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Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination.

Ufimtsev IS, Almagor L, Weis WI, Levitt M.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10819-10823. doi: 10.1073/pnas.1821513116. Epub 2019 May 14.


Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.

Almagor L, Ufimtsev IS, Ayer A, Li J, Weis WI.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10804-10812. doi: 10.1073/pnas.1821514116. Epub 2019 May 14.


Resolving indexing ambiguities in X-ray free-electron laser diffraction patterns.

Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Weis WI, Brunger AT.

Acta Crystallogr D Struct Biol. 2019 Feb 1;75(Pt 2):234-241. doi: 10.1107/S2059798318013177. Epub 2019 Feb 6.


Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.


Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.


Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.

Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 Jan 10.


Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.


Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Erratum in: Nat Chem Biol. 2019 Feb;15(2):205.


The Molecular Basis of G Protein-Coupled Receptor Activation.

Weis WI, Kobilka BK.

Annu Rev Biochem. 2018 Jun 20;87:897-919. doi: 10.1146/annurev-biochem-060614-033910. Review.


Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.


Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution.

Miller PW, Pokutta S, Mitchell JM, Chodaparambil JV, Clarke DN, Nelson WJ, Weis WI, Nichols SA.

J Biol Chem. 2018 Jul 27;293(30):11674-11686. doi: 10.1074/jbc.RA117.001325. Epub 2018 Jun 7.


Epithelial barrier dysfunction in desmoglein-1 deficiency.

Polivka L, Hadj-Rabia S, Bal E, Leclerc-Mercier S, Madrange M, Hamel Y, Bonnet D, Mallet S, Lepidi H, Ovaert C, Barbet P, Dupont C, Neven B, Munnich A, Godsel LM, Campeotto F, Weil R, Laplantine E, Marchetto S, Borg JP, Weis WI, Casanova JL, Puel A, Green KJ, Bodemer C, Smahi A.

J Allergy Clin Immunol. 2018 Aug;142(2):702-706.e7. doi: 10.1016/j.jaci.2018.04.007. Epub 2018 Apr 27. No abstract available.


Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin-binding interface.

Shao X, Kang H, Loveless T, Lee GR, Seok C, Weis WI, Choi HJ, Hardin J.

J Biol Chem. 2017 Oct 6;292(40):16477-16490. doi: 10.1074/jbc.M117.795567. Epub 2017 Aug 25.


Vinculin forms a directionally asymmetric catch bond with F-actin.

Huang DL, Bax NA, Buckley CD, Weis WI, Dunn AR.

Science. 2017 Aug 18;357(6352):703-706. doi: 10.1126/science.aan2556.


Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK.

Nature. 2017 Aug 24;548(7668):480-484. doi: 10.1038/nature23652. Epub 2017 Aug 16.


Mechanism of pathogen recognition by human dectin-2.

Feinberg H, Jégouzo SAF, Rex MJ, Drickamer K, Weis WI, Taylor ME.

J Biol Chem. 2017 Aug 11;292(32):13402-13414. doi: 10.1074/jbc.M117.799080. Epub 2017 Jun 26.


Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.

Kang H, Bang I, Jin KS, Lee B, Lee J, Shao X, Heier JA, Kwiatkowski AV, Nelson WJ, Hardin J, Weis WI, Choi HJ.

J Biol Chem. 2017 Apr 28;292(17):7077-7086. doi: 10.1074/jbc.M116.769778. Epub 2017 Mar 15.


Structure of photosystem II and substrate binding at room temperature.

Young ID, Ibrahim M, Chatterjee R, Gul S, Fuller F, Koroidov S, Brewster AS, Tran R, Alonso-Mori R, Kroll T, Michels-Clark T, Laksmono H, Sierra RG, Stan CA, Hussein R, Zhang M, Douthit L, Kubin M, de Lichtenberg C, Long Vo P, Nilsson H, Cheah MH, Shevela D, Saracini C, Bean MA, Seuffert I, Sokaras D, Weng TC, Pastor E, Weninger C, Fransson T, Lassalle L, Bräuer P, Aller P, Docker PT, Andi B, Orville AM, Glownia JM, Nelson S, Sikorski M, Zhu D, Hunter MS, Lane TJ, Aquila A, Koglin JE, Robinson J, Liang M, Boutet S, Lyubimov AY, Uervirojnangkoorn M, Moriarty NW, Liebschner D, Afonine PV, Waterman DG, Evans G, Wernet P, Dobbek H, Weis WI, Brunger AT, Zwart PH, Adams PD, Zouni A, Messinger J, Bergmann U, Sauter NK, Kern J, Yachandra VK, Yano J.

