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Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.

Jaeger K, Bruenle S, Weinert T, Guba W, Muehle J, Miyazaki T, Weber M, Furrer A, Haenggi N, Tetaz T, Huang CY, Mattle D, Vonach JM, Gast A, Kuglstatter A, Rudolph MG, Nogly P, Benz J, Dawson RJP, Standfuss J.

Cell. 2019 Aug 22;178(5):1222-1230.e10. doi: 10.1016/j.cell.2019.07.028.


Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography.

Weinert T, Skopintsev P, James D, Dworkowski F, Panepucci E, Kekilli D, Furrer A, Brünle S, Mous S, Ozerov D, Nogly P, Wang M, Standfuss J.

Science. 2019 Jul 5;365(6448):61-65. doi: 10.1126/science.aaw8634.


Improving High Viscosity Extrusion of Microcrystals for Time-resolved Serial Femtosecond Crystallography at X-ray Lasers.

James D, Weinert T, Skopintsev P, Furrer A, Gashi D, Tanaka T, Nango E, Nogly P, Standfuss J.

J Vis Exp. 2019 Feb 28;(144). doi: 10.3791/59087.


In situ serial crystallography for rapid de novo membrane protein structure determination.

Huang CY, Olieric V, Howe N, Warshamanage R, Weinert T, Panepucci E, Vogeley L, Basu S, Diederichs K, Caffrey M, Wang M.

Commun Biol. 2018 Aug 27;1:124. doi: 10.1038/s42003-018-0123-6. eCollection 2018.


Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity.

Tsai CJ, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX.

Sci Adv. 2018 Sep 19;4(9):eaat7052. doi: 10.1126/sciadv.aat7052. eCollection 2018 Sep.


CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.

Aher A, Kok M, Sharma A, Rai A, Olieric N, Rodriguez-Garcia R, Katrukha EA, Weinert T, Olieric V, Kapitein LC, Steinmetz MO, Dogterom M, Akhmanova A.

Dev Cell. 2018 Jul 2;46(1):40-58.e8. doi: 10.1016/j.devcel.2018.05.032. Epub 2018 Jun 21.


Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser.

Nogly P, Weinert T, James D, Carbajo S, Ozerov D, Furrer A, Gashi D, Borin V, Skopintsev P, Jaeger K, Nass K, Båth P, Bosman R, Koglin J, Seaberg M, Lane T, Kekilli D, Brünle S, Tanaka T, Wu W, Milne C, White T, Barty A, Weierstall U, Panneels V, Nango E, Iwata S, Hunter M, Schapiro I, Schertler G, Neutze R, Standfuss J.

Science. 2018 Jul 13;361(6398). pii: eaat0094. doi: 10.1126/science.aat0094. Epub 2018 Jun 14.


Decreased cerebral Irp-1B limits impact of social isolation in wild type and Alzheimer's disease modeled in Drosophila melanogaster.

Ruland C, Berlandi J, Eikmeier K, Weinert T, Lin FJ, Ambree O, Seggewiss J, Paulus W, Jeibmann A.

Genes Brain Behav. 2018 Jun;17(5):e12451. doi: 10.1111/gbb.12451. Epub 2018 Jan 17.


DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum.

Jiang S, Wang L, Huang M, Jia Z, Weinert T, Warkentin E, Liu C, Song X, Zhang H, Witt J, Qiu L, Peng G, Song L.

Front Immunol. 2017 Nov 29;8:1607. doi: 10.3389/fimmu.2017.01607. eCollection 2017.


Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation.

Vercellino I, Rezabkova L, Olieric V, Polyhach Y, Weinert T, Kammerer RA, Jeschke G, Korkhov VM.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9821-E9828. doi: 10.1073/pnas.1712621114. Epub 2017 Oct 30.


Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.

Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J.

Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4.


A Slowed Cell Cycle Stabilizes the Budding Yeast Genome.

Vinton PJ, Weinert T.

Genetics. 2017 Jun;206(2):811-828. doi: 10.1534/genetics.116.197590. Epub 2017 May 3.


Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial.

Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R.

BMC Complement Altern Med. 2017 Mar 28;17(1):172. doi: 10.1186/s12906-017-1676-5.


Pomegranate (Punica granatum) Seed Oil for Treating Menopausal Symptoms: An Individually Controlled Cohort Study.

Huber R, Gminski R, Tang T, Weinert T, Schulz S, Linke-Cordes M, Martin I, Fischer H.

Altern Ther Health Med. 2017 Mar;23(2):28-34.


Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A.

Markovic-Mueller S, Stuttfeld E, Asthana M, Weinert T, Bliven S, Goldie KN, Kisko K, Capitani G, Ballmer-Hofer K.

Structure. 2017 Feb 7;25(2):341-352. doi: 10.1016/j.str.2016.12.012. Epub 2017 Jan 19.


Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.

Beyer T, Weinert T.

PLoS Genet. 2016 Oct 7;12(10):e1006345. doi: 10.1371/journal.pgen.1006345. eCollection 2016 Oct.


Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study.

Schläppi M, Ewald C, Kuehn JJ, Weinert T, Huber R.

Integr Cancer Ther. 2017 Dec;16(4):479-484. doi: 10.1177/1534735416658121. Epub 2016 Jul 7.


Data-collection strategy for challenging native SAD phasing.

Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, Borca CN, Steinmetz MO, Caffrey M, Jinek M, Wang M.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):421-9. doi: 10.1107/S2059798315024110. Epub 2016 Mar 1.


In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.

Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):93-112. doi: 10.1107/S2059798315021683. Epub 2016 Jan 1.


Nifty Alleles, a Plethora of Interactions, and Imagination Advance Understanding of Smc5/6's Roles with Chromosomes.

Langston RE, Weinert T.

Mol Cell. 2015 Dec 17;60(6):832-3. doi: 10.1016/j.molcel.2015.12.006.


Corrigendum: Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Oct;11(10):815. doi: 10.1038/nchembio1015-815a. No abstract available.


Erratum: Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741d. No abstract available.


PRIGo: a new multi-axis goniometer for macromolecular crystallography.

Waltersperger S, Olieric V, Pradervand C, Glettig W, Salathe M, Fuchs MR, Curtin A, Wang X, Ebner S, Panepucci E, Weinert T, Schulze-Briese C, Wang M.

J Synchrotron Radiat. 2015 Jul;22(4):895-900. doi: 10.1107/S1600577515005354. Epub 2015 May 9.


Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Aug;11(8):586-91. doi: 10.1038/nchembio.1849. Epub 2015 Jun 29. Erratum in: Nat Chem Biol. 2015 Sep;11(9):741. Nat Chem Biol. 2015 Oct;11(10):815.


Fast native-SAD phasing for routine macromolecular structure determination.

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M.

Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Erratum in: Nat Methods. 2015 Jul;12(7):692.


Mec1 and Tel1: an arresting dance of resection.

Beyer T, Weinert T.

EMBO J. 2014 Feb 3;33(3):176-8. doi: 10.1002/embj.201387440. Epub 2014 Jan 21. No abstract available.


Structure of a methyl-coenzyme M reductase from Black Sea mats that oxidize methane anaerobically.

Shima S, Krueger M, Weinert T, Demmer U, Kahnt J, Thauer RK, Ermler U.

Nature. 2011 Nov 27;481(7379):98-101. doi: 10.1038/nature10663.


DNA replication: failures and inverted fusions.

Carr AM, Paek AL, Weinert T.

Semin Cell Dev Biol. 2011 Oct;22(8):866-74. doi: 10.1016/j.semcdb.2011.10.008. Epub 2011 Oct 18. Review.


Structure and mechanism of the diiron benzoyl-coenzyme A epoxidase BoxB.

Rather LJ, Weinert T, Demmer U, Bill E, Ismail W, Fuchs G, Ermler U.

