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Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats.

Wang D, Li H, Weir EK, Xu Y, Xu D, Chen Y.

Int J Cardiol. 2019 Jul 27. pii: S0167-5273(19)32132-1. doi: 10.1016/j.ijcard.2019.07.078. [Epub ahead of print]


Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling.

Shang L, Weng X, Wang D, Yue W, Mernaugh R, Amarnath V, Weir EK, Dudley SC, Xu Y, Hou M, Chen Y.

Free Radic Biol Med. 2019 Jun 26;141:291-298. doi: 10.1016/j.freeradbiomed.2019.06.029. [Epub ahead of print]


Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy.

Yue W, Tong L, Liu X, Weng X, Chen X, Wang D, Dudley SC, Weir EK, Ding W, Lu Z, Xu Y, Chen Y.

Redox Biol. 2019 Apr;22:101161. doi: 10.1016/j.redox.2019.101161. Epub 2019 Mar 6.


Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.

Liu X, Yang L, Kwak D, Hou L, Shang R, Meyer C, Panoskaltsis-Mortari A, Xu X, Weir EK, Chen Y.

J Cardiovasc Transl Res. 2019 Jan 24. doi: 10.1007/s12265-019-9864-y. [Epub ahead of print]


Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Olson MD, Thenappan T.

J Am Heart Assoc. 2019 Jan 22;8(2):e011464. doi: 10.1161/JAHA.118.011464.


Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again.

Prins KW, Thenappan T, Weir EK, Kalra R, Pritzker M, Archer SL.

J Am Heart Assoc. 2019 Jan 8;8(1):e011343. doi: 10.1161/JAHA.118.011343. No abstract available.


Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.

Rose L, Prins KW, Archer SL, Pritzker M, Weir EK, Misialek JR, Thenappan T.

J Heart Lung Transplant. 2019 Feb;38(2):145-155. doi: 10.1016/j.healun.2018.09.011. Epub 2018 Sep 14.


Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice.

Preissner M, Murrie RP, Bresee C, Carnibella RP, Fouras A, Weir EK, Dubsky S, Pinar IP, Jones HD.

Physiol Rep. 2018 Sep;6(19):e13875. doi: 10.14814/phy2.13875.


Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension.

Thenappan T, Chan SY, Weir EK.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1322-H1331. doi: 10.1152/ajpheart.00136.2018. Epub 2018 Aug 24.


Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Kazmirczak F, Misialek JR, Thenappan T.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1496-1499. doi: 10.1164/rccm.201712-2405LE. No abstract available.


The Nitric Oxide Pathway-A Potential Target for Precision Medicine in Pulmonary Arterial Hypertension.

Thenappan T, Weir EK.

Am J Cardiol. 2017 Oct 15;120(8S):S69-S70. doi: 10.1016/j.amjcard.2017.06.011. No abstract available.


Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.

Prins KW, Archer SL, Pritzker M, Rose L, Weir EK, Sharma A, Thenappan T.

J Heart Lung Transplant. 2018 Mar;37(3):376-384. doi: 10.1016/j.healun.2017.08.011. Epub 2017 Sep 1.


Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.


Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment.

Thenappan T, Archer SL, Weir EK.

Pulm Circ. 2017 Feb 1;7(1):275. doi: 10.1177/2045893216681025. eCollection 2017 Mar. No abstract available.


Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension.

Prins KW, Weir EK, Archer SL, Markowitz J, Rose L, Pritzker M, Madlon-Kay R, Thenappan T.

Pulm Circ. 2016 Dec;6(4):576-585. doi: 10.1086/688879.


Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012.

Anand V, Roy SS, Archer SL, Weir EK, Garg SK, Duval S, Thenappan T.

JAMA Cardiol. 2016 Dec 1;1(9):1021-1029. doi: 10.1001/jamacardio.2016.3591.


Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.


The Critical Role of Pulmonary Arterial Compliance in Pulmonary Hypertension.

