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Immunomodulatory effect of Syphacia obvelata in treatment of experimental DSS-induced colitis in mouse model.

Taghipour N, Mosaffa N, Aghdaei HA, Rostami-Nejad M, Weinstock JV, Shahnavaz S, Zali MR.

Sci Rep. 2019 Dec 13;9(1):19127. doi: 10.1038/s41598-019-55552-6.


Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.

Hang L, Kumar S, Blum AM, Urban JF Jr, Fantini MC, Weinstock JV.

J Immunol. 2019 Apr 15;202(8):2473-2481. doi: 10.4049/jimmunol.1801392. Epub 2019 Mar 8.


Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.

Leroux LP, Nasr M, Valanparambil R, Tam M, Rosa BA, Siciliani E, Hill DE, Zarlenga DS, Jaramillo M, Weinstock JV, Geary TG, Stevenson MM, Urban JF Jr, Mitreva M, Jardim A.

Sci Rep. 2018 Oct 29;8(1):15921. doi: 10.1038/s41598-018-34174-4.


Nematodes and human therapeutic trials for inflammatory disease.

Elliott DE, Weinstock JV.

Parasite Immunol. 2017 May;39(5). doi: 10.1111/pim.12407. Epub 2017 Apr 18. Review.


Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.

Hang L, Blum AM, Kumar S, Urban JF Jr, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV.

J Immunol. 2016 Oct 1;197(7):2948-57. doi: 10.4049/jimmunol.1600063. Epub 2016 Aug 24.


Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.

Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS.

Science. 2016 Mar 18;351(6279):1329-33. doi: 10.1126/science.aaf1648. Epub 2016 Feb 4.


Clinical trials of helminth therapy in autoimmune diseases: rationale and findings.

Fleming JO, Weinstock JV.

Parasite Immunol. 2015 Jun;37(6):277-92. doi: 10.1111/pim.12175. Review.


Substance P and the regulation of inflammation in infections and inflammatory bowel disease.

Weinstock JV.

Acta Physiol (Oxf). 2015 Feb;213(2):453-61. doi: 10.1111/apha.12428. Epub 2015 Jan 1. Review.


Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha.

Oxenkrug G, Turski W, Zgrajka W, Weinstock J, Ruthazer R, Summergrad P.

J Infect Dis Ther. 2014 Feb 25;2(2). pii: 131.


Do We Need Worms to Promote Immune Health?

Weinstock JV.

Clin Rev Allergy Immunol. 2015 Oct;49(2):227-31. doi: 10.1007/s12016-014-8458-3. Review.


Helminth infections decrease host susceptibility to immune-mediated diseases.

Weinstock JV, Elliott DE.

J Immunol. 2014 Oct 1;193(7):3239-47. doi: 10.4049/jimmunol.1400927.


Innate immunity in disease.

Elliott DE, Siddique SS, Weinstock JV.

Clin Gastroenterol Hepatol. 2014 May;12(5):749-55. doi: 10.1016/j.cgh.2014.03.007. Epub 2014 Mar 12. Review.


Tryptophan-kynurenine metabolism and insulin resistance in hepatitis C patients.

Oxenkrug GF, Turski WA, Zgrajka W, Weinstock JV, Summergrad P.

Hepat Res Treat. 2013;2013:149247. doi: 10.1155/2013/149247. Epub 2013 Sep 4.


Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis.

Hang L, Blum AM, Setiawan T, Urban JP Jr, Stoyanoff KM, Weinstock JV.

J Immunol. 2013 Aug 15;191(4):1927-34. doi: 10.4049/jimmunol.1201457. Epub 2013 Jul 12.


Have worms lost their luster?

Weinstock JV.

Inflamm Bowel Dis. 2013 Mar;19(3):672-3. doi: 10.1097/MIB.0b013e318281d35b. No abstract available.


Assessment of fractionated exhaled nitric oxide as a biomarker for the treatment of eosinophilic esophagitis.

Leung J, Nguyen-Traxler A, Lee EM, Yip JS, Weinstock JV, Chan WW, Ngo P, Weinstein BJ, Bonis PA.

Allergy Asthma Proc. 2012 Nov-Dec;33(6):519-24. doi: 10.2500/aap.2012.33.3606. Erratum in: Allergy Asthma Proc. 2013 Jan 1;34(1):107.


