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How to design a dose-finding study using the continual reassessment method.

Wheeler GM, Mander AP, Bedding A, Brock K, Cornelius V, Grieve AP, Jaki T, Love SB, Odondi L, Weir CJ, Yap C, Bond SJ.

BMC Med Res Methodol. 2019 Jan 18;19(1):18. doi: 10.1186/s12874-018-0638-z.


Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.

Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG.

BMC Med. 2018 Nov 16;16(1):210. doi: 10.1186/s12916-018-1196-2.


Frightening and Traumatic Memories Early after Intensive Care Discharge.

Train S, Kydonaki K, Rattray J, Stephen J, Weir CJ, Walsh TS.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):120-123. doi: 10.1164/rccm.201804-0699LE. No abstract available.


Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study.

Shankar-Hari M, Datta D, Wilson J, Assi V, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Felton JM, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown AK, Lewis SM, Mare T, Roy AI, Wright J, Hulme G, Dimmick I, Gray A, Rossi AG, Simpson AJ, Conway Morris A, Walsh TS.

Intensive Care Med. 2018 Nov;44(11):1836-1848. doi: 10.1007/s00134-018-5389-0. Epub 2018 Oct 5.


The acute medical unit model: A characterisation based upon the National Health Service in Scotland.

Reid LEM, Pretsch U, Jones MC, Lone NI, Weir CJ, Morrison Z.

PLoS One. 2018 Oct 3;13(10):e0204010. doi: 10.1371/journal.pone.0204010. eCollection 2018.


Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster-randomised trial.

Norman JE, Heazell AEP, Rodriguez A, Weir CJ, Stock SJE, Calderwood CJ, Cunningham Burley S, Fr√łen JF, Geary M, Breathnach F, Hunter A, McAuliffe FM, Higgins MF, Murdoch E, Ross-Davie M, Scott J, Whyte S; AFFIRM investigators.

Lancet. 2018 Nov 3;392(10158):1629-1638. doi: 10.1016/S0140-6736(18)31543-5. Epub 2018 Sep 27.


Diagnostic test accuracy of a novel smartphone application for the assessment of attention deficits in delirium in older hospitalised patients: a prospective cohort study protocol.

Rutter LM, Nouzova E, Stott DJ, Weir CJ, Assi V, Barnett JH, Clarke C, Duncan N, Evans J, Green S, Hendry K, McGinlay M, McKeever J, Middleton DG, Parks S, Shaw R, Tang E, Walsh T, Weir AJ, Wilson E, Quasim T, MacLullich AMJ, Tieges Z.

BMC Geriatr. 2018 Sep 17;18(1):217. doi: 10.1186/s12877-018-0901-5.


A practical guide to pre-trial simulations for Bayesian adaptive trials using SAS and BUGS.

Hansen CH, Warner P, Walker A, Parker RA, Whitaker L, Critchley HOD, Weir CJ.

Pharm Stat. 2018 Nov;17(6):854-865. doi: 10.1002/pst.1897. Epub 2018 Sep 14.


High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial.

Shah ASV, Anand A, Strachan FE, Ferry AV, Lee KK, Chapman AR, Sandeman D, Stables CL, Adamson PD, Andrews JPM, Anwar MS, Hung J, Moss AJ, O'Brien R, Berry C, Findlay I, Walker S, Cruickshank A, Reid A, Gray A, Collinson PO, Apple FS, McAllister DA, Maguire D, Fox KAA, Newby DE, Tuck C, Harkess R, Parker RA, Keerie C, Weir CJ, Mills NL; High-STEACS Investigators.

Lancet. 2018 Sep 15;392(10151):919-928. doi: 10.1016/S0140-6736(18)31923-8. Epub 2018 Aug 28.


Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis.

Connick P, De Angelis F, Parker RA, Plantone D, Doshi A, John N, Stutters J, MacManus D, Prados Carrasco F, Barkhof F, Ourselin S, Braisher M, Ross M, Cranswick G, Pavitt SH, Giovannoni G, Gandini Wheeler-Kingshott CA, Hawkins C, Sharrack B, Bastow R, Weir CJ, Stallard N, Chandran S, Chataway J; UK Multiple Sclerosis Society Clinical Trials Network.

BMJ Open. 2018 Aug 30;8(8):e021944. doi: 10.1136/bmjopen-2018-021944.


Functional strength training versus movement performance therapy for upper limb motor recovery early after stroke: a RCT.

