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Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI.

Leijenaar JF, Groeneveld GJ, Klaassen ES, Leeuwis AE, Scheltens P, Weinstein HC, van Gerven JMA, Barkhof F, van der Flier WM, Prins ND.

Alzheimers Res Ther. 2020 Jan 7;12(1):10. doi: 10.1186/s13195-019-0567-z.


Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.

J Comput Chem. 2019 Nov 21. doi: 10.1002/jcc.26105. [Epub ahead of print]


Predicting response to cognitive processing therapy: Does trauma history matter?

Roberge EM, Weinstein HR, Bryan CJ.

Psychol Trauma. 2019 Nov 18. doi: 10.1037/tra0000530. [Epub ahead of print]


CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.

Oosterveld LP, Verberk IMW, Majbour NK, El-Agnaf OM, Weinstein HC, Berendse HW, Teunissen CE, van de Berg WDJ.

Mov Disord. 2019 Nov 18. doi: 10.1002/mds.27897. [Epub ahead of print]


Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy.

van Ballegoij WJC, Kuijpers SC, Huffnagel IC, Weinstein HC, Poll-The BT, Engelen M, Bennebroek CAM, Verbraak FD.

J Neurol. 2019 Nov 12. doi: 10.1007/s00415-019-09627-z. [Epub ahead of print]


Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.

Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H.

Nat Commun. 2019 Oct 31;10(1):4972. doi: 10.1038/s41467-019-12865-4.


A Graphic Encoding Method for Quantitative Classification of Protein Structure and Representation of Conformational Changes.

Carrillo-Cabada H, Benson J, Razavi A, Mulligan B, Cuendet MA, Weinstein H, Taufer M, Estrada T.

IEEE/ACM Trans Comput Biol Bioinform. 2019 Oct 4. doi: 10.1109/TCBB.2019.2945291. [Epub ahead of print]


Design and Refinement of a Data Quality Assessment Workflow for a Large Pediatric Research Network.

Khare R, Utidjian LH, Razzaghi H, Soucek V, Burrows E, Eckrich D, Hoyt R, Weinstein H, Miller MW, Soler D, Tucker J, Bailey LC.

EGEMS (Wash DC). 2019 Aug 1;7(1):36. doi: 10.5334/egems.294.


Non-motor symptoms in Parkinson's disease: An explorative network study.

Engels G, Douw L, Kerst Y, Weinstein H, Scherder E, Vlaar A.

Parkinsonism Relat Disord. 2019 Sep;66:237-240. doi: 10.1016/j.parkreldis.2019.08.002. Epub 2019 Aug 13.


A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited.

Doktorova M, LeVine MV, Khelashvili G, Weinstein H.

Biophys J. 2019 Aug 20;117(4):790. doi: 10.1016/j.bpj.2019.07.039. Epub 2019 Aug 1. No abstract available.


The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.

LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15947-15956. doi: 10.1073/pnas.1903020116. Epub 2019 Jul 19.


To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology.

El Hassouni B, Mantini G, Li Petri G, Capula M, Boyd L, Weinstein HNW, Vallés-Marti A, Kouwenhoven MCM, Giovannetti E, Westerman BA, Peters GJ; EORTC PAMM Group.

Anticancer Res. 2019 Jul;39(7):3303-3309. doi: 10.21873/anticanres.13472. Review.


Diplopia in Parkinson's disease: visual illusion or oculomotor impairment?

Visser F, Vlaar AMM, Borm CDJM, Apostolov V, Lee YX, Notting IC, Weinstein HC, Berendse HW.

J Neurol. 2019 Oct;266(10):2457-2464. doi: 10.1007/s00415-019-09430-w. Epub 2019 Jun 18.


A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs.

Plante A, Shore DM, Morra G, Khelashvili G, Weinstein H.

Molecules. 2019 Jun 2;24(11). pii: E2097. doi: 10.3390/molecules24112097.


Inflammatory biomarkers in patients with sciatica: a systematic review.

Jungen MJ, Ter Meulen BC, van Osch T, Weinstein HC, Ostelo RWJG.

BMC Musculoskelet Disord. 2019 Apr 9;20(1):156. doi: 10.1186/s12891-019-2541-0.


Outcomes of a clinical pathway for primary outpatient management of pediatric patients with low-risk febrile neutropenia.

Paolino J, Mariani J, Lucas A, Rupon J, Weinstein H, Abrams A, Friedmann A.

Pediatr Blood Cancer. 2019 Jul;66(7):e27679. doi: 10.1002/pbc.27679. Epub 2019 Mar 27.


How Do Different Forms of Vascular Brain Injury Relate to Cognition in a Memory Clinic Population: The TRACE-VCI Study.

Boomsma JMF, Exalto LG, Barkhof F, van den Berg E, de Bresser J, Heinen R, Leeuwis AE, Prins ND, Scheltens P, Weinstein HC, van der Flier WM, Biessels GJ; behalf of the TRACE-VCI study group.

