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Stressing the potential of guanfacine as a treatment for cocaine use disorder.

Lustberg D, Weinshenker D.

Neuropsychopharmacology. 2020 Mar 9. doi: 10.1038/s41386-020-0649-4. [Epub ahead of print] No abstract available.


Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors.

Tillage RP, Sciolino NR, Plummer NW, Lustberg D, Liles LC, Hsiang M, Powell JM, Smith KG, Jensen P, Weinshenker D.

Brain Struct Funct. 2020 Mar;225(2):785-803. doi: 10.1007/s00429-020-02035-4. Epub 2020 Feb 17.


Vesicular monoamine transporter 2 mediates fear behavior in mice.

Branco RC, Burkett JP, Black CA, Winokur E, Ellsworth W, Dhamsania RK, Lohr KM, Schroeder JP, Weinshenker D, Jovanovic T, Miller GW.

Genes Brain Behav. 2020 Jan 3:e12634. doi: 10.1111/gbb.12634. [Epub ahead of print]


A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism.

Rasmussen SA, Daenzer JMI, MacWilliams JA, Head ST, Williams MB, Geurts AM, Schroeder JP, Weinshenker D, Fridovich-Keil JL.

J Inherit Metab Dis. 2019 Dec 17. doi: 10.1002/jimd.12205. [Epub ahead of print]


Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

Kang SS, Liu X, Ahn EH, Xiang J, Manfredsson FP, Yang X, Luo HR, Liles LC, Weinshenker D, Ye K.

J Clin Invest. 2020 Jan 2;130(1):422-437. doi: 10.1172/JCI130513.


Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.

Porter-Stransky KA, Petko AK, Karne SL, Liles LC, Urs NM, Caron MG, Paladini CA, Weinshenker D.

Addict Biol. 2019 Aug 23:e12823. doi: 10.1111/adb.12823. [Epub ahead of print]


Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease.

Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT.

Neurobiol Dis. 2019 Oct;130:104511. doi: 10.1016/j.nbd.2019.104511. Epub 2019 Jun 15.


Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion.

Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG.

Mol Psychiatry. 2019 Apr 11. doi: 10.1038/s41380-019-0413-5. [Epub ahead of print]


Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens.

Manvich DF, Petko AK, Branco RC, Foster SL, Porter-Stransky KA, Stout KA, Newman AH, Miller GW, Paladini CA, Weinshenker D.

Neuropsychopharmacology. 2019 Jul;44(8):1445-1455. doi: 10.1038/s41386-019-0371-2. Epub 2019 Mar 16.


Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood.

Rowson SA, Bekhbat M, Kelly SD, Binder EB, Hyer MM, Shaw G, Bent MA, Hodes G, Tharp G, Weinshenker D, Qin Z, Neigh GN.

Neuropsychopharmacology. 2019 Jun;44(7):1207-1215. doi: 10.1038/s41386-019-0321-z. Epub 2019 Jan 23.


Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal.

Porter-Stransky KA, Centanni SW, Karne SL, Odil LM, Fekir S, Wong JC, Jerome C, Mitchell HA, Escayg A, Pedersen NP, Winder DG, Mitrano DA, Weinshenker D.

Biol Psychiatry. 2019 Feb 1;85(3):237-247. doi: 10.1016/j.biopsych.2018.07.027. Epub 2018 Aug 17.


Locomotor sensitization to cocaine in adolescent and adult female Wistar rats.

Rowson SA, Foster SL, Weinshenker D, Neigh GN.

Behav Brain Res. 2018 Sep 3;349:158-162. doi: 10.1016/j.bbr.2018.04.035. Epub 2018 Apr 25.


The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice.

Manvich DF, Webster KA, Foster SL, Farrell MS, Ritchie JC, Porter JH, Weinshenker D.

Sci Rep. 2018 Mar 1;8(1):3840. doi: 10.1038/s41598-018-22116-z.


Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.

Weinshenker D.

Trends Neurosci. 2018 Apr;41(4):211-223. doi: 10.1016/j.tins.2018.01.010. Epub 2018 Feb 20. Review.


Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.

Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D.

J Neurosci. 2018 Jan 3;38(1):74-92. doi: 10.1523/JNEUROSCI.1483-17.2017. Epub 2017 Nov 13.


Effects of disulfiram on choice behavior in a rodent gambling task: association with catecholamine levels.

Di Ciano P, Manvich DF, Pushparaj A, Gappasov A, Hess EJ, Weinshenker D, Le Foll B.

Psychopharmacology (Berl). 2018 Jan;235(1):23-35. doi: 10.1007/s00213-017-4744-0. Epub 2017 Oct 30.


Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease.

Rorabaugh JM, Chalermpalanupap T, Botz-Zapp CA, Fu VM, Lembeck NA, Cohen RM, Weinshenker D.

Brain. 2017 Nov 1;140(11):3023-3038. doi: 10.1093/brain/awx232.


Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus.

Chalermpalanupap T, Weinshenker D, Rorabaugh JM.

