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Items: 1 to 50 of 210

1.

Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.

Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L.

Circulation. 2019 Jul 30;140(5):440-442. doi: 10.1161/CIRCULATIONAHA.118.039276. Epub 2019 Jul 29. No abstract available.

PMID:
31356139
2.

The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury.

Siebert V, Allencherril J, Ye Y, Wehrens XHT, Birnbaum Y.

Cardiovasc Drugs Ther. 2019 Aug;33(4):489-498. doi: 10.1007/s10557-019-06893-x.

PMID:
31332654
3.

Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.

Jones EG, Mazaheri N, Maroofian R, Zamani M, Seifi T, Sedaghat A, Shariati G, Jamshidi Y, Allen HD, Wehrens XHT, Galehdari H, Landstrom AP.

Sci Rep. 2019 Jun 21;9(1):9038. doi: 10.1038/s41598-019-44987-6.

4.

Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.

Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE.

JCI Insight. 2019 Jun 20;4(12). pii: 127116. doi: 10.1172/jci.insight.127116. eCollection 2019 Jun 20.

5.

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT.

Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12.

PMID:
31185731
6.

Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure.

Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N.

Physiol Rep. 2019 Apr;7(8):e14071. doi: 10.14814/phy2.14071.

7.

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo.

Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF.

Dev Cell. 2019 Mar 25;48(6):765-779.e7. doi: 10.1016/j.devcel.2019.01.017. Epub 2019 Feb 14.

PMID:
30773489
8.

Cardiac troponin I-more than a biomarker for myocardial ischemia?

Ni L, Wehrens XHT.

Ann Transl Med. 2018 Nov;6(Suppl 1):S17. doi: 10.21037/atm.2018.09.07. No abstract available.

9.

Protein Phosphatase 2A Regulates Cardiac Na+ Channels.

El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ.

Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350.

PMID:
30602331
10.

Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.

Ni L, Scott L Jr, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT.

Circ Res. 2019 Jan 18;124(2):256-262. doi: 10.1161/CIRCRESAHA.118.313811.

PMID:
30582449
11.

Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling.

Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L.

J Cell Physiol. 2019 Jul;234(7):11587-11601. doi: 10.1002/jcp.27791. Epub 2018 Nov 29.

PMID:
30488495
12.

STAT3: a link between CaMKII-βIV-spectrin and maladaptive remodeling?

Hulsurkar M, Quick AP, Wehrens XH.

J Clin Invest. 2018 Dec 3;128(12):5219-5221. doi: 10.1172/JCI124778. Epub 2018 Nov 12.

13.

CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.

Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA.

J Am Heart Assoc. 2018 Oct 2;7(19):e010393. doi: 10.1161/JAHA.118.010393.

14.

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation.

Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D.

Front Physiol. 2018 Oct 9;9:1383. doi: 10.3389/fphys.2018.01383. eCollection 2018.

15.

In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.

Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT.

Circ Res. 2018 Sep 28;123(8):953-963. doi: 10.1161/CIRCRESAHA.118.313369.

16.

Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development.

Wehrens XHT.

JACC Basic Transl Sci. 2018 Aug 28;3(4):518-520. doi: 10.1016/j.jacbts.2018.07.002. eCollection 2018 Aug. No abstract available.

17.

Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.

Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ragone MI, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A.

Cardiovasc Res. 2019 Mar 1;115(3):556-569. doi: 10.1093/cvr/cvy213.

PMID:
30169578
18.

Mouse Models of Cardiac Arrhythmias.

Dobrev D, Wehrens XHT.

Circ Res. 2018 Jul 20;123(3):332-334. doi: 10.1161/CIRCRESAHA.118.313406. Review. No abstract available.

19.

Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter?

Dobrev D, Fender AC, Wehrens XHT.

Cardiovasc Res. 2018 Sep 1;114(11):1428-1429. doi: 10.1093/cvr/cvy175. No abstract available.

20.

Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy.

Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Valderrábano M, Wehrens XH, Anderson AE.

Epilepsia Open. 2018 Mar 23;3(2):213-223. doi: 10.1002/epi4.12107. eCollection 2018 Jun.

21.

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.

Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I Dr, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N.

Circulation. 2018 Nov 13;138(20):2227-2242. doi: 10.1161/CIRCULATIONAHA.118.035202. Erratum in: Circulation. 2019 Apr 23;139(17):e889.

PMID:
29802206
22.

Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia.

Miyake CY, Asaki SY, Webster G, Czosek RJ, Atallah J, Avasarala K, Rao SO, Thomas PE, Kim JJ, Valdes SO, de la Uz C, Wang Y, Wehrens XHT, Abrams D.

JACC Clin Electrophysiol. 2017 Nov;3(11):1308-1317. doi: 10.1016/j.jacep.2017.05.004. Epub 2017 Aug 30.

23.

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L Jr, Heck AJR, Wehrens XHT.

Circulation. 2018 Oct 9;138(15):1569-1581. doi: 10.1161/CIRCULATIONAHA.118.034361.

24.

Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.

Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT.

Circ Arrhythm Electrophysiol. 2018 Apr;11(4):e005682. doi: 10.1161/CIRCEP.117.005682.

25.

Genetics of atrial fibrillation: an update.

Campbell HM, Wehrens XHT.

Curr Opin Cardiol. 2018 May;33(3):304-310. doi: 10.1097/HCO.0000000000000505. Review.

PMID:
29461262
26.

EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.

Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJ.

