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Items: 1 to 50 of 90

1.

Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice.

van der Velden YU, Villaudy J, Siteur-van Rijnstra E, van der Linden CA, Frankin E, Weijer K, Schermer E, Vink MA, Berkhout B, Sanders RW, van Gils MJ.

AIDS Res Hum Retroviruses. 2018 Sep;34(9):790-793. doi: 10.1089/AID.2018.0114. Epub 2018 Aug 22.

PMID:
30003812
2.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

García-Peydró M, Fuentes P, Mosquera M, García-León MJ, Alcain J, Rodríguez A, García de Miguel P, Menéndez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Muñoz-Calleja C, Sánchez-Madrid F, Toribio ML.

J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21.

3.

Different Balance of Wnt Signaling in Adult and Fetal Bone Marrow-Derived Mesenchymal Stromal Cells.

Paciejewska MM, Maijenburg MW, Gilissen C, Kleijer M, Vermeul K, Weijer K, Veltman JA, von Lindern M, van der Schoot CE, Voermans C.

Stem Cells Dev. 2016 Jun 15;25(12):934-47. doi: 10.1089/scd.2015.0263.

PMID:
27154244
4.

A novel mouse model for stable engraftment of a human immune system and human hepatocytes.

Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff E, Ahodantin J, Weijer K, Spits H, Kremsdorf D, Di Santo JP.

PLoS One. 2015 Mar 17;10(3):e0119820. doi: 10.1371/journal.pone.0119820. eCollection 2015.

5.

Acoustic devices for particle and cell manipulation and sensing.

Qiu Y, Wang H, Demore CE, Hughes DA, Glynne-Jones P, Gebhardt S, Bolhovitins A, Poltarjonoks R, Weijer K, Schönecker A, Hill M, Cochran S.

Sensors (Basel). 2014 Aug 13;14(8):14806-38. doi: 10.3390/s140814806.

6.

Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.

Centlivre M, Legrand N, Klamer S, Liu YP, Jasmijn von Eije K, Bohne M, Rijnstra ES, Weijer K, Blom B, Voermans C, Spits H, Berkhout B.

Mol Ther Nucleic Acids. 2013 Sep 3;2:e120. doi: 10.1038/mtna.2013.48.

7.

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.

Bernink JH, Peters CP, Munneke M, te Velde AA, Meijer SL, Weijer K, Hreggvidsdottir HS, Heinsbroek SE, Legrand N, Buskens CJ, Bemelman WA, Mjösberg JM, Spits H.

Nat Immunol. 2013 Mar;14(3):221-9. doi: 10.1038/ni.2534. Epub 2013 Jan 20.

PMID:
23334791
8.

A novel mouse model for Sézary syndrome using xenotransplantation of Sézary cells into immunodeficient RAG2(-/-) γc(-/-) mice.

van der Fits L, Rebel HG, Out-Luiting JJ, Pouw SM, Smit F, Vermeer KG, van Zijl L, Tensen CP, Weijer K, Vermeer MH.

Exp Dermatol. 2012 Sep;21(9):706-9. doi: 10.1111/j.1600-0625.2012.01556.x.

PMID:
22897578
9.

A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Legrand N, van der Velden GJ, Ho Tsong Fang R, Douaisi M, Weijer K, Das AT, Blom B, Uittenbogaart CH, Berkhout B, Centlivre M.

J Gen Virol. 2012 Sep;93(Pt 9):2017-27. doi: 10.1099/vir.0.042796-0. Epub 2012 May 30.

10.

Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.

Legrand N, Huntington ND, Nagasawa M, Bakker AQ, Schotte R, Strick-Marchand H, de Geus SJ, Pouw SM, Böhne M, Voordouw A, Weijer K, Di Santo JP, Spits H.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13224-9. doi: 10.1073/pnas.1101398108. Epub 2011 Jul 25.

11.

Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Plet A, Weijer K, Jacques Y, Spits H, Di Santo JP.

Eur J Immunol. 2011 Oct;41(10):2883-93. doi: 10.1002/eji.201141586. Epub 2011 Aug 30.

12.

Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations.

Kuijpers TW, Ijspeert H, van Leeuwen EM, Jansen MH, Hazenberg MD, Weijer KC, van Lier RA, van der Burg M.

Blood. 2011 Jun 2;117(22):5892-6. doi: 10.1182/blood-2011-01-329052. Epub 2011 Apr 18.

PMID:
21502542
13.

Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration.

Maijenburg MW, Gilissen C, Melief SM, Kleijer M, Weijer K, Ten Brinke A, Roelofs H, Van Tiel CM, Veltman JA, de Vries CJ, van der Schoot CE, Voermans C.

Stem Cells Dev. 2012 Jan 20;21(2):228-38. doi: 10.1089/scd.2011.0076. Epub 2011 Jun 1.

