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Items: 1 to 50 of 68

1.

Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach.

Wein T, Stücker FT, Hülter NF, Dagan T.

J Vis Exp. 2019 Dec 14;(154). doi: 10.3791/60749.

PMID:
31885375
2.

The Effect of Population Bottleneck Size and Selective Regime on Genetic Diversity and Evolvability in Bacteria.

Wein T, Dagan T.

Genome Biol Evol. 2019 Nov 1;11(11):3283-3290. doi: 10.1093/gbe/evz243.

3.

Currency, Exchange, and Inheritance in the Evolution of Symbiosis.

Wein T, Romero Picazo D, Blow F, Woehle C, Jami E, Reusch TBH, Martin WF, Dagan T.

Trends Microbiol. 2019 Oct;27(10):836-849. doi: 10.1016/j.tim.2019.05.010. Epub 2019 Jun 27. Review.

4.

Long-term Safety and Dosing of OnabotulinumtoxinA: A Prospective, Observational Study.

Wein T, Jog M, Bhogal M, Dhani S, Miller R, Ismail F, Beauchamp R, Trentin G.

Can J Neurol Sci. 2019 Nov;46(6):742-752. doi: 10.1017/cjn.2019.238.

PMID:
31256770
5.

Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance.

Wein T, Hülter NF, Mizrahi I, Dagan T.

Nat Commun. 2019 Jun 13;10(1):2595. doi: 10.1038/s41467-019-10600-7.

6.

Optimal Muscle Selection for OnabotulinumtoxinA Injections in Poststroke Lower-Limb Spasticity: A Randomized Trial.

Esquenazi A, Wein TH, Ward AB, Geis C, Liu C, Dimitrova R.

Am J Phys Med Rehabil. 2019 May;98(5):360-368. doi: 10.1097/PHM.0000000000001101.

PMID:
31003229
7.

Evolthon: A community endeavor to evolve lab evolution.

Kaminski Strauss S, Schirman D, Jona G, Brooks AN, Kunjapur AM, Nguyen Ba AN, Flint A, Solt A, Mershin A, Dixit A, Yona AH, Csörgő B, Busby BP, Hennig BP, Pál C, Schraivogel D, Schultz D, Wernick DG, Agashe D, Levi D, Zabezhinsky D, Russ D, Sass E, Tamar E, Herz E, Levy ED, Church GM, Yelin I, Nachman I, Gerst JE, Georgeson JM, Adamala KP, Steinmetz LM, Rübsam M, Ralser M, Klutstein M, Desai MM, Walunjkar N, Yin N, Aharon Hefetz N, Jakimo N, Snitser O, Adini O, Kumar P, Soo Hoo Smith R, Zeidan R, Hazan R, Rak R, Kishony R, Johnson S, Nouriel S, Vonesch SC, Foster S, Dagan T, Wein T, Karydis T, Wannier TM, Stiles T, Olin-Sandoval V, Mueller WF, Bar-On YM, Dahan O, Pilpel Y.

PLoS Biol. 2019 Mar 29;17(3):e3000182. doi: 10.1371/journal.pbio.3000182. eCollection 2019 Mar.

8.

Metabolic preference of nitrate over oxygen as an electron acceptor in foraminifera from the Peruvian oxygen minimum zone.

Glock N, Roy AS, Romero D, Wein T, Weissenbach J, Revsbech NP, Høgslund S, Clemens D, Sommer S, Dagan T.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2860-2865. doi: 10.1073/pnas.1813887116. Epub 2019 Feb 6.

9.

Adherence to Guidelines at a Stroke Prevention Clinic: A Follow-up Study.

Chen BY, Perkins H, Ehrensperger E, Minuk J, Vieira L, Wein T, Côté R.

Can J Neurol Sci. 2019 Jan;46(1):57-63. doi: 10.1017/cjn.2018.352.

PMID:
30688197
10.

Segregational Drift and the Interplay between Plasmid Copy Number and Evolvability.

Ilhan J, Kupczok A, Woehle C, Wein T, Hülter NF, Rosenstiel P, Landan G, Mizrahi I, Dagan T.

Mol Biol Evol. 2019 Mar 1;36(3):472-486. doi: 10.1093/molbev/msy225.