Neural Plast. 2017;2017:7829507. doi: 10.1155/2017/7829507. Epub 2017 Sep 5. Review.


LSD1 protects against hippocampal and cortical neurodegeneration.

Christopher MA, Myrick DA, Barwick BG, Engstrom AK, Porter-Stransky KA, Boss JM, Weinshenker D, Levey AI, Katz DJ.

Nat Commun. 2017 Oct 9;8(1):805. doi: 10.1038/s41467-017-00922-9.


GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA.

Neurobiol Dis. 2017 Oct;106:181-190. doi: 10.1016/j.nbd.2017.07.006. Epub 2017 Jul 6.


Norepinephrine regulates cocaine-primed reinstatement via α1-adrenergic receptors in the medial prefrontal cortex.

Schmidt KT, Schroeder JP, Foster SL, Squires K, Smith BM, Pitts EG, Epstein MP, Weinshenker D.

Neuropharmacology. 2017 Jun;119:134-140. doi: 10.1016/j.neuropharm.2017.04.005. Epub 2017 Apr 6.


Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.

Porter-Stransky KA, Weinshenker D.

J Pharmacol Exp Ther. 2017 Jun;361(3):341-348. doi: 10.1124/jpet.117.240622. Epub 2017 Mar 16. Review.


Noradrenergic regulation of plasticity marker expression in the adult rodent piriform cortex.

Vadodaria KC, Yanpallewar SU, Vadhvani M, Toshniwal D, Liles LC, Rommelfanger KS, Weinshenker D, Vaidya VA.

Neurosci Lett. 2017 Mar 22;644:76-82. doi: 10.1016/j.neulet.2017.02.060. Epub 2017 Feb 23.


Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders.

Rutkowski TP, Schroeder JP, Gafford GM, Warren ST, Weinshenker D, Caspary T, Mulle JG.

J Neurosci Res. 2017 May;95(5):1144-1160. doi: 10.1002/jnr.23970. Epub 2016 Nov 8. Review.


Altered motility of plaque-associated microglia in a model of Alzheimer's disease.

Gyoneva S, Swanger SA, Zhang J, Weinshenker D, Traynelis SF.

Neuroscience. 2016 Aug 25;330:410-20. doi: 10.1016/j.neuroscience.2016.05.061. Epub 2016 Jun 7.


Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut.

Moreira CG, Russell R, Mishra AA, Narayanan S, Ritchie JM, Waldor MK, Curtis MM, Winter SE, Weinshenker D, Sperandio V.

mBio. 2016 Jun 7;7(3). pii: e00826-16. doi: 10.1128/mBio.00826-16.


Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice.

Cubells JF, Schroeder JP, Barrie ES, Manvich DF, Sadee W, Berg T, Mercer K, Stowe TA, Liles LC, Squires KE, Mezher A, Curtin P, Perdomo DL, Szot P, Weinshenker D.

PLoS One. 2016 May 5;11(5):e0154864. doi: 10.1371/journal.pone.0154864. eCollection 2016.


Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

Weinshenker D, Holmes PV.

Brain Res. 2016 Jun 15;1641(Pt B):320-37. doi: 10.1016/j.brainres.2015.11.025. Epub 2015 Nov 20. Review.


A Method for Psychosocial Stress-Induced Reinstatement of Cocaine Seeking in Rats.

Manvich DF, Stowe TA, Godfrey JR, Weinshenker D.

Biol Psychiatry. 2016 Jun 1;79(11):940-6. doi: 10.1016/j.biopsych.2015.07.002. Epub 2015 Jul 8.


A new knock-in mouse model of l-DOPA-responsive dystonia.

Rose SJ, Yu XY, Heinzer AK, Harrast P, Fan X, Raike RS, Thompson VB, Pare JF, Weinshenker D, Smith Y, Jinnah HA, Hess EJ.

Brain. 2015 Oct;138(Pt 10):2987-3002. doi: 10.1093/brain/awv212. Epub 2015 Jul 27.


Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.

Gokhale A, Vrailas-Mortimer A, Larimore J, Comstra HS, Zlatic SA, Werner E, Manvich DF, Iuvone PM, Weinshenker D, Faundez V.

Hum Mol Genet. 2015 Oct 1;24(19):5512-23. doi: 10.1093/hmg/ddv282. Epub 2015 Jul 21.


Norepinephrine is necessary for experience-dependent plasticity in the developing mouse auditory cortex.

Shepard KN, Liles LC, Weinshenker D, Liu RC.

J Neurosci. 2015 Feb 11;35(6):2432-7. doi: 10.1523/JNEUROSCI.0532-14.2015.


The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats.

Ogbonmwan YE, Schroeder JP, Holmes PV, Weinshenker D.

Psychopharmacology (Berl). 2015 Apr;232(8):1395-403. doi: 10.1007/s00213-014-3778-9. Epub 2014 Oct 31.


Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.

Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman GJ, Sadee W.

Circ Res. 2014 Dec 5;115(12):1017-25. doi: 10.1161/CIRCRESAHA.116.304398. Epub 2014 Oct 17.


