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Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs.

Pioli PD, Whiteside SK, Weis JJ, Weis JH.

Immunobiology. 2016 May;221(5):618-33. doi: 10.1016/j.imbio.2016.01.007. Epub 2016 Jan 22.


Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis.

Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ.

PLoS One. 2015 Aug 7;10(8):e0135142. doi: 10.1371/journal.pone.0135142. eCollection 2015.


β-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli.

Bramwell KK, Mock K, Ma Y, Weis JH, Teuscher C, Weis JJ.

J Immunol. 2015 Aug 15;195(4):1647-56. doi: 10.4049/jimmunol.1500212. Epub 2015 Jul 13.


Age-related onset of obesity corresponds with metabolic dysregulation and altered microglia morphology in mice deficient for Ifitm proteins.

Wee YS, Weis JJ, Gahring LC, Rogers SW, Weis JH.

PLoS One. 2015 Apr 9;10(4):e0123218. doi: 10.1371/journal.pone.0123218. eCollection 2015.


Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.

Pioli PD, Chen X, Weis JJ, Weis JH.

Cell Immunol. 2015 May;295(1):1-18. doi: 10.1016/j.cellimm.2015.02.009. Epub 2015 Feb 24.


Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.

Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ.

J Immunol. 2014 Dec 15;193(12):6050-60. doi: 10.4049/jimmunol.1401746. Epub 2014 Nov 5.


Kawasaki disease patients homozygous for the rs12252-C variant of interferon-induced transmembrane protein-3 are significantly more likely to develop coronary artery lesions.

Bowles NE, Arrington CB, Hirono K, Nakamura T, Ngo L, Wee YS, Ichida F, Weis JH.

Mol Genet Genomic Med. 2014 Jul;2(4):356-61. doi: 10.1002/mgg3.79. Epub 2014 May 14. No abstract available.


Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.

Pioli PD, Debnath I, Weis JJ, Weis JH.

J Immunol. 2014 Sep 1;193(5):2546-53. doi: 10.4049/jimmunol.1401275. Epub 2014 Jul 23.


MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi.

Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ.

PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.


Snail transcription factors in hematopoietic cell development: a model of functional redundancy.

Pioli PD, Weis JH.

Exp Hematol. 2014 Jun;42(6):425-30. doi: 10.1016/j.exphem.2014.03.002. Epub 2014 Mar 24. Review.


Murine complement receptor 1 is required for germinal center B cell maintenance but not initiation.

Donius LR, Weis JJ, Weis JH.

Immunobiology. 2014 Jun;219(6):440-9. doi: 10.1016/j.imbio.2014.02.007. Epub 2014 Feb 25.


Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity.

Bramwell KK, Ma Y, Weis JH, Chen X, Zachary JF, Teuscher C, Weis JJ.

J Clin Invest. 2014 Jan;124(1):311-20. doi: 10.1172/JCI72339. Epub 2013 Dec 16.


Quantification of complement receptor 2 calcium signaling enhancement using flow cytometry.

Donius LR, Weis JH.

Methods Mol Biol. 2014;1100:311-7. doi: 10.1007/978-1-62703-724-2_25.


Detection of complement receptors 1 and 2 on mouse splenic B cells using flow cytometry.

Donius LR, Weis JH.

Methods Mol Biol. 2014;1100:305-10. doi: 10.1007/978-1-62703-724-2_24.


Generation of a novel Cr2 gene allele by homologous recombination that abrogates production of Cr2 but is sufficient for expression of Cr1.

Donius LR, Orlando CM, Weis JJ, Weis JH.

Immunobiology. 2014 Jan;219(1):53-63. doi: 10.1016/j.imbio.2013.08.003. Epub 2013 Aug 21.


Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.

Pioli PD, Dahlem TJ, Weis JJ, Weis JH.

PLoS One. 2013 Jul 16;8(7):e69216. doi: 10.1371/journal.pone.0069216. Print 2013.


Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1.

Donius LR, Handy JM, Weis JJ, Weis JH.

J Immunol. 2013 Jul 1;191(1):434-47. doi: 10.4049/jimmunol.1203176. Epub 2013 Jun 3.


Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins.

Debnath I, Roundy KM, Pioli PD, Weis JJ, Weis JH.

Int Immunol. 2013 Feb;25(2):99-115. doi: 10.1093/intimm/dxs088. Epub 2012 Oct 19.


Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease.

Michel B, Ferguson A, Johnson T, Bender H, Meyerett-Reid C, Pulford B, von Teichman A, Seelig D, Weis JH, Telling GC, Aguzzi A, Zabel MD.

J Immunol. 2012 Nov 1;189(9):4520-7. doi: 10.4049/jimmunol.1201579. Epub 2012 Sep 21.


Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue.

Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Sep 1;189(5):2488-501. doi: 10.4049/jimmunol.1201095. Epub 2012 Jul 30.


Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.

Dahlem T, Cho S, Spangrude GJ, Weis JJ, Weis JH.

Eur J Immunol. 2012 Apr;42(4):1038-43. doi: 10.1002/eji.201142193.


Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function.

Wee YS, Roundy KM, Weis JJ, Weis JH.

Innate Immun. 2012 Dec;18(6):834-45. doi: 10.1177/1753425912443392. Epub 2012 Mar 30.


