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Items: 1 to 50 of 192

1.

Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.

Barger JL, Vann JM, Cray NL, Pugh TD, Mastaloudis A, Hester SN, Wood SM, Newton MA, Weindruch R, Prolla TA.

Aging Cell. 2017 Aug;16(4):750-760. doi: 10.1111/acel.12608. Epub 2017 May 26.

2.

Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study.

Yamada Y, Kemnitz JW, Weindruch R, Anderson RM, Schoeller DA, Colman RJ.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):273-278. doi: 10.1093/gerona/glx059.

3.

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA.

PLoS One. 2017 Feb 3;12(2):e0171159. doi: 10.1371/journal.pone.0171159. eCollection 2017.

4.

Caloric restriction improves health and survival of rhesus monkeys.

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, Anderson RM.

Nat Commun. 2017 Jan 17;8:14063. doi: 10.1038/ncomms14063.

5.

Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys.

Fowler CG, Chiasson KB, Colman RJ, Kemnitz JW, Beasley TM, Weindruch RH.

Hear Res. 2015 Oct;328:78-86. doi: 10.1016/j.heares.2015.07.001. Epub 2015 Jul 7.

6.

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R.

PLoS One. 2015 Apr 1;10(4):e0120738. doi: 10.1371/journal.pone.0120738. eCollection 2015.

7.

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.

Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM.

Nat Commun. 2014 Apr 1;5:3557. doi: 10.1038/ncomms4557.

8.

Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study.

Sridharan A, Bendlin BB, Gallagher CL, Oh JM, Willette AA, Alexander AL, Kemnitz JW, Colman RJ, Weindruch RH, Johnson SC.

Neurosci Lett. 2014 May 21;569:38-42. doi: 10.1016/j.neulet.2014.03.047. Epub 2014 Mar 29.

9.

Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys.

Yamada Y, Colman RJ, Kemnitz JW, Baum ST, Anderson RM, Weindruch R, Schoeller DA.

Exp Gerontol. 2013 Nov;48(11):1226-35. doi: 10.1016/j.exger.2013.08.002. Epub 2013 Aug 13.

10.

A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys.

Pugh TD, Conklin MW, Evans TD, Polewski MA, Barbian HJ, Pass R, Anderson BD, Colman RJ, Eliceiri KW, Keely PJ, Weindruch R, Beasley TM, Anderson RM.

Aging Cell. 2013 Aug;12(4):672-81. doi: 10.1111/acel.12091. Epub 2013 May 27.

11.

Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study.

Sridharan A, Pehar M, Salamat MS, Pugh TD, Bendlin BB, Willette AA, Anderson RM, Kemnitz JW, Colman RJ, Weindruch RH, Puglielli L, Johnson SC.

Brain Res. 2013 May 1;1508:1-8. doi: 10.1016/j.brainres.2013.02.046. Epub 2013 Mar 7.

12.

Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques.

Willette AA, Coe CL, Birdsill AC, Bendlin BB, Colman RJ, Alexander AL, Allison DB, Weindruch RH, Johnson SC.

Age (Dordr). 2013 Dec;35(6):2215-27. doi: 10.1007/s11357-013-9518-y. Epub 2013 Mar 6.

13.

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains.

Collino S, Martin FP, Montoliu I, Barger JL, Da Silva L, Prolla TA, Weindruch R, Kochhar S.

Metabolites. 2013 Oct 11;3(4):881-911. doi: 10.3390/metabo3040881.

14.

Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys.

Sridharan A, Willette AA, Bendlin BB, Alexander AL, Coe CL, Voytko ML, Colman RJ, Kemnitz JW, Weindruch RH, Johnson SC.

Front Aging Neurosci. 2012 Nov 8;4:31. doi: 10.3389/fnagi.2012.00031. eCollection 2012.

15.

A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys.

Kastman EK, Willette AA, Coe CL, Bendlin BB, Kosmatka KJ, McLaren DG, Xu G, Canu E, Field AS, Alexander AL, Voytko ML, Beasley TM, Colman RJ, Weindruch RH, Johnson SC.

J Neurosci. 2012 Aug 22;32(34):11897-904.

16.

Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

Csiszar A, Sosnowska D, Tucsek Z, Gautam T, Toth P, Losonczy G, Colman RJ, Weindruch R, Anderson RM, Sonntag WE, Ungvari Z.

J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):235-49. doi: 10.1093/gerona/gls158. Epub 2012 Aug 17.

17.

Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys.

