Sort by
Items per page

Send to

Choose Destination

Search results

Items: 39


Post-Transcriptional Noise Control.

Hansen MMK, Weinberger LS.

Bioessays. 2019 Jul;41(7):e1900044. doi: 10.1002/bies.201900044. Epub 2019 Jun 21.


Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability.

Hansen MMK, Desai RV, Simpson ML, Weinberger LS.

Cell Syst. 2018 Oct 24;7(4):384-397.e6. doi: 10.1016/j.cels.2018.08.002. Epub 2018 Sep 19.


Feedback-mediated signal conversion promotes viral fitness.

Vardi N, Chaturvedi S, Weinberger LS.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8803-E8810. doi: 10.1073/pnas.1802905115. Epub 2018 Aug 27.


A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization.

Hansen MMK, Wen WY, Ingerman E, Razooky BS, Thompson CE, Dar RD, Chin CW, Simpson ML, Weinberger LS.

Cell. 2018 Jun 14;173(7):1609-1621.e15. doi: 10.1016/j.cell.2018.04.005. Epub 2018 May 10.


A Bioreactor Method to Generate High-titer, Genetically Stable, Clinical-isolate Human Cytomegalovirus.

Saykally VR, Rast LI, Sasaki J, Jung SY, Bolovan-Fritts C, Weinberger LS.

Bio Protoc. 2017 Nov 5;7(21). pii: e2589. doi: 10.21769/BioProtoc.2589.


Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean.

Razooky BS, Cao Y, Hansen MMK, Perelson AS, Simpson ML, Weinberger LS.

PLoS Biol. 2017 Oct 18;15(10):e2000841. doi: 10.1371/journal.pbio.2000841. eCollection 2017 Oct.


Fate-Regulating Circuits in Viruses: From Discovery to New Therapy Targets.

Pai A, Weinberger LS.

Annu Rev Virol. 2017 Sep 29;4(1):469-490. doi: 10.1146/annurev-virology-110615-035606. Epub 2017 Aug 11. Review.


Transient Thresholding: A Mechanism Enabling Noncooperative Transcriptional Circuitry to Form a Switch.

Aull KH, Tanner EJ, Thomson M, Weinberger LS.

Biophys J. 2017 Jun 6;112(11):2428-2438. doi: 10.1016/j.bpj.2017.05.002.


Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels.

Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS.

PLoS One. 2016 Jul 28;11(7):e0158298. doi: 10.1371/journal.pone.0158298. eCollection 2016.


Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals.

Rast LI, Rouzine IM, Rozhnova G, Bishop L, Weinberger AD, Weinberger LS.

PLoS Comput Biol. 2016 May 6;12(5):e1004799. doi: 10.1371/journal.pcbi.1004799. eCollection 2016 May.


Exploiting Genetic Interference for Antiviral Therapy.

Tanner EJ, Kirkegaard KA, Weinberger LS.

PLoS Genet. 2016 May 5;12(5):e1005986. doi: 10.1371/journal.pgen.1005986. eCollection 2016 May. Review.


A minimal fate-selection switch.

Weinberger LS.

Curr Opin Cell Biol. 2015 Dec;37:111-8. doi: 10.1016/ Epub 2015 Nov 21. Review.


The Low Noise Limit in Gene Expression.

Dar RD, Razooky BS, Weinberger LS, Cox CD, Simpson ML.

PLoS One. 2015 Oct 21;10(10):e0140969. doi: 10.1371/journal.pone.0140969. eCollection 2015.


An evolutionary role for HIV latency in enhancing viral transmission.

Rouzine IM, Weinberger AD, Weinberger LS.

Cell. 2015 Feb 26;160(5):1002-1012. doi: 10.1016/j.cell.2015.02.017.


A hardwired HIV latency program.

Razooky BS, Pai A, Aull K, Rouzine IM, Weinberger LS.

Cell. 2015 Feb 26;160(5):990-1001. doi: 10.1016/j.cell.2015.02.009.


Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.

Jung SY, Notton T, Fong E, Shusteff M, Weinberger LS.

Lab Chip. 2015 Feb 21;15(4):1000-3. doi: 10.1039/c4lc01342e.


Stochastic variability in HIV affects viral eradication.

Rouzine IM, Razooky BS, Weinberger LS.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13251-2. doi: 10.1073/pnas.1413362111. Epub 2014 Sep 8. No abstract available.


The case for transmissible antivirals to control population-wide infectious disease.

Notton T, SardanyƩs J, Weinberger AD, Weinberger LS.

Trends Biotechnol. 2014 Aug;32(8):400-5. doi: 10.1016/j.tibtech.2014.06.006. Epub 2014 Jul 10. Review.


