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Oscillatory cAMP cell-cell signalling persists during multicellular Dictyostelium development.

Singer G, Araki T, Weijer CJ.

Commun Biol. 2019 Apr 23;2(1):139. doi: 10.1038/s42003-019-0371-0.


It Does Not Matter Whether Research Interventions Are Usual Care.

Goldstein CE, Weijer C.

Am J Bioeth. 2020 Jan;20(1):47-48. doi: 10.1080/15265161.2019.1687779. No abstract available.


Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018.

Lee EJ, Patel A, Acedillo RR, Bachynski JC, Barrett I, Basile E, Battistella M, Benjamin D, Berry D, Blake PG, Chan P, Bohm CJ, Clemens KK, Cook C, Dember L, Dirk JS, Dixon S, Fowler E, Getchell L, Gholami N, Goldstein C, Hahn E, Hogeterp B, Huang S, Hughes M, Jardine MJ, Kalatharan S, Kilburn S, Lacson E Jr, Leonard S, Liberty C, Lindsay C, MacRae JM, Manns BJ, McCallum J, McIntyre CW, Molnar AO, Mustafa RA, Nesrallah GE, Oliver MJ, Pandes M, Pandeya S, Parmar MS, Rabin EZ, Riley J, Silver SA, Sontrop JM, Sood MM, Suri RS, Tangri N, Tascona DJ, Thomas A, Wald R, Walsh M, Weijer C, Weir MA, Vorster H, Zimmerman D, Garg AX.

Can J Kidney Health Dis. 2019 Dec 26;6:2054358119894394. doi: 10.1177/2054358119894394. eCollection 2019.


The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders.

Nicholls SG, Carroll K, Zwarenstein M, Brehaut JC, Weijer C, Hey SP, Goldstein CE, Graham ID, Grimshaw JM, McKenzie JE, Fergusson DA, Taljaard M; Ethics of Pragmatic Trials project.

Trials. 2019 Dec 23;20(1):765. doi: 10.1186/s13063-019-3899-x.


Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings.

Joag K, Ambrosio G, Kestler E, Weijer C, Hemming K, Van der Graaf R.

Trials. 2019 Dec 19;20(Suppl 2):703. doi: 10.1186/s13063-019-3842-1.


Towards the assessment of quality of life in patients with disorders of consciousness.

Tung J, Speechley KN, Gofton T, Gonzalez-Lara LE, Graham M, Naci L, Peterson AH, Owen AM, Weijer C.

Qual Life Res. 2019 Dec 14. doi: 10.1007/s11136-019-02390-8. [Epub ahead of print]


Stepped-wedge trials should be classified as research for the purpose of ethical review.

Hemming K, Taljaard M, Marshall T, Goldstein CE, Weijer C.

Clin Trials. 2019 Dec;16(6):580-588. doi: 10.1177/1740774519873322.


Ottawa Statement does not impede randomised evaluation of government health programmes.

Weijer C, Taljaard M.

J Med Ethics. 2020 Jan;46(1):31-33. doi: 10.1136/medethics-2019-105938. Epub 2019 Nov 26.


The ethics of psychedelic research in disorders of consciousness.

Peterson A, Tagliazucchi E, Weijer C.

Neurosci Conscious. 2019 Oct 9;2019(1):niz013. doi: 10.1093/nc/niz013. eCollection 2019.


A Stepwise Approach to Ethically Assess Pragmatic Cluster Randomized Trials: Implications for Informed Consent for Suicide Prevention Implementation Research.

Goldstein CE, Weijer C.

Am J Bioeth. 2019 Oct;19(10):101-103. doi: 10.1080/15265161.2019.1654013. No abstract available.


The ethics of cluster randomized trials: response to a proposal for revision of the Ottawa Statement.

Weijer C, Taljaard M.

J Clin Epidemiol. 2019 Dec;116:140-145. doi: 10.1016/j.jclinepi.2019.08.006. Epub 2019 Aug 23.


Working for the Weekend Is Not Meaningful Work.

Graham M, Weijer C.

Am J Bioeth. 2019 Sep;19(9):48-50. doi: 10.1080/15265161.2019.1630515. No abstract available.


Ethical Issues in Pragmatic Cluster-Randomized Trials in Dialysis Facilities.

Goldstein CE, Weijer C, Taljaard M, Al-Jaishi AA, Basile E, Brehaut J, Cook CL, Grimshaw JM, Lacson E Jr, Lindsay C, Jardine M, Dember LM, Garg AX.

Am J Kidney Dis. 2019 Nov;74(5):659-666. doi: 10.1053/j.ajkd.2019.04.019. Epub 2019 Jun 19.


Ethical issues raised by cluster randomised trials conducted in low-resource settings: identifying gaps in the Ottawa Statement through an analysis of the PURE Malawi trial.

Mtande TK, Weijer C, Hosseinipour MC, Taljaard M, Matoga M, Goldstein CE, Nyambalo B, Rosenberg NE.

J Med Ethics. 2019 Jun;45(6):388-393. doi: 10.1136/medethics-2019-105374. Epub 2019 Jun 12.