Heart Rhythm. 2018 Apr;15(4):578-586. doi: 10.1016/j.hrthm.2017.12.017. Epub 2017 Dec 14.

27.

Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension.

Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM Jr, Pandit LM.

Front Med (Lausanne). 2017 Oct 23;4:177. doi: 10.3389/fmed.2017.00177. eCollection 2017.

28.

Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes.

Lezcano N, Mariángelo JIE, Vittone L, Wehrens XHT, Said M, Mundiña-Weilenmann C.

J Mol Cell Cardiol. 2018 Jan;114:1-9. doi: 10.1016/j.yjmcc.2017.10.005. Epub 2017 Oct 14.

29.

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.

Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-Hélaouët M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ.

Circ Res. 2017 Dec 8;121(12):1346-1359. doi: 10.1161/CIRCRESAHA.117.311876. Epub 2017 Oct 10.

30.

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy.

Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M.

JCI Insight. 2017 Sep 7;2(17). pii: 93343. doi: 10.1172/jci.insight.93343. eCollection 2017 Sep 7.

31.

Calcium Signaling and Cardiac Arrhythmias.

Landstrom AP, Dobrev D, Wehrens XHT.

Circ Res. 2017 Jun 9;120(12):1969-1993. doi: 10.1161/CIRCRESAHA.117.310083. Review.

32.

Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.

Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH.

JACC Basic Transl Sci. 2017 Feb;2(1):56-67. doi: 10.1016/j.jacbts.2016.11.004.

33.

Calcium-mediated cellular triggered activity in atrial fibrillation.

Dobrev D, Wehrens XHT.

J Physiol. 2017 Jun 15;595(12):4001-4008. doi: 10.1113/JP273048. Epub 2017 Mar 22. Review.

34.

Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis.

Herrera JA, Ward CS, Wehrens XH, Neul JL.

Hum Mol Genet. 2016 Nov 15;25(22):4983-4995. doi: 10.1093/hmg/ddw326.

35.

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance.

Federico M, Portiansky EL, Sommese L, Alvarado FJ, Blanco PG, Zanuzzi CN, Dedman J, Kaetzel M, Wehrens XHT, Mattiazzi A, Palomeque J.

J Physiol. 2017 Jun 15;595(12):4089-4108. doi: 10.1113/JP273714. Epub 2017 Mar 2.

36.

Serine/Threonine Phosphatases in Atrial Fibrillation.

Heijman J, Ghezelbash S, Wehrens XH, Dobrev D.

J Mol Cell Cardiol. 2017 Feb;103:110-120. doi: 10.1016/j.yjmcc.2016.12.009. Epub 2017 Jan 7. Review.

37.

SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice.

Hinton AO Jr, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK.

PLoS One. 2016 Dec 22;11(12):e0168644. doi: 10.1371/journal.pone.0168644. eCollection 2016.

38.

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N.

Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E136-E149. doi: 10.1152/ajpendo.00150.2016. Epub 2016 Nov 15.

39.

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy.

Wang Q, Wehrens XH.

Ann Transl Med. 2016 Oct;4(Suppl 1):S23. No abstract available.

40.

Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs.

Li N, Wang Q, Sibrian-Vazquez M, Klipp RC, Reynolds JO, Word TA, Scott L Jr, Salama G, Strongin RM, Abramson JJ, Wehrens XHT.

Int J Cardiol. 2017 Jan 15;227:668-673. doi: 10.1016/j.ijcard.2016.10.078. Epub 2016 Oct 29.

41.

Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.

Munro ML, Jayasinghe ID, Wang Q, Quick A, Wang W, Baddeley D, Wehrens XH, Soeller C.

J Cell Sci. 2016 Dec 1;129(23):4388-4398. Epub 2016 Oct 21.

42.

Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy.

Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE.

J Physiol. 2016 Nov 1;594(21):6433-6435. doi: 10.1113/JP273143. No abstract available.

43.

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.

Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH.

Int J Cardiol. 2016 Dec 15;225:371-380. doi: 10.1016/j.ijcard.2016.10.021. Epub 2016 Oct 8.

44.

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.

Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH.

Circ Res. 2017 Jan 6;120(1):110-119. doi: 10.1161/CIRCRESAHA.116.309977. Epub 2016 Oct 11.

45.

Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome.

Chiang DY, Heck AJ, Dobrev D, Wehrens XH.

J Mol Cell Cardiol. 2016 Dec;101:165-172. doi: 10.1016/j.yjmcc.2016.09.009. Epub 2016 Sep 20. Review.

46.

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.

Aiba I, Wehrens XH, Noebels JL.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4895-903. doi: 10.1073/pnas.1605216113. Epub 2016 Aug 1.

47.

Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.

Becerra R, Román B, Di Carlo MN, Mariangelo JI, Salas M, Sanchez G, Donoso P, Schinella GR, Vittone L, Wehrens XH, Mundiña-Weilenmann C, Said M.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H713-24. doi: 10.1152/ajpheart.00142.2016. Epub 2016 Jul 15.

48.

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.

Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM.

J Mol Cell Cardiol. 2016 Sep;98:62-72. doi: 10.1016/j.yjmcc.2016.06.007. Epub 2016 Jun 16.

49.

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function.

Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M.

J Biol Chem. 2016 Aug 12;291(33):17247-57. doi: 10.1074/jbc.M116.728188. Epub 2016 Jun 13.

50.

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.

Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN.

Cell Rep. 2016 Jun 7;15(10):2200-2213. doi: 10.1016/j.celrep.2016.05.002. Epub 2016 May 26.

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