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Items: 22

1.

11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy.

Fenton CG, Doig CL, Fareed S, Naylor A, Morrell AP, Addison O, Wehmeyer C, Buckley CD, Cooper MS, Lavery GG, Raza K, Hardy RS.

Arthritis Res Ther. 2019 Aug 16;21(1):188. doi: 10.1186/s13075-019-1972-1.

2.

Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis.

Fenton CG, Webster JM, Martin CS, Fareed S, Wehmeyer C, Mackie H, Jones R, Seabright AP, Lewis JW, Lai YC, Goodyear CS, Jones SW, Cooper MS, Lavery GG, Langen R, Raza K, Hardy RS.

Arthritis Res Ther. 2019 Aug 1;21(1):182. doi: 10.1186/s13075-019-1962-3.

3.

Distinct fibroblast subsets drive inflammation and damage in arthritis.

Croft AP, Campos J, Jansen K, Turner JD, Marshall J, Attar M, Savary L, Wehmeyer C, Naylor AJ, Kemble S, Begum J, Dürholz K, Perlman H, Barone F, McGettrick HM, Fearon DT, Wei K, Raychaudhuri S, Korsunsky I, Brenner MB, Coles M, Sansom SN, Filer A, Buckley CD.

Nature. 2019 Jun;570(7760):246-251. doi: 10.1038/s41586-019-1263-7. Epub 2019 May 29.

PMID:
31142839
4.

Machine Learning of Coarse-Grained Molecular Dynamics Force Fields.

Wang J, Olsson S, Wehmeyer C, Pérez A, Charron NE, de Fabritiis G, Noé F, Clementi C.

ACS Cent Sci. 2019 May 22;5(5):755-767. doi: 10.1021/acscentsci.8b00913. Epub 2019 Apr 15.

5.

Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts.

Pearson MJ, Bik MA, Ospelt C, Naylor AJ, Wehmeyer C, Jones SW, Buckley CD, Gay S, Filer A, Lord JM.

Sci Rep. 2018 Aug 27;8(1):12887. doi: 10.1038/s41598-018-31173-3.

6.

Time-lagged autoencoders: Deep learning of slow collective variables for molecular kinetics.

Wehmeyer C, Noé F.

J Chem Phys. 2018 Jun 28;148(24):241703. doi: 10.1063/1.5011399.

PMID:
29960344
7.

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.

8.

Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F.

Nat Commun. 2018 Mar 9;9(1):1073. doi: 10.1038/s41467-018-03452-0.

9.

Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F.

Nat Commun. 2017 Oct 23;8(1):1095. doi: 10.1038/s41467-017-01163-6. Erratum in: Nat Commun. 2018 Mar 9;9(1):1073.

10.

The role of stromal cells in inflammatory bone loss.

Wehmeyer C, Pap T, Buckley CD, Naylor AJ.

Clin Exp Immunol. 2017 Jul;189(1):1-11. doi: 10.1111/cei.12979. Epub 2017 May 18. Review.

11.

MHC class II complexes sample intermediate states along the peptide exchange pathway.

Wieczorek M, Sticht J, Stolzenberg S, Günther S, Wehmeyer C, El Habre Z, Álvaro-Benito M, Noé F, Freund C.

Nat Commun. 2016 Nov 9;7:13224. doi: 10.1038/ncomms13224.

12.

Multiensemble Markov models of molecular thermodynamics and kinetics.

Wu H, Paul F, Wehmeyer C, Noé F.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3221-30. doi: 10.1073/pnas.1525092113. Epub 2016 May 25. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 24;:.

13.

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.

Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B.

Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16.

PMID:
27089204
14.

A Coupled Molecular Dynamics/Kinetic Monte Carlo Approach for Protonation Dynamics in Extended Systems.

Kabbe G, Wehmeyer C, Sebastiani D.

J Chem Theory Comput. 2014 Oct 14;10(10):4221-8. doi: 10.1021/ct500482k.

PMID:
26588120
15.

PyEMMA 2: A Software Package for Estimation, Validation, and Analysis of Markov Models.

Scherer MK, Trendelkamp-Schroer B, Paul F, Pérez-Hernández G, Hoffmann M, Plattner N, Wehmeyer C, Prinz JH, Noé F.

J Chem Theory Comput. 2015 Nov 10;11(11):5525-42. doi: 10.1021/acs.jctc.5b00743. Epub 2015 Oct 14.

PMID:
26574340
16.

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.

Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T.

Nat Med. 2015 Sep;21(9):1085-90. doi: 10.1038/nm.3917. Epub 2015 Aug 3.

PMID:
26236992
17.

The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations.

Vener MV, Odinokov AV, Wehmeyer C, Sebastiani D.

J Chem Phys. 2015 Jun 7;142(21):215106. doi: 10.1063/1.4922165.

PMID:
26049530
18.

Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis.

Wäldele S, Koers-Wunrau C, Beckmann D, Korb-Pap A, Wehmeyer C, Pap T, Dankbar B.

Arthritis Res Ther. 2015 Jan 20;17:12. doi: 10.1186/s13075-015-0524-6.

19.

Cell surface-bound TIMP3 induces apoptosis in mesenchymal Cal78 cells through ligand-independent activation of death receptor signaling and blockade of survival pathways.

Koers-Wunrau C, Wehmeyer C, Hillmann A, Pap T, Dankbar B.

PLoS One. 2013 Jul 24;8(7):e70709. doi: 10.1371/journal.pone.0070709. Print 2013.

20.

Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB.

Frank S, Peters MA, Wehmeyer C, Strietholt S, Koers-Wunrau C, Bertrand J, Heitzmann M, Hillmann A, Sherwood J, Seyfert C, Gay S, Pap T.

Ann Rheum Dis. 2013 Nov;72(11):1874-81. doi: 10.1136/annrheumdis-2012-202080. Epub 2013 Feb 16.

21.

Foraging on the potential energy surface: a swarm intelligence-based optimizer for molecular geometry.

Wehmeyer C, Falk von Rudorff G, Wolf S, Kabbe G, Schärf D, Kühne TD, Sebastiani D.

J Chem Phys. 2012 Nov 21;137(19):194110. doi: 10.1063/1.4766821.

PMID:
23181297
22.

Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.

Hebbelmann I, Selinski J, Wehmeyer C, Goss T, Voss I, Mulo P, Kangasjärvi S, Aro EM, Oelze ML, Dietz KJ, Nunes-Nesi A, Do PT, Fernie AR, Talla SK, Raghavendra AS, Linke V, Scheibe R.

J Exp Bot. 2012 Feb;63(3):1445-59. doi: 10.1093/jxb/err386. Epub 2011 Dec 3.

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