Oscillatory cAMP cell-cell signalling persists during multicellular Dictyostelium development.

Singer G, Araki T, Weijer CJ.

Commun Biol. 2019 Apr 23;2:139. doi: 10.1038/s42003-019-0371-0. eCollection 2019.


Informed consent for functional MRI research on comatose patients following severe brain injury: balancing the social benefits of research against patient autonomy.

Bruni T, Graham M, Norton L, Gofton T, Owen AM, Weijer C.

J Med Ethics. 2019 May;45(5):299-303. doi: 10.1136/medethics-2018-104867. Epub 2019 Feb 25.


Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.


Reporting of stepped wedge cluster randomised trials: extension of the CONSORT 2010 statement with explanation and elaboration.

Hemming K, Taljaard M, McKenzie JE, Hooper R, Copas A, Thompson JA, Dixon-Woods M, Aldcroft A, Doussau A, Grayling M, Kristunas C, Goldstein CE, Campbell MK, Girling A, Eldridge S, Campbell MJ, Lilford RJ, Weijer C, Forbes AB, Grimshaw JM.

BMJ. 2018 Nov 9;363:k1614. doi: 10.1136/bmj.k1614. No abstract available.


In reply: When and how should we cluster and cross over: methodological and ethical issues (letters 1 and 2).

Goldstein CE, Giraudeau B, Weijer C, Taljaard M.

Can J Anaesth. 2019 Feb;66(2):239-240. doi: 10.1007/s12630-018-1239-3. Epub 2018 Oct 19. No abstract available.


Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.


FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.


Accommodating quality and service improvement research within existing ethical principles.

Goldstein CE, Weijer C, Brehaut JC, Campbell M, Fergusson DA, Grimshaw JM, Hemming K, Horn AR, Taljaard M.

Trials. 2018 Jun 25;19(1):334. doi: 10.1186/s13063-018-2724-2.


Using neuroimaging to uncover awareness in brain-injured and anesthetized patients.

Graham M, Owen AM, Weijer C, Naci L.

Front Biosci (Schol Ed). 2018 Jun 1;10:337-349.


When and how should we cluster and cross over: methodological and ethical issues.

Goldstein CE, Giraudeau B, Weijer C, Taljaard M.

Can J Anaesth. 2018 Jul;65(7):760-765. doi: 10.1007/s12630-018-1131-1. Epub 2018 May 4. No abstract available.


Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers.

Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M.

J Med Ethics. 2018 Sep;44(9):593-598. doi: 10.1136/medethics-2017-104282. Epub 2018 Apr 27.


An Ethical Analysis of the SUPPORT Trial: Addressing Challenges Posed by a Pragmatic Comparative Effectiveness Randomized Controlled Trial.

Horn AR, Weijer C, Grimshaw J, Brehaut J, Fergusson D, Goldstein CE, Taljaard M.

Kennedy Inst Ethics J. 2018;28(1):85-118. doi: 10.1353/ken.2018.0003.


Ethical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation.

Goldstein CE, Weijer C, Brehaut JC, Fergusson DA, Grimshaw JM, Horn AR, Taljaard M.

BMC Med Ethics. 2018 Feb 27;19(1):14. doi: 10.1186/s12910-018-0253-x. Review.


Ethical implications of excessive cluster sizes in cluster randomised trials.

Hemming K, Taljaard M, Forbes G, Eldridge SM, Weijer C.

BMJ Qual Saf. 2018 Aug;27(8):664-670. doi: 10.1136/bmjqs-2017-007164. Epub 2018 Feb 20.


Research ethics for emerging trial designs: does equipoise need to adapt?

Hey SP, Weijer C, Taljaard M, Kesselheim AS.

BMJ. 2018 Jan 25;360:k226. doi: 10.1136/bmj.k226. No abstract available.


Is the concept of clinical equipoise still relevant to research?

Hey SP, London AJ, Weijer C, Rid A, Miller F.

BMJ. 2017 Dec 28;359:j5787. doi: 10.1136/bmj.j5787. No abstract available. Erratum in: BMJ. 2018 Mar 5;360:k1065.


TwiC or treat? Are trials within cohorts ethically defensible?

Weijer C, Goldstein CE, Taljaard M.

Clin Trials. 2018 Feb;15(1):21-24. doi: 10.1177/1740774517746622. Epub 2017 Dec 17. No abstract available.


Does Consent Form Follow Function?

Goldstein CE, Brehaut J, Weijer C.

Am J Bioeth. 2017 Dec;17(12):29-31. doi: 10.1080/15265161.2017.1388876. No abstract available.


When is a randomised controlled trial health equity relevant? Development and validation of a conceptual framework.

Jull J, Whitehead M, Petticrew M, Kristjansson E, Gough D, Petkovic J, Volmink J, Weijer C, Taljaard M, Edwards S, Mbuagbaw L, Cookson R, McGowan J, Lyddiatt A, Boyer Y, Cuervo LG, Armstrong R, White H, Yoganathan M, Pantoja T, Shea B, Pottie K, Norheim O, Baird S, Robberstad B, Sommerfelt H, Asada Y, Wells G, Tugwell P, Welch V.

