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Items: 1 to 50 of 53

1.

Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease.

Cain JT, Likhite S, White KA, Timm DJ, Davis SS, Johnson TB, Dennys-Rivers CN, Rinaldi F, Motti D, Corcoran S, Morales P, Pierson C, Hughes SM, Lee SY, Kaspar BK, Meyer K, Weimer JM.

Mol Ther. 2019 Jul 10. pii: S1525-0016(19)30311-9. doi: 10.1016/j.ymthe.2019.06.015. [Epub ahead of print]

2.

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.

Khanna R, Moutal A, White KA, Chefdeville A, Negrao de Assis P, Cai S, Swier VJ, Bellampalli SS, Giunta MD, Darbro BW, Quelle DE, Sieren JC, Wallace MR, Rogers CS, Meyerholz DK, Weimer JM.

Pain. 2019 Jul 17. doi: 10.1097/j.pain.0000000000001648. [Epub ahead of print]

PMID:
31246731
3.

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.

Moutal A, White KA, Chefdeville A, Laufmann RN, Vitiello PF, Feinstein D, Weimer JM, Khanna R.

Mol Neurobiol. 2019 Mar 27. doi: 10.1007/s12035-019-1568-4. [Epub ahead of print] Review.

PMID:
30915713
4.

Therapeutic landscape for Batten disease: current treatments and future prospects.

Johnson TB, Cain JT, White KA, Ramirez-Montealegre D, Pearce DA, Weimer JM.

Nat Rev Neurol. 2019 Mar;15(3):161-178. doi: 10.1038/s41582-019-0138-8. Review.

5.

Tracking sex-dependent differences in a mouse model of CLN6-Batten disease.

Poppens MJ, Cain JT, Johnson TB, White KA, Davis SS, Laufmann R, Kloth AD, Weimer JM.

Orphanet J Rare Dis. 2019 Jan 21;14(1):19. doi: 10.1186/s13023-019-0994-8.

6.

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.

Yu J, Moutal A, Dorame A, Bellampalli SS, Chefdeville A, Kanazawa I, Pham NYN, Park KD, Weimer JM, Khanna R.

Mol Neurobiol. 2019 Jul;56(7):5241-5255. doi: 10.1007/s12035-018-1445-6. Epub 2018 Dec 18.

PMID:
30565051
7.

Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1.

Johnson TB, Mechels K, Anderson RE, Cain JT, Sturdevant DA, Braddock S, Pinz H, Wilson MA, Landsverk M, Roux KJ, Weimer JM.

Sci Rep. 2018 Nov 1;8(1):16161. doi: 10.1038/s41598-018-34437-0.

8.
9.

Cancer exosomes induce tumor innervation.

Madeo M, Colbert PL, Vermeer DW, Lucido CT, Cain JT, Vichaya EG, Grossberg AJ, Muirhead D, Rickel AP, Hong Z, Zhao J, Weimer JM, Spanos WC, Lee JH, Dantzer R, Vermeer PD.

Nat Commun. 2018 Oct 16;9(1):4284. doi: 10.1038/s41467-018-06640-0.

10.

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network.

Brudvig JJ, Cain JT, Sears RM, Schmidt-Grimminger GG, Wittchen ES, Adler KB, Ghashghaei HT, Weimer JM.

Sci Rep. 2018 Sep 5;8(1):13278. doi: 10.1038/s41598-018-31578-0.

11.

Searching for novel biomarkers using a mouse model of CLN3-Batten disease.

Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM.

PLoS One. 2018 Aug 7;13(8):e0201470. doi: 10.1371/journal.pone.0201470. eCollection 2018.

12.

A porcine model of neurofibromatosis type 1 that mimics the human disease.

White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS, Sieren JC, Quelle DE, Weimer JM.

JCI Insight. 2018 Jun 21;3(12). pii: 120402. doi: 10.1172/jci.insight.120402. eCollection 2018 Jun 21.

13.

Short-Term Administration of Mycophenolate Is Well-Tolerated in CLN3 Disease (Juvenile Neuronal Ceroid Lipofuscinosis).

Augustine EF, Beck CA, Adams HR, Defendorf S, Vierhile A, Timm D, Weimer JM, Mink JW, Marshall FJ.

JIMD Rep. 2019;43:117-124. doi: 10.1007/8904_2018_113. Epub 2018 Jun 20.

14.

MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.

Brudvig JJ, Cain JT, Schmidt-Grimminger GG, Stumpo DJ, Roux KJ, Blackshear PJ, Weimer JM.

Mol Neurobiol. 2018 Nov;55(11):8388-8402. doi: 10.1007/s12035-018-0990-3. Epub 2018 Mar 15.

PMID:
29546593
15.

Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.

Meyerholz DK, Ofori-Amanfo GK, Leidinger MR, Goeken JA, Khanna R, Sieren JC, Darbro BW, Quelle DE, Weimer JM.

J Histochem Cytochem. 2017 Oct;65(10):607-618. doi: 10.1369/0022155417729357. Epub 2017 Aug 28.