Screening for noise in gene expression identifies drug synergies.

Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS.

Science. 2014 Jun 20;344(6190):1392-6. doi: 10.1126/science.1250220. Epub 2014 Jun 5.


Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo.

Rouzine IM, Coffin JM, Weinberger LS.

PLoS Genet. 2014 Feb 20;10(2):e1004179. doi: 10.1371/journal.pgen.1004179. eCollection 2014 Feb. No abstract available.


Acoustic focusing with engineered node locations for high-performance microfluidic particle separation.

Fong EJ, Johnston AC, Notton T, Jung SY, Rose KA, Weinberger LS, Shusteff M.

Analyst. 2014 Mar 7;139(5):1192-200. doi: 10.1039/c4an00034j. Epub 2014 Jan 22.


Stochastic fate selection in HIV-infected patients.

Weinberger AD, Weinberger LS.

Cell. 2013 Oct 24;155(3):497-9. doi: 10.1016/j.cell.2013.09.039. Epub 2013 Oct 24.


Reply to "Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict".

Rouzine IM, Weinberger LS.

J Virol. 2013 Sep;87(17):9960-2. doi: 10.1128/JVI.00932-13. No abstract available.


Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies.

Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran T, Britt W, Weinberger LS, Tortorella D.

Clin Vaccine Immunol. 2013 Apr;20(4):540-50. doi: 10.1128/CVI.00644-12. Epub 2013 Feb 6.


An endogenous accelerator for viral gene expression confers a fitness advantage.

Teng MW, Bolovan-Fritts C, Dar RD, Womack A, Simpson ML, Shenk T, Weinberger LS.

Cell. 2012 Dec 21;151(7):1569-80. doi: 10.1016/j.cell.2012.11.051. Erratum in: Cell. 2013 Feb 28;152(5):1195.


Design requirements for interfering particles to maintain coadaptive stability with HIV-1.

Rouzine IM, Weinberger LS.

J Virol. 2013 Feb;87(4):2081-93. doi: 10.1128/JVI.02741-12. Epub 2012 Dec 5.


Transcriptional burst frequency and burst size are equally modulated across the human genome.

Dar RD, Razooky BS, Singh A, Trimeloni TV, McCollum JM, Cox CD, Simpson ML, Weinberger LS.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17454-9. doi: 10.1073/pnas.1213530109. Epub 2012 Oct 11.


Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes.

Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS.

Lab Chip. 2012 Nov 7;12(21):4305-12. doi: 10.1039/c2lc40170c.


Dynamics of protein noise can distinguish between alternate sources of gene-expression variability.

Singh A, Razooky BS, Dar RD, Weinberger LS.

Mol Syst Biol. 2012;8:607. doi: 10.1038/msb.2012.38.


Lentiviral vectors to study stochastic noise in gene expression.

Franz K, Singh A, Weinberger LS.

Methods Enzymol. 2011;497:603-22. doi: 10.1016/B978-0-12-385075-1.00026-3.


Autonomous targeting of infectious superspreaders using engineered transmissible therapies.

Metzger VT, Lloyd-Smith JO, Weinberger LS.

PLoS Comput Biol. 2011 Mar;7(3):e1002015. doi: 10.1371/journal.pcbi.1002015. Epub 2011 Mar 17.


Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise.

Razooky BS, Weinberger LS.

Methods. 2011 Jan;53(1):68-77. doi: 10.1016/j.ymeth.2010.12.006. Epub 2010 Dec 16. Review.


Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression.

Singh A, Razooky B, Cox CD, Simpson ML, Weinberger LS.

Biophys J. 2010 Apr 21;98(8):L32-4. doi: 10.1016/j.bpj.2010.03.001.


Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.

Weinberger AD, Perelson AS, Ribeiro RM, Weinberger LS.

PLoS Comput Biol. 2009 Aug;5(8):e1000467. doi: 10.1371/journal.pcbi.1000467. Epub 2009 Aug 14.


Stochastic gene expression as a molecular switch for viral latency.

Singh A, Weinberger LS.

Curr Opin Microbiol. 2009 Aug;12(4):460-6. doi: 10.1016/j.mib.2009.06.016. Review.


Transient-mediated fate determination in a transcriptional circuit of HIV.

Weinberger LS, Dar RD, Simpson ML.

Nat Genet. 2008 Apr;40(4):466-70. doi: 10.1038/ng.116. Epub 2008 Mar 16.


Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity.

Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV.

Cell. 2005 Jul 29;122(2):169-82.


Supplemental Content

Loading ...
Support Center