Pomeroy VM, Hunter SM, Johansen-Berg H, Ward NS, Kennedy N, Chandler E, Weir CJ, Rothwell J, Wing A, Grey M, Barton G, Leavey N.

Southampton (UK): NIHR Journals Library; 2018 Jun.


Diagnostic yield of an ambulatory patch monitor in patients with unexplained syncope after initial evaluation in the emergency department: the PATCH-ED study.

Reed MJ, Grubb NR, Lang CC, Gray AJ, Simpson K, MacRaild A, Weir CJ.

Emerg Med J. 2018 Aug;35(8):477-485. doi: 10.1136/emermed-2018-207570. Epub 2018 Jun 19.


Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study.

Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown KA, Lewis SM, Mare T, Roy AI, Hulme G, Dimmick I, Rossi AG, Simpson AJ, Walsh TS.

Intensive Care Med. 2018 May;44(5):627-635. doi: 10.1007/s00134-018-5247-0. Epub 2018 Jun 7.


Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study.

Marshall I, Thrippleton MJ, Bastin ME, Mollison D, Dickie DA, Chappell FM, Semple SIK, Cooper A, Pavitt S, Giovannoni G, Wheeler-Kingshott CAMG, Solanky BS, Weir CJ, Stallard N, Hawkins C, Sharrack B, Chataway J, Connick P, Chandran S; MS-SMART Trialists.

J Neurol. 2018 Aug;265(8):1795-1802. doi: 10.1007/s00415-018-8903-y. Epub 2018 May 30.


Trends in epilepsy admissions in children, 1981-2013: population-based observational study using the Scottish national hospital discharge database.

Chin RFM, Stephen J, Weir CJ, Wood R.

Arch Dis Child. 2018 Nov;103(11):1042-1047. doi: 10.1136/archdischild-2017-313944. Epub 2018 Apr 28.


Palliative care for people with advanced liver disease: A feasibility trial of a supportive care liver nurse specialist.

Kimbell B, Murray SA, Byrne H, Baird A, Hayes PC, MacGilchrist A, Finucane A, Brookes Young P, O'Carroll RE, Weir CJ, Kendall M, Boyd K.

Palliat Med. 2018 May;32(5):919-929. doi: 10.1177/0269216318760441. Epub 2018 Mar 8.


Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review.

Weir CJ, Butcher I, Assi V, Lewis SC, Murray GD, Langhorne P, Brady MC.

BMC Med Res Methodol. 2018 Mar 7;18(1):25. doi: 10.1186/s12874-018-0483-0.


Adaptive designs in clinical trials: why use them, and how to run and report them.

Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR, Villar SS, Wason JMS, Weir CJ, Wheeler GM, Yap C, Jaki T.

BMC Med. 2018 Feb 28;16(1):29. doi: 10.1186/s12916-018-1017-7.


Functional Strength Training and Movement Performance Therapy for Upper Limb Recovery Early Poststroke-Efficacy, Neural Correlates, Predictive Markers, and Cost-Effectiveness: FAST-INdiCATE Trial.

Hunter SM, Johansen-Berg H, Ward N, Kennedy NC, Chandler E, Weir CJ, Rothwell J, Wing AM, Grey MJ, Barton G, Leavey NM, Havis C, Lemon RN, Burridge J, Dymond A, Pomeroy VM.

Front Neurol. 2018 Jan 25;8:733. doi: 10.3389/fneur.2017.00733. eCollection 2017.


Protocol for validation of the 4AT, a rapid screening tool for delirium: a multicentre prospective diagnostic test accuracy study.

Shenkin SD, Fox C, Godfrey M, Siddiqi N, Goodacre S, Young J, Anand A, Gray A, Smith J, Ryan T, Hanley J, MacRaild A, Steven J, Black PL, Boyd J, Weir CJ, MacLullich AM.

BMJ Open. 2018 Feb 10;8(2):e015572. doi: 10.1136/bmjopen-2016-015572.


The provision of seven day multidisciplinary staffing in Scottish acute medical units: a cross-sectional study.

Reid LEM, Lone NI, Morrison ZJ, Weir CJ, Jones MC.

QJM. 2018 May 1;111(5):295-301. doi: 10.1093/qjmed/hcy024.


Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics.

Weir CJ, Mitchell SJ, Lambert JJ.

Br J Anaesth. 2017 Dec 1;119(suppl_1):i167-i175. doi: 10.1093/bja/aex369. Review.


How is it best to deliver care in acute medical units? A systematic review.