14.

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.

Reijmers RM, Groen RW, Kuil A, Weijer K, Kimberley FC, Medema JP, van Kuppevelt TH, Li JP, Spaargaren M, Pals ST.

Blood. 2011 Jun 9;117(23):6162-71. doi: 10.1182/blood-2010-12-325522. Epub 2011 Apr 6.

PMID:
21471524
15.

IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.

Huntington ND, Alves NL, Legrand N, Lim A, Strick-Marchand H, Mention JJ, Plet A, Weijer K, Jacques Y, Becker PD, Guzman C, Soussan P, Kremsdorf D, Spits H, Di Santo JP.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6217-22. doi: 10.1073/pnas.1019167108. Epub 2011 Mar 28.

16.

Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.

Becker PD, Legrand N, van Geelen CM, Noerder M, Huntington ND, Lim A, Yasuda E, Diehl SA, Scheeren FA, Ott M, Weijer K, Wedemeyer H, Di Santo JP, Beaumont T, Guzman CA, Spits H.

PLoS One. 2010 Oct 4;5(10). pii: e13137. doi: 10.1371/journal.pone.0013137.

17.

Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation.

Scheeren FA, van Lent AU, Nagasawa M, Weijer K, Spits H, Legrand N, Blom B.

Eur J Immunol. 2010 Apr;40(4):955-65. doi: 10.1002/eji.200939419.

18.

In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice.

van Lent AU, Centlivre M, Nagasawa M, Karrich JJ, Pouw SM, Weijer K, Spits H, Blom B, Legrand N.

Methods Mol Biol. 2010;595:87-115. doi: 10.1007/978-1-60761-421-0_6.

PMID:
19941107
19.

IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.

van Lent AU, Dontje W, Nagasawa M, Siamari R, Bakker AQ, Pouw SM, Maijoor KA, Weijer K, Cornelissen JJ, Blom B, Di Santo JP, Spits H, Legrand N.

J Immunol. 2009 Dec 15;183(12):7645-55. doi: 10.4049/jimmunol.0902019.

20.

Cell cycle and tissue of origin contribute to the migratory behaviour of human fetal and adult mesenchymal stromal cells.

Maijenburg MW, Noort WA, Kleijer M, Kompier CJ, Weijer K, van Buul JD, van der Schoot CE, Voermans C.

Br J Haematol. 2010 Feb;148(3):428-40. doi: 10.1111/j.1365-2141.2009.07960.x. Epub 2009 Oct 22.

PMID:
19863541
21.

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

Centlivre M, Zhou X, Pouw SM, Weijer K, Kleibeuker W, Das AT, Blom B, Seppen J, Berkhout B, Legrand N.

Gene Ther. 2010 Jan;17(1):14-25. doi: 10.1038/gt.2009.109. Epub 2009 Sep 3.

PMID:
19727135
22.

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Nörder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M.

Am J Pathol. 2009 Oct;175(4):1483-92. doi: 10.2353/ajpath.2009.090117. Epub 2009 Aug 28.

23.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P.

Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006. Review.

24.

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.

Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP.

J Exp Med. 2009 Jan 16;206(1):25-34. doi: 10.1084/jem.20082013. Epub 2008 Dec 22.

25.

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.

Cupedo T, Crellin NK, Papazian N, Rombouts EJ, Weijer K, Grogan JL, Fibbe WE, Cornelissen JJ, Spits H.

Nat Immunol. 2009 Jan;10(1):66-74. doi: 10.1038/ni.1668. Epub 2008 Nov 23.

PMID:
19029905
26.

T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells.

Scheeren FA, Nagasawa M, Weijer K, Cupedo T, Kirberg J, Legrand N, Spits H.

J Exp Med. 2008 Sep 1;205(9):2033-42. doi: 10.1084/jem.20070447. Epub 2008 Aug 11.

27.

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model.

ter Brake O, Legrand N, von Eije KJ, Centlivre M, Spits H, Weijer K, Blom B, Berkhout B.

Gene Ther. 2009 Jan;16(1):148-53. doi: 10.1038/gt.2008.124. Epub 2008 Jul 31.

PMID:
18668146
28.

Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice.

Legrand N, Weijer K, Spits H.

Methods Mol Biol. 2008;415:65-82. doi: 10.1007/978-1-59745-570-1_4.

PMID:
18370148
29.

Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection.

An DS, Poon B, Ho Tsong Fang R, Weijer K, Blom B, Spits H, Chen IS, Uittenbogaart CH.

Clin Vaccine Immunol. 2007 Apr;14(4):391-6. Epub 2007 Feb 21.

30.

In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions.

Deurholt T, ten Bloemendaal L, Chhatta AA, van Wijk AC, Weijer K, Seppen J, Elferink RP, Chamuleau RA, Hoekstra R.

