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Items: 49

1.

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.

Hanson JE, Ma K, Elstrott J, Weber M, Saillet S, Khan AS, Simms J, Liu B, Kim TA, Yu GQ, Chen Y, Wang TM, Jiang Z, Liederer BM, Deshmukh G, Solanoy H, Chan C, Sellers BD, Volgraf M, Schwarz JB, Hackos DH, Weimer RM, Sheng M, Gill TM, Scearce-Levie K, Palop JJ.

Cell Rep. 2020 Jan 14;30(2):381-396.e4. doi: 10.1016/j.celrep.2019.12.030.

2.

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.

Blennow K, Chen C, Cicognola C, Wildsmith KR, Manser PT, Bohorquez SMS, Zhang Z, Xie B, Peng J, Hansson O, Kvartsberg H, Portelius E, Zetterberg H, Lashley T, Brinkmalm G, Kerchner GA, Weimer RM, Ye K, Höglund K.

Brain. 2020 Feb 1;143(2):650-660. doi: 10.1093/brain/awz346.

PMID:
31834365
3.

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions.

Easley-Neal C, Foreman O, Sharma N, Zarrin AA, Weimer RM.

Front Immunol. 2019 Sep 20;10:2199. doi: 10.3389/fimmu.2019.02199. eCollection 2019.

4.

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.

Lin W, Xu D, Austin CD, Caplazi P, Senger K, Sun Y, Jeet S, Young J, Delarosa D, Suto E, Huang Z, Zhang J, Yan D, Corzo C, Barck K, Rajan S, Looney C, Gandham V, Lesch J, Liang WC, Mai E, Ngu H, Ratti N, Chen Y, Misner D, Lin T, Danilenko D, Katavolos P, Doudemont E, Uppal H, Eastham J, Mak J, de Almeida PE, Bao K, Hadadianpour A, Keir M, Carano RAD, Diehl L, Xu M, Wu Y, Weimer RM, DeVoss J, Lee WP, Balazs M, Walsh K, Alatsis KR, Martin F, Zarrin AA.

Front Immunol. 2019 Sep 4;10:2019. doi: 10.3389/fimmu.2019.02019. eCollection 2019.

5.

Disruption of IRE1α through its kinase domain attenuates multiple myeloma.

Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1.

6.

Cross-sectional associations between [18F]GTP1 tau PET and cognition in Alzheimer's disease.

Teng E, Ward M, Manser PT, Sanabria-Bohorquez S, Ray RD, Wildsmith KR, Baker S, Kerchner GA, Weimer RM.

Neurobiol Aging. 2019 Sep;81:138-145. doi: 10.1016/j.neurobiolaging.2019.05.026. Epub 2019 Jun 6.

PMID:
31280117
7.

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer's disease.

Sanabria Bohórquez S, Marik J, Ogasawara A, Tinianow JN, Gill HS, Barret O, Tamagnan G, Alagille D, Ayalon G, Manser P, Bengtsson T, Ward M, Williams SP, Kerchner GA, Seibyl JP, Marek K, Weimer RM.

Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2077-2089. doi: 10.1007/s00259-019-04399-0. Epub 2019 Jun 28.

PMID:
31254035
8.

Publisher Correction: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.

Katschke KJ Jr, Xi H, Cox C, Truong T, Malato Y, Lee WP, McKenzie B, Arceo R, Tao J, Rangell L, Reichelt M, Diehl L, Elstrott J, Weimer RM, van Lookeren Campagne M.

Sci Rep. 2018 Aug 24;8(1):13055. doi: 10.1038/s41598-018-30162-w.

9.

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.

Katschke KJ Jr, Xi H, Cox C, Truong T, Malato Y, Lee WP, McKenzie B, Arceo R, Tao J, Rangell L, Reichelt M, Diehl L, Elstrott J, Weimer RM, van Lookeren Campagne M.

Sci Rep. 2018 May 9;8(1):7348. doi: 10.1038/s41598-018-25557-8. Erratum in: Sci Rep. 2018 Aug 24;8(1):13055.

10.

Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects.

Barret O, Alagille D, Sanabria S, Comley RA, Weimer RM, Borroni E, Mintun M, Seneca N, Papin C, Morley T, Marek K, Seibyl JP, Tamagnan GD, Jennings D.

J Nucl Med. 2017 Jul;58(7):1124-1131. doi: 10.2967/jnumed.116.182881. Epub 2016 Dec 1.

11.

IL-33 amplifies an innate immune response in the degenerating retina.

Xi H, Katschke KJ Jr, Li Y, Truong T, Lee WP, Diehl L, Rangell L, Tao J, Arceo R, Eastham-Anderson J, Hackney JA, Iglesias A, Cote-Sierra J, Elstrott J, Weimer RM, van Lookeren Campagne M.