Erratum: Assessment of fractionated exhaled nitric oxide as a biomarker for the treatment of eosinophilic esophagitis.

Leung J, Nguyen-Traxler A, Lee EM, Yip JS, Weinstock JV, Chan WW, Ngo P, Weinstein BJ, Bonis PA.

Allergy Asthma Proc. 2013 Jan 1;34(1):107. doi: 10.2500/aap.2013.34.2233. No abstract available.


Translatability of helminth therapy in inflammatory bowel diseases.

Weinstock JV, Elliott DE.

Int J Parasitol. 2013 Mar;43(3-4):245-51. doi: 10.1016/j.ijpara.2012.10.016. Epub 2012 Nov 21. Review.


Autoimmunity: The worm returns.

Weinstock JV.

Nature. 2012 Nov 8;491(7423):183-5. doi: 10.1038/491183a. No abstract available.


Where are we on worms?

Elliott DE, Weinstock JV.

Curr Opin Gastroenterol. 2012 Nov;28(6):551-6. doi: 10.1097/MOG.0b013e3283572f73. Review.


Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses.

Blum AM, Hang L, Setiawan T, Urban JP Jr, Stoyanoff KM, Leung J, Weinstock JV.

J Immunol. 2012 Sep 1;189(5):2512-20. doi: 10.4049/jimmunol.1102892. Epub 2012 Jul 27.


Helminth-host immunological interactions: prevention and control of immune-mediated diseases.

Elliott DE, Weinstock JV.

Ann N Y Acad Sci. 2012 Jan;1247:83-96. doi: 10.1111/j.1749-6632.2011.06292.x. Epub 2012 Jan 12. Review.


Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus.

Walk ST, Blum AM, Ewing SA, Weinstock JV, Young VB.

Inflamm Bowel Dis. 2010 Nov;16(11):1841-9. doi: 10.1002/ibd.21299.


Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity.

Hang L, Setiawan T, Blum AM, Urban J, Stoyanoff K, Arihiro S, Reinecker HC, Weinstock JV.

J Immunol. 2010 Sep 15;185(6):3184-9. doi: 10.4049/jimmunol.1000941. Epub 2010 Aug 11.


TGF-beta regulates T-cell neurokinin-1 receptor internalization and function.

Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4293-8. doi: 10.1073/pnas.0905877107. Epub 2010 Feb 16.


Trichuris suis might be effective in treating allergic rhinitis.

Summers RW, Elliott DE, Weinstock JV.

J Allergy Clin Immunol. 2010 Mar;125(3):766-7. doi: 10.1016/j.jaci.2009.12.937. Epub 2010 Feb 11. No abstract available.


Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.

Ruyssers NE, De Winter BY, De Man JG, Ruyssers ND, Van Gils AJ, Loukas A, Pearson MS, Weinstock JV, Pelckmans PA, Moreels TG.

World J Gastroenterol. 2010 Feb 14;16(6):703-12.


Helminthic therapy: using worms to treat immune-mediated disease.

Elliott DE, Weinstock JV.

Adv Exp Med Biol. 2009;666:157-66. Review.


Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells.

Clay BS, Shilling RA, Bandukwala HS, Moore TV, Cannon JL, Welcher AA, Weinstock JV, Sperling AI.

PLoS One. 2009 Nov 4;4(11):e7525. doi: 10.1371/journal.pone.0007525.


Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma.

Tong J, Clay BS, Ferreira CM, Bandukwala HS, Moore TV, Blaine KM, Williams JW, Hoffman LM, Hamann KJ, Shilling RA, Weinstock JV, Sperling AI.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):342-8. doi: 10.1165/rcmb.2008-0454OC. Epub 2009 Oct 23.


CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.

Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI.

Cell Immunol. 2009;259(2):177-84. doi: 10.1016/j.cellimm.2009.06.013. Epub 2009 Jul 10.


Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation.

Ince MN, Elliott DE, Setiawan T, Metwali A, Blum A, Chen HL, Urban JF, Flavell RA, Weinstock JV.

Eur J Immunol. 2009 Jul;39(7):1870-8. doi: 10.1002/eji.200838956.


Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice.

Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG.

Inflamm Bowel Dis. 2009 Apr;15(4):491-500. doi: 10.1002/ibd.20787.


Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis.

Bazzone LE, Smith PM, Rutitzky LI, Shainheit MG, Urban JF, Setiawan T, Blum AM, Weinstock JV, Stadecker MJ.

Infect Immun. 2008 Nov;76(11):5164-72. doi: 10.1128/IAI.00673-08. Epub 2008 Aug 18.


Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production.

Elliott DE, Metwali A, Leung J, Setiawan T, Blum AM, Ince MN, Bazzone LE, Stadecker MJ, Urban JF Jr, Weinstock JV.

J Immunol. 2008 Aug 15;181(4):2414-9.


Helminths and the IBD hygiene hypothesis.

Weinstock JV, Elliott DE.

Inflamm Bowel Dis. 2009 Jan;15(1):128-33. doi: 10.1002/ibd.20633. Review.


ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes.

Tesciuba AG, Shilling RA, Agarwal MD, Bandukwala HS, Clay BS, Moore TV, Weinstock JV, Welcher AA, Sperling AI.

J Immunol. 2008 Jul 15;181(2):1019-24.


Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation.

Blum A, Setiawan T, Hang L, Stoyanoff K, Weinstock JV.

Infect Immun. 2008 Aug;76(8):3651-6. doi: 10.1128/IAI.00358-08. Epub 2008 May 27.


Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation.

Bandukwala HS, Clay BS, Tong J, Mody PD, Cannon JL, Shilling RA, Verbeek JS, Weinstock JV, Solway J, Sperling AI.

J Exp Med. 2007 Aug 6;204(8):1875-89. Epub 2007 Jul 30.


Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine.

Setiawan T, Metwali A, Blum AM, Ince MN, Urban JF Jr, Elliott DE, Weinstock JV.

Infect Immun. 2007 Sep;75(9):4655-63. Epub 2007 Jul 2.


Helminths as governors of immune-mediated inflammation.

Elliott DE, Summers RW, Weinstock JV.

Int J Parasitol. 2007 Apr;37(5):457-64. Epub 2006 Dec 28. Review.


Therapeutic colonization with Trichuris suis.

Summers RW, Elliott DE, Weinstock JV.

Arch Pathol Lab Med. 2006 Dec;130(12):1753; author reply 1753-4. No abstract available.


Helminths and mucosal immune modulation.

Weinstock JV.

Ann N Y Acad Sci. 2006 Aug;1072:356-64. Review.


Substance P receptor mediated maintenance of chronic inflammation in EAE.

Reinke EK, Johnson MJ, Ling C, Karman J, Lee J, Weinstock JV, Sandor M, Fabry Z.

J Neuroimmunol. 2006 Nov;180(1-2):117-25. Epub 2006 Aug 30.


Intestinal helminths protect in a murine model of asthma.

Kitagaki K, Businga TR, Racila D, Elliott DE, Weinstock JV, Kline JN.

J Immunol. 2006 Aug 1;177(3):1628-35.


Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection.

Metwali A, Setiawan T, Blum AM, Urban J, Elliott DE, Hang L, Weinstock JV.

Am J Physiol Gastrointest Liver Physiol. 2006 Aug;291(2):G253-9.


Mechanisms of disease: the hygiene hypothesis revisited.

Guarner F, Bourdet-Sicard R, Brandtzaeg P, Gill HS, McGuirk P, van Eden W, Versalovic J, Weinstock JV, Rook GA.

Nat Clin Pract Gastroenterol Hepatol. 2006 May;3(5):275-84. Review.


Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma.

Tong J, Bandulwala HS, Clay BS, Anders RA, Shilling RA, Balachandran DD, Chen B, Weinstock JV, Solway J, Hamann KJ, Sperling AI.

J Exp Med. 2006 May 15;203(5):1173-84. Epub 2006 Apr 17.


Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation.

Ince MN, Elliott DE, Setiawan T, Blum A, Metwali A, Wang Y, Urban JF Jr, Weinstock JV.

J Immunol. 2006 Jan 15;176(2):726-9.


Is there a role for helminths in the therapy of inflammatory bowel disease?

Summers RW, Elliott DE, Weinstock JV.

Nat Clin Pract Gastroenterol Hepatol. 2005 Feb;2(2):62-3. No abstract available.


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