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Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S.

J Clin Invest. 2019 Jun 17;130. pii: 123825. doi: 10.1172/JCI123825. eCollection 2019 Jun 17.


Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo.

Qin X, He L, Tian M, Hu P, Yang J, Lu H, Chen W, Jiang X, Zhang C, Gao J, Chen M, Weinstein LS, Zhang Y, Zhang W.

J Mol Cell Cardiol. 2019 Jul;132:49-59. doi: 10.1016/j.yjmcc.2019.05.002. Epub 2019 May 7.


Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling.

Chen M, Wilson EA, Cui Z, Sun H, Shrestha YB, Podyma B, Le CH, Naglieri B, Pacak K, Gavrilova O, Weinstein LS.

Mol Metab. 2019 Apr 12. pii: S2212-8778(19)30285-6. doi: 10.1016/j.molmet.2019.04.005. [Epub ahead of print]


High prevalence of chronic kidney disease in patients with multiple endocrine neoplasia type 1 and improved kidney function after parathyroidectomy.

Green P, Zagzag J, Patel D, Weinstein LS, Simonds WF, Blau J, Marx S, Kebebew E, Perrier N, Nilubol N.

Surgery. 2019 Jan;165(1):124-128. doi: 10.1016/j.surg.2018.04.064. Epub 2018 Nov 7.


Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice.

Patyra K, Jaeschke H, Löf C, Jännäri M, Ruohonen ST, Undeutsch H, Khalil M, Kero A, Poutanen M, Toppari J, Chen M, Weinstein LS, Paschke R, Kero J.

FASEB J. 2018 May 25:fj201800211R. doi: 10.1096/fj.201800211R. [Epub ahead of print]


The stimulatory G protein Gsα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.

Podyma B, Sun H, Wilson EA, Carlson B, Pritikin E, Gavrilova O, Weinstein LS, Chen M.

J Biol Chem. 2018 Jul 13;293(28):10993-11005. doi: 10.1074/jbc.RA118.003450. Epub 2018 May 24.


Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas.

Parekh VI, Modali SD, Welch J, Simonds WF, Weinstein LS, Kebebew E, Agarwal SK.

Endocr Relat Cancer. 2018 May;25(5):L31-L35. doi: 10.1530/ERC-17-0311. Epub 2018 Feb 21. No abstract available.


Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage.

Lachmann P, Hickmann L, Steglich A, Al-Mekhlafi M, Gerlach M, Jetschin N, Jahn S, Hamann B, Wnuk M, Madsen K, Djonov V, Chen M, Weinstein LS, Hohenstein B, Hugo CPM, Todorov VT.

J Am Soc Nephrol. 2017 Dec;28(12):3479-3489. doi: 10.1681/ASN.2017020173. Epub 2017 Aug 3.


Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

Kaucka M, Zikmund T, Tesarova M, Gyllborg D, Hellander A, Jaros J, Kaiser J, Petersen J, Szarowska B, Newton PT, Dyachuk V, Li L, Qian H, Johansson AS, Mishina Y, Currie JD, Tanaka EM, Erickson A, Dudley A, Brismar H, Southam P, Coen E, Chen M, Weinstein LS, Hampl A, Arenas E, Chagin AS, Fried K, Adameyko I.

Elife. 2017 Apr 17;6. pii: e25902. doi: 10.7554/eLife.25902.


Heterotrimeric G Stimulatory Protein α Subunit Is Required for Intestinal Smooth Muscle Contraction in Mice.

Qin X, Liu S, Lu Q, Zhang M, Jiang X, Hu S, Li J, Zhang C, Gao J, Zhu MS, Feil R, Li H, Chen M, Weinstein LS, Zhang Y, Zhang W.

Gastroenterology. 2017 Apr;152(5):1114-1125.e5. doi: 10.1053/j.gastro.2016.12.017. Epub 2016 Dec 30.


Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.

Chen M, Shrestha YB, Podyma B, Cui Z, Naglieri B, Sun H, Ho T, Wilson EA, Li YQ, Gavrilova O, Weinstein LS.

J Clin Invest. 2017 Feb 1;127(2):500-510. doi: 10.1172/JCI88622. Epub 2016 Dec 19.


A patient with MEN1 typical features and MEN2-like features.

El-Maouche D, Welch J, Agarwal SK, Weinstein LS, Simonds WF, Marx SJ.

Int J Endocr Oncol. 2016 May;3(2):89-95. Epub 2016 Apr 8.


Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism.

Keutgen XM, Nilubol N, Agarwal S, Welch J, Cochran C, Marx SJ, Weinstein LS, Simonds WF, Kebebew E.

Ann Surg Oncol. 2016 Dec;23(Suppl 5):701-707. Epub 2016 Jul 27.


