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Items: 30


Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1.

Emu B, Fessel J, Schrader S, Kumar P, Richmond G, Win S, Weinheimer S, Marsolais C, Lewis S.

N Engl J Med. 2018 Aug 16;379(7):645-654. doi: 10.1056/NEJMoa1711460.


Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling.

Mitra P, Weinheimer S, Michalewicz M, Taub ME.

Drug Metab Dispos. 2018 Jul;46(7):953-963. doi: 10.1124/dmd.118.080614. Epub 2018 Apr 17.


Development of oseltamivir phosphonate congeners as anti-influenza agents.

Cheng TJ, Weinheimer S, Tarbet EB, Jan JT, Cheng YS, Shie JJ, Chen CL, Chen CA, Hsieh WC, Huang PW, Lin WH, Wang SY, Fang JM, Hu OY, Wong CH.

J Med Chem. 2012 Oct 25;55(20):8657-70. doi: 10.1021/jm3008486. Epub 2012 Oct 12.


The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment.

Fessel WJ, Anderson B, Follansbee SE, Winters MA, Lewis ST, Weinheimer SP, Petropoulos CJ, Shafer RW.

Antiviral Res. 2011 Dec;92(3):484-7. doi: 10.1016/j.antiviral.2011.09.010. Epub 2011 Oct 4.


Loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab.

Toma J, Weinheimer SP, Stawiski E, Whitcomb JM, Lewis ST, Petropoulos CJ, Huang W.

J Virol. 2011 Apr;85(8):3872-80. doi: 10.1128/JVI.02237-10. Epub 2011 Feb 2.


Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults.

Jacobson JM, Kuritzkes DR, Godofsky E, DeJesus E, Larson JA, Weinheimer SP, Lewis ST.

Antimicrob Agents Chemother. 2009 Feb;53(2):450-7. doi: 10.1128/AAC.00942-08. Epub 2008 Nov 17.


Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.

Tenney DJ, Levine SM, Rose RE, Walsh AW, Weinheimer SP, Discotto L, Plym M, Pokornowski K, Yu CF, Angus P, Ayres A, Bartholomeusz A, Sievert W, Thompson G, Warner N, Locarnini S, Colonno RJ.

Antimicrob Agents Chemother. 2004 Sep;48(9):3498-507.


The role of viruses in human cancer development and antiviral approaches for intervention.

Kadow JF, Regueiro-Ren A, Weinheimer SP.

Curr Opin Investig Drugs. 2002 Nov;3(11):1574-9. Review.


Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.

Sperandio D, Gangloff AR, Litvak J, Goldsmith R, Hataye JM, Wang VR, Shelton EJ, Elrod K, Janc JW, Clark JM, Rice K, Weinheimer S, Yeung KS, Meanwell NA, Hernandez D, Staab AJ, Venables BL, Spencer JR.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3129-33.


Efficacies of entecavir against lamivudine-resistant hepatitis B virus replication and recombinant polymerases in vitro.

Levine S, Hernandez D, Yamanaka G, Zhang S, Rose R, Weinheimer S, Colonno RJ.

Antimicrob Agents Chemother. 2002 Aug;46(8):2525-32.


Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease.

Yeung KS, Meanwell NA, Qiu Z, Hernandez D, Zhang S, McPhee F, Weinheimer S, Clark JM, Janc JW.

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2355-9.


Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus.

Gao M, Robertson BJ, McCann PJ, O'Boyle DR, Weller SK, Newcomb WW, Brown JC, Weinheimer SP.

Virology. 1998 Sep 30;249(2):460-70.


The human cytomegalovirus UL98 gene encodes the conserved herpesvirus alkaline nuclease.

Sheaffer AK, Weinheimer SP, Tenney DJ.

J Gen Virol. 1997 Nov;78 ( Pt 11):2953-61.


Identification of a novel peptide substrate of HSV-1 protease using substrate phage display.

O'Boyle DR 2nd, Pokornowski KA, McCann PJ 3rd, Weinheimer SP.

Virology. 1997 Sep 29;236(2):338-47.


Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.

Lam Q, Smibert CA, Koop KE, Lavery C, Capone JP, Weinheimer SP, Smiley JR.

EMBO J. 1996 May 15;15(10):2575-81.


Stimulation of the herpes simplex virus type I protease by antichaeotrophic salts.

Yamanaka G, DiIanni CL, O'Boyle DR 2nd, Stevens J, Weinheimer SP, Deckman IC, Matusick-Kumar L, Colonno RJ.

J Biol Chem. 1995 Dec 15;270(50):30168-72.


The C-terminal 25 amino acids of the protease and its substrate ICP35 of herpes simplex virus type 1 are involved in the formation of sealed capsids.

Matusick-Kumar L, Newcomb WW, Brown JC, McCann PJ 3rd, Hurlburt W, Weinheimer SP, Gao M.

J Virol. 1995 Jul;69(7):4347-56.


The effect of internal autocleavage on kinetic properties of the human cytomegalovirus protease catalytic domain.

O'Boyle DR 2nd, Wager-Smith K, Stevens JT 3rd, Weinheimer SP.

J Biol Chem. 1995 Mar 3;270(9):4753-8.


In vitro proteolytic activity and active-site identification of the human cytomegalovirus protease.

Stevens JT, Mapelli C, Tsao J, Hail M, O'Boyle D 2nd, Weinheimer SP, Diianni CL.

Eur J Biochem. 1994 Dec 1;226(2):361-7.


Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus.

Matusick-Kumar L, Hurlburt W, Weinheimer SP, Newcomb WW, Brown JC, Gao M.

J Virol. 1994 Sep;68(9):5384-94.


Identification of the serine residue at the active site of the herpes simplex virus type 1 protease.

DiIanni CL, Stevens JT, Bolgar M, O'Boyle DR 2nd, Weinheimer SP, Colonno RJ.

J Biol Chem. 1994 Apr 29;269(17):12672-6.


In vitro activity of the herpes simplex virus type 1 protease with peptide substrates.

DiIanni CL, Mapelli C, Drier DA, Tsao J, Natarajan S, Riexinger D, Festin SM, Bolgar M, Yamanaka G, Weinheimer SP, et al.

J Biol Chem. 1993 Dec 5;268(34):25449-54.


Autoproteolysis of herpes simplex virus type 1 protease releases an active catalytic domain found in intermediate capsid particles.

Weinheimer SP, McCann PJ 3rd, O'Boyle DR 2nd, Stevens JT, Boyd BA, Drier DA, Yamanaka GA, DiIanni CL, Deckman IC, Cordingley MG.

J Virol. 1993 Oct;67(10):5813-22.


Deletion of the VP16 open reading frame of herpes simplex virus type 1.

Weinheimer SP, Boyd BA, Durham SK, Resnick JL, O'Boyle DR 2nd.

J Virol. 1992 Jan;66(1):258-69.


A genetic approach to promoter recognition during trans induction of viral gene expression.

Coen DM, Weinheimer SP, McKnight SL.

Science. 1986 Oct 3;234(4772):53-9.


Egocentrism and social influence in children.

Weinheimer S.

Child Dev. 1972 Jun;43(2):567-78. No abstract available.


"Inner speech" and "external speech": characteristics and communication effectiveness of socially and nonsocially encoded messages.

Krauss RM, Vivekananthan PS, Weinheimer S.

J Pers Soc Psychol. 1968 Aug;9(4):295-300. No abstract available.


Concurrent feedback, confirmation, and the encoding of referents in verbal communication.

Krauss RM, Weinheimer S.

J Pers Soc Psychol. 1966 Sep;4(3):343-6. No abstract available.


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