Reid LEM, Crookshanks AJF, Jones MC, Morrison ZJ, Lone NI, Weir CJ.

QJM. 2017 Aug 4. doi: 10.1093/qjmed/hcx161. [Epub ahead of print]


Can promoting awareness of fetal movements and focusing interventions reduce fetal mortality? A stepped-wedge cluster randomised trial (AFFIRM).

Heazell AEP, Weir CJ, Stock SJE, Calderwood CJ, Burley SC, Froen JF, Geary M, Hunter A, McAuliffe FM, Murdoch E, Rodriguez A, Ross-Davie M, Scott J, Whyte S, Norman JE.

BMJ Open. 2017 Aug 11;7(8):e014813. doi: 10.1136/bmjopen-2016-014813.


Comparison of non-traditional biomarkers, and combinations of biomarkers, for vascular risk prediction in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study.

Price AH, Weir CJ, Welsh P, McLachlan S, Strachan MWJ, Sattar N, Price JF.

Atherosclerosis. 2017 Sep;264:67-73. doi: 10.1016/j.atherosclerosis.2017.07.009. Epub 2017 Jul 12.


Embracing model-based designs for dose-finding trials.

Love SB, Brown S, Weir CJ, Harbron C, Yap C, Gaschler-Markefski B, Matcham J, Caffrey L, McKevitt C, Clive S, Craddock C, Spicer J, Cornelius V.

Br J Cancer. 2017 Jul 25;117(3):332-339. doi: 10.1038/bjc.2017.186. Epub 2017 Jun 29. Review.


Models for estimating and projecting global, regional and national prevalence and disease burden of asthma: protocol for a systematic review.

Bhuia MR, Nwaru BI, Weir CJ, Sheikh A.

BMJ Open. 2017 May 17;7(5):e015441. doi: 10.1136/bmjopen-2016-015441.


Home monitoring of breathing rate in people with chronic obstructive pulmonary disease: observational study of feasibility, acceptability, and change after exacerbation.

Rubio N, Parker RA, Drost EM, Pinnock H, Weir CJ, Hanley J, Mantoani LC, MacNee W, McKinstry B, Rabinovich RA.

Int J Chron Obstruct Pulmon Dis. 2017 Apr 20;12:1221-1231. doi: 10.2147/COPD.S120706. eCollection 2017.


A pilot randomised controlled trial investigating a Mediterranean diet intervention in pregnant women for the primary prevention of allergic diseases in infants.

Sewell DA, Hammersley VS, Robertson A, Devereux G, Stoddart A, Weir CJ, Worth A, Sheikh A.

J Hum Nutr Diet. 2017 Oct;30(5):604-614. doi: 10.1111/jhn.12469. Epub 2017 Feb 16.


Application of Mixed Effects Limits of Agreement in the Presence of Multiple Sources of Variability: Exemplar from the Comparison of Several Devices to Measure Respiratory Rate in COPD Patients.

Parker RA, Weir CJ, Rubio N, Rabinovich R, Pinnock H, Hanley J, McCloughan L, Drost EM, Mantoani LC, MacNee W, McKinstry B.

PLoS One. 2016 Dec 14;11(12):e0168321. doi: 10.1371/journal.pone.0168321. eCollection 2016.


Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers.

Datta D, Conway Morris A, Antonelli J, Warner N, Brown KA, Wright J, Simpson AJ, Rennie J, Hulme G, Lewis SM, Mare TA, Cookson S, Weir CJ, Dimmick I, Keenan J, Rossi AG, Shankar-Hari M, Walsh TS; ExPRES Sepsis Investigators.

BMJ Open. 2016 Aug 1;6(8):e011335. doi: 10.1136/bmjopen-2016-011335.


Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial.

Walsh TS, Kydonaki K, Antonelli J, Stephen J, Lee RJ, Everingham K, Hanley J, Phillips EC, Uutela K, Peltola P, Cole S, Quasim T, Ruddy J, McDougall M, Davidson A, Rutherford J, Richards J, Weir CJ; Development and Evaluation of Strategies to Improve Sedation Practice in Intensive Care (DESIST) study investigators.

Lancet Respir Med. 2016 Oct;4(10):807-817. doi: 10.1016/S2213-2600(16)30178-3. Epub 2016 Jul 26.


Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study).

Conway Morris A, Datta D, Shankar-Hari M, Weir CJ, Rennie J, Antonelli J, Rossi AG, Warner N, Keenan J, Wang A, Brown KA, Lewis S, Mare T, Simpson AJ, Hulme G, Dimmick I, Walsh TS.