G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis.

Lei R, Zhang K, Wei Y, Chen M, Weinstein LS, Hong Y, Zhu M, Li H, Li H.

PLoS One. 2016 Feb 9;11(2):e0147535. doi: 10.1371/journal.pone.0147535. eCollection 2016.


Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

Li YQ, Shrestha YB, Chen M, Chanturiya T, Gavrilova O, Weinstein LS.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):446-51. doi: 10.1073/pnas.1517142113. Epub 2015 Dec 28.


Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity.

Shao X, Liu K, Fan Y, Ding Z, Chen M, Zhu M, Weinstein LS, Li H, Li H.

J Genet Genomics. 2015 Nov 20;42(11):613-624. doi: 10.1016/j.jgg.2015.08.006. Epub 2015 Oct 20.


Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.

Berger A, Kablan A, Yao C, Ho T, Podyma B, Weinstein LS, Chen M.

Endocrinology. 2016 Feb;157(2):600-10. doi: 10.1210/en.2015-1700. Epub 2015 Dec 15.


Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D.

Zhu Y, He Q, Aydin C, Rubera I, Tauc M, Chen M, Weinstein LS, Marshansky V, Jüppner H, Bastepe M.

Endocrinology. 2016 Feb;157(2):497-507. doi: 10.1210/en.2015-1639. Epub 2015 Dec 15.


Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.

Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY.

J Biol Chem. 2016 Jan 22;291(4):1631-42. doi: 10.1074/jbc.M115.679753. Epub 2015 Nov 23.


G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.

Li YQ, Shrestha Y, Pandey M, Chen M, Kablan A, Gavrilova O, Offermanns S, Weinstein LS.

J Clin Invest. 2016 Jan;126(1):40-9. doi: 10.1172/JCI76348. Epub 2015 Nov 23.


Limited Parathyroidectomy in Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism: A Setup for Failure.

Nilubol N, Weinstein LS, Simonds WF, Jensen RT, Marx SJ, Kebebew E.

Ann Surg Oncol. 2016 Feb;23(2):416-23. doi: 10.1245/s10434-015-4865-9. Epub 2015 Nov 5.


Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS.

Nat Cell Biol. 2015 Jun;17(6):793-803. doi: 10.1038/ncb3164. Epub 2015 May 11.


Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression.

Liu K, Lin Q, Wei Y, He R, Shao X, Ding Z, Zhang J, Zhu M, Weinstein LS, Hong Y, Li H, Li H.

Neurosci Lett. 2015 Jun 15;597:97-103. doi: 10.1016/j.neulet.2015.04.034. Epub 2015 Apr 24.


Role of G(s)α in central regulation of energy and glucose metabolism.

Weinstein LS.

Horm Metab Res. 2014 Nov;46(12):841-4. doi: 10.1055/s-0034-1387798. Epub 2014 Sep 18. Review.


The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.

He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR.

Nat Med. 2014 Sep;20(9):1035-42. doi: 10.1038/nm.3666. Epub 2014 Aug 24.


Loss of Gsα early in the osteoblast lineage favors adipogenic differentiation of mesenchymal progenitors and committed osteoblast precursors.

Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Pajevic PD, Kronenberg HM, Wu JY.

J Bone Miner Res. 2014 Nov;29(11):2414-26. doi: 10.1002/jbmr.2270.


G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.

Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM.

Nat Commun. 2014 Apr 30;5:3673. doi: 10.1038/ncomms4673.


Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.

Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F, Chen M, Finkel T, Weinstein LS, Li JJ.

Dev Cell. 2014 Apr 28;29(2):217-32. doi: 10.1016/j.devcel.2014.03.012. Epub 2014 Apr 17.


Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.

Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.

Nat Med. 2013 Nov;19(11):1505-12. doi: 10.1038/nm.3314. Epub 2013 Sep 29.


Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.

Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Yu CR, Storm DR, Nishizumi H, Sakano H.

Cell. 2013 Sep 12;154(6):1314-25. doi: 10.1016/j.cell.2013.08.033.


Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.

Muniyappa R, Warren MA, Zhao X, Aney SC, Courville AB, Chen KY, Brychta RJ, Germain-Lee EL, Weinstein LS, Skarulis MC.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1796-801. doi: 10.1210/jc.2013-1594. Epub 2013 Sep 12.


Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone resistance owing to heterozygous Gαs disruption.

Turan S, Fernandez-Rebollo E, Aydin C, Zoto T, Reyes M, Bounoutas G, Chen M, Weinstein LS, Erben RG, Marshansky V, Bastepe M.

J Bone Miner Res. 2014 Mar;29(3):749-60. doi: 10.1002/jbmr.2070.


Utility of intraoperative parathyroid hormone monitoring in patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial parathyroidectomy.