11.

Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries.

Hauke TJ, Wein T, Höfner G, Wanner KT.

J Med Chem. 2018 Nov 21;61(22):10310-10332. doi: 10.1021/acs.jmedchem.8b01602. Epub 2018 Nov 8.

PMID:
30376325
12.

Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Rappenglück S, Sichler S, Höfner G, Wein T, Niessen KV, Seeger T, Paintner FF, Worek F, Thiermann H, Wanner KT.

ChemMedChem. 2018 Dec 20;13(24):2653-2663. doi: 10.1002/cmdc.201800539. Epub 2018 Nov 27.

PMID:
30362667
13.

A Novel Eukaryotic Denitrification Pathway in Foraminifera.

Woehle C, Roy AS, Glock N, Wein T, Weissenbach J, Rosenstiel P, Hiebenthal C, Michels J, Schönfeld J, Dagan T.

Curr Biol. 2018 Aug 20;28(16):2536-2543.e5. doi: 10.1016/j.cub.2018.06.027. Epub 2018 Aug 2.

14.

Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Rappenglück S, Sichler S, Höfner G, Wein T, Niessen KV, Seeger T, Paintner FF, Worek F, Thiermann H, Wanner KT.

ChemMedChem. 2018 Sep 6;13(17):1806-1816. doi: 10.1002/cmdc.201800325. Epub 2018 Aug 1.

PMID:
29974635
15.

New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.

Wein T, Wanner KT, Rappenglück S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H.

Curr Comput Aided Drug Des. 2019;15(1):104-109. doi: 10.2174/1573409914666180703120201.

PMID:
29968541
16.

Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.

Lutz T, Wein T, Höfner G, Pabel J, Eder M, Dine J, Wanner KT.

J Med Chem. 2018 Jul 26;61(14):6211-6235. doi: 10.1021/acs.jmedchem.8b00629. Epub 2018 Jul 6.

PMID:
29924931
17.

A Delphi-Based Consensus Statement on the Management of Anticoagulated Patients With Botulinum Toxin for Limb Spasticity.

Boulias C, Ismail F, Phadke CP, Bagg S, Bureau I, Charest S, Chen R, Cheng A, Ethans K, Fink M, Finlayson H, Gulasingam S, Guo M, Haziza M, Hosseini H, Khan O, Lang M, Lapp T, Leckey R, Li Pi Shan R, Liem N, Lo A, Mason M, McNeil S, McVeigh S, Miller T, Mills PB, Naud P, O'Connell C, Petitclerc M, Prevost J, Reebye R, Richardson D, Satkunam L, Sharma S, Short C, Sirois G, Unarket M, Wein T, Wilkins K, Winston P.

Arch Phys Med Rehabil. 2018 Nov;99(11):2183-2189. doi: 10.1016/j.apmr.2018.04.023. Epub 2018 May 24.

PMID:
29803825
18.

Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children.

Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M, Milot A, Bolli P, Tremblay G, McLean D, Padwal RS, Tran KC, Grover S, Rabkin SW, Moe GW, Howlett JG, Lindsay P, Hill MD, Sharma M, Field T, Wein TH, Shoamanesh A, Dresser GK, Hamet P, Herman RJ, Burgess E, Gryn SE, Grégoire JC, Lewanczuk R, Poirier L, Campbell TS, Feldman RD, Lavoie KL, Tsuyuki RT, Honos G, Prebtani APH, Kline G, Schiffrin EL, Don-Wauchope A, Tobe SW, Gilbert RE, Leiter LA, Jones C, Woo V, Hegele RA, Selby P, Pipe A, McFarlane PA, Oh P, Gupta M, Bacon SL, Kaczorowski J, Trudeau L, Campbell NRC, Hiremath S, Roerecke M, Arcand J, Ruzicka M, Prasad GVR, Vallée M, Edwards C, Sivapalan P, Penner SB, Fournier A, Benoit G, Feber J, Dionne J, Magee LA, Logan AG, Côté AM, Rey E, Firoz T, Kuyper LM, Gabor JY, Townsend RR, Rabi DM, Daskalopoulou SS; Hypertension Canada.

