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Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.

Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz-Muñoz A, Weiner OD.

PLoS Biol. 2019 Oct 10;17(10):e3000457. doi: 10.1371/journal.pbio.3000457. [Epub ahead of print]


Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity.

Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD.

Elife. 2019 May 24;8. pii: e41769. doi: 10.7554/eLife.41769.


Multiple sources of signal amplification within the B-cell Ras/MAPK pathway.

Mclaurin JD, Weiner OD.

Mol Biol Cell. 2019 Jun 15;30(13):1610-1620. doi: 10.1091/mbc.E18-09-0560. Epub 2019 May 1.


In pursuit of the mechanics that shape cell surfaces.

Diz-Muñoz A, Weiner OD, Fletcher DA.

Nat Phys. 2018 Jul;14(7):648-652. doi: 10.1038/s41567-018-0187-8. Epub 2018 Jul 4.


Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling.

Tischer DK, Weiner OD.

Elife. 2019 Apr 5;8. pii: e42498. doi: 10.7554/eLife.42498.


A size-invariant bud-duration timer enables robustness in yeast cell size control.

Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR.

PLoS One. 2018 Dec 21;13(12):e0209301. doi: 10.1371/journal.pone.0209301. eCollection 2018.


Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.

Liu Z, Woo S, Weiner OD.

Development. 2018 Sep 14;145(17). pii: dev163535. doi: 10.1242/dev.163535.


Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics.

Saha S, Nagy TL, Weiner OD.

Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747). pii: 20170145. doi: 10.1098/rstb.2017.0145. Review.


Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.

Genuth MA, Allen CDC, Mikawa T, Weiner OD.

Dev Biol. 2018 Dec 1;444 Suppl 1:S252-S261. doi: 10.1016/j.ydbio.2018.02.016. Epub 2018 Mar 6.


Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning.

Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M.

Dev Cell. 2017 Nov 20;43(4):507-521.e4. doi: 10.1016/j.devcel.2017.10.028.


A module for Rac temporal signal integration revealed with optogenetics.

Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD.

J Cell Biol. 2017 Aug 7;216(8):2515-2531. doi: 10.1083/jcb.201604113. Epub 2017 Jul 7.


TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control.

Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S.

Development. 2017 Jan 15;144(2):345-355. doi: 10.1242/dev.139238. Epub 2016 Dec 19.


Positioning the cleavage furrow: All you need is Rho.

Liu Z, Weiner OD.

J Cell Biol. 2016 Jun 20;213(6):605-7. doi: 10.1083/jcb.201606010.


Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD.

PLoS Biol. 2016 Jun 9;14(6):e1002474. doi: 10.1371/journal.pbio.1002474. eCollection 2016 Jun.


Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration.

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD.

PLoS Biol. 2016 Feb 18;14(2):e1002381. doi: 10.1371/journal.pbio.1002381. eCollection 2016 Feb.


Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo.

Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JDW.

Dev Cell. 2016 Jan 11;36(1):117-126. doi: 10.1016/j.devcel.2015.12.011.


Cell Migration: Recoiling from an Embrace.

Genuth MA, Weiner OD.

Curr Biol. 2015 Jun 29;25(13):R566-8. doi: 10.1016/j.cub.2015.05.015.


A naturally monomeric infrared fluorescent protein for protein labeling in vivo.

Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X.

Nat Methods. 2015 Aug;12(8):763-5. doi: 10.1038/nmeth.3447. Epub 2015 Jun 22.


Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function.

Jost AP, Weiner OD.

ACS Synth Biol. 2015 Oct 16;4(10):1077-85. doi: 10.1021/acssynbio.5b00053. Epub 2015 Jun 2.


Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase.

Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA.

J Cell Biol. 2015 Apr 27;209(2):275-88. doi: 10.1083/jcb.201409001.


Homer3 regulates the establishment of neutrophil polarity.

Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD.

Mol Biol Cell. 2015 May 1;26(9):1629-39. doi: 10.1091/mbc.E14-07-1197. Epub 2015 Mar 4.


Illuminating cell signalling with optogenetic tools.

Tischer D, Weiner OD.

Nat Rev Mol Cell Biol. 2014 Aug;15(8):551-8. doi: 10.1038/nrm3837. Epub 2014 Jul 16. Review.


Self-organization of protrusions and polarity during eukaryotic chemotaxis.

Graziano BR, Weiner OD.

Curr Opin Cell Biol. 2014 Oct;30:60-7. doi: 10.1016/ Epub 2014 Jul 5. Review.


Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.

Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5896-901. doi: 10.1073/pnas.1402087111. Epub 2014 Apr 7.


How to understand and outwit adaptation.

Hoeller O, Gong D, Weiner OD.

Dev Cell. 2014 Mar 31;28(6):607-616. doi: 10.1016/j.devcel.2014.03.009.


How should we be selecting our graduate students?

Weiner OD.

