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Items: 47


Clinical association to FKBP5 rs1360780 in patients with depression.

Dam H, Buch JOD, Nielsen AB, Weikop P, Werge T, Jørgensen MB.

Psychiatr Genet. 2019 Jun 18. doi: 10.1097/YPG.0000000000000228. [Epub ahead of print]


Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs.

Christensen STJ, Staalsø JM, Jørgensen A, Weikop P, Olsen NV, Jørgensen MB.

Psychiatry Res. 2019 Jan;271:239-246. doi: 10.1016/j.psychres.2018.11.035. Epub 2018 Nov 23.


Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.

Xu H, Rajsombath MM, Weikop P, Selkoe DJ.

EMBO Mol Med. 2018 Sep;10(9). pii: e8931. doi: 10.15252/emmm.201808931.


Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons.

Runegaard AH, Sørensen AT, Fitzpatrick CM, Jørgensen SH, Petersen AV, Hansen NW, Weikop P, Andreasen JT, Mikkelsen JD, Perrier JF, Woldbye D, Rickhag M, Wortwein G, Gether U.

eNeuro. 2018 Jun 18;5(3). pii: ENEURO.0345-17.2018. doi: 10.1523/ENEURO.0345-17.2018. eCollection 2018 May-Jun.


PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis.

Jensen KL, Sørensen G, Dencker D, Owens WA, Rahbek-Clemmensen T, Brett Lever M, Runegaard AH, Riis Christensen N, Weikop P, Wörtwein G, Fink-Jensen A, Madsen KL, Daws L, Gether U, Rickhag M.

eNeuro. 2018 Jun 11;5(3). pii: ENEURO.0422-17.2018. doi: 10.1523/ENEURO.0422-17.2018. eCollection 2018 May-Jun.


Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats.

Dencker D, Molander A, Thomsen M, Schlumberger C, Wortwein G, Weikop P, Benveniste H, Volkow ND, Fink-Jensen A.

Alcohol Clin Exp Res. 2018 Feb;42(2):270-277. doi: 10.1111/acer.13560. Epub 2017 Dec 23.


Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake.

Jensen KL, Runegaard AH, Weikop P, Gether U, Rickhag M.

J Vis Exp. 2017 Sep 21;(127). doi: 10.3791/56093.


The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice.

Thomsen M, Dencker D, Wörtwein G, Weikop P, Egecioglu E, Jerlhag E, Fink-Jensen A, Molander A.

Pharmacol Biochem Behav. 2017 Sep;160:14-20. doi: 10.1016/j.pbb.2017.07.014. Epub 2017 Aug 1.


Cerebral serotonin release correlates with [11C]AZ10419369 PET measures of 5-HT1B receptor binding in the pig brain.

Jørgensen LM, Weikop P, Svarer C, Feng L, Keller SH, Knudsen GM.

J Cereb Blood Flow Metab. 2018 Jul;38(7):1243-1252. doi: 10.1177/0271678X17719390. Epub 2017 Jul 7.


Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine.

Dall C, Weikop P, Dencker D, Molander AC, Wörtwein G, Conn PJ, Fink-Jensen A, Thomsen M.

Drug Alcohol Depend. 2017 Jul 1;176:154-161. doi: 10.1016/j.drugalcdep.2017.03.014. Epub 2017 May 16.


The Circadian Oscillator of the Cerebral Cortex: Molecular, Biochemical and Behavioral Effects of Deleting the Arntl Clock Gene in Cortical Neurons.

Bering T, Carstensen MB, Wörtwein G, Weikop P, Rath MF.

Cereb Cortex. 2018 Feb 1;28(2):644-657. doi: 10.1093/cercor/bhw406.


Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice.

Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U, Rickhag M.

Eur J Neurosci. 2017 Jan;45(1):121-128. doi: 10.1111/ejn.13347. Epub 2016 Aug 22.


The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo.

Hansen HH, Weikop P, Mikkelsen MD, Rode F, Mikkelsen JD.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):46-51. doi: 10.1111/bcpt.12636. Epub 2016 Aug 23.


Decreased spontaneous activity in AMPK α2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism.

Møller LL, Sylow L, Gøtzsche CR, Serup AK, Christiansen SH, Weikop P, Kiens B, Woldbye DP, Richter EA.