J Alzheimers Dis. 2019;68(3):1273-1286. doi: 10.3233/JAD-180696.


Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.

Doktorova M, Heberle FA, Marquardt D, Rusinova R, Sanford RL, Peyear TA, Katsaras J, Feigenson GW, Weinstein H, Andersen OS.

Biophys J. 2019 Mar 5;116(5):860-873. doi: 10.1016/j.bpj.2019.01.016. Epub 2019 Jan 25.


A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited.

Doktorova M, LeVine MV, Khelashvili G, Weinstein H.

Biophys J. 2019 Feb 5;116(3):487-502. doi: 10.1016/j.bpj.2018.12.016. Epub 2019 Jan 3. Erratum in: Biophys J. 2019 Aug 20;117(4):790.


How do people with dementia respond to different types of art? An explorative study into interactive museum programs.

Hendriks I, Meiland FJM, Slotwinska K, Kroeze R, Weinstein H, Gerritsen DL, Dröes RM.

Int Psychogeriatr. 2018 Dec 18:1-12. doi: 10.1017/S1041610218001266. [Epub ahead of print]


Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles.

Doktorova M, Weinstein H.

Biophys J. 2018 Nov 6;115(9):1638-1643. doi: 10.1016/j.bpj.2018.09.008. Epub 2018 Sep 15.


Cognitive functioning in patients with carotid artery occlusion; a systematic review.

Oudeman EA, Kappelle LJ, Van den Berg-Vos RM, Weinstein HC, van den Berg E, Klijn CJM.

J Neurol Sci. 2018 Nov 15;394:132-137. doi: 10.1016/j.jns.2018.09.006. Epub 2018 Sep 6.


Clinical pain and functional network topology in Parkinson's disease: a resting-state fMRI study.

Engels G, McCoy B, Vlaar A, Theeuwes J, Weinstein H, Scherder E, Douw L.

J Neural Transm (Vienna). 2018 Oct;125(10):1449-1459. doi: 10.1007/s00702-018-1916-y. Epub 2018 Aug 21.


Excellent outcomes in children and adolescents with CNS+ Burkitt lymphoma or other mature B-NHL using only intrathecal and systemic chemoimmunotherapy: results from FAB/LMB96 and COG ANHL01P1.

Frazer JK, Li KJ, Galardy PJ, Perkins SL, Auperin A, Anderson JR, Pinkerton R, Buxton A, Gross TG, Michon J, Leverger G, Weinstein HJ, Harrison L, Shiramizu B, Barth MJ, Goldman SC, Patte C, Cairo MS.

Br J Haematol. 2019 Apr;185(2):374-377. doi: 10.1111/bjh.15520. Epub 2018 Aug 16. No abstract available.


Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.

Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A.

Nat Commun. 2018 Aug 14;9(1):3251. doi: 10.1038/s41467-018-05724-1.


The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi: 10.1073/pnas.1717444115. Epub 2018 Aug 6.


Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk.

Van Someren EJW, Oosterman JM, Van Harten B, Vogels RL, Gouw AA, Weinstein HC, Poggesi A, Scheltens P, Scherder EJA.

Neurobiol Learn Mem. 2019 Apr;160:132-138. doi: 10.1016/j.nlm.2018.05.017. Epub 2018 Jun 1.


An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.

Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, Weinstein H, Kjærulff O, Stamou D, Gether U, Madsen KL.

Cell Rep. 2018 May 15;23(7):2056-2069. doi: 10.1016/j.celrep.2018.04.074.


Symptomatic Treatment of Vascular Cognitive Impairment (STREAM-VCI): Protocol for a Cross-Over Trial.

Leijenaar JF, Groeneveld GJ, van der Flier WM, Scheltens P, Klaassen ES, Weinstein HC, Biessels GJ, Barkhof F, Prins ND.

JMIR Res Protoc. 2018 Mar 20;7(3):e80. doi: 10.2196/resprot.9192.


How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties.

Razavi AM, Khelashvili G, Weinstein H.

BMC Biol. 2018 Mar 14;16(1):31. doi: 10.1186/s12915-018-0495-6.


In vivo exploration of retinal nerve fiber layer morphology in Parkinson's disease patients.

Visser F, Vermeer KA, Ghafaryasl B, Vlaar AMM, Apostolov V, van Hellenberg Hubar J, Weinstein HC, de Boer JF, Berendse HW.

J Neural Transm (Vienna). 2018 Jun;125(6):931-936. doi: 10.1007/s00702-018-1872-6. Epub 2018 Mar 8.


A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.

Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC.

Nat Commun. 2018 Jan 15;9(1):230. doi: 10.1038/s41467-017-02202-y.


Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin.

Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G.

Structure. 2018 Feb 6;26(2):356-367.e3. doi: 10.1016/j.str.2017.11.020. Epub 2017 Dec 28.


Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.

LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H.

Biophys J. 2018 Jan 9;114(1):10-14. doi: 10.1016/j.bpj.2017.10.030. Epub 2017 Nov 15.


