Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 94

1.

Role of hydration water in the onset of protein structural dynamics.

Schirò G, Weik M.

J Phys Condens Matter. 2019 Nov 20;31(46):463002. doi: 10.1088/1361-648X/ab388a. Epub 2019 Aug 5.

PMID:
31382251
2.

X-ray radiation damage to biological samples: recent progress.

Garman EF, Weik M.

J Synchrotron Radiat. 2019 Jul 1;26(Pt 4):907-911. doi: 10.1107/S1600577519009408. Epub 2019 Jul 1.

PMID:
31274412
3.

MHz data collection of a microcrystalline mixture of different jack bean proteins.

Grünbein ML, Bielecki J, Gorel A, Stricker M, Bean R, Cammarata M, Dörner K, Fröhlich L, Hartmann E, Hauf S, Hilpert M, Kim Y, Kloos M, Letrun R, Messerschmidt M, Mills G, Nass Kovacs G, Ramilli M, Roome CM, Sato T, Scholz M, Sliwa M, Sztuk-Dambietz J, Weik M, Weinhausen B, Al-Qudami N, Boukhelef D, Brockhauser S, Ehsan W, Emons M, Esenov S, Fangohr H, Kaukher A, Kluyver T, Lederer M, Maia L, Manetti M, Michelat T, Münnich A, Pallas F, Palmer G, Previtali G, Raab N, Silenzi A, Szuba J, Venkatesan S, Wrona K, Zhu J, Doak RB, Shoeman RL, Foucar L, Colletier JP, Mancuso AP, Barends TRM, Stan CA, Schlichting I.

Sci Data. 2019 Apr 3;6(1):18. doi: 10.1038/s41597-019-0010-0.

4.

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Heyes DJ, Hardman SJO, Pedersen MN, Woodhouse J, De La Mora E, Wulff M, Weik M, Cammarata M, Scrutton NS, Schirò G.

Commun Biol. 2019 Jan 3;2:1. doi: 10.1038/s42003-018-0242-0. eCollection 2019.

5.

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.

Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman J, Weik M, Maurice T, Dallemagne P, Rochais C.

Eur J Med Chem. 2019 Jan 15;162:234-248. doi: 10.1016/j.ejmech.2018.10.064. Epub 2018 Nov 8.

PMID:
30447434
6.

Megahertz data collection from protein microcrystals at an X-ray free-electron laser.

Grünbein ML, Bielecki J, Gorel A, Stricker M, Bean R, Cammarata M, Dörner K, Fröhlich L, Hartmann E, Hauf S, Hilpert M, Kim Y, Kloos M, Letrun R, Messerschmidt M, Mills G, Nass Kovacs G, Ramilli M, Roome CM, Sato T, Scholz M, Sliwa M, Sztuk-Dambietz J, Weik M, Weinhausen B, Al-Qudami N, Boukhelef D, Brockhauser S, Ehsan W, Emons M, Esenov S, Fangohr H, Kaukher A, Kluyver T, Lederer M, Maia L, Manetti M, Michelat T, Münnich A, Pallas F, Palmer G, Previtali G, Raab N, Silenzi A, Szuba J, Venkatesan S, Wrona K, Zhu J, Doak RB, Shoeman RL, Foucar L, Colletier JP, Mancuso AP, Barends TRM, Stan CA, Schlichting I.

Nat Commun. 2018 Aug 28;9(1):3487. doi: 10.1038/s41467-018-05953-4.

7.

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.

Santoni G, de Sousa J, de la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F.

J Med Chem. 2018 Sep 13;61(17):7630-7639. doi: 10.1021/acs.jmedchem.8b00592. Epub 2018 Aug 31.

PMID:
30125110
8.

Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.

Zorbaz T, Braïki A, Maraković N, Renou J, de la Mora E, Maček Hrvat N, Katalinić M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Pérez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY.

Chemistry. 2018 Jul 5;24(38):9675-9691. doi: 10.1002/chem.201801394. Epub 2018 Jun 8.

PMID:
29672968
9.

Photochemical Mechanism of an Atypical Algal Phytochrome.

Choudry U, Heyes DJ, Hardman SJO, Sakuma M, Sazanovich IV, Woodhouse J, De La Mora E, Pedersen MN, Wulff M, Weik M, Schirò G, Scrutton NS.

Chembiochem. 2018 May 18;19(10):1036-1043. doi: 10.1002/cbic.201800016. Epub 2018 Apr 20.

