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Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.

Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML.

Dev Cell. 2014 Dec 22;31(6):707-21. doi: 10.1016/j.devcel.2014.11.023.


Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.

Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G.

Dev Cell. 2012 Jun 12;22(6):1299-312. doi: 10.1016/j.devcel.2012.04.005. Epub 2012 May 31.


Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis.

Shergill B, Meloty-Kapella L, Musse AA, Weinmaster G, Botvinick E.

Dev Cell. 2012 Jun 12;22(6):1313-20. doi: 10.1016/j.devcel.2012.04.007. Epub 2012 May 31.


Notch ligand endocytosis: mechanistic basis of signaling activity.

Musse AA, Meloty-Kapella L, Weinmaster G.

Semin Cell Dev Biol. 2012 Jun;23(4):429-36. doi: 10.1016/j.semcdb.2012.01.011. Epub 2012 Jan 24. Review.


Notch ligand ubiquitylation: what is it good for?

Weinmaster G, Fischer JA.

Dev Cell. 2011 Jul 19;21(1):134-44. doi: 10.1016/j.devcel.2011.06.006. Review.


Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.

Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, Iruela-Arispe ML.

Development. 2010 Dec;137(23):4061-72. doi: 10.1242/dev.052118.


Canonical and non-canonical Notch ligands.

D'Souza B, Meloty-Kapella L, Weinmaster G.

Curr Top Dev Biol. 2010;92:73-129. doi: 10.1016/S0070-2153(10)92003-6. Review.


Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F.

J Bone Miner Res. 2010 Apr;25(4):782-95. doi: 10.1359/jbmr.091024.


Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.

Bozkulak EC, Weinmaster G.

Mol Cell Biol. 2009 Nov;29(21):5679-95. doi: 10.1128/MCB.00406-09. Epub 2009 Aug 24.


Numb regulates post-endocytic trafficking and degradation of Notch1.

McGill MA, Dho SE, Weinmaster G, McGlade CJ.

J Biol Chem. 2009 Sep 25;284(39):26427-38. doi: 10.1074/jbc.M109.014845. Epub 2009 Jun 30.


The many facets of Notch ligands.

D'Souza B, Miyamoto A, Weinmaster G.

Oncogene. 2008 Sep 1;27(38):5148-67. doi: 10.1038/onc.2008.229. Review.


Notch signaling--constantly on the move.

Nichols JT, Miyamoto A, Weinmaster G.

Traffic. 2007 Aug;8(8):959-69. Epub 2007 Jun 5. Review.


DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur.

Nichols JT, Miyamoto A, Olsen SL, D'Souza B, Yao C, Weinmaster G.

J Cell Biol. 2007 Feb 12;176(4):445-58.


A garden of Notch-ly delights.

Weinmaster G, Kopan R.

Development. 2006 Sep;133(17):3277-82. Erratum in: Development. 2006 Dec;133(23):4793.


Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.

Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G.

J Biol Chem. 2006 Apr 14;281(15):10089-97. Epub 2006 Feb 20.


The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands.

Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster G.

J Cell Biol. 2005 Sep 12;170(6):983-92. Epub 2005 Sep 6.


Functional analysis of a recurrent missense mutation in Notch3 in CADASIL.

Haritunians T, Chow T, De Lange RP, Nichols JT, Ghavimi D, Dorrani N, St Clair DM, Weinmaster G, Schanen C.

J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1242-8.


The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface.

Nehring LC, Miyamoto A, Hein PW, Weinmaster G, Shipley JM.

J Biol Chem. 2005 May 27;280(21):20349-55. Epub 2005 Mar 23.


Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.

Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G.

Mol Biol Cell. 2005 Feb;16(2):927-42. Epub 2004 Dec 1.


Modulation of notch signaling during somitogenesis.

Weinmaster G, Kintner C.

Annu Rev Cell Dev Biol. 2003;19:367-95.


Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures.

Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI.