16.

Midwest Science Festival: Exploring Students' and Parents' Participation in and Attitudes Toward Science.

Dippel EA, Mechels KB, Griese ER, Laufmann RN, Weimer JM.

S D Med. 2016 Aug;69(8):343-349.

PMID:
28806002
17.

Genetic ataxia telangiectasia porcine model phenocopies the multisystemic features of the human disease.

Beraldi R, Meyerholz DK, Savinov A, Kovács AD, Weimer JM, Dykstra JA, Geraets RD, Pearce DA.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2862-2870. doi: 10.1016/j.bbadis.2017.07.020. Epub 2017 Jul 23.

18.

A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies.

Geraets RD, Langin LM, Cain JT, Parker CM, Beraldi R, Kovacs AD, Weimer JM, Pearce DA.

PLoS One. 2017 May 2;12(5):e0176526. doi: 10.1371/journal.pone.0176526. eCollection 2017.

19.

Nonsense pathogenic variants in exon 1 of PHOX2B lead to translational reinitiation in congenital central hypoventilation syndrome.

Cain JT, Kim DI, Quast M, Shivega WG, Patrick RJ, Moser C, Reuter S, Perez M, Myers A, Weimer JM, Roux KJ, Landsverk M.

Am J Med Genet A. 2017 May;173(5):1200-1207. doi: 10.1002/ajmg.a.38162. Epub 2017 Mar 29.

20.

Acute Cytotoxic and Vasogenic Edema after Subarachnoid Hemorrhage: A Quantitative MRI Study.

Weimer JM, Jones SE, Frontera JA.

AJNR Am J Neuroradiol. 2017 May;38(5):928-934. doi: 10.3174/ajnr.A5181. Epub 2017 Mar 31.

21.

Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction.

Dykstra JA, Facile T, Patrick RJ, Francis KR, Milanovich S, Weimer JM, Kota DJ.

Stem Cells Transl Med. 2017 Apr;6(4):1096-1108. doi: 10.1002/sctm.16-0337. Epub 2017 Jan 6. Review.

22.

Family caregivers' level of mastery predicts survival of patients with glioblastoma: A preliminary report.

Boele FW, Given CW, Given BA, Donovan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS, Sherwood PR.

Cancer. 2017 Mar 1;123(5):832-840. doi: 10.1002/cncr.30428. Epub 2016 Oct 27.

23.

Dural Traction a Possible Cause of Hemodynamic Changes During Single-Level Transforaminal Lumbar Interbody Fusion.

Weimer JM, Marinov M, Avitsian R.

World Neurosurg. 2017 Jan;97:761.e1-761.e3. doi: 10.1016/j.wneu.2016.09.102. Epub 2016 Oct 7.

PMID:
27725296
24.

The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage.

Frontera JA, Provencio JJ, Sehba FA, McIntyre TM, Nowacki AS, Gordon E, Weimer JM, Aledort L.

Neurocrit Care. 2017 Feb;26(1):48-57. doi: 10.1007/s12028-016-0292-4.

25.

Diet-induced obesity prolongs neuroinflammation and recruits CCR2(+) monocytes to the brain following herpes simplex virus (HSV)-1 latency in mice.

White KA, Hutton SR, Weimer JM, Sheridan PA.

Brain Behav Immun. 2016 Oct;57:68-78. doi: 10.1016/j.bbi.2016.06.007. Epub 2016 Jun 13.

26.

Predictors of Functional Outcome After Subdural Hematoma: A Prospective Study.

Weimer JM, Gordon E, Frontera JA.

Neurocrit Care. 2017 Feb;26(1):70-79. doi: 10.1007/s12028-016-0279-1.

PMID:
27230968
27.

Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis.

Geraets RD, Koh Sy, Hastings ML, Kielian T, Pearce DA, Weimer JM.

Orphanet J Rare Dis. 2016 Apr 16;11:40. doi: 10.1186/s13023-016-0414-2. Review.

28.

Withdrawal of Life-Sustaining Therapy in Patients With Intracranial Hemorrhage: Self-Fulfilling Prophecy or Accurate Prediction of Outcome?

Weimer JM, Nowacki AS, Frontera JA.

Crit Care Med. 2016 Jun;44(6):1161-72. doi: 10.1097/CCM.0000000000001570.

PMID:
26807687
29.

The Role of FEIBA in Reversing Novel Oral Anticoagulants in Intracerebral Hemorrhage.

Dibu JR, Weimer JM, Ahrens C, Manno E, Frontera JA.

Neurocrit Care. 2016 Jun;24(3):413-9. doi: 10.1007/s12028-015-0213-y.

PMID:
26545367
30.

X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease.

Brudvig JJ, Weimer JM.

Front Cell Neurosci. 2015 Oct 13;9:407. doi: 10.3389/fncel.2015.00407. eCollection 2015. Review.

31.

A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease.