Nature. 2016 Dec 15;540(7633):453-457. doi: 10.1038/nature20161. Epub 2016 Nov 21.


Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.

Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Zhou Q, Zhao M, Brewster AS, Michels-Clark T, Holton JM, Sauter NK, Weis WI, Brunger AT.

Elife. 2016 Oct 12;5. pii: e18740. doi: 10.7554/eLife.18740.


Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle.

Feinberg H, Rambaruth ND, Jégouzo SA, Jacobsen KM, Djurhuus R, Poulsen TB, Weis WI, Taylor ME, Drickamer K.

J Biol Chem. 2016 Sep 30;291(40):21222-21233. Epub 2016 Aug 19.


Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.


IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images.

Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Murray TD, Sauter NK, Berger JM, Weis WI, Brunger AT.

J Appl Crystallogr. 2016 May 11;49(Pt 3):1057-1064. eCollection 2016 Jun 1.


Characterization of the Cadherin-Catenin Complex of the Sea Anemone Nematostella vectensis and Implications for the Evolution of Metazoan Cell-Cell Adhesion.

Clarke DN, Miller PW, Lowe CJ, Weis WI, Nelson WJ.

Mol Biol Evol. 2016 Aug;33(8):2016-29. doi: 10.1093/molbev/msw084. Epub 2016 Apr 28.


25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details.

Nelson WJ, Weis WI.

Trends Cell Biol. 2016 Jul;26(7):471-473. doi: 10.1016/j.tcb.2016.04.010. Epub 2016 May 7.


Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.

Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A.

Nature. 2016 Mar 17;531(7594):335-40. doi: 10.1038/nature17188. Epub 2016 Mar 9.


Purification, crystallization and initial crystallographic analysis of the α-catenin homologue HMP-1 from Caenorhabditis elegans.

Kang H, Bang I, Weis WI, Choi HJ.

Acta Crystallogr F Struct Biol Commun. 2016 Mar;72(Pt 3):234-9. doi: 10.1107/S2053230X16001862. Epub 2016 Feb 19.


High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1.


Structure of the Intermediate Filament-Binding Region of Desmoplakin.

Kang H, Weiss TM, Bang I, Weis WI, Choi HJ.

PLoS One. 2016 Jan 25;11(1):e0147641. doi: 10.1371/journal.pone.0147641. eCollection 2016.


The linac coherent light source single particle imaging road map.

Aquila A, Barty A, Bostedt C, Boutet S, Carini G, dePonte D, Drell P, Doniach S, Downing KH, Earnest T, Elmlund H, Elser V, Gühr M, Hajdu J, Hastings J, Hau-Riege SP, Huang Z, Lattman EE, Maia FR, Marchesini S, Ourmazd A, Pellegrini C, Santra R, Schlichting I, Schroer C, Spence JC, Vartanyants IA, Wakatsuki S, Weis WI, Williams GJ.

Struct Dyn. 2015 Apr 21;2(4):041701. doi: 10.1063/1.4918726. eCollection 2015 Jul.


Purification and Structural Analysis of Desmoplakin.

Choi HJ, Weis WI.

Methods Enzymol. 2016;569:197-213. doi: 10.1016/bs.mie.2015.05.006. Epub 2015 May 30.


A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.

Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W.

Cancer Res. 2016 Feb 15;76(4):891-901. doi: 10.1158/0008-5472.CAN-15-1519. Epub 2015 Dec 8.


Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS.

Elife. 2015 Sep 30;4. pii: e07574. doi: 10.7554/eLife.07574.