Dev Neurosci. 2003 Mar-Aug;25(2-4):162-72.


Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation.

Patten BA, Peyrin JM, Weinmaster G, Corfas G.

J Neurosci. 2003 Jul 9;23(14):6132-40.


Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1.

Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA.

J Biol Chem. 2003 Jul 4;278(27):24359-70. Epub 2003 Apr 16.


Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.

Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S.

J Neurosci. 2003 Mar 1;23(5):1730-41.


Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.

Yun K, Fischman S, Johnson J, Hrabe de Angelis M, Weinmaster G, Rubenstein JL.

Development. 2002 Nov;129(21):5029-40.


Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.

Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE.

J Neurosci Res. 2002 Sep 15;69(6):848-60.


A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling.

Hicks C, Ladi E, Lindsell C, Hsieh JJ, Hayward SD, Collazo A, Weinmaster G.

J Neurosci Res. 2002 Jun 15;68(6):655-67.


CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand.

Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, Schanen C.

Circ Res. 2002 Mar 22;90(5):506-8.


Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord.

Yamamoto S, Nagao M, Sugimori M, Kosako H, Nakatomi H, Yamamoto N, Takebayashi H, Nabeshima Y, Kitamura T, Weinmaster G, Nakamura K, Nakafuku M.

J Neurosci. 2001 Dec 15;21(24):9814-23.


The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.

Walker L, Carlson A, Tan-Pertel HT, Weinmaster G, Gasson J.

Stem Cells. 2001;19(6):543-52.


Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G.

Mech Dev. 2001 Oct;108(1-2):161-4.


Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.

Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M.

J Biol Chem. 2001 Nov 30;276(48):45031-40. Epub 2001 Sep 19.


Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development.

Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI.

J Comp Neurol. 2001 Jul 23;436(2):167-81.


The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.

Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H.

Mol Cell Biol. 2001 Jun;21(12):3888-900.


Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1.

Jiménez E, Vicente A, Sacedón R, Muñoz JJ, Weinmaster G, Zapata AG, Varas A.

J Immunol. 2001 May 15;166(10):5898-908.


Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT.

Ann N Y Acad Sci. 2000;920:223-6.


Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.

McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T.

Development. 2001 Feb;128(4):491-502.


Ligand-induced signaling in the absence of furin processing of Notch1.

Bush G, diSibio G, Miyamoto A, Denault JB, Leduc R, Weinmaster G.

Dev Biol. 2001 Jan 15;229(2):494-502.


Notch signaling enhances survival and alters differentiation of 32D myeloblasts.

Tan-Pertel HT, Walker L, Browning D, Miyamoto A, Weinmaster G, Gasson JC.

J Immunol. 2000 Oct 15;165(8):4428-36.


Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells.

Uyttendaele H, Closson V, Wu G, Roux F, Weinmaster G, Kitajewski J.

Microvasc Res. 2000 Sep;60(2):91-103.


Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G.

Nat Cell Biol. 2000 Aug;2(8):515-20.


Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.

J Neurochem. 2000 Aug;75(2):583-93.


Notch signal transduction: a real rip and more.

Weinmaster G.

Curr Opin Genet Dev. 2000 Aug;10(4):363-9. Review.


Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P.

Diabetes. 2000 Feb;49(2):163-76.


Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.

Morrison SJ, Perez SE, Qiao Z, Verdi JM, Hicks C, Weinmaster G, Anderson DJ.

Cell. 2000 May 26;101(5):499-510.


SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.

Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD.

Mol Cell Biol. 2000 Apr;20(7):2400-10.


Nuclear Notch1 signaling and the regulation of dendritic development.

Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A.

Nat Neurosci. 2000 Jan;3(1):30-40.


Hepatic jagged1 expression studies.

Louis AA, Van Eyken P, Haber BA, Hicks C, Weinmaster G, Taub R, Rand EB.

Hepatology. 1999 Nov;30(5):1269-75.


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