J Exp Med. 2016 Feb 8;213(2):189-207. doi: 10.1084/jem.20150894. Epub 2016 Jan 11.

12.

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ.

Neuron. 2016 Jan 6;89(1):70-82. doi: 10.1016/j.neuron.2015.11.024. Epub 2015 Dec 10.

13.

The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.

Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ.

Nat Immunol. 2015 Jan;16(1):75-84. doi: 10.1038/ni.3035. Epub 2014 Oct 27.

14.

Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons.

Chen Y, Wang Y, Ertürk A, Kallop D, Jiang Z, Weimer RM, Kaminker J, Sheng M.

Neuron. 2014 Jul 16;83(2):431-443. doi: 10.1016/j.neuron.2014.05.027. Epub 2014 Jun 26.

15.

Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.

Hanson JE, Meilandt WJ, Gogineni A, Reynen P, Herrington J, Weimer RM, Scearce-Levie K, Zhou Q.

J Neurosci. 2014 Jun 11;34(24):8277-88. doi: 10.1523/JNEUROSCI.5106-13.2014.

16.

Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.

Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M.

J Neurosci. 2014 May 7;34(19):6438-47. doi: 10.1523/JNEUROSCI.3522-13.2014.

17.

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM.

J Neurosci. 2014 May 7;34(19):6425-37. doi: 10.1523/JNEUROSCI.4963-13.2014.

18.

Axons degenerate in the absence of mitochondria in C. elegans.

Rawson RL, Yam L, Weimer RM, Bend EG, Hartwieg E, Horvitz HR, Clark SG, Jorgensen EM.

Curr Biol. 2014 Mar 31;24(7):760-5. doi: 10.1016/j.cub.2014.02.025. Epub 2014 Mar 13.

19.

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.

Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ.

J Exp Med. 2014 Feb 10;211(2):233-44. doi: 10.1084/jem.20131660. Epub 2014 Jan 27.

20.

Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin.

Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M.

Neuron. 2013 Dec 4;80(5):1175-89. doi: 10.1016/j.neuron.2013.08.034. Epub 2013 Nov 7.

21.

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.

Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, Weimer RM, Kirkpatrick DS, Lewcock JW.

J Exp Med. 2013 Nov 18;210(12):2553-67. doi: 10.1084/jem.20122832. Epub 2013 Oct 28.

22.

An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins.

Hazen M, Bhakta S, Vij R, Randle S, Kallop D, Chiang V, Hötzel I, Jaiswal BS, Ervin KE, Li B, Weimer RM, Polakis P, Scheller RH, Junutula JR, Hongo JA.

MAbs. 2014 Jan-Feb;6(1):95-107.

23.

Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.

Gogineni A, Caunt M, Crow A, Lee CV, Fuh G, van Bruggen N, Ye W, Weimer RM.

PLoS One. 2013 Jul 16;8(7):e68755. doi: 10.1371/journal.pone.0068755. Print 2013.

24.

A caspase cascade regulating developmental axon degeneration.

Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O'Leary DD, Hannoush RN, Tessier-Lavigne M.

J Neurosci. 2012 Dec 5;32(49):17540-53. doi: 10.1523/JNEUROSCI.3012-12.2012.

25.

Spatially coordinated kinase signaling regulates local axon degeneration.

Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ.

J Neurosci. 2012 Sep 26;32(39):13439-53.

26.

Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth.

Wilson NS, Yang A, Yang B, Couto S, Stern H, Gogineni A, Pitti R, Marsters S, Weimer RM, Singh M, Ashkenazi A.

Cancer Cell. 2012 Jul 10;22(1):80-90. doi: 10.1016/j.ccr.2012.05.014.

27.

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.

J Neurosci. 2012 Jul 11;32(28):9677-89. doi: 10.1523/JNEUROSCI.4742-11.2012.

28.

Imaging synaptic protein dynamics using photoactivatable green fluorescent protein.

Weimer RM, Hill TC, Hamilton AM, Zito K.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):771-7. doi: 10.1101/pdb.prot070029.

PMID:
22753605
29.

An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo.

Kozlowski C, Weimer RM.

PLoS One. 2012;7(2):e31814. doi: 10.1371/journal.pone.0031814. Epub 2012 Feb 28.

30.

Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.

Gleason EJ, Hartley PD, Henderson M, Hill-Harfe KL, Price PW, Weimer RM, Kroft TL, Zhu GD, Cordovado S, L'Hernault SW.

Genetics. 2012 Jun;191(2):477-91. doi: 10.1534/genetics.112.139618. Epub 2012 Mar 23.

