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Identification of Pneumococcal Factors Affecting Pneumococcal Shedding Shows that the dlt Locus Promotes Inflammation and Transmission.

Zafar MA, Hammond AJ, Hamaguchi S, Wu W, Kono M, Zhao L, Weiser JN.

MBio. 2019 Jun 18;10(3). pii: e01032-19. doi: 10.1128/mBio.01032-19.


Immediate pre-learning stress enhances baseline startle response and fear acquisition in a fear-potentiated startle paradigm.

Riggenbach MR, Weiser JN, Mosley BE, Hipskind JJ, Wireman LE, Hess KL, Duffy TJ, Handel JK, Kaschalk MG, Reneau KE, Rorabaugh BR, Norrholm SD, Jovanovic T, Zoladz PR.

Behav Brain Res. 2019 Oct 3;371:111980. doi: 10.1016/j.bbr.2019.111980. Epub 2019 May 27.


Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.

Lees JA, Ferwerda B, Kremer PHC, Wheeler NE, Serón MV, Croucher NJ, Gladstone RA, Bootsma HJ, Rots NY, Wijmega-Monsuur AJ, Sanders EAM, Trzciński K, Wyllie AL, Zwinderman AH, van den Berg LH, van Rheenen W, Veldink JH, Harboe ZB, Lundbo LF, de Groot LCPGM, van Schoor NM, van der Velde N, Ängquist LH, Sørensen TIA, Nohr EA, Mentzer AJ, Mills TC, Knight JC, du Plessis M, Nzenze S, Weiser JN, Parkhill J, Madhi S, Benfield T, von Gottberg A, van der Ende A, Brouwer MC, Barrett JC, Bentley SD, van de Beek D.

Nat Commun. 2019 May 15;10(1):2176. doi: 10.1038/s41467-019-09976-3.


Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by Streptococcus pneumoniae.

Wang Y, Li Y, Zhang P, Baker ST, Wolfson MR, Weiser JN, Tian Y, Shen H.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8493-8498. doi: 10.1073/pnas.1818522116. Epub 2019 Apr 10.


Fast and flexible bacterial genomic epidemiology with PopPUNK.

Lees JA, Harris SR, Tonkin-Hill G, Gladstone RA, Lo SW, Weiser JN, Corander J, Bentley SD, Croucher NJ.

Genome Res. 2019 Feb;29(2):304-316. doi: 10.1101/gr.241455.118. Epub 2019 Jan 24.


Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.

Copin R, Sause WE, Fulmer Y, Balasubramanian D, Dyzenhaus S, Ahmed JM, Kumar K, Lees J, Stachel A, Fisher JC, Drlica K, Phillips M, Weiser JN, Planet PJ, Uhlemann AC, Altman DR, Sebra R, van Bakel H, Lighter J, Torres VJ, Shopsin B.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1745-1754. doi: 10.1073/pnas.1814265116. Epub 2019 Jan 11. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 25;:.


Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.

Shen P, Lees JA, Bee GCW, Brown SP, Weiser JN.

Nat Microbiol. 2019 Jan;4(1):198-208. doi: 10.1038/s41564-018-0314-4. Epub 2018 Dec 10.


pyseer: a comprehensive tool for microbial pangenome-wide association studies.

Lees JA, Galardini M, Bentley SD, Weiser JN, Corander J.

Bioinformatics. 2018 Dec 15;34(24):4310-4312. doi: 10.1093/bioinformatics/bty539.


Age-related differences in IL-1 signaling and capsule serotype affect persistence of Streptococcus pneumoniae colonization.

Kuipers K, Lokken KL, Zangari T, Boyer MA, Shin S, Weiser JN.

PLoS Pathog. 2018 Oct 31;14(10):e1007396. doi: 10.1371/journal.ppat.1007396. eCollection 2018 Oct.


Streptococcus pneumoniae: transmission, colonization and invasion.

Weiser JN, Ferreira DM, Paton JC.

Nat Rev Microbiol. 2018 Jun;16(6):355-367. doi: 10.1038/s41579-018-0001-8. Review.


Capsule Prolongs Survival of Streptococcus pneumoniae during Starvation.

Hamaguchi S, Zafar MA, Cammer M, Weiser JN.

Infect Immun. 2018 Feb 20;86(3). pii: e00802-17. doi: 10.1128/IAI.00802-17. Print 2018 Mar.


The immunological mechanisms that control pneumococcal carriage.

Jochems SP, Weiser JN, Malley R, Ferreira DM.

PLoS Pathog. 2017 Dec 21;13(12):e1006665. doi: 10.1371/journal.ppat.1006665. eCollection 2017 Dec. Review.


The neonatal window of opportunity-early priming for life.

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW.

