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Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?

Thenappan T, Khoruts A, Chen Y, Weir EK.

Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1093-H1101. doi: 10.1152/ajpheart.00416.2019. Epub 2019 Sep 6.


Dermal sinus tracts.

Foster MT, Moxon CA, Weir E, Sinha A.

BMJ. 2019 Sep 4;366:l5202. doi: 10.1136/bmj.l5202. No abstract available.


Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats.

Wang D, Li H, Weir EK, Xu Y, Xu D, Chen Y.

Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.


Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling.

Shang L, Weng X, Wang D, Yue W, Mernaugh R, Amarnath V, Weir EK, Dudley SC, Xu Y, Hou M, Chen Y.

Free Radic Biol Med. 2019 Sep;141:291-298. doi: 10.1016/j.freeradbiomed.2019.06.029. Epub 2019 Jun 26.


Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy.

Yue W, Tong L, Liu X, Weng X, Chen X, Wang D, Dudley SC, Weir EK, Ding W, Lu Z, Xu Y, Chen Y.

Redox Biol. 2019 Apr;22:101161. doi: 10.1016/j.redox.2019.101161. Epub 2019 Mar 6.


Mepolizumab in adolescents with severe eosinophilic asthma not eligible for omalizumab: one center's early clinical experience.

Weir E, Paton J.

J Asthma. 2019 Feb 22:1-4. doi: 10.1080/02770903.2019.1579833. [Epub ahead of print] No abstract available.


Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.

Liu X, Yang L, Kwak D, Hou L, Shang R, Meyer C, Panoskaltsis-Mortari A, Xu X, Weir EK, Chen Y.

J Cardiovasc Transl Res. 2019 Aug;12(4):271-279. doi: 10.1007/s12265-019-9864-y. Epub 2019 Jan 24.


Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Olson MD, Thenappan T.

J Am Heart Assoc. 2019 Jan 22;8(2):e011464. doi: 10.1161/JAHA.118.011464.


Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again.

Prins KW, Thenappan T, Weir EK, Kalra R, Pritzker M, Archer SL.

J Am Heart Assoc. 2019 Jan 8;8(1):e011343. doi: 10.1161/JAHA.118.011343. No abstract available.


Don't go there - It's not a nice place: Older adults' experiences of delirium.

Weir E, O'Brien AJ.

Int J Ment Health Nurs. 2019 Apr;28(2):582-591. doi: 10.1111/inm.12563. Epub 2018 Dec 13.


Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.

Rose L, Prins KW, Archer SL, Pritzker M, Weir EK, Misialek JR, Thenappan T.

J Heart Lung Transplant. 2019 Feb;38(2):145-155. doi: 10.1016/j.healun.2018.09.011. Epub 2018 Sep 14.


Multicentric Mucinous Adenocarcinoma in the Periorbital Region.

Furst M, Somogyi MB, Vrcek I, Weir E, Shore JW.

Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec;34(6):e204-e206. doi: 10.1097/IOP.0000000000001248.


Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice.

Preissner M, Murrie RP, Bresee C, Carnibella RP, Fouras A, Weir EK, Dubsky S, Pinar IP, Jones HD.

Physiol Rep. 2018 Sep;6(19):e13875. doi: 10.14814/phy2.13875.


Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension.

Thenappan T, Chan SY, Weir EK.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1322-H1331. doi: 10.1152/ajpheart.00136.2018. Epub 2018 Aug 24. Review.


Could this be whooping cough?

Nee P, Weir E, Vardhan M, Vaidya A.

Emerg Med J. 2018 Oct;35(10):639-642. doi: 10.1136/emermed-2018-207792. Epub 2018 Aug 10.


Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study.

Weir E, Gibbs J, Appleton R.

Seizure. 2018 Apr;57:66-69. doi: 10.1016/j.seizure.2018.03.002. Epub 2018 Mar 5.


Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension.

Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Kazmirczak F, Misialek JR, Thenappan T.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1496-1499. doi: 10.1164/rccm.201712-2405LE. No abstract available.


The Nitric Oxide Pathway-A Potential Target for Precision Medicine in Pulmonary Arterial Hypertension.

Thenappan T, Weir EK.

Am J Cardiol. 2017 Oct 15;120(8S):S69-S70. doi: 10.1016/j.amjcard.2017.06.011. No abstract available.


Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.

Prins KW, Archer SL, Pritzker M, Rose L, Weir EK, Sharma A, Thenappan T.

J Heart Lung Transplant. 2018 Mar;37(3):376-384. doi: 10.1016/j.healun.2017.08.011. Epub 2017 Sep 1.


Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.


Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment.

Thenappan T, Archer SL, Weir EK.

Pulm Circ. 2017 Feb 1;7(1):275. doi: 10.1177/2045893216681025. eCollection 2017 Mar. No abstract available.


Establishing a deanery teaching programme for trainees sitting the MRCPCH clinical examination.

Harry C, Weir E, Grattan R, Skeoch C, Evans P.

J R Coll Physicians Edinb. 2017 Jun;47(2):159-163. doi: 10.4997/JRCPE.2017.214.


Dementia-friendly communities: where home care and mental health intersect.

Weir E, Seitz D.

CMAJ. 2017 Apr 24;189(16):E581-E582. doi: 10.1503/cmaj.170370. No abstract available.


Using the Upshur principles to discuss medical fitness to drive.

Weir E.

Can Fam Physician. 2017 Apr;63(4):269-272. No abstract available.


Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension.

Prins KW, Weir EK, Archer SL, Markowitz J, Rose L, Pritzker M, Madlon-Kay R, Thenappan T.

Pulm Circ. 2016 Dec;6(4):576-585. doi: 10.1086/688879.


Cardiopulmonary exercise testing in children with cystic fibrosis: one centre's experience.

Weir E, Burns PD, Devenny A, Young D, Paton JY.

Arch Dis Child. 2017 May;102(5):440-444. doi: 10.1136/archdischild-2016-310651. Epub 2016 Dec 5.


Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012.

Anand V, Roy SS, Archer SL, Weir EK, Garg SK, Duval S, Thenappan T.

JAMA Cardiol. 2016 Dec 1;1(9):1021-1029. doi: 10.1001/jamacardio.2016.3591.


The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.

Raman N, Weir E, Müller S.

Mol Cell. 2016 Nov 3;64(3):607-615. doi: 10.1016/j.molcel.2016.09.039.


Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.


Social acceptability of phytoremediation: The role of risk and values.

Weir E, Doty S.

Int J Phytoremediation. 2016 Oct 2;18(10):1029-36. doi: 10.1080/15226514.2016.1183571.


The Critical Role of Pulmonary Arterial Compliance in Pulmonary Hypertension.

Thenappan T, Prins KW, Pritzker MR, Scandurra J, Volmers K, Weir EK.

Ann Am Thorac Soc. 2016 Feb;13(2):276-84. doi: 10.1513/AnnalsATS.201509-599FR. Review.


Is cardiac resynchronization therapy for right ventricular failure in pulmonary arterial hypertension of benefit?

Rasmussen JT, Thenappan T, Benditt DG, Weir EK, Pritzker MR.

Pulm Circ. 2014 Dec;4(4):552-9. doi: 10.1086/678470. Review.


Deprescribing for older patients.

Frank C, Weir E.

CMAJ. 2014 Dec 9;186(18):1369-76. doi: 10.1503/cmaj.131873. Epub 2014 Sep 2. Review. No abstract available.


Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus.

Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL.

J Mol Med (Berl). 2014 Sep;92(9):995-1007. doi: 10.1007/s00109-014-1162-1. Epub 2014 Jun 8.


Redox regulation of ion channels in the pulmonary circulation.