Extending julius seizure, a bang-sensitive gene, as a model for studying epileptogenesis: Cold shock, and a new insertional mutation.

Dean D, Weinstein H, Amin S, Karno B, McAvoy E, Hoy R, Recknagel A, Jarvis C, Deitcher D.

Fly (Austin). 2018 Jan 2;12(1):55-61. doi: 10.1080/19336934.2017.1402993. Epub 2017 Dec 8.


Using Physician-Level Emergency Department Utilization Reports to Address Avoidable Visits by Patients Managed by Pediatric Specialists.

Lee J, Israel E, Weinstein H, Kinane TB, Pasternack M, Linov P, Kaafarani HMA, Greenspan P, Rao SK.

Hosp Pediatr. 2017 Nov;7(11):686-691. doi: 10.1542/hpeds.2017-0054.


Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms.

Hobbs GS, Hanasoge Somasundara AV, Kleppe M, Litvin R, Arcila M, Ahn J, McKenney AS, Knapp K, Ptashkin R, Weinstein H, Heinemann MH, Francis J, Chanel S, Berman E, Mauro M, Tallman MS, Heaney ML, Levine RL, Rampal RK.

Haematologica. 2018 Jan;103(1):e5-e9. doi: 10.3324/haematol.2017.177600. Epub 2017 Oct 19. No abstract available.


Complexity perspectives on clinical decision making in an intensive care unit.

de Bock BA, Willems DL, Weinstein HC.

J Eval Clin Pract. 2018 Feb;24(1):308-313. doi: 10.1111/jep.12794. Epub 2017 Aug 1.


Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC.

Nature. 2017 Jul 6;547(7661):68-73. doi: 10.1038/nature22354. Epub 2017 Jun 7.


Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins.

Wragg RT, Parisotto DA, Li Z, Terakawa MS, Snead D, Basu I, Weinstein H, Eliezer D, Dittman JS.

Front Mol Neurosci. 2017 May 26;10:146. doi: 10.3389/fnmol.2017.00146. eCollection 2017.


Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial.

Ter Meulen BC, Maas ET, Vyas A, van der Vegt M, de Priester K, de Boer MR, van Tulder MW, Weinstein HC, Ostelo RWJG.

BMC Musculoskelet Disord. 2017 May 25;18(1):215. doi: 10.1186/s12891-017-1571-8.


Vascular Cognitive Impairment in a Memory Clinic Population: Rationale and Design of the "Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment" (TRACE-VCI) Study.

Boomsma JMF, Exalto LG, Barkhof F, van den Berg E, de Bresser J, Heinen R, Koek HL, Prins ND, Scheltens P, Weinstein HC, van der Flier WM, Biessels GJ.

JMIR Res Protoc. 2017 Apr 19;6(4):e60. doi: 10.2196/resprot.6864.


Cardiorespiratory fitness, cognition and brain structure after TIA or minor ischemic stroke.

Boss HM, Van Schaik SM, Witkamp TD, Geerlings MI, Weinstein HC, Van den Berg-Vos RM.

Int J Stroke. 2017 Oct;12(7):724-731. doi: 10.1177/1747493017702666. Epub 2017 Apr 6.


The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

Stolzenberg S, Li Z, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L.

J Biol Chem. 2017 May 5;292(18):7372-7384. doi: 10.1074/jbc.M116.757153. Epub 2017 Mar 20.


Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP.

J Cell Sci. 2017 Mar 1;130(5):868-878. doi: 10.1242/jcs.196436. Epub 2017 Jan 19.


Cardiorespiratory Fitness after Transient Ischemic Attack and Minor Ischemic Stroke: Baseline Data of the MoveIT Study.

Boss HM, Deijle IA, Van Schaik SM, de Melker EC, van den Berg BTJ, Weinstein HC, Geerlings MI, Kappelle LJ, Van den Berg-Vos RM.

J Stroke Cerebrovasc Dis. 2017 May;26(5):1114-1120. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.029. Epub 2017 Jan 12.


A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.

Razavi AM, Khelashvili G, Weinstein H.

Sci Rep. 2017 Jan 6;7:40076. doi: 10.1038/srep40076.


Lifestyle Interventions to Prevent Cardiovascular Events After Stroke and Transient Ischemic Attack: Systematic Review and Meta-Analysis.

Deijle IA, Van Schaik SM, Van Wegen EE, Weinstein HC, Kwakkel G, Van den Berg-Vos RM.

Stroke. 2017 Jan;48(1):174-179. doi: 10.1161/STROKEAHA.116.013794. Epub 2016 Dec 6. Review. Erratum in: Stroke. 2017 Sep;48(9):e271.


Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB.

Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:1-9. doi: 10.1016/j.pnpbp.2016.11.004. Epub 2016 Nov 24.


The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems.

Cuendet MA, Weinstein H, LeVine MV.

J Chem Theory Comput. 2016 Dec 13;12(12):5758-5767. Epub 2016 Nov 22.

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