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Items: 1 to 50 of 51

1.

Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial.

Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D.

Lancet Oncol. 2020 Jan 14. pii: S1470-2045(19)30728-4. doi: 10.1016/S1470-2045(19)30728-4. [Epub ahead of print]

PMID:
31952975
2.

Genomic clustering of fitness-affecting mutations favors the evolution of chromosomal instability.

Raynes Y, Weinreich DM.

Evol Appl. 2018 Oct 11;12(2):301-313. doi: 10.1111/eva.12717. eCollection 2019 Feb.

3.

Migration promotes mutator alleles in subdivided populations.

Raynes Y, Sniegowski PD, Weinreich DM.

Evolution. 2019 Mar;73(3):600-608. doi: 10.1111/evo.13681. Epub 2019 Jan 16.

4.

The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography.

Weinreich DM, Lan Y, Jaffe J, Heckendorn RB.

J Stat Phys. 2018;172(1):208-225. doi: 10.1007/s10955-018-1975-3. Epub 2018 Feb 7.

5.

Patterns of musculoskeletal growth and dimensional changes associated with selection and developmental plasticity in domestic and wild strain turkeys.

Stover KK, Weinreich DM, Roberts TJ, Brainerd EL.

Ecol Evol. 2018 Feb 19;8(6):3229-3239. doi: 10.1002/ece3.3881. eCollection 2018 Mar.

6.

Sign of selection on mutation rate modifiers depends on population size.

Raynes Y, Wylie CS, Sniegowski PD, Weinreich DM.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3422-3427. doi: 10.1073/pnas.1715996115. Epub 2018 Mar 12.

7.

Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.

Knies JL, Cai F, Weinreich DM.

Mol Biol Evol. 2017 May 1;34(5):1040-1054. doi: 10.1093/molbev/msx053.

8.

Variability in fitness effects can preclude selection of the fittest.

Graves CJ, Weinreich DM.

Annu Rev Ecol Evol Syst. 2017;48(1):399-417. doi: 10.1146/annurev-ecolsys-110316-022722. Epub 2017 Aug 28.

9.

Genetically Determined Variation in Lysis Time Variance in the Bacteriophage φX174.

Baker CW, Miller CR, Thaweethai T, Yuan J, Baker MH, Joyce P, Weinreich DM.

G3 (Bethesda). 2016 Apr 7;6(4):939-55. doi: 10.1534/g3.115.024075.

10.

Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.

Ogbunugafor CB, Wylie CS, Diakite I, Weinreich DM, Hartl DL.

PLoS Comput Biol. 2016 Jan 25;12(1):e1004710. doi: 10.1371/journal.pcbi.1004710. eCollection 2016 Jan.

11.

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.

Meini MR, Tomatis PE, Weinreich DM, Vila AJ.

Mol Biol Evol. 2015 Jul;32(7):1774-87. doi: 10.1093/molbev/msv059. Epub 2015 Mar 12.

12.

The evolution of phenotypic correlations and "developmental memory".

Watson RA, Wagner GP, Pavlicev M, Weinreich DM, Mills R.

Evolution. 2014 Apr;68(4):1124-38. doi: 10.1111/evo.12337. Epub 2014 Feb 1.

13.

Should evolutionary geneticists worry about higher-order epistasis?

Weinreich DM, Lan Y, Wylie CS, Heckendorn RB.

Curr Opin Genet Dev. 2013 Dec;23(6):700-7. doi: 10.1016/j.gde.2013.10.007. Epub 2013 Nov 27. Review.

14.
15.

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors.

Doi T, Ohtsu A, Fuse N, Yoshino T, Tahara M, Shibayama K, Takubo T, Weinreich DM.

Cancer Chemother Pharmacol. 2013 Jan;71(1):227-35. doi: 10.1007/s00280-012-2000-1. Epub 2012 Nov 3.

16.

The interface of protein structure, protein biophysics, and molecular evolution.

Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, Lakner C, Lartillot N, Lovell SC, Naylor G, Perica T, Pollock DD, Pupko T, Regan L, Roger A, Rubinstein N, Shakhnovich E, Sjölander K, Sunyaev S, Teufel AI, Thorne JL, Thornton JW, Weinreich DM, Whelan S.

Protein Sci. 2012 Jun;21(6):769-85. doi: 10.1002/pro.2071. Epub 2012 Apr 23. Review.

17.

Exposure-response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection.

Lu JF, Rasmussen E, Karlan BY, Vergote IB, Navale L, Kuchimanchi M, Melara R, Stepan DE, Weinreich DM, Sun YN.

Cancer Chemother Pharmacol. 2012 May;69(5):1135-44. doi: 10.1007/s00280-011-1787-5. Epub 2012 Jan 1.

18.

Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer.

Karlan BY, Oza AM, Richardson GE, Provencher DM, Hansen VL, Buck M, Chambers SK, Ghatage P, Pippitt CH Jr, Brown JV 3rd, Covens A, Nagarkar RV, Davy M, Leath CA 3rd, Nguyen H, Stepan DE, Weinreich DM, Tassoudji M, Sun YN, Vergote IB.

J Clin Oncol. 2012 Feb 1;30(4):362-71. doi: 10.1200/JCO.2010.34.3178. Epub 2011 Dec 19.

PMID:
22184370
19.

High-throughput identification of genetic interactions in HIV-1.

Weinreich DM.

Nat Genet. 2011 May;43(5):398-400. doi: 10.1038/ng.820. No abstract available.

PMID:
21522176
20.

Genome structure and the benefit of sex.

Watson RA, Weinreich DM, Wakeley J.

Evolution. 2011 Feb;65(2):523-36. doi: 10.1111/j.1558-5646.2010.01144.x. Epub 2010 Nov 5.

PMID:
21029076
21.

Causes and evolutionary significance of genetic convergence.

Christin PA, Weinreich DM, Besnard G.

Trends Genet. 2010 Sep;26(9):400-5. doi: 10.1016/j.tig.2010.06.005. Epub 2010 Aug 3.

PMID:
20685006
22.

Geographic differences in sexual reassortment in RNA phage.

O'Keefe KJ, Silander OK, McCreery H, Weinreich DM, Wright KM, Chao L, Edwards SV, Remold SK, Turner PE.

Evolution. 2010 Oct;64(10):3010-23. doi: 10.1111/j.1558-5646.2010.01040.x. Epub 2010 Aug 19.

PMID:
20500219
23.

Three selections are better than one: clinal variation of thermal QTL from independent selection experiments in Drosophila.

Rand DM, Weinreich DM, Lerman D, Folk D, Gilchrist GW.

Evolution. 2010 Oct;64(10):2921-34. doi: 10.1111/j.1558-5646.2010.01039.x. Epub 2010 Aug 19.

24.

Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways.

Brown KM, Depristo MA, Weinreich DM, Hartl DL.

Mol Biol Evol. 2009 Nov;26(11):2455-62. doi: 10.1093/molbev/msp151. Epub 2009 Jul 14.

25.

Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Lozovsky ER, Chookajorn T, Brown KM, Imwong M, Shaw PJ, Kamchonwongpaisan S, Neafsey DE, Weinreich DM, Hartl DL.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12025-30. doi: 10.1073/pnas.0905922106. Epub 2009 Jul 8.

26.

The path to student-centered teaching in gerontology and geriatrics.

Weinreich DM.

Gerontol Geriatr Educ. 2008;29(3):210-24. doi: 10.1080/07399330802359435.

PMID:
19042500
27.

Collaborating, teaching and learning in a cyberspace community: a virtual AGE experience.

Tompkins CJ, Weinreich DM.

J Gerontol Soc Work. 2007;50(1-2):119-34.

PMID:
18032303
28.

Mutational reversions during adaptive protein evolution.