Mol Biol Cell. 2014 Feb;25(4):429-30. doi: 10.1091/mbc.E13-11-0646.


An optogenetic gene expression system with rapid activation and deactivation kinetics.

Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH.

Nat Chem Biol. 2014 Mar;10(3):196-202. doi: 10.1038/nchembio.1430. Epub 2014 Jan 12.


Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.

Toettcher JE, Weiner OD, Lim WA.

Cell. 2013 Dec 5;155(6):1422-34. doi: 10.1016/j.cell.2013.11.004.


Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils.

Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130008. doi: 10.1098/rstb.2013.0008. Print 2013.


The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration.

Parent CA, Weiner OD.

Curr Opin Cell Biol. 2013 Oct;25(5):523-5. doi: 10.1016/ Epub 2013 Aug 5. No abstract available.


Two distinct functions for PI3-kinases in macropinocytosis.

Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR.

J Cell Sci. 2013 Sep 15;126(Pt 18):4296-307. doi: 10.1242/jcs.134015. Epub 2013 Jul 10.


A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast.

Yang X, Jost AP, Weiner OD, Tang C.

Mol Biol Cell. 2013 Aug;24(15):2419-30. doi: 10.1091/mbc.E13-03-0126. Epub 2013 Jun 12.


Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.

Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ.

Cell Rep. 2013 May 30;3(5):1607-16. doi: 10.1016/j.celrep.2013.04.009. Epub 2013 May 9.


Use the force: membrane tension as an organizer of cell shape and motility.

Diz-Muñoz A, Fletcher DA, Weiner OD.

Trends Cell Biol. 2013 Feb;23(2):47-53. doi: 10.1016/j.tcb.2012.09.006. Epub 2012 Nov 2. Review.


Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1.

Woo S, Housley MP, Weiner OD, Stainier DY.

J Cell Biol. 2012 Sep 3;198(5):941-52. doi: 10.1083/jcb.201203012.


Network crosstalk dynamically changes during neutrophil polarization.

Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF.

Cell. 2012 May 25;149(5):1073-83. doi: 10.1016/j.cell.2012.03.044.


Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging.

Millius A, Watanabe N, Weiner OD.

J Cell Sci. 2012 Mar 1;125(Pt 5):1165-76. doi: 10.1242/jcs.091157. Epub 2012 Feb 20.


Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD.

Cell. 2012 Jan 20;148(1-2):175-88. doi: 10.1016/j.cell.2011.10.050.


Light-based feedback for controlling intracellular signaling dynamics.

Toettcher JE, Gong D, Lim WA, Weiner OD.

Nat Methods. 2011 Sep 11;8(10):837-9. doi: 10.1038/nmeth.1700.


A pharmacological cocktail for arresting actin dynamics in living cells.

Peng GE, Wilson SR, Weiner OD.

Mol Biol Cell. 2011 Nov;22(21):3986-94. doi: 10.1091/mbc.E11-04-0379. Epub 2011 Aug 31.


Light control of plasma membrane recruitment using the Phy-PIF system.

Toettcher JE, Gong D, Lim WA, Weiner OD.

Methods Enzymol. 2011;497:409-23. doi: 10.1016/B978-0-12-385075-1.00017-2.


The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

Toettcher JE, Voigt CA, Weiner OD, Lim WA.

Nat Methods. 2011 Jan;8(1):35-8. doi: 10.1038/nmeth.f.326. Epub 2010 Dec 20. No abstract available.


Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M.

Cell. 2010 Nov 24;143(5):761-73. doi: 10.1016/j.cell.2010.10.003.


Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration.

Millius A, Weiner OD.

Methods Mol Biol. 2010;591:147-58. doi: 10.1007/978-1-60761-404-3_9.


Cell stimulation with optically manipulated microsources.

Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER.

Nat Methods. 2009 Dec;6(12):905-9. doi: 10.1038/nmeth.1400. Epub 2009 Nov 15.


Compete globally, bud locally.

Houk AR, Millius A, Weiner OD.

Cell. 2009 Nov 13;139(4):656-8. doi: 10.1016/j.cell.2009.10.028.


Chemotaxis in neutrophil-like HL-60 cells.

Millius A, Weiner OD.

Methods Mol Biol. 2009;571:167-77. doi: 10.1007/978-1-60761-198-1_11.


Spatiotemporal control of cell signalling using a light-switchable protein interaction.

Levskaya A, Weiner OD, Lim WA, Voigt CA.

Nature. 2009 Oct 15;461(7266):997-1001. doi: 10.1038/nature08446. Epub 2009 Sep 13.


Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.

Millius A, Dandekar SN, Houk AR, Weiner OD.

Curr Biol. 2009 Feb 10;19(3):253-9. doi: 10.1016/j.cub.2008.12.044.


An actin-based wave generator organizes cell motility.

Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW.

PLoS Biol. 2007 Sep;5(9):e221.

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