PMID:
29544024
10.

Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities.

El-Khatib M, Nasrallah C, Lopes J, Tran QT, Tetreau G, Basbous H, Fenel D, Gallet B, Lethier M, Bolla JM, Pagès JM, Vivaudou M, Weik M, Winterhalter M, Colletier JP.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2220-E2228. doi: 10.1073/pnas.1714582115. Epub 2018 Feb 23.

11.

Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography.

Coquelle N, Sliwa M, Woodhouse J, Schirò G, Adam V, Aquila A, Barends TRM, Boutet S, Byrdin M, Carbajo S, De la Mora E, Doak RB, Feliks M, Fieschi F, Foucar L, Guillon V, Hilpert M, Hunter MS, Jakobs S, Koglin JE, Kovacsova G, Lane TJ, Lévy B, Liang M, Nass K, Ridard J, Robinson JS, Roome CM, Ruckebusch C, Seaberg M, Thepaut M, Cammarata M, Demachy I, Field M, Shoeman RL, Bourgeois D, Colletier JP, Schlichting I, Weik M.

Nat Chem. 2018 Jan;10(1):31-37. doi: 10.1038/nchem.2853. Epub 2017 Sep 11.

PMID:
29256511
12.

Radiation Damage in Macromolecular Crystallography.

Garman EF, Weik M.

Methods Mol Biol. 2017;1607:467-489. doi: 10.1007/978-1-4939-7000-1_20. Review.

PMID:
28573586
13.

X-ray radiation damage to biological macromolecules: further insights.

Garman EF, Weik M.

J Synchrotron Radiat. 2017 Jan 1;24(Pt 1):1-6. doi: 10.1107/S160057751602018X. Epub 2017 Jan 1.

PMID:
28009541
14.

The role of protein dynamics in the evolution of new enzyme function.

Campbell E, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ.

Nat Chem Biol. 2016 Nov;12(11):944-950. doi: 10.1038/nchembio.2175. Epub 2016 Sep 12.

PMID:
27618189
15.

Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane.

Zaccai G, Bagyan I, Combet J, Cuello GJ, Demé B, Fichou Y, Gallat FX, Galvan Josa VM, von Gronau S, Haertlein M, Martel A, Moulin M, Neumann M, Weik M, Oesterhelt D.

Sci Rep. 2016 Aug 16;6:31434. doi: 10.1038/srep31434.

16.

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.

Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ.

Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May 19.

17.

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability.

Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ.

J Mol Biol. 2016 Jun 5;428(11):2359-2371. doi: 10.1016/j.jmb.2016.03.014. Epub 2016 Mar 22.

PMID:
27016206
18.

Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP.

Colletier JP, Sliwa M, Gallat FX, Sugahara M, Guillon V, Schirò G, Coquelle N, Woodhouse J, Roux L, Gotthard G, Royant A, Uriarte LM, Ruckebusch C, Joti Y, Byrdin M, Mizohata E, Nango E, Tanaka T, Tono K, Yabashi M, Adam V, Cammarata M, Schlichting I, Bourgeois D, Weik M.

J Phys Chem Lett. 2016 Mar 3;7(5):882-7. doi: 10.1021/acs.jpclett.5b02789. Epub 2016 Feb 25.

PMID:
26866390
19.

Molecular Dynamics Simulations of a Powder Model of the Intrinsically Disordered Protein Tau.

Fichou Y, Heyden M, Zaccai G, Weik M, Tobias DJ.

J Phys Chem B. 2015 Oct 1;119(39):12580-9. doi: 10.1021/acs.jpcb.5b05849. Epub 2015 Sep 18.

PMID:
26351734
20.

Hydration water mobility is enhanced around tau amyloid fibers.

Fichou Y, Schirò G, Gallat FX, Laguri C, Moulin M, Combet J, Zamponi M, Härtlein M, Picart C, Mossou E, Lortat-Jacob H, Colletier JP, Tobias DJ, Weik M.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6365-70. doi: 10.1073/pnas.1422824112. Epub 2015 Apr 27.

21.

Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins.

Schirò G, Fichou Y, Gallat FX, Wood K, Gabel F, Moulin M, Härtlein M, Heyden M, Colletier JP, Orecchini A, Paciaroni A, Wuttke J, Tobias DJ, Weik M.

Nat Commun. 2015 Mar 16;6:6490. doi: 10.1038/ncomms7490.

22.

