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Items: 1 to 50 of 59

1.

Preface.

Weimbs T.

Methods Cell Biol. 2019;154:xiii-xiv. doi: 10.1016/S0091-679X(19)30115-3. No abstract available.

PMID:
31493824
2.

Preface.

Weimbs T.

Methods Cell Biol. 2019;153:xiii-xiv. doi: 10.1016/S0091-679X(19)30104-9. No abstract available.

PMID:
31395387
3.

Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease.

Torres JA, Rezaei M, Broderick C, Lin L, Wang X, Hoppe B, Cowley BD Jr, Savica V, Torres VE, Khan S, Holmes RP, Mrug M, Weimbs T.

J Clin Invest. 2019 Jul 30;130:4506-4522. doi: 10.1172/JCI128503.

4.

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.

Weimbs T, Shillingford JM, Torres J, Kruger SL, Bourgeois BC.

Clin Kidney J. 2018 Dec;11(Suppl 1):i27-i38. doi: 10.1093/ckj/sfy089. Epub 2018 Dec 17. Review.

5.

Are Cyst-Associated Macrophages in Polycystic Kidney Disease the Equivalent to TAMs in Cancer?

Weimbs T.

J Am Soc Nephrol. 2018 Oct;29(10):2447-2448. doi: 10.1681/ASN.2018080846. Epub 2018 Sep 12. No abstract available.

6.

Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease.

Kipp KR, Kruger SL, Schimmel MF, Parker N, Shillingford JM, Leamon CP, Weimbs T.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F395-F405. doi: 10.1152/ajprenal.00057.2018. Epub 2018 May 2.

7.

Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T.

Bio Protoc. 2018 Feb 5;8(3). pii: e2453. doi: 10.21769/BioProtoc.2453.

8.

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouzé C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, Fautrel A, Mrug M, Wallace D, Tran PV, Trudel M, Bukanov N, Ibraghimov-Beskrovnaya O, Meijer L.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F57-F73. doi: 10.1152/ajprenal.00489.2017. Epub 2018 Mar 14.

9.

Identification of targets of IL-13 and STAT6 signaling in polycystic kidney disease.

Olsan EE, West JD, Torres JA, Doerr N, Weimbs T.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F86-F96. doi: 10.1152/ajprenal.00346.2017. Epub 2018 Mar 7.

10.

Soluble syntaxin 3 functions as a transcriptional regulator.

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T.

J Biol Chem. 2018 Apr 13;293(15):5478-5491. doi: 10.1074/jbc.RA117.000874. Epub 2018 Feb 23.

11.

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T.

Mol Biol Cell. 2017 Oct 15;28(21):2843-2853. doi: 10.1091/mbc.E17-07-0461. Epub 2017 Aug 16.

12.

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons.

Soo Hoo L, Banna CD, Radeke CM, Sharma N, Albertolle ME, Low SH, Weimbs T, Vandenberg CA.

PLoS One. 2016 Sep 23;11(9):e0163671. doi: 10.1371/journal.pone.0163671. eCollection 2016.

13.

Regulation of Polycystin-1 Function by Calmodulin Binding.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T.

PLoS One. 2016 Aug 25;11(8):e0161525. doi: 10.1371/journal.pone.0161525. eCollection 2016.

14.

A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease.

Kipp KR, Rezaei M, Lin L, Dewey EC, Weimbs T.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F726-F731. doi: 10.1152/ajprenal.00551.2015. Epub 2016 Jan 13.

15.

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.

Rothé B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB.

Mol Cell Biol. 2015 Oct;35(19):3339-53. doi: 10.1128/MCB.00341-15. Epub 2015 Jul 27.

16.

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.

Olsan EE, Matsushita T, Rezaei M, Weimbs T.

J Biol Chem. 2015 Jun 19;290(25):15679-86. doi: 10.1074/jbc.M114.607929. Epub 2015 Apr 28.

17.

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T.

J Am Soc Nephrol. 2014 Aug;25(8):1737-48. doi: 10.1681/ASN.2013091026. Epub 2014 Feb 27.

18.

STAT3 Signaling in Polycystic Kidney Disease.

Weimbs T, Talbot JJ.

Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4):e113-e118.

19.

Regulation of STATs by polycystin-1 and their role in polycystic kidney disease.

Weimbs T, Olsan EE, Talbot JJ.

JAKSTAT. 2013 Apr 1;2(2):e23650. doi: 10.4161/jkst.23650. Review.

20.

Folate-conjugated rapamycin slows progression of polycystic kidney disease.

Shillingford JM, Leamon CP, Vlahov IR, Weimbs T.

J Am Soc Nephrol. 2012 Oct;23(10):1674-81. Epub 2012 Aug 2.

21.

Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus.

Stayner C, Shields J, Slobbe L, Shillingford JM, Weimbs T, Eccles MR.

Nephrology (Carlton). 2012 Nov;17(8):739-47. doi: 10.1111/j.1440-1797.2012.01639.x.