Cell Transplant. 2006;15(8-9):811-22.

PMID:
17269451
31.

Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells.

Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E.

J Immunother. 2007 Jan;30(1):116-22.

PMID:
17198090
32.

Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice.

Legrand N, Cupedo T, van Lent AU, Ebeli MJ, Weijer K, Hanke T, Spits H.

Blood. 2006 Jul 1;108(1):238-45. Epub 2006 Mar 2.

PMID:
16514056
33.

Experimental models to study development and function of the human immune system in vivo.

Legrand N, Weijer K, Spits H.

J Immunol. 2006 Feb 15;176(4):2053-8. Review.

34.

Novel treatment strategies in clear-cell metastatic renal cell carcinoma.

van Spronsen DJ, de Weijer KJ, Mulders PF, De Mulder PH.

Anticancer Drugs. 2005 Aug;16(7):709-17. Review.

PMID:
16027518
35.

Development and activation of regulatory T cells in the human fetus.

Cupedo T, Nagasawa M, Weijer K, Blom B, Spits H.

Eur J Immunol. 2005 Feb;35(2):383-90.

36.

The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.

Schotte R, Nagasawa M, Weijer K, Spits H, Blom B.

J Exp Med. 2004 Dec 6;200(11):1503-9.

37.

Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.

Gimeno R, Weijer K, Voordouw A, Uittenbogaart CH, Legrand N, Alves NL, Wijnands E, Blom B, Spits H.

Blood. 2004 Dec 15;104(13):3886-93. Epub 2004 Aug 19.

PMID:
15319293
38.

Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.

Verra NC, Jorritsma A, Weijer K, Ruizendaal JJ, Voordouw A, Weder P, Hooijberg E, Schumacher TN, Haanen JB, Spits H, Luiten RM.

Cancer Res. 2004 Mar 15;64(6):2153-61.

39.

A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.

van Rijn RS, Simonetti ER, Hagenbeek A, Hogenes MC, de Weger RA, Canninga-van Dijk MR, Weijer K, Spits H, Storm G, van Bloois L, Rijkers G, Martens AC, Ebeling SB.

Blood. 2003 Oct 1;102(7):2522-31. Epub 2003 Jun 5.

PMID:
12791667
40.

The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development.

Schotte R, Rissoan MC, Bendriss-Vermare N, Bridon JM, Duhen T, Weijer K, Brière F, Spits H.

Blood. 2003 Feb 1;101(3):1015-23. Epub 2002 Sep 19.

PMID:
12393575
41.

Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo.

Weijer K, Uittenbogaart CH, Voordouw A, Couwenberg F, Seppen J, Blom B, Vyth-Dreese FA, Spits H.

Blood. 2002 Apr 15;99(8):2752-9.

PMID:
11929763
42.
43.

Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.

Cangul IT, van Garderen E, van der Poel HJ, Weijer K, Misdorp W.

APMIS. 1999 Nov;107(11):982-8.

PMID:
10598869
44.

Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3.

Jaleco AC, Stegmann AP, Heemskerk MH, Couwenberg F, Bakker AQ, Weijer K, Spits H.

Blood. 1999 Oct 15;94(8):2637-46.

PMID:
10515867
45.

HGF/SF and its receptor c-MET play a minor role in the dissemination of human B-lymphoma cells in SCID mice.

Weimar IS, Weijer K, van den Berk PC, Muller EJ, Miranda N, Bakker AQ, Heemskerk MH, Hekman A, de Gast GC, Gerritsen WR.

Br J Cancer. 1999 Sep;81(1):43-53.

46.

Early stages in the development of human T, natural killer and thymic dendritic cells.

Spits H, Blom B, Jaleco AC, Weijer K, Verschuren MC, van Dongen JJ, Heemskerk MH, Res PC.

Immunol Rev. 1998 Oct;165:75-86. Review.

PMID:
9850853
47.

Characterization of CD34+ thymic stromal cells located in the subcapsular cortex of the human thymus.

Martínez-Cáceres E, Jaleco AC, Res P, Noteboom E, Weijer K, Spits H.

Exp Hematol. 1998 Jul;26(7):588-96.

PMID:
9657133
48.

Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.

Heemskerk MH, Blom B, Nolan G, Stegmann AP, Bakker AQ, Weijer K, Res PC, Spits H.

J Exp Med. 1997 Nov 3;186(9):1597-602.

49.

Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells.

Jaleco AC, Blom B, Res P, Weijer K, Lanier LL, Phillips JH, Spits H.

J Immunol. 1997 Jul 15;159(2):694-702.

PMID:
9218584
50.

Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage.

Blom B, Res P, Noteboom E, Weijer K, Spits H.

J Immunol. 1997 Apr 15;158(8):3571-7.

PMID:
9103417

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