Olschewski A, Weir EK.

Antioxid Redox Signal. 2015 Feb 20;22(6):465-85. doi: 10.1089/ars.2014.5899. Epub 2014 Jun 30. Review.


Improving collaboration between public health and family health teams in Ontario.

Green ME, Weir E, Hogg W, Etches V, Moore K, Hunter D, Birtwhistle R.

Healthc Policy. 2013 Feb;8(3):e93-104.


Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.

Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL.

Circ Res. 2013 Mar 1;112(5):802-15. doi: 10.1161/CIRCRESAHA.111.300285. Epub 2013 Jan 18.


Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma.

Levin LI, Chang ET, Ambinder RF, Lennette ET, Rubertone MV, Mann RB, Borowitz M, Weir EG, Abbondanzo SL, Mueller NE.

Blood. 2012 Nov 1;120(18):3750-5. doi: 10.1182/blood-2011-12-390823. Epub 2012 Sep 12.


Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries.

Nagaraj C, Tang B, Bálint Z, Wygrecka M, Hrzenjak A, Kwapiszewska G, Stacher E, Lindenmann J, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2013 Jan;41(1):85-95. doi: 10.1183/09031936.00211811. Epub 2012 Apr 20.


Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL.

Circ Res. 2012 May 25;110(11):1484-97. doi: 10.1161/CIRCRESAHA.111.263848. Epub 2012 Apr 17.


Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease.

Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, Huo Y, Weir EK.

Hypertension. 2012 Jun;59(6):1170-8. doi: 10.1161/HYPERTENSIONAHA.111.186072. Epub 2012 Apr 16.


Characterization of blaCMY-2 plasmids in Salmonella and Escherichia coli isolates from food animals in Canada.

Martin LC, Weir EK, Poppe C, Reid-Smith RJ, Boerlin P.

Appl Environ Microbiol. 2012 Feb;78(4):1285-7. doi: 10.1128/AEM.06498-11. Epub 2011 Dec 9.


Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.

Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y.

Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.


Intergenerational Ambivalence: Aging Mothers Whose Adult Daughters are Mentally Ill.

Ingersoll-Dayton B, Dunkle RE, Chadiha L, Lawrence-Jacobson A, Li L, Weir E, Satorius J.

Fam Soc. 2011;92(1):114-119.


A Canadian framework for applying the precautionary principle to public health issues.

Weir E, Schabas R, Wilson K, Mackie C.

Can J Public Health. 2010 Sep-Oct;101(5):396-8.


Increase in GLUT1 in smooth muscle alters vascular contractility and increases inflammation in response to vascular injury.

Adhikari N, Basi DL, Carlson M, Mariash A, Hong Z, Lehman U, Mullegama S, Weir EK, Hall JL.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):86-94. doi: 10.1161/ATVBAHA.110.215004. Epub 2010 Oct 14.


Severe human rhinovirus outbreak associated with fatalities in a long-term care facility in Ontario, Canada.

Longtin J, Winter AL, Heng D, Marchand-Austin A, Eshaghi A, Patel S, Jamieson F, Weir E, Low DE, Gubbay JB.

J Am Geriatr Soc. 2010 Oct;58(10):2036-8. doi: 10.1111/j.1532-5415.2010.03091.x. No abstract available.


Redesign of internal-medicine teaching.

Weir EK.

N Engl J Med. 2010 Aug 5;363(6):593; author reply 594-5. doi: 10.1056/NEJMc1005271. No abstract available.


The role of redox changes in oxygen sensing.

Weir EK, Archer SL.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):182-91. doi: 10.1016/j.resp.2010.08.015. Epub 2010 Aug 27. Review.


Superoxide dismutase: master and commander?

Weir EK, Hong Z, Chen Y.

Eur Respir J. 2010 Aug;36(2):234-6. doi: 10.1183/09031936.00062510. No abstract available.

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