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Items: 44

1.

Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.

Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA.

Life Sci Alliance. 2019 May 27;2(3). pii: e201900328. doi: 10.26508/lsa.201900328. Print 2019 Jun.

2.

Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors Through TGF-β1.

Sippel TR, Johnson AM, Li HY, Hanson D, Nguyen TT, Bullock BL, Poczobutt JM, Kwak JW, Kleczko EK, Weiser-Evans MC, Nemenoff RA.

Mol Cancer Res. 2019 May 14. pii: molcanres.0236.2019. doi: 10.1158/1541-7786.MCR-19-0236. [Epub ahead of print]

PMID:
31088909
3.

CD8+ T cells modulate autosomal dominant polycystic kidney disease progression.

Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K.

Kidney Int. 2018 Dec;94(6):1127-1140. doi: 10.1016/j.kint.2018.06.025. Epub 2018 Sep 21.

4.

Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support.

Ambardekar AV, Weiser-Evans MCM, Li M, Purohit SN, Aftab M, Reece TB, Moulton KS.

Circ Heart Fail. 2018 May;11(5):e004491. doi: 10.1161/CIRCHEARTFAILURE.117.004491.

5.

Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.

Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA.

Oncoimmunology. 2018 Feb 13;7(5):e1423182. doi: 10.1080/2162402X.2017.1423182. eCollection 2018.

6.

PTEN deficiency promotes pathological vascular remodeling of human coronary arteries.

Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC.

JCI Insight. 2018 Feb 22;3(4). pii: 97228. doi: 10.1172/jci.insight.97228. eCollection 2018 Feb 22.

7.

Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA.

Cancer Res. 2018 Jan 1;78(1):143-156. doi: 10.1158/0008-5472.CAN-17-0240. Epub 2017 Nov 8.

8.

IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer.

Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff R, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL.

Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F356-F366. doi: 10.1152/ajprenal.00040.2017. Epub 2017 Oct 25.

9.

Smooth Muscle Differentiation Control Comes Full Circle: The Circular Noncoding RNA, circActa2, Functions as a miRNA Sponge to Fine-Tune α-SMA Expression.

Weiser-Evans MCM.

Circ Res. 2017 Sep 1;121(6):591-593. doi: 10.1161/CIRCRESAHA.117.311722. No abstract available.

10.

The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade.

Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA.

Cancer Immunol Res. 2017 Sep;5(9):767-777. doi: 10.1158/2326-6066.CIR-16-0365. Epub 2017 Aug 17.

11.

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4.

Majesky MW, Horita H, Ostriker A, Lu S, Regan JN, Bagchi A, Dong XR, Poczobutt J, Nemenoff RA, Weiser-Evans MC.

Circ Res. 2017 Jan 20;120(2):296-311. doi: 10.1161/CIRCRESAHA.116.309322. Epub 2016 Nov 9.

12.

Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells.

Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Prostaglandins Other Lipid Mediat. 2016 Nov;126:1-8. doi: 10.1016/j.prostaglandins.2016.08.001. Epub 2016 Aug 21.

13.

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation.

Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC.

Nat Commun. 2016 Mar 4;7:10830. doi: 10.1038/ncomms10830.

14.

Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer.

Poczobutt JM, De S, Yadav VK, Nguyen TT, Li H, Sippel TR, Weiser-Evans MC, Nemenoff RA.

J Immunol. 2016 Mar 15;196(6):2847-59. doi: 10.4049/jimmunol.1502364. Epub 2016 Feb 12.

15.

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.

Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA.

J Immunol. 2016 Jan 15;196(2):891-901. doi: 10.4049/jimmunol.1501648. Epub 2015 Dec 11.

16.

CD4 T cell knockout does not protect against kidney injury and worsens cancer.

Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL.

J Mol Med (Berl). 2016 Apr;94(4):443-55. doi: 10.1007/s00109-015-1366-z. Epub 2015 Dec 1.

PMID:
26620676
17.

Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy.

Roe ND, Xu X, Kandadi MR, Hu N, Pang J, Weiser-Evans MC, Ren J.

Biochim Biophys Acta. 2015 Feb;1852(2):290-8. doi: 10.1016/j.bbadis.2014.09.002. Epub 2014 Sep 16.

18.

Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.

Lehman AM, Montford JR, Horita H, Ostriker AC, Weiser-Evans MC, Nemenoff RA, Furgeson SB.

Mol Pharmacol. 2014 Nov;86(5):570-9. doi: 10.1124/mol.114.092163. Epub 2014 Aug 28.

19.

Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma.

Marek LA, Hinz TK, von Mässenhausen A, Olszewski KA, Kleczko EK, Boehm D, Weiser-Evans MC, Nemenoff RA, Hoffmann H, Warth A, Gozgit JM, Perner S, Heasley LE.

Mol Cancer Res. 2014 Oct;12(10):1460-9. doi: 10.1158/1541-7786.MCR-14-0038. Epub 2014 Jun 25.

20.

Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages.

Ostriker A, Horita HN, Poczobutt J, Weiser-Evans MC, Nemenoff RA.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):877-86. doi: 10.1161/ATVBAHA.114.303214. Epub 2014 Feb 13.

21.

Inhibition of mammalian target of rapamycin with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN.

Xu X, Roe ND, Weiser-Evans MC, Ren J.

Hypertension. 2014 Apr;63(4):729-39. doi: 10.1161/HYPERTENSIONAHA.113.02526. Epub 2014 Jan 20. Erratum in: Hypertension. 2016 Mar;67(3):e5.