Willette AA, Bendlin BB, Colman RJ, Kastman EK, Field AS, Alexander AL, Sridharan A, Allison DB, Anderson R, Voytko ML, Kemnitz JW, Weindruch RH, Johnson SC.

Diabetes. 2012 May;61(5):1036-42. doi: 10.2337/db11-1187. Epub 2012 Mar 13.

18.

The caloric restriction paradigm: implications for healthy human aging.

Anderson RM, Weindruch R.

Am J Hum Biol. 2012 Mar-Apr;24(2):101-6. doi: 10.1002/ajhb.22243. Epub 2012 Jan 30. Review.

19.

Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys.

McKiernan SH, Colman RJ, Aiken E, Evans TD, Beasley TM, Aiken JM, Weindruch R, Anderson RM.

Exp Gerontol. 2012 Mar;47(3):229-36. doi: 10.1016/j.exger.2011.12.009. Epub 2011 Dec 28.

20.

Skeletal effects of long-term caloric restriction in rhesus monkeys.

Colman RJ, Beasley TM, Allison DB, Weindruch R.

Age (Dordr). 2012 Oct;34(5):1133-43. Epub 2011 Dec 22.

21.

Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys.

Willette AA, Coe CL, Colman RJ, Bendlin BB, Kastman EK, Field AS, Alexander AL, Allison DB, Weindruch RH, Johnson SC.

Psychoneuroendocrinology. 2012 Jul;37(7):903-16. doi: 10.1016/j.psyneuen.2011.10.006. Epub 2011 Nov 25.

22.

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse.

Barger JL, Kayo T, Pugh TD, Vann JA, Power R, Dawson K, Weindruch R, Prolla TA.

Genes Nutr. 2012 Apr;7(2):155-65. doi: 10.1007/s12263-011-0243-9. Epub 2011 Aug 17.

23.

Can rodent longevity studies be both short and powerful?

Robertson HT, Smith DL, Pajewski NM, Weindruch RH, Garland T Jr, Argyropoulos G, Bokov A, Allison DB.

J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):279-86. doi: 10.1093/gerona/glq190. Epub 2010 Nov 4.

24.

Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle.

McKiernan SH, Colman RJ, Lopez M, Beasley TM, Aiken JM, Anderson RM, Weindruch R.

Exp Gerontol. 2011 Jan;46(1):23-9. doi: 10.1016/j.exger.2010.09.011. Epub 2010 Sep 29.

25.

Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys.

Willette AA, Gallagher C, Bendlin BB, McLaren DG, Kastman EK, Canu E, Kosmatka KJ, Field AS, Alexander AL, Colman RJ, Voytko ML, Weindruch RH, Coe CL, Johnson SC.

Neurobiol Aging. 2012 Apr;33(4):670-80. doi: 10.1016/j.neurobiolaging.2010.06.003. Epub 2010 Aug 5.

26.

Effects of aging and calorie restriction on white matter in rhesus macaques.

Bendlin BB, Canu E, Willette A, Kastman EK, McLaren DG, Kosmatka KJ, Xu G, Field AS, Colman RJ, Coe CL, Weindruch RH, Alexander AL, Johnson SC.

Neurobiol Aging. 2011 Dec;32(12):2319.e1-11. doi: 10.1016/j.neurobiolaging.2010.04.008. Epub 2010 Jun 11.

27.

A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys.

Kastman EK, Willette AA, Coe CL, Bendlin BB, Kosmatka KJ, McLaren DG, Xu G, Canu E, Field AS, Alexander AL, Voytko ML, Beasley TM, Colman RJ, Weindruch RH, Johnson SC.

J Neurosci. 2010 Jun 9;30(23):7940-7. doi: 10.1523/JNEUROSCI.0835-10.2010. Erratum in: J Neurosci. 2012 Aug 22;32(34):11904. Corrected and republished in: J Neurosci. 2012 Aug 22;32(34):11897-904.

28.

Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys.

Willette AA, Bendlin BB, McLaren DG, Canu E, Kastman EK, Kosmatka KJ, Xu G, Field AS, Alexander AL, Colman RJ, Weindruch RH, Coe CL, Johnson SC.

Neuroimage. 2010 Jul 1;51(3):987-94. doi: 10.1016/j.neuroimage.2010.03.015. Epub 2010 Mar 15.

29.

Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.

Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T.

Curr Aging Sci. 2010 Feb;3(1):20-5. Review.

30.

Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later.

