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Items: 15


Genome Editing: Insights from Chemical Biology to Support Safe and Transformative Therapeutic Applications.

Wegrzyn RD, Lee AH, Jenkins AL, Stoddard CD, Cheever AE.

ACS Chem Biol. 2018 Feb 16;13(2):333-342. doi: 10.1021/acschembio.7b00689. Epub 2017 Oct 18.


In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide.

Nyborg AC, Moll JR, Wegrzyn RD, Havas D, Hutter-Paier B, Feuerstein GG, Rudolph AS.

J Alzheimers Dis. 2013;34(4):957-67. doi: 10.3233/JAD-122107.


Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein Mca1.

Erhardt M, Wegrzyn RD, Deuerling E.

PLoS One. 2010 Mar 29;5(3):e9929. doi: 10.1371/journal.pone.0009929.


Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.

Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andréasson C, Lindquist S, Bukau B.

PLoS One. 2008 Mar 12;3(3):e1763. doi: 10.1371/journal.pone.0001763.


Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast.

Ganusova EE, Ozolins LN, Bhagat S, Newnam GP, Wegrzyn RD, Sherman MY, Chernoff YO.

Mol Cell Biol. 2006 Jan;26(2):617-29.


A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains.

Wegrzyn RD, Hofmann D, Merz F, Nikolay R, Rauch T, Graf C, Deuerling E.

J Biol Chem. 2006 Feb 3;281(5):2847-57. Epub 2005 Nov 29.


Molecular guardians for newborn proteins: ribosome-associated chaperones and their role in protein folding.

Wegrzyn RD, Deuerling E.

Cell Mol Life Sci. 2005 Dec;62(23):2727-38. Review.


Dissecting functional similarities of ribosome-associated chaperones from Saccharomyces cerevisiae and Escherichia coli.

Rauch T, Hundley HA, Pfund C, Wegrzyn RD, Walter W, Kramer G, Kim SY, Craig EA, Deuerling E.

Mol Microbiol. 2005 Jul;57(2):357-65.


Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].

Allen KD, Wegrzyn RD, Chernova TA, Müller S, Newnam GP, Winslett PA, Wittich KB, Wilkinson KD, Chernoff YO.

Genetics. 2005 Mar;169(3):1227-42. Epub 2004 Nov 15.


Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains.

Kramer G, Rutkowska A, Wegrzyn RD, Patzelt H, Kurz TA, Merz F, Rauch T, Vorderwülbecke S, Deuerling E, Bukau B.

J Bacteriol. 2004 Jun;186(12):3777-84.


Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'.

Borchsenius AS, Wegrzyn RD, Newnam GP, Inge-Vechtomov SG, Chernoff YO.

EMBO J. 2001 Dec 3;20(23):6683-91.


Mechanism of prion loss after Hsp104 inactivation in yeast.

Wegrzyn RD, Bapat K, Newnam GP, Zink AD, Chernoff YO.

Mol Cell Biol. 2001 Jul;21(14):4656-69.


An antiprion effect of the anticytoskeletal drug latrunculin A in yeast.

Bailleul-Winslett PA, Newnam GP, Wegrzyn RD, Chernoff YO.

Gene Expr. 2000;9(3):145-56.


A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.

Jung G, Jones G, Wegrzyn RD, Masison DC.

Genetics. 2000 Oct;156(2):559-70.


Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing.

Newnam GP, Wegrzyn RD, Lindquist SL, Chernoff YO.

Mol Cell Biol. 1999 Feb;19(2):1325-33.

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