A, Seuwen K, Baumgarten B, Ruffner H, Aebi A, Rausch M, Kiessling F, Bartneck M, Weiskirchen R, Tacke F, Storm G, Lammers T, Ludwig MG.

Biomaterials. 2018 Sep;178:481-495. doi: 10.1016/j.biomaterials.2018.04.006. Epub 2018 Apr 5.


Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

Meurer SK, Weiskirchen R.

Front Pharmacol. 2018 Feb 12;9:98. doi: 10.3389/fphar.2018.00098. eCollection 2018.


SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice.

Jenkitkasemwong S, Akinyode A, Paulus E, Weiskirchen R, Hojyo S, Fukada T, Giraldo G, Schrier J, Garcia A, Janus C, Giasson B, Knutson MD.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778. doi: 10.1073/pnas.1720739115. Epub 2018 Feb 7. Erratum in: Proc Natl Acad Sci U S A. 2018 May 7;:.


Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry.

Moreno D, Murillo O, Gazquez C, Hernandez-Alcoceba R, Uerlings R, Gonzalez-Aseguinolaza G, Weiskirchen R.

J Hepatol. 2018 May;68(5):1088-1090. doi: 10.1016/j.jhep.2017.12.022. Epub 2018 Jan 6. No abstract available.


The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.

Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017.


Lipocalin-2 in Fructose-Induced Fatty Liver Disease.

Lambertz J, Berger T, Mak TW, van Helden J, Weiskirchen R.

Front Physiol. 2017 Nov 28;8:964. doi: 10.3389/fphys.2017.00964. eCollection 2017.


Combining GP73 with liver stiffness measurements: A proof-of-concept for non-invasive fibrosis assessment in antiviral-naïve HBV patients.

Weiskirchen R, Tacke F.

Liver Int. 2017 Nov;37(11):1605-1607. doi: 10.1111/liv.13563. No abstract available.


Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease.

Lambertz J, Weiskirchen S, Landert S, Weiskirchen R.

Front Immunol. 2017 Sep 19;8:1159. doi: 10.3389/fimmu.2017.01159. eCollection 2017. Review.


Endoglin in human liver disease and murine models of liver fibrosis-A protective factor against liver fibrosis.

Alsamman M, Sterzer V, Meurer SK, Sahin H, Schaeper U, Kuscuoglu D, Strnad P, Weiskirchen R, Trautwein C, Scholten D.

Liver Int. 2018 May;38(5):858-867. doi: 10.1111/liv.13595. Epub 2017 Oct 23.


Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis.

Krenkel O, Puengel T, Govaere O, Abdallah AT, Mossanen JC, Kohlhepp M, Liepelt A, Lefebvre E, Luedde T, Hellerbrand C, Weiskirchen R, Longerich T, Costa IG, Anstee QM, Trautwein C, Tacke F.

Hepatology. 2018 Apr;67(4):1270-1283. doi: 10.1002/hep.29544. Epub 2018 Feb 19.


ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death.

Rose M, Meurer SK, Kloten V, Weiskirchen R, Denecke B, Antonopoulos W, Deckert M, Knüchel R, Dahl E.

Mol Carcinog. 2018 Feb;57(2):167-181. doi: 10.1002/mc.22742. Epub 2017 Oct 30.


Non-equivalence of anti-Müllerian hormone automated assays-clinical implications for use as a companion diagnostic for individualised gonadotrophin dosing.

Iliodromiti S, Salje B, Dewailly D, Fairburn C, Fanchin R, Fleming R, Li HWR, Lukaszuk K, Ng EHY, Pigny P, Tadros T, van Helden J, Weiskirchen R, Nelson SM.

Hum Reprod. 2017 Aug 1;32(8):1710-1715. doi: 10.1093/humrep/dex219.


Isolation and Culture of Primary Murine Hepatic Stellate Cells.

Weiskirchen S, Tag CG, Sauer-Lehnen S, Tacke F, Weiskirchen R.

Methods Mol Biol. 2017;1627:165-191. doi: 10.1007/978-1-4939-7113-8_11.


False-negative results in the immunoassay analysis of drugs of abuse: can adulterants be detected by sample check test?

Matriciani B, Huppertz B, Keller R, Weiskirchen R.

Ann Clin Biochem. 2018 May;55(3):348-354. doi: 10.1177/0004563217725089. Epub 2017 Sep 20.


Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis.

Asimakopoulou A, Borkham-Kamphorst E, de Leur EV, Weiskirchen R.

Data Brief. 2017 Jul 1;13:644-649. doi: 10.1016/j.dib.2017.06.048. eCollection 2017 Aug.


Therapeutic targeting of the mitochondrial reactive oxygen species engine prevents portal hypertension and hepatic fibrogenesis.

Weiskirchen R.

Liver Int. 2017 Jul;37(7):963-965. doi: 10.1111/liv.13442. No abstract available.