Radiation damage to macromolecules: kill or cure?

Garman EF, Weik M.

J Synchrotron Radiat. 2015 Mar;22(2):195-200. doi: 10.1107/S160057751500380X. Epub 2015 Feb 27. Review.

PMID:
25723921
23.

Low-dose X-ray radiation induces structural alterations in proteins.

Borshchevskiy V, Round E, Erofeev I, Weik M, Ishchenko A, Gushchin I, Mishin A, Willbold D, Büldt G, Gordeliy V.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2675-85. doi: 10.1107/S1399004714017295. Epub 2014 Sep 27.

PMID:
25286851
24.

Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.

Trapp M, Tehei M, Trovaslet M, Nachon F, Martinez N, Koza MM, Weik M, Masson P, Peters J.

J R Soc Interface. 2014 Aug 6;11(97):20140372. doi: 10.1098/rsif.2014.0372.

25.

300-Fold increase in production of the Zn2+-dependent dechlorinase TrzN in soluble form via apoenzyme stabilization.

Jackson CJ, Coppin CW, Carr PD, Aleksandrov A, Wilding M, Sugrue E, Ubels J, Paks M, Newman J, Peat TS, Russell RJ, Field M, Weik M, Oakeshott JG, Scott C.

Appl Environ Microbiol. 2014 Jul;80(13):4003-11. doi: 10.1128/AEM.00916-14. Epub 2014 Apr 25.

26.

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.

Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboléas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R.

Eur J Med Chem. 2014 May 6;78:455-67. doi: 10.1016/j.ejmech.2014.03.044. Epub 2014 Mar 15.

PMID:
24704618
27.

Reaction site-driven regioselective synthesis of AChE inhibitors.

Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY.

Org Biomol Chem. 2014 Jan 7;12(1):156-61. doi: 10.1039/c3ob42109k. Epub 2013 Nov 11.

PMID:
24216754
28.

Perspectives in biological physics: the nDDB project for a neutron Dynamics Data Bank for biological macromolecules.

Rusevich L, García Sakai V, Franzetti B, Johnson M, Natali F, Pellegrini E, Peters J, Pieper J, Weik M, Zaccai G.

Eur Phys J E Soft Matter. 2013 Jul;36(7):80. doi: 10.1140/epje/i2013-13080-5. Epub 2013 Jul 17.

PMID:
23884625
29.

Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance.

Jackson CJ, Liu JW, Carr PD, Younus F, Coppin C, Meirelles T, Lethier M, Pandey G, Ollis DL, Russell RJ, Weik M, Oakeshott JG.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10177-82. doi: 10.1073/pnas.1304097110. Epub 2013 Jun 3.

30.

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry.

Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M.

Chem Res Toxicol. 2013 Feb 18;26(2):280-9. doi: 10.1021/tx3004505. Epub 2013 Feb 5.

PMID:
23339663
31.

Radiation damage to biological macromolecules: some answers and more questions.

Garman EF, Weik M.

J Synchrotron Radiat. 2013 Jan;20(Pt 1):1-6. doi: 10.1107/S0909049512050418. Epub 2012 Dec 19.

PMID:
23254650
32.

Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart.

Trapp M, Trovaslet M, Nachon F, Koza MM, van Eijck L, Hill F, Weik M, Masson P, Tehei M, Peters J.

J Phys Chem B. 2012 Dec 27;116(51):14744-53. doi: 10.1021/jp304704h. Epub 2012 Dec 13.

PMID:
23186408
33.

Protein surface and core dynamics show concerted hydration-dependent activation.

Wood K, Gallat FX, Otten R, van Heel AJ, Lethier M, van Eijck L, Moulin M, Haertlein M, Weik M, Mulder FA.

Angew Chem Int Ed Engl. 2013 Jan 7;52(2):665-8. doi: 10.1002/anie.201205898. Epub 2012 Nov 14.

PMID:
23154872
34.

Relation between dynamics, activity and thermal stability within the cholinesterase family.

Trovaslet M, Trapp M, Weik M, Nachon F, Masson P, Tehei M, Peters J.

Chem Biol Interact. 2013 Mar 25;203(1):14-8. doi: 10.1016/j.cbi.2012.08.004. Epub 2012 Aug 25.

PMID:
22940283
35.

A polymer surfactant corona dynamically replaces water in solvent-free protein liquids and ensures macromolecular flexibility and activity.