High-throughput genotyping of advanced congenic lines by high resolution melting analysis for identification of Bbaa2, a QTL controlling Lyme arthritis.

Bramwell KK, Ma Y, Weis JH, Teuscher C, Weis JJ.

Biotechniques. 2012 Mar;52(3):183-90. doi: 10.2144/000113838.


Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-γ-mediated Lyme arthritis.

Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Feb 1;188(3):1381-93. doi: 10.4049/jimmunol.1102359. Epub 2011 Dec 16.


The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.

Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ.

Infect Immun. 2010 Jul;78(7):3144-53. doi: 10.1128/IAI.01070-09. Epub 2010 Apr 19.


The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors.

Roundy KM, Jacobson AC, Weis JJ, Weis JH.

Eur J Immunol. 2010 Apr;40(4):1139-49. doi: 10.1002/eji.200939661.


Deletion of putative intronic control sequences does not alter cell or stage specific expression of Cr2.

Roundy KM, Weis JJ, Weis JH.

Mol Immunol. 2009 Dec;47(2-3):517-25. doi: 10.1016/j.molimm.2009.08.016. Epub 2009 Sep 9.


Regulation of murine splenic B cell CR3 expression by complement component 3.

Jacobson AC, Roundy KM, Weis JJ, Weis JH.

J Immunol. 2009 Sep 15;183(6):3963-70. doi: 10.4049/jimmunol.0900038. Epub 2009 Aug 26.


Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12.

Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ.

Infect Immun. 2009 Aug;77(8):3302-11. doi: 10.1128/IAI.00396-09. Epub 2009 Jun 1.


CD21 signaling via C3 regulates Purkinje cell protein 4 expression.

Jacobson AC, Weis JJ, Weis JH.

Mol Immunol. 2009 Apr;46(7):1488-93. doi: 10.1016/j.molimm.2008.12.030. Epub 2009 Feb 7.


A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.

Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ.

J Immunol. 2008 Dec 15;181(12):8492-503.


Defining a transcriptional fingerprint of murine splenic B-cell development.

Debnath I, Roundy KM, Dunn DM, Weiss RB, Weis JJ, Weis JH.

Genes Immun. 2008 Dec;9(8):706-20. doi: 10.1038/gene.2008.70. Epub 2008 Sep 11.


Comparative functional evolution of human and mouse CR1 and CR2.

Jacobson AC, Weis JH.

J Immunol. 2008 Sep 1;181(5):2953-9. Review. No abstract available.


Purification of cosmid and plasmid clones.

Weis JH.

Curr Protoc Mol Biol. 2001 May;Chapter 6:Unit6.6. doi: 10.1002/0471142727.mb0606s17.


Plating and transferring cosmid and plasmid libraries.

Weis JH.

Curr Protoc Mol Biol. 2001 May;Chapter 6:Unit6.2. doi: 10.1002/0471142727.mb0602s24.


Size fractionation using sucrose gradients.

Weis JH, Quertermous T.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.3. doi: 10.1002/0471142727.mb0503s00.


Amplification of cosmid and plasmid libraries.

Weis JH.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.11. doi: 10.1002/0471142727.mb0511s34.


T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice.

Wang X, Ma Y, Yoder A, Crandall H, Zachary JF, Fujinami RS, Weis JH, Weis JJ.

FEMS Immunol Med Microbiol. 2008 Jan;52(1):124-33. Epub 2007 Dec 11.


Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.

Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A.

J Immunol. 2007 Nov 1;179(9):6144-52.


Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes.

Debnath I, Roundy KM, Weis JJ, Weis JH.

J Immunol. 2007 Jun 1;178(11):7139-50.


Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.

Jacobson AC, Ma Y, Zachary JF, Weis JJ, Weis JH.

Infect Immun. 2007 Apr;75(4):2075-8. Epub 2007 Feb 5.


Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23.

Debnath I, Roundy KM, Weis JJ, Weis JH.

Mol Immunol. 2007 Mar;44(9):2388-99. Epub 2006 Nov 30.


Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis.

Crandall H, Dunn DM, Ma Y, Wooten RM, Zachary JF, Weis JH, Weiss RB, Weis JJ.

J Immunol. 2006 Dec 1;177(11):7930-42.


Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.

Bolz DD, Sundsbak RS, Ma Y, Akira S, Weis JH, Schwan TG, Weis JJ.

Infect Immun. 2006 Dec;74(12):6750-60. Epub 2006 Oct 9.


Altered localization of CXCL13 expressing cells in mice deficient in Pactolus following an inflammatory stimulus.

Hojgaard A, Close R, Dunn DM, Weiss RB, Weis JJ, Weis JH.

Immunology. 2006 Oct;119(2):212-23. Epub 2006 Jul 12.


Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin).

Hale JS, Dahlem TJ, Margraf RL, Debnath I, Weis JJ, Weis JH.

J Leukoc Biol. 2006 Aug;80(2):383-98. Epub 2006 May 30.


Allergy test might have avoided drug-trial disaster.

Weis JH.

Nature. 2006 May 11;441(7090):150. No abstract available.


Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes.

Smith RA, Young J, Weis JJ, Weis JH.

Genes Immun. 2006 Mar;7(2):113-21.


Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs.

Roundy KM, Spangrude G, Weis JJ, Weis JH.

Int Immunol. 2005 Nov;17(11):1495-503. Epub 2005 Sep 26.


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