Can J Cardiol. 2018 May;34(5):506-525. doi: 10.1016/j.cjca.2018.02.022. Epub 2018 Mar 1.

PMID:
29731013
19.

Carrying Capacity and Colonization Dynamics of Curvibacter in the Hydra Host Habitat.

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH, Hülter NF.

Front Microbiol. 2018 Mar 14;9:443. doi: 10.3389/fmicb.2018.00443. eCollection 2018.

20.

Secondary stroke prevention services in Canada: a cross-sectional survey and geospatial analysis of resources, capacity and geographic access.

Jewett L, Harroud A, Hill MD, Côté R, Wein T, Smith EE, Gubitz G, Demchuk AM, Sahlas DJ, Gladstone DJ, Lindsay MP.

CMAJ Open. 2018 Feb 21;6(1):E95-E102. doi: 10.9778/cmajo.20170130.

21.

OnabotulinumtoxinA for the Treatment of Poststroke Distal Lower Limb Spasticity: A Randomized Trial.

Wein T, Esquenazi A, Jost WH, Ward AB, Pan G, Dimitrova R.

PM R. 2018 Jul;10(7):693-703. doi: 10.1016/j.pmrj.2017.12.006. Epub 2018 Jan 9.

PMID:
29330071
22.

Canadian stroke best practice recommendations: Secondary prevention of stroke, sixth edition practice guidelines, update 2017.

Wein T, Lindsay MP, Côté R, Foley N, Berlingieri J, Bhogal S, Bourgoin A, Buck BH, Cox J, Davidson D, Dowlatshahi D, Douketis J, Falconer J, Field T, Gioia L, Gubitz G, Habert J, Jaspers S, Lum C, McNamara Morse D, Pageau P, Rafay M, Rodgerson A, Semchuk B, Sharma M, Shoamanesh A, Tamayo A, Smitko E, Gladstone DJ; Heart and Stroke Foundation Canadian Stroke Best Practice Committees.

Int J Stroke. 2018 Jun;13(4):420-443. doi: 10.1177/1747493017743062. Epub 2017 Nov 24.

PMID:
29171361
23.

Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor.

Sichler S, Höfner G, Rappenglück S, Wein T, Niessen KV, Seeger T, Worek F, Thiermann H, Paintner FF, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:172-183. doi: 10.1016/j.toxlet.2017.11.013. Epub 2017 Nov 14.

PMID:
29146291
24.

Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.

Wein T, Höfner G, Rappenglück S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:184-189. doi: 10.1016/j.toxlet.2017.10.024. Epub 2017 Oct 31.

PMID:
29097222
25.

In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers.

Niessen KV, Seeger T, Rappenglück S, Wein T, Höfner G, Wanner KT, Thiermann H, Worek F.

Toxicol Lett. 2018 Sep 1;293:190-197. doi: 10.1016/j.toxlet.2017.10.009. Epub 2017 Oct 10.

PMID:
29024789
26.

Biceps Femoris Injury a Rarity: A Case Report.

Strasser R, Wein T, Wieder M, Erhardt J, Kaufmann J.

Surg J (N Y). 2017 Sep 7;3(3):e143-e144. doi: 10.1055/s-0037-1606316. eCollection 2017 Jul.

27.

An evolutionary perspective on plasmid lifestyle modes.

Hülter N, Ilhan J, Wein T, Kadibalban AS, Hammerschmidt K, Dagan T.

Curr Opin Microbiol. 2017 Aug;38:74-80. doi: 10.1016/j.mib.2017.05.001. Epub 2017 May 21. Review.

28.

Overcoming resistance against managed care - insights from a bargaining model.

Ehlert A, Wein T, Zweifel P.

Health Econ Rev. 2017 Dec;7(1):19. doi: 10.1186/s13561-017-0156-4. Epub 2017 May 22.

29.

Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents.

Lutz T, Wein T, Höfner G, Wanner KT.

ChemMedChem. 2017 Mar 7;12(5):362-371. doi: 10.1002/cmdc.201600599. Epub 2017 Feb 10.

PMID:
28125164
30.

