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Clin Infect Dis. 2019 Aug 11. pii: ciz723. doi: 10.1093/cid/ciz723. [Epub ahead of print]

Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine.

Author information

1
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

KEYWORDS:

H3N2; Influenza virus; hemagglutinin; influenza vaccine

PMID:
31400756
DOI:
10.1093/cid/ciz723

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