Fast progression of liver damage in lysosomal acid lipase deficiency.

Weiskirchen R.

Curr Med Res Opin. 2017 Nov;33(11):2081-2083. doi: 10.1080/03007995.2017.1335193. Epub 2017 Jun 7. No abstract available.


Age-independent anti-Müllerian hormone (AMH) standard deviation scores to estimate ovarian function.

Helden JV, Weiskirchen R.

Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:64-70. doi: 10.1016/j.ejogrb.2017.04.029. Epub 2017 Apr 18.


Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis.

Asimakopoulou A, Fülöp A, Borkham-Kamphorst E, de Leur EV, Gassler N, Berger T, Beine B, Meyer HE, Mak TW, Hopf C, Henkel C, Weiskirchen R.

Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2093-2110. doi: 10.1016/j.bbadis.2017.04.006. Epub 2017 Apr 7.


ITIH5 mediates epigenetic reprogramming of breast cancer cells.

Rose M, Kloten V, Noetzel E, Gola L, Ehling J, Heide T, Meurer SK, Gaiko-Shcherbak A, Sechi AS, Huth S, Weiskirchen R, Klaas O, Antonopoulos W, Lin Q, Wagner W, Veeck J, Gremse F, Steitz J, Knüchel R, Dahl E.

Mol Cancer. 2017 Feb 23;16(1):44. doi: 10.1186/s12943-017-0610-2.


Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells.

Weiskirchen R, Tacke F.

Cell Mol Immunol. 2017 Feb;14(2):143-145. doi: 10.1038/cmi.2016.62. Epub 2016 Dec 26. No abstract available.


Latent TGF-β binding protein-1 deficiency decreases female fertility.

Dietzel E, Weiskirchen S, Floehr J, Horiguchi M, Todorovic V, Rifkin DB, Jahnen-Dechent W, Weiskirchen R.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1387-1392. doi: 10.1016/j.bbrc.2016.12.046. Epub 2016 Dec 9.


The CSRP2BP histone acetyltransferase drives smooth muscle gene expression.

Ma Y, Li Q, Li A, Wei Y, Long P, Jiang X, Sun F, Weiskirchen R, Wu B, Liang C, Grötzinger J, Wei Y, Yu W, Mercola M, Huang Y, Wang J, Yu Y, Schwartz RJ.

Nucleic Acids Res. 2017 Apr 7;45(6):3046-3058. doi: 10.1093/nar/gkw1227.


Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes.

Dietzel E, Floehr J, Van de Leur E, Weiskirchen R, Jahnen-Dechent W.

Mol Hum Reprod. 2017 Jan;23(1):25-33. doi: 10.1093/molehr/gaw067. Epub 2016 Oct 12.


Zinc supplementation augments TGF-β1-dependent regulatory T cell induction.

Maywald M, Meurer SK, Weiskirchen R, Rink L.

Mol Nutr Food Res. 2017 Mar;61(3). doi: 10.1002/mnfr.201600493. Epub 2016 Nov 30.


Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy.

Asimakopoulou A, Weiskirchen S, Weiskirchen R.

Front Physiol. 2016 Sep 27;7:430. eCollection 2016. Review.


Exercise-Induced Release of Pharmacologically Active Substances and Their Relevance for Therapy of Hepatic Injury.

Schon HT, Weiskirchen R.

Front Pharmacol. 2016 Aug 30;7:283. doi: 10.3389/fphar.2016.00283. eCollection 2016. Review.


Relevance of serum sclerostin concentrations in critically ill patients.

Koch A, Weiskirchen R, Ludwig S, Buendgens L, Bruensing J, Yagmur E, Baeck C, Herbers U, Trautwein C, Tacke F.

J Crit Care. 2017 Feb;37:38-44. doi: 10.1016/j.jcrc.2016.08.019. Epub 2016 Aug 22.


Editorial: Liver Myofibroblasts.

Kanta J, Mrkvicová A, Weiskirchen R.

Front Physiol. 2016 Aug 5;7:343. doi: 10.3389/fphys.2016.00343. eCollection 2016. No abstract available.


Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response.

Borkham-Kamphorst E, Steffen BT, Van de Leur E, Tihaa L, Haas U, Woitok MM, Meurer SK, Weiskirchen R.

Biochim Biophys Acta. 2016 Nov;1863(11):2604-2612. doi: 10.1016/j.bbamcr.2016.07.006. Epub 2016 Jul 22.


Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?

Weiskirchen S, Weiskirchen R.

Adv Nutr. 2016 Jul 15;7(4):706-18. doi: 10.3945/an.115.011627. Print 2016 Jul. Review.


IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.

Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11.


Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice.

Meurer SK, Neß M, Weiskirchen S, Kim P, Tag CG, Kauffmann M, Huber M, Weiskirchen R.

PLoS One. 2016 Jun 23;11(6):e0158104. doi: 10.1371/journal.pone.0158104. eCollection 2016.

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