Poster 312 Muscle Selection Patterns for Injection of OnabotulinumtoxinA in Adult Patients with Post-Stroke Lower-Limb Spasticity Influence Outcome: Results from a Double-Blind, Placebo-Controlled Phase 3 Clinical Trial.

Esquenazi A, Geis C, Wein T, Ward AB, Liu C, Dimitrova R.

PM R. 2016 Sep;8(9S):S262. doi: 10.1016/j.pmrj.2016.07.482. Epub 2016 Sep 24. No abstract available.

PMID:
27673066
31.

A Screening Tool to Identify Spasticity in Need of Treatment.

Zorowitz RD, Wein TH, Dunning K, Deltombe T, Olver JH, Davé SJ, Dimyan MA, Kelemen J, Pagan FL, Evans CJ, Gillard PJ, Kissela BM.

Am J Phys Med Rehabil. 2017 May;96(5):315-320. doi: 10.1097/PHM.0000000000000605.

32.

Real-World, Long-Term Quality of Life Following Therapeutic OnabotulinumtoxinA Treatment.

Jog M, Wein T, Bhogal M, Dhani S, Miller R, Ismail F, Beauchamp R, Trentin G.

Can J Neurol Sci. 2016 Sep;43(5):687-96. doi: 10.1017/cjn.2016.262. Epub 2016 Jul 19.

PMID:
27430524
33.

Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.

Hellenbrand T, Höfner G, Wein T, Wanner KT.

Bioorg Med Chem. 2016 May 1;24(9):2072-96. doi: 10.1016/j.bmc.2016.03.038. Epub 2016 Mar 22.

PMID:
27039250
34.

Different Binding Modes of Small and Large Binders of GAT1.

Wein T, Petrera M, Allmendinger L, Höfner G, Pabel J, Wanner KT.

ChemMedChem. 2016 Mar 4;11(5):509-18. doi: 10.1002/cmdc.201500534. Epub 2016 Jan 25.

PMID:
26804464
35.

Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions.

Petrera M, Wein T, Allmendinger L, Sindelar M, Pabel J, Höfner G, Wanner KT.

ChemMedChem. 2016 Mar 4;11(5):519-38. doi: 10.1002/cmdc.201500490. Epub 2015 Dec 18.

PMID:
26683881
36.

Rapid Assessment and Treatment of Transient Ischemic Attacks and Minor Stroke in Canadian Emergency Departments: Time for a Paradigm Shift.

Kamal N, Hill MD, Blacquiere DP, Boulanger JM, Boyle K, Buck B, Butcher K, Camden MC, Casaubon LK, Côté R, Demchuk AM, Dowlatshahi D, Dubuc V, Field TS, Ghrooda E, Gioia L, Gladstone DJ, Goyal M, Gubitz GJ, Harris D, Hart RG, Hunter G, Jeerakathil T, Jin A, Khan K, Lang E, Lanthier S, Lindsay MP, Mackey A, Mandzia J, Mehdiratta M, Minuk J, Oczkowski W, Odier C, Penn A, Perry J, Pettersen JA, Phillips SJ, Poppe AY, Saposnik G, Selchen D, Shamy M, Sharma M, Shoamanesh A, Shuaib A, Silver F, Stotts G, Swartz R, Tamayo A, Teitelbaum J, Verreault S, Wein T, Yip S, Coutts SB.

Stroke. 2015 Oct;46(10):2987-90. doi: 10.1161/STROKEAHA.115.010454. Epub 2015 Aug 27. No abstract available.

PMID:
26316346
37.

Canadian Stroke Best Practice Recommendations: secondary prevention of stroke guidelines, update 2014.

Coutts SB, Wein TH, Lindsay MP, Buck B, Cote R, Ellis P, Foley N, Hill MD, Jaspers S, Jin AY, Kwiatkowski B, MacPhail C, McNamara-Morse D, McMurtry MS, Mysak T, Pipe A, Silver K, Smith EE, Gubitz G; Heart, and Stroke Foundation Canada Canadian Stroke Best Practices Advisory Committee.

Int J Stroke. 2015 Apr;10(3):282-91. doi: 10.1111/ijs.12439. Epub 2014 Dec 23.

PMID:
25535808
38.