Physiol Behav. 2016 Oct 1;164(Pt A):300-5. doi: 10.1016/j.physbeh.2016.06.010. Epub 2016 Jun 13.


Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels.

Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A.

Transl Psychiatry. 2016 May 17;6:e809. doi: 10.1038/tp.2016.86.


Effect of recombinant erythropoietin on inflammatory markers in patients with affective disorders: A randomised controlled study.

Vinberg M, Weikop P, Olsen NV, Kessing LV, Miskowiak K.

Brain Behav Immun. 2016 Oct;57:53-57. doi: 10.1016/j.bbi.2016.05.006. Epub 2016 May 12.


Cerebral 5-HT release correlates with [11C]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brain.

Jørgensen LM, Weikop P, Villadsen J, Visnapuu T, Ettrup A, Hansen HD, Baandrup AO, Andersen FL, Bjarkam CR, Thomsen C, Jespersen B, Knudsen GM.

J Cereb Blood Flow Metab. 2017 Feb;37(2):425-434. doi: 10.1177/0271678X16629483. Epub 2016 Jul 20.


Simulation-based multiprofessional obstetric anaesthesia training conducted in situ versus off-site leads to similar individual and team outcomes: a randomised educational trial.

Sørensen JL, van der Vleuten C, Rosthøj S, Østergaard D, LeBlanc V, Johansen M, Ekelund K, Starkopf L, Lindschou J, Gluud C, Weikop P, Ottesen B.

BMJ Open. 2015 Oct 6;5(10):e008344. doi: 10.1136/bmjopen-2015-008344. Erratum in: BMJ Open. 2017 Nov 8;7(11):e008344corr1.


Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse.

Sørensen EM, Bertelsen F, Weikop P, Skovborg MM, Banke T, Drasbek KR, Scheel-Krüger J.

Behav Pharmacol. 2015 Dec;26(8 Spec No):733-40. doi: 10.1097/FBP.0000000000000152.


The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice.

Sørensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A, Fink-Jensen A.

Physiol Behav. 2015 Oct 1;149:262-8. doi: 10.1016/j.physbeh.2015.06.013. Epub 2015 Jun 11.


Elevated levels of IL-6 and IL-18 in manic and hypomanic states in rapid cycling bipolar disorder patients.

Munkholm K, Weikop P, Kessing LV, Vinberg M.

Brain Behav Immun. 2015 Jan;43:205-13. doi: 10.1016/j.bbi.2014.09.021. Epub 2014 Oct 14.


Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice.

de la Cour C, Sørensen G, Wortwein G, Weikop P, Dencker D, Fink-Jensen A, Molander A.

Eur J Pharmacol. 2015 Jan 5;746:1-5. doi: 10.1016/j.ejphar.2014.10.050. Epub 2014 Nov 20.


Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.

Brindisi M, Butini S, Franceschini S, Brogi S, Trotta F, Ros S, Cagnotto A, Salmona M, Casagni A, Andreassi M, Saponara S, Gorelli B, Weikop P, Mikkelsen JD, Scheel-Kruger J, Sandager-Nielsen K, Novellino E, Campiani G, Gemma S.

J Med Chem. 2014 Nov 26;57(22):9578-97. doi: 10.1021/jm501119j. Epub 2014 Nov 7.


Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat.

Hansen HH, Jensen MM, Overgaard A, Weikop P, Mikkelsen JD.

Pharmacol Biochem Behav. 2013 Sep;110:265-71. doi: 10.1016/j.pbb.2013.07.018. Epub 2013 Aug 7.


'In situ simulation' versus 'off site simulation' in obstetric emergencies and their effect on knowledge, safety attitudes, team performance, stress, and motivation: study protocol for a randomized controlled trial.

Sørensen JL, Van der Vleuten C, Lindschou J, Gluud C, Østergaard D, LeBlanc V, Johansen M, Ekelund K, Albrechtsen CK, Pedersen BW, Kjærgaard H, Weikop P, Ottesen B.

Trials. 2013 Jul 17;14:220. doi: 10.1186/1745-6215-14-220.


TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1817-26. doi: 10.1073/pnas.1305623110. Epub 2013 Apr 22.


Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture.