Nilubol N, Weisbrod AB, Weinstein LS, Simonds WF, Jensen RT, Phan GQ, Hughes MS, Libutti SK, Marx S, Kebebew E.

World J Surg. 2013 Aug;37(8):1966-72. doi: 10.1007/s00268-013-2054-1.


The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins.

Sebastian S, Ang R, Abramowitz J, Weinstein LS, Chen M, Ludwig A, Birnbaumer L, Tinker A.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 15;305(4):R435-42. doi: 10.1152/ajpregu.00037.2013. Epub 2013 May 22.


Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.

Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P.

Blood. 2013 Feb 7;121(6):930-9. doi: 10.1182/blood-2012-06-437160. Epub 2012 Nov 16.


Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.

Weisbrod AB, Nilubol N, Weinstein LS, Simonds WF, Libutti SK, Jensen RT, Marx SJ, Kebebew E.

J Clin Endocrinol Metab. 2013 Jan;98(1):E109-14. doi: 10.1210/jc.2012-2781. Epub 2012 Oct 23.


Development and treatment of tertiary hyperparathyroidism in patients with pseudohypoparathyroidism type 1B.

Neary NM, El-Maouche D, Hopkins R, Libutti SK, Moses AM, Weinstein LS.

J Clin Endocrinol Metab. 2012 Sep;97(9):3025-30. doi: 10.1210/jc.2012-1655. Epub 2012 Jun 26.


Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.

Chen M, Berger A, Kablan A, Zhang J, Gavrilova O, Weinstein LS.

Endocrinology. 2012 Sep;153(9):4256-65. doi: 10.1210/en.2012-1113. Epub 2012 Jun 25.


Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.

Yavuz S, Simonds WF, Weinstein LS, Collins MT, Kebebew E, Nilubol N, Phan GQ, Libutti SK, Remaley AT, Van Deventer M, Marx SJ.

J Clin Endocrinol Metab. 2012 Jun;97(6):1834-41. doi: 10.1210/jc.2011-3030. Epub 2012 Apr 16.


Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.

Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E.

J Clin Invest. 2012 Mar;122(3):963-73. doi: 10.1172/JCI59097. Epub 2012 Feb 13.


Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.

Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20101-6. doi: 10.1073/pnas.1114656108. Epub 2011 Nov 21.


Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics.

Schneider AM, Rawat D, Weinstein LS, Gupte SA, Richards WO.

Surg Endosc. 2012 Mar;26(3):823-30. doi: 10.1007/s00464-011-1959-8. Epub 2011 Nov 15.


Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.

Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK, Chen M, Poulton IJ, Purton LE, Sims NA, Weinstein LS, Kronenberg HM.

J Clin Invest. 2011 Sep;121(9):3492-504. doi: 10.1172/JCI46406. Epub 2011 Aug 1.


Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.

Chen M, Mema E, Kelleher J, Nemechek N, Berger A, Wang J, Xie T, Gavrilova O, Drucker DJ, Weinstein LS.

Endocrinology. 2011 Sep;152(9):3343-50. doi: 10.1210/en.2011-0012. Epub 2011 Jul 19.


Improved fatigue resistance in Gsα-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers.

Feng HZ, Chen M, Weinstein LS, Jin JP.

J Appl Physiol (1985). 2011 Sep;111(3):834-43. doi: 10.1152/japplphysiol.00031.2011. Epub 2011 Jun 16.


Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo.

Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Fröhlich LF, Bastepe M.

Endocrinology. 2011 Apr;152(4):1222-33. doi: 10.1210/en.2010-1034. Epub 2011 Feb 8.


Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.

Franco AT, Malaguarnera R, Refetoff S, Liao XH, Lundsmith E, Kimura S, Pritchard C, Marais R, Davies TF, Weinstein LS, Chen M, Rosen N, Ghossein R, Knauf JA, Fagin JA.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1615-20. doi: 10.1073/pnas.1015557108. Epub 2011 Jan 10.


Effects of deficiency of the G protein Gsα on energy and glucose homeostasis.

Chen M, Nemechek NM, Mema E, Wang J, Weinstein LS.

Eur J Pharmacol. 2011 Jun 11;660(1):119-24. doi: 10.1016/j.ejphar.2010.10.105. Epub 2011 Jan 3. Review.


Renal failure in mice with Gsalpha deletion in juxtaglomerular cells.

Chen L, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J.

Am J Nephrol. 2010;32(1):83-94. doi: 10.1159/000314635. Epub 2010 Jun 11.


Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.

Xie T, Chen M, Weinstein LS.

J Endocrinol. 2010 Sep;206(3):261-9. doi: 10.1677/JOE-10-0030. Epub 2010 Jun 11.

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