PMID:
24446058
22.

Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension.

Horita H, Furgeson SB, Ostriker A, Olszewski KA, Sullivan T, Villegas LR, Levine M, Parr JE, Cool CD, Nemenoff RA, Weiser-Evans MC.

J Am Heart Assoc. 2013 May 31;2(3):e000188. doi: 10.1161/JAHA.113.000188.

23.

Smooth muscle cell plasticity: fact or fiction?

Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK.

Circ Res. 2013 Jan 4;112(1):17-22. doi: 10.1161/CIRCRESAHA.112.281048. Epub 2012 Oct 23. No abstract available.

24.

Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword.

Li H, Weiser-Evans MC, Nemenoff R.

PPAR Res. 2012;2012:362085. doi: 10.1155/2012/362085. Epub 2012 Aug 12.

25.

Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.

Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA.

Circ Res. 2012 Mar 2;110(5):739-48. doi: 10.1161/CIRCRESAHA.111.258426. Epub 2012 Jan 26.

26.

Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Li H, Sorenson AL, Poczobutt J, Amin J, Joyal T, Sullivan T, Crossno JT Jr, Weiser-Evans MC, Nemenoff RA.

PLoS One. 2011;6(12):e28133. doi: 10.1371/journal.pone.0028133. Epub 2011 Dec 1.

27.

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.

Horita HN, Simpson PA, Ostriker A, Furgeson S, Van Putten V, Weiser-Evans MC, Nemenoff RA.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2909-19. doi: 10.1161/ATVBAHA.111.233585. Epub 2011 Sep 22.

28.

Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice.

Andrés-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff R, He Z, Ishimoto T, Simpson PA, Weiser-Evans MC, Bacalja J, Faubel S.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F907-16. doi: 10.1152/ajprenal.00107.2011. Epub 2011 Jun 15.

29.

SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.

Nemenoff RA, Horita H, Ostriker AC, Furgeson SB, Simpson PA, VanPutten V, Crossno J, Offermanns S, Weiser-Evans MC.

Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1300-8. doi: 10.1161/ATVBAHA.111.223701. Epub 2011 Mar 17.

30.
31.

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.

Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC.

Cardiovasc Res. 2010 May 1;86(2):274-82. doi: 10.1093/cvr/cvp425. Epub 2010 Jan 5.

32.

Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.

Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA.

Cancer Res. 2009 Mar 1;69(5):1733-8. doi: 10.1158/0008-5472.CAN-08-3766. Epub 2009 Feb 10.

33.

Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.

Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC.

Circ Res. 2008 May 9;102(9):1036-45. doi: 10.1161/CIRCRESAHA.107.169896. Epub 2008 Mar 13.

PMID:
18340011
34.

Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.

Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC.

Circ Res. 2006 Mar 31;98(6):846-55. Epub 2006 Feb 16.

PMID:
16484612
35.

Depletion of serum response factor by RNA interference mimics the mitogenic effects of platelet derived growth factor-BB in vascular smooth muscle cells.

Kaplan-Albuquerque N, Van Putten V, Weiser-Evans MC, Nemenoff RA.

Circ Res. 2005 Sep 2;97(5):427-33. Epub 2005 Aug 4.

PMID:
16081871
36.
37.

Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.

Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MC.

Circulation. 2004 Mar 16;109(10):1299-306. Epub 2004 Mar 1.

PMID:
14993145
38.

Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN.

Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC.

Circ Res. 2004 Feb 6;94(2):175-83. Epub 2003 Dec 1.

PMID:
14656929
39.

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling.

Walker HA, Whitelock JM, Garl PJ, Nemenoff RA, Stenmark KR, Weiser-Evans MC.

Mol Biol Cell. 2003 May;14(5):1941-52. Epub 2003 Jan 26.

40.

Changes in perlecan expression during vascular injury: role in the inhibition of smooth muscle cell proliferation in the late lesion.

Kinsella MG, Tran PK, Weiser-Evans MC, Reidy M, Majack RA, Wight TN.

Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):608-14. Epub 2003 Feb 27.

PMID:
12615671
41.

Novel embryonic genes are preferentially expressed by autonomously replicating rat embryonic and neointimal smooth muscle cells.

Weiser-Evans MC, Schwartz PE, Grieshaber NA, Quinn BE, Grieshaber SS, Belknap JK, Mourani PM, Majack RA, Stenmark KR.

Circ Res. 2000 Sep 29;87(7):608-15.

PMID:
11009567
42.

Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury.

Weiser-Evans MC, Quinn BE, Burkard MR, Stenmark KR.

J Cell Physiol. 2000 Jan;182(1):12-23.

PMID:
10567912
43.

Special communicationthe critical role of mechanical forces in blood vessel development, physiology and pathology

Gimbrone MA Jr, Anderson KR, Topper JN, Langille BL, Clowes AW, Bercel S, Davies MG, Stenmark KR, Frid MG, Weiser-Evans MC, Aldashev AA, Nemenoff RA, Majesky MW, Landerholm TE, Lu J, Ito WD, Arras M, Scholz D, Imhof B, Aurrand-Lions M, Schaper W, Nagel TE, Resnick N, Dewey CF, Gimbrone MA, Davies PF.

J Vasc Surg. 1999 Jun;29(6):1104-51.

PMID:
10359945
44.

Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature.

Belknap JK, Weiser-Evans MC, Grieshaber SS, Majack RA, Stenmark KR.

Am J Respir Cell Mol Biol. 1999 Jan;20(1):24-34.

PMID:
9870914

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