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Multiparametric Assays for Accelerating Early Drug Discovery.

Herholt A, Galinski S, Geyer PE, Rossner MJ, Wehr MC.

Trends Pharmacol Sci. 2020 Mar 27. pii: S0165-6147(20)30058-4. doi: 10.1016/ [Epub ahead of print] Review.


Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-controlled trial.

Hasan A, Roeh A, Leucht S, Langguth B, Hansbauer M, Oviedo-Salcedo T, Kirchner SK, Papazova I, Löhrs L, Wagner E, Maurus I, Strube W, Rossner MJ, Wehr MC, Bauer I, Heres S, Leucht C, Kreuzer PM, Zimmermann S, Schneider-Axmann T, Görlitz T, Karch S, Egert-Schwender S, Schossow B, Rothe P, Falkai P.

Contemp Clin Trials Commun. 2020 Jan 28;17:100537. doi: 10.1016/j.conctc.2020.100537. eCollection 2020 Mar.


A Cortico-Collicular Amplification Mechanism for Gap Detection.

Weible AP, Yavorska I, Wehr M.

Cereb Cortex. 2020 Feb 14. pii: bhz328. doi: 10.1093/cercor/bhz328. [Epub ahead of print]


Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice.

O'Sullivan C, Weible AP, Wehr M.

Front Neurosci. 2020 Jan 10;13:1394. doi: 10.3389/fnins.2019.01394. eCollection 2019.


Auditory Cortex Contributes to Discrimination of Pure Tones.

O'Sullivan C, Weible AP, Wehr M.

eNeuro. 2019 Oct 16;6(5). pii: ENEURO.0340-19.2019. doi: 10.1523/ENEURO.0340-19.2019. Print 2019 Sep/Oct.


Correction to: Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays.

Wintgens JP, Wichert SP, Popovic L, Rossner MJ, Wehr MC.

Cell Mol Life Sci. 2019 Oct;76(19):3915. doi: 10.1007/s00018-019-03244-9.


Mice can learn phonetic categories.

Saunders JL, Wehr M.

J Acoust Soc Am. 2019 Mar;145(3):1168. doi: 10.1121/1.5091776.


5XFAD Mice Show Early Onset Gap Detection Deficits.

Kaylegian K, Stebritz AJ, Weible AP, Wehr M.

Front Aging Neurosci. 2019 Apr 2;11:66. doi: 10.3389/fnagi.2019.00066. eCollection 2019.


Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays.

Wintgens JP, Wichert SP, Popovic L, Rossner MJ, Wehr MC.

Cell Mol Life Sci. 2019 Mar;76(6):1185-1199. doi: 10.1007/s00018-018-03003-2. Epub 2019 Jan 8. Erratum in: Cell Mol Life Sci. 2019 Aug 3;:.


Pathway sensor-based functional genomics screening identifies modulators of neuronal activity.

Herholt A, Brankatschk B, Kannaiyan N, Papiol S, Wichert SP, Wehr MC, Rossner MJ.

Sci Rep. 2018 Dec 4;8(1):17597. doi: 10.1038/s41598-018-36008-9.


Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts.

Galinski S, Wichert SP, Rossner MJ, Wehr MC.

Sci Rep. 2018 May 25;8(1):8137. doi: 10.1038/s41598-018-26401-9.


Gap encoding by parvalbumin-expressing interneurons in auditory cortex.

Keller CH, Kaylegian K, Wehr M.

J Neurophysiol. 2018 Jul 1;120(1):105-114. doi: 10.1152/jn.00911.2017. Epub 2018 Mar 28.


Rapid Rebalancing of Excitation and Inhibition by Cortical Circuitry.

Moore AK, Weible AP, Balmer TS, Trussell LO, Wehr M.

Neuron. 2018 Mar 21;97(6):1341-1355.e6. doi: 10.1016/j.neuron.2018.01.045. Epub 2018 Mar 1.


Highly anisotropic electric conductivity in PAN-based carbon nanofibers.

Aprojanz J, Dreyer B, Wehr M, Wiegand J, Baringhaus J, Koch J, Renz F, Sindelar R, Tegenkamp C.

J Phys Condens Matter. 2017 Dec 13;29(49):494002. doi: 10.1088/1361-648X/aa9494.


Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.

Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ.

EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691.


Characterizing Dynamic Protein-Protein Interactions Using the Genetically Encoded Split Biosensor Assay Technique Split TEV.

Wintgens JP, Rossner MJ, Wehr MC.

Methods Mol Biol. 2017;1596:219-238. doi: 10.1007/978-1-4939-6940-1_14.


Vision Drives Accurate Approach Behavior during Prey Capture in Laboratory Mice.

Hoy JL, Yavorska I, Wehr M, Niell CM.

Curr Biol. 2016 Nov 21;26(22):3046-3052. doi: 10.1016/j.cub.2016.09.009. Epub 2016 Oct 20.


Somatostatin-Expressing Inhibitory Interneurons in Cortical Circuits.

Yavorska I, Wehr M.

Front Neural Circuits. 2016 Sep 29;10:76. eCollection 2016. Review.


Split protein biosensor assays in molecular pharmacological studies.

Wehr MC, Rossner MJ.

Drug Discov Today. 2016 Mar;21(3):415-29. doi: 10.1016/j.drudis.2015.11.004. Epub 2015 Nov 21. Review.


A coding transformation for temporally structured sounds within auditory cortical neurons.

Gao X, Wehr M.

Neuron. 2015 Apr 8;86(1):292-303. doi: 10.1016/j.neuron.2015.03.004. Epub 2015 Mar 26.


Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV.

Wehr MC, Galinski S, Rossner MJ.

Methods Mol Biol. 2015;1272:107-18. doi: 10.1007/978-1-4939-2336-6_8.


Auditory cortex is required for fear potentiation of gap detection.

Weible AP, Liu C, Niell CM, Wehr M.

J Neurosci. 2014 Nov 12;34(46):15437-45. doi: 10.1523/JNEUROSCI.3408-14.2014.


Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders.

Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, Rossner MJ.

PLoS One. 2014 Oct 23;9(10):e110310. doi: 10.1371/journal.pone.0110310. eCollection 2014.


Synaptic mechanisms underlying interaural level difference selectivity in rat auditory cortex.

Kyweriga M, Stewart W, Cahill C, Wehr M.

J Neurophysiol. 2014 Nov 15;112(10):2561-71. doi: 10.1152/jn.00389.2014. Epub 2014 Sep 3.


Perceptual gap detection is mediated by gap termination responses in auditory cortex.

Weible AP, Moore AK, Liu C, DeBlander L, Wu H, Kentros C, Wehr M.

Curr Biol. 2014 Jul 7;24(13):1447-55. doi: 10.1016/j.cub.2014.05.031.


Evolutionary and molecular facts link the WWC protein family to Hippo signaling.

Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstädt H, Duning K, Kremerskothen J.

Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27.


Neuronal interaural level difference response shifts are level-dependent in the rat auditory cortex.

Kyweriga M, Stewart W, Wehr M.

J Neurophysiol. 2014 Mar;111(5):930-8. doi: 10.1152/jn.00648.2013. Epub 2013 Dec 11.


Parvalbumin-expressing inhibitory interneurons in auditory cortex are well-tuned for frequency.

Moore AK, Wehr M.

J Neurosci. 2013 Aug 21;33(34):13713-23. doi: 10.1523/JNEUROSCI.0663-13.2013.


Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.

Hoy JL, Haeger PA, Constable JR, Arias RJ, McCallum R, Kyweriga M, Davis L, Schnell E, Wehr M, Castillo PE, Washbourne P.

J Neurosci. 2013 May 29;33(22):9364-84. doi: 10.1523/JNEUROSCI.4660-12.2013.


Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

Wehr MC, Holder MV, Gailite I, Saunders RE, Maile TM, Ciirdaeva E, Instrell R, Jiang M, Howell M, Rossner MJ, Tapon N.

Nat Cell Biol. 2013 Jan;15(1):61-71.


Isoflurane blocks temporary tinnitus.

Norman M, Tomscha K, Wehr M.

Hear Res. 2012 Aug;290(1-2):64-71. doi: 10.1016/j.heares.2012.03.015. Epub 2012 May 22.


Auditory cortical neurons convey maximal stimulus-specific information at their best frequency.

Montgomery N, Wehr M.

J Neurosci. 2010 Oct 6;30(40):13362-6. doi: 10.1523/JNEUROSCI.2899-10.2010.


Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.

Ribeiro PS, Josué F, Wepf A, Wehr MC, Rinner O, Kelly G, Tapon N, Gstaiger M.

Mol Cell. 2010 Aug 27;39(4):521-34. doi: 10.1016/j.molcel.2010.08.002.


Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N.

Dev Cell. 2010 Feb 16;18(2):300-8. doi: 10.1016/j.devcel.2009.12.011.


Nonoverlapping sets of synapses drive on responses and off responses in auditory cortex.

Scholl B, Gao X, Wehr M.

Neuron. 2010 Feb 11;65(3):412-21. doi: 10.1016/j.neuron.2010.01.020.


Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR).

Wehr M, Hostick U, Kyweriga M, Tan A, Weible AP, Wu H, Wu W, Callaway EM, Kentros C.

J Neurophysiol. 2009 Oct;102(4):2554-62. doi: 10.1152/jn.00480.2009. Epub 2009 Aug 19. Erratum in: J Neurophysiol. 2009 Dec;102(6):3781.


Balanced tone-evoked synaptic excitation and inhibition in mouse auditory cortex.

Tan AY, Wehr M.

Neuroscience. 2009 Nov 10;163(4):1302-15. doi: 10.1016/j.neuroscience.2009.07.032. Epub 2009 Jul 21.


Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction.

Saher G, Quintes S, Möbius W, Wehr MC, Krämer-Albers EM, Brügger B, Nave KA.

J Neurosci. 2009 May 13;29(19):6094-104. doi: 10.1523/JNEUROSCI.0686-09.2009.


Split-cre complementation indicates coincident activity of different genes in vivo.

Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F.

PLoS One. 2009;4(1):e4286. doi: 10.1371/journal.pone.0004286. Epub 2009 Jan 27.


[Acute coronary syndrome in the elderly. Optimal revascularisation strategies].

Wehr MH.

Internist (Berl). 2008 Sep;49(9):1061-7. doi: 10.1007/s00108-008-2078-z. Review. German.


Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice.

Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA.

PLoS One. 2008 Jul 23;3(7):e2762. doi: 10.1371/journal.pone.0002762.


Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV.

Wehr MC, Reinecke L, Botvinnik A, Rossner MJ.

BMC Biotechnol. 2008 Jul 13;8:55. doi: 10.1186/1472-6750-8-55.


Disruption of balanced cortical excitation and inhibition by acoustic trauma.

Scholl B, Wehr M.

J Neurophysiol. 2008 Aug;100(2):646-56. doi: 10.1152/jn.90406.2008. Epub 2008 Jun 4.


Level dependence of contextual modulation in auditory cortex.

Scholl B, Gao X, Wehr M.

J Neurophysiol. 2008 Apr;99(4):1616-27. doi: 10.1152/jn.01172.2007. Epub 2008 Jan 23.


Monitoring regulated protein-protein interactions using split TEV.

Wehr MC, Laage R, Bolz U, Fischer TM, Grünewald S, Scheek S, Bach A, Nave KA, Rossner MJ.

Nat Methods. 2006 Dec;3(12):985-93. Epub 2006 Oct 29.


Synaptic mechanisms of forward suppression in rat auditory cortex.

Wehr M, Zador AM.

Neuron. 2005 Aug 4;47(3):437-45.


High cholesterol level is essential for myelin membrane growth.

Saher G, Brügger B, Lappe-Siefke C, Möbius W, Tozawa R, Wehr MC, Wieland F, Ishibashi S, Nave KA.

Nat Neurosci. 2005 Apr;8(4):468-75. Epub 2005 Mar 27.


Antibody levels against Chlamydia pneumoniae and outcome of roxithromycin therapy in patients with acute myocardial infarction. Results from a sub-study of the randomised Antibiotic Therapy in Acute Myocardial Infarction (ANTIBIO) trial.

Burkhardt U, Zahn R, Höffler U, Siegler KE, Frilling B, Weber M, Gottwik M, Wehr M, Seidel F, Rosocha S, Tebbe U, Senges J.

Z Kardiol. 2004 Sep;93(9):671-8.


Linearity of cortical receptive fields measured with natural sounds.

Machens CK, Wehr MS, Zador AM.

J Neurosci. 2004 Feb 4;24(5):1089-100.

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