BMJ Open. 2016 Jul 18;6(7):e011326. doi: 10.1136/bmjopen-2016-011326.


The effectiveness and variation of acute medical units: a systematic review.

Reid LE, Dinesen LC, Jones MC, Morrison ZJ, Weir CJ, Lone NI.

Int J Qual Health Care. 2016 Sep;28(4):433-46. doi: 10.1093/intqhc/mzw056. Epub 2016 Jun 16. Review.


Phase 2 Randomised Controlled Trial and Feasibility Study of Future Care Planning in Patients with Advanced Heart Disease.

Denvir MA, Cudmore S, Highet G, Robertson S, Donald L, Stephen J, Haga K, Hogg K, Weir CJ, Murray SA, Boyd K.

Sci Rep. 2016 Apr 19;6:24619. doi: 10.1038/srep24619.


Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study).

Walsh TS, Kydonaki K, Antonelli J, Stephen J, Lee RJ, Everingham K, Hanley J, Uutelo K, Peltola P, Weir CJ; Development and Evaluation of Strategies to Improve Sedation practice in in Tensive care Study Investigators.

BMJ Open. 2016 Mar 4;6(3):e010148. doi: 10.1136/bmjopen-2015-010148.


Development of Process Control Methodology for Tracking the Quality and Safety of Pain, Agitation, and Sedation Management in Critical Care Units.

Walsh TS, Kydonaki K, Lee RJ, Everingham K, Antonelli J, Harkness RT, Cole S, Quasim T, Ruddy J, McDougall M, Davidson A, Rutherford J, Richards J, Weir CJ; Development and Evaluation of Strategies to Improve Sedation practice in inTensive care Study Investigators.

Crit Care Med. 2016 Mar;44(3):564-74. doi: 10.1097/CCM.0000000000001463.


Socioeconomic status, comorbidity and mortality in patients with type 2 diabetes mellitus in Scotland 2004-2011: a cohort study.

Walker J, Halbesma N, Lone N, McAllister D, Weir CJ, Wild SH; Scottish Diabetes Research Network Epidemiology Group.

J Epidemiol Community Health. 2016 Jun;70(6):596-601. doi: 10.1136/jech-2015-206702. Epub 2015 Dec 17.


Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model.

Weir CJ, Hudson AL, Peters L, Howell VM.

J Vis Exp. 2015 Oct 2;(104). doi: 10.3791/53019.


Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study.

Holm Hansen C, Warner P, Parker RA, Walker BR, Critchley HO, Weir CJ.

Stat Methods Med Res. 2017 Dec;26(6):2681-2699. doi: 10.1177/0962280215606155. Epub 2015 Sep 30.


Statistical approaches for evaluating surrogate outcomes in clinical trials: A systematic review.

Ensor H, Lee RJ, Sudlow C, Weir CJ.

J Biopharm Stat. 2016;26(5):859-79. doi: 10.1080/10543406.2015.1094811. Epub 2015 Sep 21. Review.


Clinical and cost effectiveness of enhanced oral healthcare in stroke care settings (SOCLE II): a pilot, stepped wedge, cluster randomized, controlled trial protocol.

Brady MC, Stott D, Weir CJ, Chalmers C, Sweeney P, Donaldson C, Barr J, Barr M, Pollock A, McGowan S, Bowers N, Langhorne P.

Int J Stroke. 2015 Aug;10(6):979-84. doi: 10.1111/ijs.12530. Epub 2015 Jun 16.


Prescription of emergency antiepileptic medication after a first childhood seizure: analysis of routine administrative data.

Chin RF, Ajetunmobi O, Weir CJ, Wood R.

Epileptic Disord. 2015 Jun;17(2):172-6. doi: 10.1684/epd.2015.0745.


Cancer treatment-related neuropathic pain: proof of concept study with menthol--a TRPM8 agonist.

Fallon MT, Storey DJ, Krishan A, Weir CJ, Mitchell R, Fleetwood-Walker SM, Scott AC, Colvin LA.

Support Care Cancer. 2015 Sep;23(9):2769-77. doi: 10.1007/s00520-015-2642-8. Epub 2015 Feb 15.


Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).

Warner P, Weir CJ, Hansen CH, Douglas A, Madhra M, Hillier SG, Saunders PT, Iredale JP, Semple S, Walker BR, Critchley HO.

BMJ Open. 2015 Jan 14;5(1):e006837. doi: 10.1136/bmjopen-2014-006837.

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