DePristo MA, Hartl DL, Weinreich DM.

Mol Biol Evol. 2007 Aug;24(8):1608-10. Epub 2007 Jun 7.

PMID:
17556755
29.

Empirical fitness landscapes reveal accessible evolutionary paths.

Poelwijk FJ, Kiviet DJ, Weinreich DM, Tans SJ.

Nature. 2007 Jan 25;445(7126):383-6.

PMID:
17251971
30.

Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes.

Polz MF, Hunt DE, Preheim SP, Weinreich DM.

Philos Trans R Soc Lond B Biol Sci. 2006 Nov 29;361(1475):2009-21. Review.

31.

Effects of intra-gene fitness interactions on the benefit of sexual recombination.

Watson RA, Weinreich DM, Wakeley J.

Biochem Soc Trans. 2006 Aug;34(Pt 4):560-1.

PMID:
16856860
32.

Darwinian evolution can follow only very few mutational paths to fitter proteins.

Weinreich DM, Delaney NF, Depristo MA, Hartl DL.

Science. 2006 Apr 7;312(5770):111-4.

33.

The role of interleukin 1 in growth and metastasis of human cancer xenografts.

Elaraj DM, Weinreich DM, Varghese S, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Alexander HR.

Clin Cancer Res. 2006 Feb 15;12(4):1088-96.

34.

Interferon gamma-inducible protein 10 selectively inhibits proliferation and induces apoptosis in endothelial cells.

Feldman ED, Weinreich DM, Carroll NM, Burness ML, Feldman AL, Turner E, Xu H, Alexander HR Jr.

Ann Surg Oncol. 2006 Jan;13(1):125-33. Epub 2006 Jan 1.

PMID:
16378159
35.

Widespread genetic exchange among terrestrial bacteriophages.

Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19009-14. Epub 2005 Dec 19.

36.

Interleukin-1beta induced vascular permeability is dependent on induction of endothelial tissue factor (TF) activity.

Puhlmann M, Weinreich DM, Farma JM, Carroll NM, Turner EM, Alexander HR Jr.

J Transl Med. 2005 Sep 30;3:37.

38.

Missense meanderings in sequence space: a biophysical view of protein evolution.

DePristo MA, Weinreich DM, Hartl DL.

Nat Rev Genet. 2005 Sep;6(9):678-87. Review.

PMID:
16074985
39.
40.

Perspective: Sign epistasis and genetic constraint on evolutionary trajectories.

Weinreich DM, Watson RA, Chao L.

Evolution. 2005 Jun;59(6):1165-74. Review.

PMID:
16050094
41.

Alterations in tumor necrosis factor-induced endothelial cell procoagulant activity by hyperthermia.

Carroll NM, Elaraj DM, Puhlmann M, Weinreich DM, Turner EM, Xu H, Alexander HR Jr.

Int J Cancer. 2004 Sep 1;111(3):457-62.

43.

Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude mice.

Weinreich DM, Elaraj DM, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Spiess PJ, Alexander HR.

Cancer Res. 2003 Sep 15;63(18):5957-61.

45.

Transarterial perfusion of liver metastases.

Weinreich DM, Alexander HR.

Semin Oncol. 2002 Apr;29(2):136-44. Review.

PMID:
11951211
46.

Neutrality tests of conservative-radical amino acid changes in nuclear- and mitochondrially-encoded proteins.

Rand DM, Weinreich DM, Cezairliyan BO.

Gene. 2000 Dec 30;261(1):115-25.

PMID:
11164043
47.

The rates of molecular evolution in rodent and primate mitochondrial DNA.

Weinreich DM.

J Mol Evol. 2001 Jan;52(1):40-50.

PMID:
11139293
48.
50.

Streamlining outpatient geriatric assessment: essential social, environmental and economic variables.

Saltz CC, Schaefer T, Weinreich DM.

Soc Work Health Care. 1998;27(1):1-14.

PMID:
9579013

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