Gallat FX, Brogan AP, Fichou Y, McGrath N, Moulin M, Härtlein M, Combet J, Wuttke J, Mann S, Zaccai G, Jackson CJ, Perriman AW, Weik M.

J Am Chem Soc. 2012 Aug 15;134(32):13168-71. doi: 10.1021/ja303894g. Epub 2012 Aug 2.

PMID:
22853639
36.

Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins.

Gallat FX, Laganowsky A, Wood K, Gabel F, van Eijck L, Wuttke J, Moulin M, Härtlein M, Eisenberg D, Colletier JP, Zaccai G, Weik M.

Biophys J. 2012 Jul 3;103(1):129-36. doi: 10.1016/j.bpj.2012.05.027.

37.

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.

Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY.

ChemMedChem. 2012 Mar 5;7(3):400-5. doi: 10.1002/cmdc.201100438. Epub 2011 Nov 4. No abstract available.

PMID:
22052791
38.

Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization.

Orru R, Dudek HM, Martinoli C, Torres Pazmiño DE, Royant A, Weik M, Fraaije MW, Mattevi A.

J Biol Chem. 2011 Aug 19;286(33):29284-91. doi: 10.1074/jbc.M111.255075. Epub 2011 Jun 22.

39.

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.

Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M.

Protein Sci. 2011 Jul;20(7):1114-8. doi: 10.1002/pro.661. Epub 2011 Jun 10.

40.

Similarities and differences in radiation damage at 100 K versus 160 K in a crystal of thermolysin.

Juers DH, Weik M.

J Synchrotron Radiat. 2011 May;18(Pt 3):329-37. doi: 10.1107/S0909049511007631. Epub 2011 Apr 9.

PMID:
21525640
41.

Macromolecular crystallography radiation damage research: what's new?

Garman EF, Weik M.

J Synchrotron Radiat. 2011 May;18(Pt 3):313-7. doi: 10.1107/S0909049511013859. Epub 2011 Apr 27.

42.

Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis.

Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P.

Chem Res Toxicol. 2011 Jun 20;24(6):797-808. doi: 10.1021/tx100447k. Epub 2011 Apr 18.

43.

Infrared protein crystallography.

Sage JT, Zhang Y, McGeehan J, Ravelli RB, Weik M, van Thor JJ.

Biochim Biophys Acta. 2011 Jun;1814(6):760-77. doi: 10.1016/j.bbapap.2011.02.012. Epub 2011 Mar 2. Review.

PMID:
21376143
44.

Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase.

Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL.

Biophys J. 2010 Dec 15;99(12):4003-11. doi: 10.1016/j.bpj.2010.10.047.

45.

European collaborative evaluation of the Enzygnost HBsAg 6.0 assay: performance on hepatitis B virus surface antigen variants.

Avellón A, Echevarría JM, Weber B, Weik M, Schobel U, Willems WR, Gerlich WH.

J Med Virol. 2011 Jan;83(1):95-100. doi: 10.1002/jmv.21943.

PMID:
21108344
46.

Raman-assisted crystallography suggests a mechanism of X-ray-induced disulfide radical formation and reparation.

Carpentier P, Royant A, Weik M, Bourgeois D.

Structure. 2010 Nov 10;18(11):1410-9. doi: 10.1016/j.str.2010.09.010.

47.

Temperature-dependent macromolecular X-ray crystallography.

Weik M, Colletier JP.

Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):437-46. doi: 10.1107/S0907444910002702. Epub 2010 Mar 24.

48.

The low-temperature inflection observed in neutron scattering measurements of proteins is due to methyl rotation: direct evidence using isotope labeling and molecular dynamics simulations.

Wood K, Tobias DJ, Kessler B, Gabel F, Oesterhelt D, Mulder FA, Zaccai G, Weik M.

J Am Chem Soc. 2010 Apr 14;132(14):4990-1. doi: 10.1021/ja910502g.

PMID:
20302295
49.

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime.

Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M.

J Med Chem. 2009 Dec 10;52(23):7593-603. doi: 10.1021/jm900433t.

PMID:
19642642
50.

Simultaneous measurements of solvent dynamics and functional kinetics in a light-activated enzyme.

Durin G, Delaunay A, Darnault C, Heyes DJ, Royant A, Vernede X, Hunter CN, Weik M, Bourgeois D.

Biophys J. 2009 Mar 4;96(5):1902-10. doi: 10.1016/j.bpj.2008.10.065.

Supplemental Content

Support Center