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Items: 19

1.

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.

Smith JS, Nicholson LT, Suwanpradid J, Glenn RA, Knape NM, Alagesan P, Gundry JN, Wehrman TS, Atwater AR, Gunn MD, MacLeod AS, Rajagopal S.

Sci Signal. 2018 Nov 6;11(555). pii: eaaq1075. doi: 10.1126/scisignal.aaq1075.

PMID:
30401786
2.

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC.

Elife. 2017 May 12;6. pii: e22882. doi: 10.7554/eLife.22882.

3.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.

4.

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.

Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, Traynor JR, Gerritz SW, Alt A.

J Med Chem. 2015 May 28;58(10):4220-9. doi: 10.1021/acs.jmedchem.5b00007. Epub 2015 May 7.

5.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC.

Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26.

6.

Biased agonism as a mechanism for differential signaling by chemokine receptors.

Rajagopal S, Bassoni DL, Campbell JJ, Gerard NP, Gerard C, Wehrman TS.

J Biol Chem. 2013 Dec 6;288(49):35039-48. doi: 10.1074/jbc.M113.479113. Epub 2013 Oct 21.

7.

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10830-5. doi: 10.1073/pnas.1300393110. Epub 2013 Jun 10.

8.

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S.

J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8.

PMID:
23396314
9.

Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation.

Bassoni DL, Raab WJ, Achacoso PL, Loh CY, Wehrman TS.

Methods Mol Biol. 2012;897:181-203. doi: 10.1007/978-1-61779-909-9_9.

PMID:
22674166
10.

Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays.

Bassoni DL, Jafri Q, Sastry S, Mathrubutham M, Wehrman TS.

Methods Mol Biol. 2012;897:171-80. doi: 10.1007/978-1-61779-909-9_8.

PMID:
22674165
11.

Imaging beta-galactosidase activity in vivo using sequential reporter-enzyme luminescence.

von Degenfeld G, Wehrman TS, Blau HM.

Methods Mol Biol. 2009;574:249-59. doi: 10.1007/978-1-60327-321-3_20.

12.

A novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization.

Hammer MM, Wehrman TS, Blau HM.

FASEB J. 2007 Dec;21(14):3827-34. Epub 2007 Oct 17.

PMID:
17942829
13.

A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals.

von Degenfeld G, Wehrman TS, Hammer MM, Blau HM.

FASEB J. 2007 Dec;21(14):3819-26. Epub 2007 Oct 17.

PMID:
17942828
14.

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.

Wehrman TS, Raab WJ, Casipit CL, Doyonnas R, Pomerantz JH, Blau HM.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19063-8. Epub 2006 Dec 5.

15.

Luminescent imaging of beta-galactosidase activity in living subjects using sequential reporter-enzyme luminescence.

Wehrman TS, von Degenfeld G, Krutzik PO, Nolan GP, Blau HM.

Nat Methods. 2006 Apr;3(4):295-301.

PMID:
16554835
16.

mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage.

Sen GL, Wehrman TS, Blau HM.

Differentiation. 2005 Jul;73(6):287-93.

PMID:
16138829
17.

Enzymatic detection of protein translocation.

Wehrman TS, Casipit CL, Gewertz NM, Blau HM.

Nat Methods. 2005 Jul;2(7):521-7.

PMID:
15973423
18.

Restriction enzyme-generated siRNA (REGS) vectors and libraries.

Sen G, Wehrman TS, Myers JW, Blau HM.

Nat Genet. 2004 Feb;36(2):183-9. Epub 2004 Jan 4.

19.

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