BMJ Open. 2017 Sep 25;7(9):e015815. doi: 10.1136/bmjopen-2016-015815.


Minimizing the Harm of Accidental Awareness Under General Anesthesia: New Perspectives From Patients Misdiagnosed as Being in a Vegetative State.

Graham M, Owen AM, Çipi K, Weijer C, Naci L.

Anesth Analg. 2018 Mar;126(3):1073-1076. doi: 10.1213/ANE.0000000000002495. Review. No abstract available.


How to design efficient cluster randomised trials.

Hemming K, Eldridge S, Forbes G, Weijer C, Taljaard M.

BMJ. 2017 Jul 14;358:j3064. doi: 10.1136/bmj.j3064. No abstract available.


Active Vertex Model for cell-resolution description of epithelial tissue mechanics.

Barton DL, Henkes S, Weijer CJ, Sknepnek R.

PLoS Comput Biol. 2017 Jun 30;13(6):e1005569. doi: 10.1371/journal.pcbi.1005569. eCollection 2017 Jun.


Do doctors have a duty to take part in pragmatic randomised trials?

Campbell MK, Weijer C, Goldstein CE, Edwards SJL.

BMJ. 2017 Jun 14;357:j2817. doi: 10.1136/bmj.j2817. No abstract available.


Inadequacy of ethical conduct and reporting of stepped wedge cluster randomized trials: Results from a systematic review.

Taljaard M, Hemming K, Shah L, Giraudeau B, Grimshaw JM, Weijer C.

Clin Trials. 2017 Aug;14(4):333-341. doi: 10.1177/1740774517703057. Epub 2017 Apr 8. Review.


Covert narrative capacity: Mental life in patients thought to lack consciousness.

Naci L, Graham M, Owen AM, Weijer C.

Ann Clin Transl Neurol. 2016 Dec 14;4(1):61-70. doi: 10.1002/acn3.376. eCollection 2017 Jan.


Assessing Decision-Making Capacity in Patients with Communication Impairments.

Cairncross M, Peterson A, Lazosky A, Gofton T, Weijer C.

Camb Q Healthc Ethics. 2016 Oct;25(4):691-9. doi: 10.1017/S0963180116000414.


Illuminating Awareness: Implications of fMRI Research in Disorders of Consciousness.

Mikulis D, Weijer C, Young GB.

Can J Neurol Sci. 2015 Jul;42(4):211-2. No abstract available.


The multicellularity genes of dictyostelid social amoebas.

Glöckner G, Lawal HM, Felder M, Singh R, Singer G, Weijer CJ, Schaap P.

Nat Commun. 2016 Jun 30;7:12085. doi: 10.1038/ncomms12085.


What questions can a placebo answer?

Hey SP, Weijer C.

Monash Bioeth Rev. 2016 Mar;34(1):23-36. doi: 10.1007/s40592-016-0057-z. Review.


Ethical Criteria for Human Challenge Studies in Infectious Diseases.

Bambery B, Selgelid M, Weijer C, Savulescu J, Pollard AJ.

Public Health Ethics. 2016 Apr;9(1):92-103. doi: 10.1093/phe/phv026. Epub 2015 Sep 27.


Cluster-randomized trials: A closer look.

McRae AD, Taljaard M, Weijer C.

Clin Trials. 2016 Jun;13(3):294-300. doi: 10.1177/1740774516629405. Epub 2016 Mar 1.


The ethics of future trials: qualitative analysis of physicians' decision making.

Webster F, Weijer C, Todd L, Grimshaw JM, Marshall AP, Cook D, MacLennan G, Cuthbertson BH, Francis JJ; SuDDICU international group.

Trials. 2016 Jan 6;17:12. doi: 10.1186/s13063-015-1137-8.


Protocol for the development of a CONSORT-equity guideline to improve reporting of health equity in randomized trials.

Welch V, Jull J, Petkovic J, Armstrong R, Boyer Y, Cuervo LG, Edwards S, Lydiatt A, Gough D, Grimshaw J, Kristjansson E, Mbuagbaw L, McGowan J, Moher D, Pantoja T, Petticrew M, Pottie K, Rader T, Shea B, Taljaard M, Waters E, Weijer C, Wells GA, White H, Whitehead M, Tugwell P.

Implement Sci. 2015 Oct 21;10:146. doi: 10.1186/s13012-015-0332-z.


Mail merge can be used to create personalized questionnaires in complex surveys.

Taljaard M, Chaudhry SH, Brehaut JC, Weijer C, Grimshaw JM.

BMC Res Notes. 2015 Oct 16;8:574. doi: 10.1186/s13104-015-1570-5.


Ethical considerations in functional magnetic resonance imaging research in acutely comatose patients.

Weijer C, Bruni T, Gofton T, Young GB, Norton L, Peterson A, Owen AM.

Brain. 2016 Jan;139(Pt 1):292-9. doi: 10.1093/brain/awv272. Epub 2015 Sep 15. No abstract available.

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