22.

Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18067-72. doi: 10.1073/pnas.1111966108. Epub 2011 Oct 24.

23.

Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity.

Reales E, Sharma N, Low SH, Fölsch H, Weimbs T.

PLoS One. 2011;6(6):e21181. doi: 10.1371/journal.pone.0021181. Epub 2011 Jun 15.

24.

Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.

25.

Third-hit signaling in renal cyst formation.

Weimbs T.

J Am Soc Nephrol. 2011 May;22(5):793-5. doi: 10.1681/ASN.2011030284. Epub 2011 Apr 14. No abstract available.

26.

Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases.

Torres VE, Boletta A, Chapman A, Gattone V, Pei Y, Qian Q, Wallace DP, Weimbs T, Wüthrich RP.

Clin J Am Soc Nephrol. 2010 Jul;5(7):1312-29. doi: 10.2215/CJN.01360210. Epub 2010 May 24. Review.

27.

Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

Shillingford JM, Piontek KB, Germino GG, Weimbs T.

J Am Soc Nephrol. 2010 Mar;21(3):489-97. doi: 10.1681/ASN.2009040421. Epub 2010 Jan 14.

28.

Syntaxin specificity of aquaporins in the inner medullary collecting duct.

Mistry AC, Mallick R, Klein JD, Weimbs T, Sands JM, Fröhlich O.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F292-300. doi: 10.1152/ajprenal.00196.2009. Epub 2009 Jun 10.

29.

Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1.

Weimbs T.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1423-32. Epub 2007 Aug 22. Review.

30.

Apical targeting in polarized epithelial cells: There's more afloat than rafts.

Weimbs T, Low SH, Chapin SJ, Mostov KE.

Trends Cell Biol. 1997 Oct;7(10):393-9.

PMID:
17708988
31.

Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis.

Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D.

Traffic. 2007 Oct;8(10):1365-74. Epub 2007 Jul 20.

32.

Image Segmentation, Registration and Visualization of Serial MR Images for Therapeutic Assessment of Polycystic Kidney Disease in Transgenic Mice.

Fei B, Flask C, Wang H, Pi A, Wilson D, Shillingford J, Murcia N, Weimbs T, Duerk J.

Conf Proc IEEE Eng Med Biol Soc. 2005;1:467-9.

PMID:
17282217
33.

Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?

Weimbs T.

Cell Cycle. 2006 Nov 1;5(21):2425-9. Epub 2006 Sep 13. Review.

PMID:
17102641
34.
35.

A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells.

Kidd GJ, Yadav VK, Huang P, Brand SL, Low SH, Weimbs T, Trapp BD.

Glia. 2006 Aug 1;54(2):135-45.

PMID:
16788992
36.

Apical targeting of syntaxin 3 is essential for epithelial cell polarity.

Sharma N, Low SH, Misra S, Pallavi B, Weimbs T.

J Cell Biol. 2006 Jun 19;173(6):937-48.

37.

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. Epub 2006 Mar 27.

38.

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T.

Dev Cell. 2006 Jan;10(1):57-69.

39.

Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity.

Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T.

Mol Biol Cell. 2006 Feb;17(2):977-89. Epub 2005 Dec 7.

40.

Regulation of nuclear functions--nucleocytoplasmic transport in context.

Tartakoff AM, Matera AG, Pimplikar SW, Weimbs T.

Eur J Cell Biol. 2004 Jul;83(5):185-92. Review. No abstract available.

PMID:
15346808
41.

Polarity proteins control ciliogenesis via kinesin motor interactions.

Fan S, Hurd TW, Liu CJ, Straight SW, Weimbs T, Hurd EA, Domino SE, Margolis B.

Curr Biol. 2004 Aug 24;14(16):1451-61.

42.

SNAREs and epithelial cells.

Weimbs T, Low SH, Li X, Kreitzer G.

Methods. 2003 Jul;30(3):191-7. Review.

PMID:
12798133
43.

Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells.

Low SH, Li X, Miura M, Kudo N, Quiñones B, Weimbs T.

Dev Cell. 2003 May;4(5):753-9.

44.
45.

Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells.

Kreitzer G, Schmoranzer J, Low SH, Li X, Gan Y, Weimbs T, Simon SM, Rodriguez-Boulan E.

Nat Cell Biol. 2003 Feb;5(2):126-36.

PMID:
12545172
46.

Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype.

Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T.

J Cell Sci. 2002 Dec 1;115(Pt 23):4545-53.

47.

SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes.

Li X, Low SH, Miura M, Weimbs T.

Am J Physiol Renal Physiol. 2002 Nov;283(5):F1111-22.

48.
49.

Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins.

Lim SN, Bonzelius F, Low SH, Wille H, Weimbs T, Herman GA.

Mol Biol Cell. 2001 Apr;12(4):981-95.

50.

Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity.

Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T.

Mol Biol Cell. 2000 Sep;11(9):3045-60.

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