31.

Death receptors DR6 and TROY regulate brain vascular development.

Tam SJ, Richmond DL, Kaminker JS, Modrusan Z, Martin-McNulty B, Cao TC, Weimer RM, Carano RA, van Bruggen N, Watts RJ.

Dev Cell. 2012 Feb 14;22(2):403-17. doi: 10.1016/j.devcel.2011.11.018.

32.

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms.

Goergen CJ, Azuma J, Barr KN, Magdefessel L, Kallop DY, Gogineni A, Grewall A, Weimer RM, Connolly AJ, Dalman RL, Taylor CA, Tsao PS, Greve JM.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):270-9. doi: 10.1161/ATVBAHA.110.216481. Epub 2010 Nov 11.

33.

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity.

Blum G, Weimer RM, Edgington LE, Adams W, Bogyo M.

PLoS One. 2009 Jul 28;4(7):e6374. doi: 10.1371/journal.pone.0006374.

34.

Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools.

Sato K, Ernstrom GG, Watanabe S, Weimer RM, Chen CH, Sato M, Siddiqui A, Jorgensen EM, Grant BD.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1139-44. doi: 10.1073/pnas.0809541106. Epub 2009 Jan 16.

35.

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo.

Gray NW, Weimer RM, Bureau I, Svoboda K.

PLoS Biol. 2006 Nov;4(11):e370.

37.

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.

Gracheva EO, Burdina AO, Holgado AM, Berthelot-Grosjean M, Ackley BD, Hadwiger G, Nonet ML, Weimer RM, Richmond JE.

PLoS Biol. 2006 Jul;4(8):e261.

38.

UNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains.

Weimer RM, Gracheva EO, Meyrignac O, Miller KG, Richmond JE, Bessereau JL.

J Neurosci. 2006 Aug 2;26(31):8040-7. Erratum in: J Neurosci. 2006 Sep 13;26(37):9603.

39.

Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans.

Abraham C, Hutter H, Palfreyman MT, Spatkowski G, Weimer RM, Windoffer R, Jorgensen EM, Leube RE.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8227-32. Epub 2006 May 12.

40.

Diverse modes of axon elaboration in the developing neocortex.

Portera-Cailliau C, Weimer RM, De Paola V, Caroni P, Svoboda K.

PLoS Biol. 2005 Aug;3(8):e272. Epub 2005 Jul 26.

41.

Identification of genes involved in synaptogenesis using a fluorescent active zone marker in Caenorhabditis elegans.

Yeh E, Kawano T, Weimer RM, Bessereau JL, Zhen M.

J Neurosci. 2005 Apr 13;25(15):3833-41.

42.

Synaptic vesicle docking: a putative role for the Munc18/Sec1 protein family.

Weimer RM, Richmond JE.

Curr Top Dev Biol. 2005;65:83-113. Review. No abstract available.

PMID:
15642380
43.

Preservation of immunoreactivity and fine structure of adult C. elegans tissues using high-pressure freezing.

Rostaing P, Weimer RM, Jorgensen EM, Triller A, Bessereau JL.

J Histochem Cytochem. 2004 Jan;52(1):1-12. Erratum in: J Histochem Cytochem. 2004 Apr;52(4):555.

PMID:
14688212
44.

Defects in synaptic vesicle docking in unc-18 mutants.

Weimer RM, Richmond JE, Davis WS, Hadwiger G, Nonet ML, Jorgensen EM.

Nat Neurosci. 2003 Oct;6(10):1023-30. Epub 2003 Sep 14.

45.

Controversies in synaptic vesicle exocytosis.

Weimer RM, Jorgensen EM.

J Cell Sci. 2003 Sep 15;116(Pt 18):3661-6. Review. No abstract available.

46.

The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces.

Bosher JM, Hahn BS, Legouis R, Sookhareea S, Weimer RM, Gansmuller A, Chisholm AD, Rose AM, Bessereau JL, Labouesse M.

J Cell Biol. 2003 May 26;161(4):757-68. Epub 2003 May 19.

47.

A post-docking role for active zone protein Rim.

Koushika SP, Richmond JE, Hadwiger G, Weimer RM, Jorgensen EM, Nonet ML.

Nat Neurosci. 2001 Oct;4(10):997-1005.

48.

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming.

Richmond JE, Weimer RM, Jorgensen EM.

Nature. 2001 Jul 19;412(6844):338-41.

49.

A chaperone in the HSP70 family controls production of extracellular fibrils in Myxococcus xanthus.

Weimer RM, Creighton Cx, Stassinopoulos A, Youderian P, Hartzell PL.

J Bacteriol. 1998 Oct;180(20):5357-68.

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