J Biol Chem. 2011 Aug 19;286(33):29241-8. doi: 10.1074/jbc.M111.236893. Epub 2011 Jun 1.


Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae.

Kaochar S, Shanks L, Weinert T.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21605-10. doi: 10.1073/pnas.1001938107. Epub 2010 Nov 23.


Choreography of the 9-1-1 checkpoint complex: DDK puts a check on the checkpoints.

Paek AL, Weinert T.

Mol Cell. 2010 Nov 24;40(4):505-6. doi: 10.1016/j.molcel.2010.11.015.


The role of replication bypass pathways in dicentric chromosome formation in budding yeast.

Paek AL, Jones H, Kaochar S, Weinert T.

Genetics. 2010 Dec;186(4):1161-73. doi: 10.1534/genetics.110.122663. Epub 2010 Sep 13.


Genetics. Replication error amplified.

Kaochar S, Paek AL, Weinert T.

Science. 2010 Aug 20;329(5994):911-3. doi: 10.1126/science.1194261. No abstract available.


Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast.

Paek AL, Kaochar S, Jones H, Elezaby A, Shanks L, Weinert T.

Genes Dev. 2009 Dec 15;23(24):2861-75. doi: 10.1101/gad.1862709.


The replication fork's five degrees of freedom, their failure and genome rearrangements.

Weinert T, Kaochar S, Jones H, Paek A, Clark AJ.

Curr Opin Cell Biol. 2009 Dec;21(6):778-84. doi: 10.1016/ Epub 2009 Nov 11. Review.


tRNA traffic meets a cell-cycle checkpoint.

Weinert T, Hopper AK.

Cell. 2007 Nov 30;131(5):838-40.


Cell biology. What a cell should know (but may not).

Weinert T.

Science. 2007 Mar 9;315(5817):1374-5. No abstract available.


Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast.

Admire A, Shanks L, Danzl N, Wang M, Weier U, Stevens W, Hunt E, Weinert T.

Genes Dev. 2006 Jan 15;20(2):159-73. Epub 2005 Dec 29.


Do telomeres ask checkpoint proteins: "gimme shelter-in"?

Weinert T.

Dev Cell. 2005 Dec;9(6):725-6. Review.


A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint.

Michelson RJ, Rosenstein S, Weinert T.

Genes Dev. 2005 Nov 1;19(21):2546-59. Epub 2005 Oct 17.


Details and concerns regarding the G2/M DNA damage checkpoint in budding yeast.

Weinert T, Little E, Shanks L, Admire A, Gardner R, Putnam C, Michelson R, Nyberg K, Sundareshan P.

Cold Spring Harb Symp Quant Biol. 2000;65:433-41. Review. No abstract available.


Toward maintaining the genome: DNA damage and replication checkpoints.

Nyberg KA, Michelson RJ, Putnam CW, Weinert TA.

Annu Rev Genet. 2002;36:617-56. Epub 2002 Jun 11. Review.


Closing the gaps among a web of DNA repair disorders.

Michelson RJ, Weinert T.

Bioessays. 2000 Nov;22(11):966-9. Review.


Sensor-less checkpoint activation?

Michelson R, Weinert T.

Nat Cell Biol. 1999 Nov;1(7):E177-9. No abstract available.


Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.

Grushcow JM, Holzen TM, Park KJ, Weinert T, Lichten M, Bishop DK.

Genetics. 1999 Oct;153(2):607-20.


RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast.

Gardner R, Putnam CW, Weinert T.

EMBO J. 1999 Jun 1;18(11):3173-85.


Forever hopeful relations: chromatin, telomeres and checkpoints.

Weinert T, Lundblad V.

Nat Genet. 1999 Feb;21(2):151-2. No abstract available.


DNA damage and checkpoint pathways: molecular anatomy and interactions with repair.

Weinert T.

Cell. 1998 Sep 4;94(5):555-8. Review. No abstract available.


DNA damage checkpoints update: getting molecular.

Weinert T.

Curr Opin Genet Dev. 1998 Apr;8(2):185-93. Review.


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