Fowler CG, Chiasson KB, Leslie TH, Thomas D, Beasley TM, Kemnitz JW, Weindruch R.

Hear Res. 2010 Mar;261(1-2):75-81. doi: 10.1016/j.heares.2010.01.006. Epub 2010 Jan 15.

31.

Metabolic reprogramming, caloric restriction and aging.

Anderson RM, Weindruch R.

Trends Endocrinol Metab. 2010 Mar;21(3):134-41. doi: 10.1016/j.tem.2009.11.005. Epub 2009 Dec 7. Review.

32.

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7. doi: 10.1073/pnas.0908786106. Epub 2009 Nov 9.

33.

Caloric restriction delays disease onset and mortality in rhesus monkeys.

Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R.

Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.

34.

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants.

Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA.

Aging Cell. 2009 Aug;8(4):484-95. doi: 10.1111/j.1474-9726.2009.00496.x. Epub 2009 Jun 25.

35.

Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates.

Rezzi S, Martin FP, Shanmuganayagam D, Colman RJ, Nicholson JK, Weindruch R.

Exp Gerontol. 2009 May;44(5):356-62. doi: 10.1016/j.exger.2009.02.008. Epub 2009 Mar 3.

36.

Caloric restriction and aging: studies in mice and monkeys.

Anderson RM, Shanmuganayagam D, Weindruch R.

Toxicol Pathol. 2009 Jan;37(1):47-51. doi: 10.1177/0192623308329476. Epub 2008 Dec 15. Review.

37.

Longitudinal analysis of early stage sarcopenia in aging rhesus monkeys.

McKiernan SH, Colman R, Lopez M, Beasley TM, Weindruch R, Aiken JM.

Exp Gerontol. 2009 Mar;44(3):170-6. doi: 10.1016/j.exger.2008.09.014. Epub 2008 Oct 17.

38.

Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.

Hagopian K, Ramsey JJ, Weindruch R.

Biogerontology. 2009 Aug;10(4):471-9. doi: 10.1007/s10522-008-9191-1. Epub 2008 Oct 25.

39.

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate.

Fu VX, Dobosy JR, Desotelle JA, Almassi N, Ewald JA, Srinivasan R, Berres M, Svaren J, Weindruch R, Jarrard DF.

Cancer Res. 2008 Aug 15;68(16):6797-802. doi: 10.1158/0008-5472.CAN-08-1714.

40.

Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.

Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R.

Exp Gerontol. 2008 Sep;43(9):859-66. doi: 10.1016/j.exger.2008.06.013. Epub 2008 Jul 9.

PMID:
18657603
41.

Attenuation of sarcopenia by dietary restriction in rhesus monkeys.

Colman RJ, Beasley TM, Allison DB, Weindruch R.

J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):556-9.

42.

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.

PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5.

43.

alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice.

Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, Prolla TA.

J Nutr. 2008 Jun;138(6):1010-8.

44.

A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate.

Dobosy JR, Fu VX, Desotelle JA, Srinivasan R, Kenowski ML, Almassi N, Weindruch R, Svaren J, Jarrard DF.

Prostate. 2008 Aug 1;68(11):1187-95. doi: 10.1002/pros.20782.

PMID:
18459101
45.

Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities.

Hagopian K, Ramsey JJ, Weindruch R.

Biosci Rep. 2008 Apr;28(2):107-15. doi: 10.1042/BSR20080015.

46.

Tympanometry in rhesus monkeys: effects of aging and caloric restriction.

Fowler CG, Chiasson KB, Hart DB, Beasley TM, Kemnitz J, Weindruch R.

Int J Audiol. 2008 Apr;47(4):209-14. doi: 10.1080/14992020701851882.

PMID:
18389417
47.

Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.

Li H, Costantini C, Scrable H, Weindruch R, Puglielli L.

Neurobiol Aging. 2009 Dec;30(12):2010-20. doi: 10.1016/j.neurobiolaging.2008.02.015. Epub 2008 Apr 2.

48.

Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response.

Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R.

Aging Cell. 2008 Jan;7(1):101-11. Epub 2007 Nov 21.

49.

Metabolizable energy intake during long-term calorie restriction in rhesus monkeys.

Raman A, Baum ST, Colman RJ, Kemnitz JW, Weindruch R, Schoeller DA.

Exp Gerontol. 2007 Oct;42(10):988-94. Epub 2007 Jul 6.

50.

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program.

Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA.

BMC Genomics. 2007 Mar 23;8:80.

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