Thenappan T, Prins KW, Pritzker MR, Scandurra J, Volmers K, Weir EK.

Ann Am Thorac Soc. 2016 Feb;13(2):276-84. doi: 10.1513/AnnalsATS.201509-599FR. Review.


Is cardiac resynchronization therapy for right ventricular failure in pulmonary arterial hypertension of benefit?

Rasmussen JT, Thenappan T, Benditt DG, Weir EK, Pritzker MR.

Pulm Circ. 2014 Dec;4(4):552-9. doi: 10.1086/678470. Review.


Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.

Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL.

J Mol Med (Berl). 2014 Sep;92(9):995-1007. doi: 10.1007/s00109-014-1162-1. Epub 2014 Jun 8.


Redox regulation of ion channels in the pulmonary circulation.

Olschewski A, Weir EK.

Antioxid Redox Signal. 2015 Feb 20;22(6):465-85. doi: 10.1089/ars.2014.5899. Epub 2014 Jun 30. Review.


Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.

Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL.

Circ Res. 2013 Mar 1;112(5):802-15. doi: 10.1161/CIRCRESAHA.111.300285. Epub 2013 Jan 18.


Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries.

Nagaraj C, Tang B, Bálint Z, Wygrecka M, Hrzenjak A, Kwapiszewska G, Stacher E, Lindenmann J, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2013 Jan;41(1):85-95. doi: 10.1183/09031936.00211811. Epub 2012 Apr 20.


Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL.

Circ Res. 2012 May 25;110(11):1484-97. doi: 10.1161/CIRCRESAHA.111.263848. Epub 2012 Apr 17.


Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease.

Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, Huo Y, Weir EK.

Hypertension. 2012 Jun;59(6):1170-8. doi: 10.1161/HYPERTENSIONAHA.111.186072. Epub 2012 Apr 16.


Characterization of blaCMY-2 plasmids in Salmonella and Escherichia coli isolates from food animals in Canada.

Martin LC, Weir EK, Poppe C, Reid-Smith RJ, Boerlin P.

Appl Environ Microbiol. 2012 Feb;78(4):1285-7. doi: 10.1128/AEM.06498-11. Epub 2011 Dec 9.


Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.

Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y.

Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.


Increase in GLUT1 in smooth muscle alters vascular contractility and increases inflammation in response to vascular injury.

Adhikari N, Basi DL, Carlson M, Mariash A, Hong Z, Lehman U, Mullegama S, Weir EK, Hall JL.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):86-94. doi: 10.1161/ATVBAHA.110.215004. Epub 2010 Oct 14.


Redesign of internal-medicine teaching.

Weir EK.

N Engl J Med. 2010 Aug 5;363(6):593; author reply 594-5. doi: 10.1056/NEJMc1005271. No abstract available.


The role of redox changes in oxygen sensing.

Weir EK, Archer SL.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):182-91. doi: 10.1016/j.resp.2010.08.015. Epub 2010 Aug 27. Review.


Superoxide dismutase: master and commander?

Weir EK, Hong Z, Chen Y.

Eur Respir J. 2010 Aug;36(2):234-6. doi: 10.1183/09031936.00062510. No abstract available.


Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies.

Archer SL, Weir EK, Wilkins MR.

Circulation. 2010 May 11;121(18):2045-66. doi: 10.1161/CIRCULATIONAHA.108.847707. Review. No abstract available.


The role of ion channels in hypoxic pulmonary vasoconstriction.

Weir EK, Cabrera JA, Mahapatra S, Peterson DA, Hong Z.

Adv Exp Med Biol. 2010;661:3-14. doi: 10.1007/978-1-60761-500-2_1. Review.


Cellular and molecular basis of pulmonary arterial hypertension.

Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S20-31. doi: 10.1016/j.jacc.2009.04.018. Review.


Assessment of graft patency during coronary artery bypass graft surgery: mitigating the risk.

Ward HB, Kelly RF, Weir EK.