Functional goal achievement in post-stroke spasticity patients: the BOTOX® Economic Spasticity Trial (BEST).

Ward AB, Wissel J, Borg J, Ertzgaard P, Herrmann C, Kulkarni J, Lindgren K, Reuter I, Sakel M, Säterö P, Sharma S, Wein T, Wright N, Fulford-Smith A; BEST Study Group.

J Rehabil Med. 2014 Jun;46(6):504-13. doi: 10.2340/16501977-1817.

39.

An open-label trial of a sumatriptan auto-injector for migraine in patients currently treated with subcutaneous sumatriptan.

Landy SH, Tepper SJ, Wein T, Schweizer E, Ramos E.

Headache. 2013 Jan;53(1):118-125. doi: 10.1111/j.1526-4610.2012.02295.x. Epub 2012 Nov 13.

PMID:
23148799
40.

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

Michalakis S, Zong X, Becirovic E, Hammelmann V, Wein T, Wanner KT, Biel M.

J Neurosci. 2011 Jan 5;31(1):133-41. doi: 10.1523/JNEUROSCI.4735-10.2011.

41.

Rationale and design of a multicentre, double-blind, prospective, randomized, European and Canadian study: evaluating patient outcomes and costs of managing adults with post-stroke focal spasticity.

Borg J, Ward AB, Wissel J, Kulkarni J, Sakel M, Ertzgaard P, Åkerlund P, Reuter I, Herrmann C, Satkunam L, Wein T, Girod I, Wright N; BEST Study Group.

J Rehabil Med. 2011 Jan;43(1):15-22. doi: 10.2340/16501977-0663.

42.

An unusual case of retro-orbital pain with diplopia.

Paci M, Wein TH, Bekhor S.

Can J Neurol Sci. 2010 Nov;37(6):888-9. No abstract available.

PMID:
21059561
43.

Generation of a 3D model for human GABA transporter hGAT-1 using molecular modeling and investigation of the binding of GABA.

Wein T, Wanner KT.

J Mol Model. 2010 Jan;16(1):155-61. doi: 10.1007/s00894-009-0520-3. Epub 2009 Jun 9.

PMID:
19506924
44.

Safety of tissue plasminogen activator for acute stroke in menstruating women.

Wein TH, Hickenbottom SL, Morgenstern LB, Demchuk AM, Grotta JC.

Stroke. 2002 Oct;33(10):2506-8. Review.

PMID:
12364745
45.

Electrodiagnostic approach to the patient with suspected peripheral polyneuropathy.

Wein TH, Albers JW.

Neurol Clin. 2002 May;20(2):503-26, vii.

PMID:
12152445
46.

Improving delivery of acute stroke therapy: The TLL Temple Foundation Stroke Project.

Morgenstern LB, Staub L, Chan W, Wein TH, Bartholomew LK, King M, Felberg RA, Burgin WS, Groff J, Hickenbottom SL, Saldin K, Demchuk AM, Kalra A, Dhingra A, Grotta JC.

Stroke. 2002 Jan;33(1):160-6.

PMID:
11779906
47.

Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial.

Kasner SE, Wein T, Piriyawat P, Villar-Cordova CE, Chalela JA, Krieger DW, Morgenstern LB, Kimmel SE, Grotta JC.

Stroke. 2002 Jan;33(1):130-4.

PMID:
11779901
48.

Acute stroke care in non-urban emergency departments.

Burgin WS, Staub L, Chan W, Wein TH, Felberg RA, Grotta JC, Demchuk AM, Hickenbottom SL, Morgenstern LB.

Neurology. 2001 Dec 11;57(11):2006-12.

PMID:
11739817
49.

Diabetic neuropathies.

Wein TH, Albers JW.

Phys Med Rehabil Clin N Am. 2001 May;12(2):307-20, ix. Review.

PMID:
11345009
50.

Activation of emergency medical services for acute stroke in a nonurban population: the T.L.L. Temple Foundation Stroke Project.

Wein TH, Staub L, Felberg R, Hickenbottom SL, Chan W, Grotta JC, Demchuk AM, Groff J, Bartholomew LK, Morgenstern LB.

Stroke. 2000 Aug;31(8):1925-8.

PMID:
10926958

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