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Items: 26


Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.

Cao J, Zhu Z, Wang H, Nichols TC, Lui GYL, Deng S, Rejto PA, VanArsdale T, Hardwick JS, Weinrich SL, Wei P.

Oncogene. 2019 May;38(21):4125-4141. doi: 10.1038/s41388-019-0708-7. Epub 2019 Jan 30.


Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J.

J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29.


Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.

Fadeyi O, Parikh MD, Chen MZ, Kyne RE Jr, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP.

Chembiochem. 2016 Oct 17;17(20):1925-1930. doi: 10.1002/cbic.201600427. Epub 2016 Aug 30.


Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna D, Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre RA, Gajiwala KS, Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S, Lafontaine J, Lunney B, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas MA, Orr ST, Pairish M, Planken S, Ren S, Richter D, Ryan K, Sach N, Shen H, Smeal T, Solowiej J, Sutton S, Tran K, Tseng E, Vernier W, Walls M, Wang S, Weinrich SL, Xin S, Xu H, Yin MJ, Zientek M, Zhou R, Kath JC.

J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.


Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry.

Greig MJ, Niessen S, Weinrich SL, Feng JL, Shi M, Johnson TO.

Int J Cell Biol. 2015;2015:798936. doi: 10.1155/2015/798936. Epub 2015 Nov 24.


Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES.

Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516.


Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE.

Clin Cancer Res. 2013 Jun 1;19(11):2929-40. doi: 10.1158/1078-0432.CCR-12-2307. Epub 2013 Feb 12.


A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.

Xie T, D' Ario G, Lamb JR, Martin E, Wang K, Tejpar S, Delorenzi M, Bosman FT, Roth AD, Yan P, Bougel S, Di Narzo AF, Popovici V, Budinsk√° E, Mao M, Weinrich SL, Rejto PA, Hodgson JG.

PLoS One. 2012;7(7):e42001. doi: 10.1371/journal.pone.0042001. Epub 2012 Jul 31.


IGFBP-5 Metabolism Is Disrupted in the Rat Medial Meniscal Tear Model of Osteoarthritis.

Yates MP, Settle SL, Yocum SA, Aggarwal P, Vickery LE, Aguiar DJ, Skepner AP, Kellner D, Weinrich SL, Sverdrup FM.

Cartilage. 2010 Jan;1(1):43-54. doi: 10.1177/1947603509359189.


Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease.

Barve RA, Minnerly JC, Weiss DJ, Meyer DM, Aguiar DJ, Sullivan PM, Weinrich SL, Head RD.

Osteoarthritis Cartilage. 2007 Oct;15(10):1190-8. Epub 2007 May 14.


Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells.

Mikuni O, Trager JB, Ackerly H, Weinrich SL, Asai A, Yamashita Y, Mizukami T, Anazawa H.

Biochem Biophys Res Commun. 2002 Oct 18;298(1):144-50.


Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.

Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB.

Nat Genet. 1997 Dec;17(4):498-502.


Telomerase catalytic subunit homologs from fission yeast and human.

Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR.

Science. 1997 Aug 15;277(5328):955-9.


The RNA component of human telomerase.

Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al.

Science. 1995 Sep 1;269(5228):1236-41.



Kim NW, Harley CB, Prowse KR, Weinrich SL, Piatyszek MA, Wright WE, Shay JW.

Science. 1995 May 26;268(5214):1116-7. No abstract available.


Specific association of human telomerase activity with immortal cells and cancer.

Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW.

Science. 1994 Dec 23;266(5193):2011-5.


Telomerase, cell immortality, and cancer.

Harley CB, Kim NW, Prowse KR, Weinrich SL, Hirsch KS, West MD, Bacchetti S, Hirte HW, Counter CM, Greider CW, et al.

Cold Spring Harb Symp Quant Biol. 1994;59:307-15. Review. No abstract available.


A pancreatic exocrine cell factor and AP4 bind overlapping sites in the amylase 2A enhancer.

Fodor E, Weinrich SL, Meister A, Mermod N, Rutter WJ.

Biochemistry. 1991 Aug 20;30(33):8102-8.


The chymotrypsin enhancer core. Specific factor binding and biological activity.

Meister A, Weinrich SL, Nelson C, Rutter WJ.

J Biol Chem. 1989 Dec 5;264(34):20744-51.


Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.

Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ.

Mol Cell Biol. 1988 Jun;8(6):2456-64.


Noncoordinate regulation of a vaccinia virus late gene cluster.

Weinrich SL, Hruby DE.

J Virol. 1987 Mar;61(3):639-45.


A tandemly-oriented late gene cluster within the vaccinia virus genome.

Weinrich SL, Hruby DE.

Nucleic Acids Res. 1986 Apr 11;14(7):3003-16.


Transcriptional and translational analysis of the vaccinia virus late gene L65.

Weinrich SL, Niles EG, Hruby DE.

J Virol. 1985 Aug;55(2):450-7.

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