JACC Cardiovasc Imaging. 2009 May;2(5):613-5. doi: 10.1016/j.jcmg.2009.01.009. No abstract available.


Subinhibitory concentrations of tetracycline affect virulence gene expression in a multi-resistant Salmonella enterica subsp. enterica serovar Typhimurium DT104.

Weir EK, Martin LC, Poppe C, Coombes BK, Boerlin P.

Microbes Infect. 2008 Jul;10(8):901-7. doi: 10.1016/j.micinf.2008.05.005. Epub 2008 Jun 18.


Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus.

Weir EK, Obreztchikova M, Vargese A, Cabrera JA, Peterson DA, Hong Z.

Br J Pharmacol. 2008 Oct;155(3):300-7. doi: 10.1038/bjp.2008.291. Epub 2008 Jul 21. Review.


The metabolic basis of vascular oxygen sensing: diversity, compartmentalization, and lessons from cancer.

Michelakis ED, Weir EK.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H928-H930. doi: 10.1152/ajpheart.00697.2008. Epub 2008 Jul 11. No abstract available.


Generation of oxidants by hypoxic human pulmonary and coronary smooth-muscle cells.

Mehta JP, Campian JL, Guardiola J, Cabrera JA, Weir EK, Eaton JW.

Chest. 2008 Jun;133(6):1410-1414. doi: 10.1378/chest.07-2984. Epub 2008 Mar 13.


Fenfluramine: riddle or Rosetta stone?

Weir EK, Obreztchikova M, Hong Z.

Eur Respir J. 2008 Feb;31(2):232-5. doi: 10.1183/09031936.00160407. No abstract available.


Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.

Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H570-8. Epub 2007 Dec 14. Review.


Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.

Ross JJ, Hong Z, Willenbring B, Zeng L, Isenberg B, Lee EH, Reyes M, Keirstead SA, Weir EK, Tranquillo RT, Verfaillie CM.

J Clin Invest. 2006 Dec;116(12):3139-49. Epub 2006 Nov 9. Erratum in: J Clin Invest. 2007 Jul;117(7):2014.


Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus.

Hong Z, Hong F, Olschewski A, Cabrera JA, Varghese A, Nelson DP, Weir EK.

Circulation. 2006 Sep 26;114(13):1372-9. Epub 2006 Sep 18.


Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species.

Weir EK, Archer SL.

J Appl Physiol (1985). 2006 Sep;101(3):995-8; discussion 998. No abstract available.


Acute normoxia increases fetal pulmonary artery endothelial cell cytosolic Ca2+ via Ca2+-induced Ca2+ release.

Tirosh R, Resnik ER, Herron J, Sukovich DJ, Hong Z, Weir EK, Cornfield DN.

Pediatr Res. 2006 Sep;60(3):258-63. Epub 2006 Jul 20.


Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia.

Weir EK, Olschewski A.

Cardiovasc Res. 2006 Sep 1;71(4):630-41. Epub 2006 Apr 27. Review.


An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL.

Circulation. 2006 Jun 6;113(22):2630-41. Epub 2006 May 30.


A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system.

Archer SL, Michelakis ED, Thébaud B, Bonnet S, Moudgil R, Wu XC, Weir EK.

Novartis Found Symp. 2006;272:157-71; discussion 171-5, 214-7. Review.


Serotonin-induced inhibition of KV current: a supporting role in pulmonary vasoconstriction?

Varghese A, Hong Z, Weir EK.

Circ Res. 2006 Apr 14;98(7):860-2. No abstract available.


Impact of TASK-1 in human pulmonary artery smooth muscle cells.

Olschewski A, Li Y, Tang B, Hanze J, Eul B, Bohle RM, Wilhelm J, Morty RE, Brau ME, Weir EK, Kwapiszewska G, Klepetko W, Seeger W, Olschewski H.

Circ Res. 2006 Apr 28;98(8):1072-80. Epub 2006 Mar 30.


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