Reevaluating αE-catenin monomer and homodimer functions by characterizing E-cadherin/αE-catenin chimeras.

Bianchini JM, Kitt KN, Gloerich M, Pokutta S, Weis WI, Nelson WJ.

J Cell Biol. 2015 Sep 28;210(7):1065-74. doi: 10.1083/jcb.201411080.


Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.

Nature. 2015 Sep 3;525(7567):62-7. doi: 10.1038/nature14975. Epub 2015 Aug 17.


Structural insights into µ-opioid receptor activation.

Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK.

Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5.


A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.

Jégouzo SA, Feinberg H, Dungarwalla T, Drickamer K, Weis WI, Taylor ME.

J Biol Chem. 2015 Jul 3;290(27):16759-71. doi: 10.1074/jbc.M115.660613. Epub 2015 May 20.


A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.

Choi HJ, Loveless T, Lynch AM, Bang I, Hardin J, Weis WI.

Dev Cell. 2015 Apr 6;33(1):82-93. doi: 10.1016/j.devcel.2015.02.005.


Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals.

Uervirojnangkoorn M, Zeldin OB, Lyubimov AY, Hattne J, Brewster AS, Sauter NK, Brunger AT, Weis WI.

Elife. 2015 Mar 17;4. doi: 10.7554/eLife.05421.


Purification, crystallization and preliminary X-ray diffraction studies of the β-catenin homolog HMP-2 from Caenorhabditis elegans.

Choi HJ, Weis WI.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):272-6. doi: 10.1107/S2053230X15000643. Epub 2015 Feb 19.


Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT.

J Biol Chem. 2015 Apr 17;290(16):10518-34. doi: 10.1074/jbc.M114.630772. Epub 2015 Feb 25.


Data Exploration Toolkit for serial diffraction experiments.

Zeldin OB, Brewster AS, Hattne J, Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Zhao M, Weis WI, Sauter NK, Brunger AT.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):352-6. doi: 10.1107/S1399004714025875. Epub 2015 Jan 23.


Three αSNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF).

Shah N, Colbert KN, Enos MD, Herschlag D, Weis WI.

J Biol Chem. 2015 Jan 23;290(4):2175-88. doi: 10.1074/jbc.M114.620849. Epub 2014 Dec 9.


Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.

Thorsen TS, Matt R, Weis WI, Kobilka BK.

Structure. 2014 Nov 4;22(11):1657-64. doi: 10.1016/j.str.2014.08.022. Epub 2014 Oct 23.


Mechano-transduction: from molecules to tissues.

Pruitt BL, Dunn AR, Weis WI, Nelson WJ.

PLoS Biol. 2014 Nov 18;12(11):e1001996. doi: 10.1371/journal.pbio.1001996. eCollection 2014 Nov.


Goniometer-based femtosecond crystallography with X-ray free electron lasers.

Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17122-7. doi: 10.1073/pnas.1418733111. Epub 2014 Oct 31.


Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.

Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR.

Science. 2014 Oct 31;346(6209):1254211. doi: 10.1126/science.1254211.


Studying epithelial morphogenesis in Dictyostelium.

Dickinson DJ, Nelson WJ, Weis WI.

Methods Mol Biol. 2015;1189:267-81. doi: 10.1007/978-1-4939-1164-6_18.


Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab.

Feinberg H, Saldanha JW, Diep L, Goel A, Widom A, Veldman GM, Weis WI, Schenk D, Basi GS.

Alzheimers Res Ther. 2014 Jun 2;6(3):31. doi: 10.1186/alzrt261. eCollection 2014.


Structural and thermodynamic characterization of cadherin·β-catenin·α-catenin complex formation.

Pokutta S, Choi HJ, Ahlsen G, Hansen SD, Weis WI.

J Biol Chem. 2014 May 9;289(19):13589-601. doi: 10.1074/jbc.M114.554709. Epub 2014 Apr 1.


Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.

Stamos JL, Chu ML, Enos MD, Shah N, Weis WI.

Elife. 2014 Mar 18;3:e01998. doi: 10.7554/eLife.01998.

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