Beraldi R, Chan CH, Rogers CS, Kovács AD, Meyerholz DK, Trantzas C, Lambertz AM, Darbro BW, Weber KL, White KA, Rheeden RV, Kruer MC, Dacken BA, Wang XJ, Davis BT, Rohret JA, Struzynski JT, Rohret FA, Weimer JM, Pearce DA.

Hum Mol Genet. 2015 Nov 15;24(22):6473-84. doi: 10.1093/hmg/ddv356. Epub 2015 Sep 15.

32.

Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

Watzlawik JO, Kahoud RJ, O'Toole RJ, White KA, Ogden AR, Painter MM, Wootla B, Papke LM, Denic A, Weimer JM, Carey WA, Rodriguez M.

PLoS One. 2015 May 28;10(5):e0128007. doi: 10.1371/journal.pone.0128007. eCollection 2015.

33.

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging.

Muthusamy N, Sommerville LJ, Moeser AJ, Stumpo DJ, Sannes P, Adler K, Blackshear PJ, Weimer JM, Ghashghaei HT.

Aging Cell. 2015 Oct;14(5):764-73. doi: 10.1111/acel.12354. Epub 2015 May 25.

34.

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.

Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Söll D, Walsh CA, Nabbout R.

Am J Hum Genet. 2014 Apr 3;94(4):547-58. doi: 10.1016/j.ajhg.2014.03.003. Epub 2014 Mar 20.

35.

A murine model of variant late infantile ceroid lipofuscinosis recapitulates behavioral and pathological phenotypes of human disease.

Morgan JP, Magee H, Wong A, Nelson T, Koch B, Cooper JD, Weimer JM.

PLoS One. 2013 Nov 1;8(11):e78694. doi: 10.1371/journal.pone.0078694. eCollection 2013.

36.

Mutations in VLDLR associated with ataxia with secondary vitamin E deficiency.

Kruer MC, Jepperson TN, Weimer JM, Mroch A, Davis-Keppen L, Crotwell P, Parboosingh J.

Mov Disord. 2013 Nov;28(13):1904-5. doi: 10.1002/mds.25573. Epub 2013 Jun 27. No abstract available.

PMID:
23813796
37.

Locke-Wallace Short Marital-Adjustment Test: psychometric evaluation in caregivers for persons with primary malignant brain tumor.

Jiang Y, Terhorst L, Donovan HS, Weimer JM, Choi CW, Schulz R, Given B, Sherwood PR.

J Nurs Meas. 2013;21(3):502-15.

38.

Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia.

Moy SS, Ghashghaei HT, Nonneman RJ, Weimer JM, Yokota Y, Lee D, Lai C, Threadgill DW, Anton ES.

J Neurodev Disord. 2009 Dec;1(4):302-12. doi: 10.1007/s11689-009-9017-8. Epub 2009 May 27.

39.

MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.

Weimer JM, Yokota Y, Stanco A, Stumpo DJ, Blackshear PJ, Anton ES.

Development. 2009 Sep;136(17):2965-75. doi: 10.1242/dev.036616.

40.

Cerebellar defects in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Weimer JM, Benedict JW, Getty AL, Pontikis CC, Lim MJ, Cooper JD, Pearce DA.

Brain Res. 2009 Apr 17;1266:93-107. doi: 10.1016/j.brainres.2009.02.009. Epub 2009 Feb 20.

41.

A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system.

Weimer JM, Stanco A, Cheng JG, Vargo AC, Voora S, Anton ES.

Glia. 2008 Jul;56(9):935-41. doi: 10.1002/glia.20666.

42.

Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex.

Ghashghaei HT, Weimer JM, Schmid RS, Yokota Y, McCarthy KD, Popko B, Anton ES.

Genes Dev. 2007 Dec 15;21(24):3258-71.

43.

Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.

Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA.

Brain Res. 2007 Aug 8;1162:98-112. Epub 2007 May 21.

44.

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease.

Kovács AD, Weimer JM, Pearce DA.

Neurobiol Dis. 2006 Jun;22(3):575-85. Epub 2006 Feb 17.

PMID:
16483786
45.

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons.

Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA.

Neurobiol Dis. 2006 May;22(2):284-93. Epub 2006 Jan 18.

47.

Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype.

Kwon JM, Rothberg PG, Leman AR, Weimer JM, Mink JW, Pearce DA.

Neurosci Lett. 2005 Oct 21;387(2):111-4.

PMID:
16087292
48.

Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.

Weimer JM, Chattopadhyay S, Custer AW, Pearce DA.

Biochem Biophys Res Commun. 2005 May 20;330(4):1176-81.

PMID:
15823567
49.

CLN3, the protein associated with batten disease: structure, function and localization.

Phillips SN, Benedict JW, Weimer JM, Pearce DA.

J Neurosci Res. 2005 Mar 1;79(5):573-83. Review.

PMID:
15657902
50.

Branded versus generic clozapine for treatment of schizophrenia.

Makela EH, Cutlip WD, Stevenson JM, Weimer JM, Abdallah ES, Akhtar RS, Aboraya AS, Gunel E.

Ann Pharmacother. 2003 Mar;37(3):350-3.

PMID:
12639161

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