J Allergy Clin Immunol. 2018 Apr;141(4):1212-1214. doi: 10.1016/j.jaci.2017.11.019. Epub 2017 Dec 14. No abstract available.


Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae.

Zafar MA, Hamaguchi S, Zangari T, Cammer M, Weiser JN.

MBio. 2017 Aug 22;8(4). pii: e00989-17. doi: 10.1128/mBio.00989-17.


Streptococcus pneumoniae Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model.

Zangari T, Wang Y, Weiser JN.

MBio. 2017 Mar 14;8(2). pii: e00188-17. doi: 10.1128/mBio.00188-17.


Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.

Zafar MA, Wang Y, Hamaguchi S, Weiser JN.

Cell Host Microbe. 2017 Jan 11;21(1):73-83. doi: 10.1016/j.chom.2016.12.005.


Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae.

Kono M, Zafar MA, Zuniga M, Roche AM, Hamaguchi S, Weiser JN.

PLoS Pathog. 2016 Oct 12;12(10):e1005887. doi: 10.1371/journal.ppat.1005887. eCollection 2016 Oct.


Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage.

Mitsi E, Roche AM, Reiné J, Zangari T, Owugha JT, Pennington SH, Gritzfeld JF, Wright AD, Collins AM, van Selm S, de Jonge MI, Gordon SB, Weiser JN, Ferreira DM.

Mucosal Immunol. 2017 Mar;10(2):385-394. doi: 10.1038/mi.2016.71. Epub 2016 Aug 31.


Infant Mouse Model for the Study of Shedding and Transmission during Streptococcus pneumoniae Monoinfection.

Zafar MA, Kono M, Wang Y, Zangari T, Weiser JN.

Infect Immun. 2016 Aug 19;84(9):2714-22. doi: 10.1128/IAI.00416-16. Print 2016 Sep.


Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection.

Wang Y, Jiang B, Guo Y, Li W, Tian Y, Sonnenberg GF, Weiser JN, Ni X, Shen H.

Mucosal Immunol. 2017 Jan;10(1):250-259. doi: 10.1038/mi.2016.41. Epub 2016 Apr 27.


Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.

Hergott CB, Roche AM, Tamashiro E, Clarke TB, Bailey AG, Laughlin A, Bushman FD, Weiser JN.

Blood. 2016 May 19;127(20):2460-71. doi: 10.1182/blood-2015-10-675173. Epub 2016 Mar 17.


Mechanisms of Bacterial Colonization of the Respiratory Tract.

Siegel SJ, Weiser JN.

Annu Rev Microbiol. 2015;69:425-44. doi: 10.1146/annurev-micro-091014-104209. Review.


Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.

Hergott CB, Roche AM, Naidu NA, Mesaros C, Blair IA, Weiser JN.

J Clin Invest. 2015 Oct 1;125(10):3878-90. doi: 10.1172/JCI81888. Epub 2015 Aug 31.


Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.

Siegel SJ, Tamashiro E, Weiser JN.

PLoS Pathog. 2015 Jun 24;11(6):e1005004. doi: 10.1371/journal.ppat.1005004. eCollection 2015 Jun.


Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance.

Lemon JK, Miller MR, Weiser JN.

Infect Immun. 2015 Aug;83(8):3204-12. doi: 10.1128/IAI.00224-15. Epub 2015 Jun 1.


Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation.

Weiser JN, Roche AM, Hergott CB, LaRose MI, Connolly T, Jorgensen WL, Leng L, Bucala R, Das R.

J Infect Dis. 2015 Nov 15;212(10):1677-82. doi: 10.1093/infdis/jiv262. Epub 2015 May 5.


Degradation products of the extracellular pathogen Streptococcus pneumoniae access the cytosol via its pore-forming toxin.

Lemon JK, Weiser JN.

MBio. 2015 Jan 20;6(1). pii: e02110-14. doi: 10.1128/mBio.02110-14.


Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA.

Singh AK, Pluvinage B, Higgins MA, Dalia AB, Woodiga SA, Flynn M, Lloyd AR, Weiser JN, Stubbs KA, Boraston AB, King SJ.

PLoS Pathog. 2014 Sep 11;10(9):e1004364. doi: 10.1371/journal.ppat.1004364. eCollection 2014 Sep.


TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.

Richard AL, Siegel SJ, Erikson J, Weiser JN.

PLoS Pathog. 2014 Aug 28;10(8):e1004339. doi: 10.1371/journal.ppat.1004339. eCollection 2014 Aug.


Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus.

Wolf AI, Strauman MC, Mozdzanowska K, Whittle JR, Williams KL, Sharpe AH, Weiser JN, Caton AJ, Hensley SE, Erikson J.