Galanin mediates features of neural and behavioral stress resilience afforded by exercise.

Sciolino NR, Smith JM, Stranahan AM, Freeman KG, Edwards GL, Weinshenker D, Holmes PV.

Neuropharmacology. 2015 Feb;89:255-64. doi: 10.1016/j.neuropharm.2014.09.029. Epub 2014 Oct 6.


Norepinephrine Protects against Amyloid-β Toxicity via TrkB.

Liu X, Ye K, Weinshenker D.

J Alzheimers Dis. 2015;44(1):251-60. doi: 10.3233/JAD-141062.


Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.

Gaval-Cruz M, Goertz RB, Puttick DJ, Bowles DE, Meyer RC, Hall RA, Ko D, Paladini CA, Weinshenker D.

Addict Biol. 2016 Jan;21(1):35-48. doi: 10.1111/adb.12174. Epub 2014 Aug 13.


The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex.

Ogbonmwan YE, Sciolino NR, Groves-Chapman JL, Freeman KG, Schroeder JP, Edwards GL, Holmes PV, Weinshenker D.

Addict Biol. 2015 Jul;20(4):701-13. doi: 10.1111/adb.12166. Epub 2014 Jul 23.


Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.

Kummer MP, Hammerschmidt T, Martinez A, Terwel D, Eichele G, Witten A, Figura S, Stoll M, Schwartz S, Pape HC, Schultze JL, Weinshenker D, Heneka MT, Urban I.

J Neurosci. 2014 Jun 25;34(26):8845-54. doi: 10.1523/JNEUROSCI.4027-13.2014. Erratum in: J Neurosci. 2015 Feb 4;35(5):2321. Urban, Inga [Added].


Effects of pharmacologic dopamine β-hydroxylase inhibition on cocaine-induced reinstatement and dopamine neurochemistry in squirrel monkeys.

Cooper DA, Kimmel HL, Manvich DF, Schmidt KT, Weinshenker D, Howell LL.

J Pharmacol Exp Ther. 2014 Jul;350(1):144-52. doi: 10.1124/jpet.113.212357. Epub 2014 May 9.


BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning.

Heldt SA, Zimmermann K, Parker K, Gaval M, Weinshenker D, Ressler KJ.

J Neurosci. 2014 Feb 12;34(7):2444-50. doi: 10.1523/JNEUROSCI.4085-12.2014. Erratum in: J Neurosci. 2014 Mar 26;34(13):4756. Weinshenker, David [added].


Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviors.

Schmidt KT, Weinshenker D.

Mol Pharmacol. 2014 Apr;85(4):640-50. doi: 10.1124/mol.113.090118. Epub 2014 Feb 5. Review.


D1-dopamine and α1-adrenergic receptors co-localize in dendrites of the rat prefrontal cortex.

Mitrano DA, Pare JF, Smith Y, Weinshenker D.

Neuroscience. 2014 Jan 31;258:90-100. doi: 10.1016/j.neuroscience.2013.11.002. Epub 2013 Nov 11.


The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.

Schank JR, King CE, Sun H, Cheng K, Rice KC, Heilig M, Weinshenker D, Schroeder JP.

Neuropsychopharmacology. 2014 Apr;39(5):1093-101. doi: 10.1038/npp.2013.309. Epub 2013 Oct 31.


Dopamine β-hydroxylase inhibitors enhance the discriminative stimulus effects of cocaine in rats.

Manvich DF, DePoy LM, Weinshenker D.

J Pharmacol Exp Ther. 2013 Dec;347(3):564-73. doi: 10.1124/jpet.113.207746. Epub 2013 Sep 25.


7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Zhang Z, Liu X, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K.

Neuropsychopharmacology. 2014 Feb;39(3):638-50. doi: 10.1038/npp.2013.243. Epub 2013 Sep 11.


Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity.

Epps SA, Kahn AB, Holmes PV, Boss-Williams KA, Weiss JM, Weinshenker D.

Epilepsy Behav. 2013 Oct;29(1):47-52. doi: 10.1016/j.yebeh.2013.06.023. Epub 2013 Aug 8.


Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease.

Chalermpalanupap T, Kinkead B, Hu WT, Kummer MP, Hammerschmidt T, Heneka MT, Weinshenker D, Levey AI.

Alzheimers Res Ther. 2013 Apr 29;5(2):21. doi: 10.1186/alzrt175. eCollection 2013. Review.


Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.

Purcell RH, Papale LA, Makinson CD, Sawyer NT, Schroeder JP, Escayg A, Weinshenker D.

Psychopharmacology (Berl). 2013 Jul;228(2):263-70. doi: 10.1007/s00213-013-3034-8. Epub 2013 Mar 14.


The selective dopamine β-hydroxylase inhibitor nepicastat attenuates multiple aspects of cocaine-seeking behavior.

Schroeder JP, Epps SA, Grice TW, Weinshenker D.

Neuropsychopharmacology. 2013 May;38(6):1032-8. doi: 10.1038/npp.2012.267. Epub 2013 Jan 3.

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