Staalsø JM, Bergström A, Edsen T, Weikop P, Romner B, Olsen NV.

Stroke. 2013 May;44(5):1273-81. doi: 10.1161/STROKEAHA.111.000605. Epub 2013 Mar 5.


An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine.

Dencker D, Weikop P, Sørensen G, Woldbye DP, Wörtwein G, Wess J, Fink-Jensen A.

Psychopharmacology (Berl). 2012 Nov;224(2):277-87. doi: 10.1007/s00213-012-2751-8. Epub 2012 May 31.


Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease.

Dencker D, Thomsen M, Wörtwein G, Weikop P, Cui Y, Jeon J, Wess J, Fink-Jensen A.

ACS Chem Neurosci. 2012;3(2):80-89.


Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

Sørensen G, Jensen M, Weikop P, Dencker D, Christiansen SH, Loland CJ, Bengtsen CH, Petersen JH, Fink-Jensen A, Wörtwein G, Woldbye DP.

Psychopharmacology (Berl). 2012 Aug;222(4):565-77. doi: 10.1007/s00213-012-2651-y. Epub 2012 Feb 25.


Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.

Decressac M, Mattsson B, Lundblad M, Weikop P, Björklund A.

Neurobiol Dis. 2012 Mar;45(3):939-53. doi: 10.1016/j.nbd.2011.12.013. Epub 2011 Dec 11.


Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline.

Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DP, Wess J, Fink-Jensen A.

J Neurosci. 2011 Apr 20;31(16):5905-8. doi: 10.1523/JNEUROSCI.0370-11.2011.


Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DP, Wortwein G, Fink-Jensen A.

Psychopharmacology (Berl). 2011 Aug;216(3):367-78. doi: 10.1007/s00213-011-2225-4. Epub 2011 Mar 5.


An approach for serotonin depletion in pigs: effects on serotonin receptor binding.

Ettrup A, Kornum BR, Weikop P, Knudsen GM.

Synapse. 2011 Feb;65(2):136-45. doi: 10.1002/syn.20827.


SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors.

Jacobsen JP, Weikop P, Hansen HH, Mikkelsen JD, Redrobe JP, Holst D, Bond CT, Adelman JP, Christophersen P, Mirza NR.

Genes Brain Behav. 2008 Nov;7(8):836-48. doi: 10.1111/j.1601-183X.2008.00416.x. Epub 2008 Jul 28.


Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.

Jacobsen JP, Nielsen EØ, Hummel R, Redrobe JP, Mirza N, Weikop P.

Psychopharmacology (Berl). 2008 Aug;199(2):137-50. doi: 10.1007/s00213-008-1142-7. Epub 2008 May 22.


The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.

Hansen HH, Andreasen JT, Weikop P, Mirza N, Scheel-Krüger J, Mikkelsen JD.

Eur J Pharmacol. 2007 Sep 10;570(1-3):77-88. Epub 2007 Jun 5.


Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain.

Weikop P, Yoshitake T, Kehr J.

Eur Neuropsychopharmacol. 2007 Oct;17(10):658-71. Epub 2007 Mar 26.


The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat.

Hansen HH, Ebbesen C, Mathiesen C, Weikop P, Rønn LC, Waroux O, Scuvée-Moreau J, Seutin V, Mikkelsen JD.

J Pharmacol Exp Ther. 2006 Sep;318(3):1006-19. Epub 2006 Jun 14.


Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus.

Kornum BR, Weikop P, Moller A, Ronn LC, Knudsen GM, Aznar S.

Brain Res. 2006 Feb 16;1073-1074:262-8. Epub 2006 Jan 19.


Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes.

Kornum BR, Licht CL, Weikop P, Knudsen GM, Aznar S.

Neurosci Lett. 2006 Jan 9;392(1-2):129-34. Epub 2005 Oct 6.


Local anaesthetics attenuates spinal nociception and HPA-axis activation during experimental laparotomy in pigs.

Lykkegaard K, Lauritzen B, Tessem L, Weikop P, Svendsen O.

Res Vet Sci. 2005 Dec;79(3):245-51. Epub 2005 Feb 26.


Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.

Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Müller WE, Ogren SO, Kehr J.

Br J Pharmacol. 2004 Jun;142(3):414-8. Epub 2004 May 17.

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