J Virol. 2014 Oct;88(20):11995-2005. doi: 10.1128/JVI.01833-14. Epub 2014 Aug 6.


Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance.

Langereis JD, de Jonge MI, Weiser JN.

Mol Microbiol. 2014 Oct;94(1):89-106. doi: 10.1111/mmi.12741. Epub 2014 Aug 18.


Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

Siegel SJ, Roche AM, Weiser JN.

Cell Host Microbe. 2014 Jul 9;16(1):55-67. doi: 10.1016/j.chom.2014.06.005.


Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.

Wolf AI, Strauman MC, Mozdzanowska K, Williams KL, Osborne LC, Shen H, Liu Q, Garlick D, Artis D, Hensley SE, Caton AJ, Weiser JN, Erikson J.

Virology. 2014 Aug;462-463:254-65. doi: 10.1016/j.virol.2014.06.019. Epub 2014 Jul 5.


Antibody blocks acquisition of bacterial colonization through agglutination.

Roche AM, Richard AL, Rahkola JT, Janoff EN, Weiser JN.

Mucosal Immunol. 2015 Jan;8(1):176-85. doi: 10.1038/mi.2014.55. Epub 2014 Jun 25.


Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization.

Das R, LaRose MI, Hergott CB, Leng L, Bucala R, Weiser JN.

J Immunol. 2014 Jul 15;193(2):764-72. doi: 10.4049/jimmunol.1400133. Epub 2014 Jun 13.


Tolerance of a phage element by Streptococcus pneumoniae leads to a fitness defect during colonization.

DeBardeleben HK, Lysenko ES, Dalia AB, Weiser JN.

J Bacteriol. 2014 Jul;196(14):2670-80. doi: 10.1128/JB.01556-14. Epub 2014 May 9.


The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.

Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS.

Nat Med. 2014 May;20(5):524-30. doi: 10.1038/nm.3542. Epub 2014 Apr 20.


Pneumococcal IgA1 protease subverts specific protection by human IgA1.

Janoff EN, Rubins JB, Fasching C, Charboneau D, Rahkola JT, Plaut AG, Weiser JN.

Mucosal Immunol. 2014 Mar;7(2):249-56. doi: 10.1038/mi.2013.41. Epub 2013 Jul 3.


Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells.

Jen FE, Warren MJ, Schulz BL, Power PM, Swords WE, Weiser JN, Apicella MA, Edwards JL, Jennings MP.

PLoS Pathog. 2013;9(5):e1003377. doi: 10.1371/journal.ppat.1003377. Epub 2013 May 16.


Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae.

Clark SE, Eichelberger KR, Weiser JN.

Mol Microbiol. 2013 May;88(3):603-18. doi: 10.1111/mmi.12214. Epub 2013 Apr 12.


The battle with the host over microbial size.

Weiser JN.

Curr Opin Microbiol. 2013 Feb;16(1):59-62. doi: 10.1016/j.mib.2013.01.001. Epub 2013 Feb 8. Review.


Microbial modulation of host immunity with the small molecule phosphorylcholine.

Clark SE, Weiser JN.

Infect Immun. 2013 Feb;81(2):392-401. doi: 10.1128/IAI.01168-12. Epub 2012 Dec 10. Review.


MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.

Dorrington MG, Roche AM, Chauvin SE, Tu Z, Mossman KL, Weiser JN, Bowdish DM.

J Immunol. 2013 Jan 1;190(1):250-8. doi: 10.4049/jimmunol.1202113. Epub 2012 Nov 28.


Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia.

Bachman MA, Lenio S, Schmidt L, Oyler JE, Weiser JN.

MBio. 2012 Nov 20;3(6). pii: e00224-11. doi: 10.1128/mBio.00224-11.


Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine.

Mukerji R, Mirza S, Roche AM, Widener RW, Croney CM, Rhee DK, Weiser JN, Szalai AJ, Briles DE.

J Immunol. 2012 Dec 1;189(11):5327-35. doi: 10.4049/jimmunol.1201967. Epub 2012 Oct 26.


Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase.

Lijek RS, Luque SL, Liu Q, Parker D, Bae T, Weiser JN.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13823-8. doi: 10.1073/pnas.1208075109. Epub 2012 Aug 6.


Increased chain length promotes pneumococcal adherence and colonization.

Rodriguez JL, Dalia AB, Weiser JN.

Infect Immun. 2012 Oct;80(10):3454-9. doi: 10.1128/IAI.00587-12. Epub 2012 Jul 23.


Co-infection subverts mucosal immunity in the upper respiratory tract.

Lijek RS, Weiser JN.

Curr Opin Immunol. 2012 Aug;24(4):417-23. doi: 10.1016/j.coi.2012.05.005. Epub 2012 Jun 2. Review.

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