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Items: 45

1.

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway.

Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B.

J Immunol. 2019 May 15;202(10):2982-2990. doi: 10.4049/jimmunol.1701443. Epub 2019 Apr 5.

PMID:
30952817
2.

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma.

Daneshmandi S, Wegiel B, Seth P.

Cancers (Basel). 2019 Mar 29;11(4). pii: E450. doi: 10.3390/cancers11040450.

3.

Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury.

Hedblom A, Hejazi SM, Canesin G, Choudhury R, Hanafy KA, Csizmadia E, Persson JL, Wegiel B.

Cell Death Dis. 2019 Jan 25;10(2):72. doi: 10.1038/s41419-019-1342-6.

4.

Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy.

Wegiel B, Vuerich M, Daneshmandi S, Seth P.

Front Oncol. 2018 Aug 13;8:284. doi: 10.3389/fonc.2018.00284. eCollection 2018. Review.

5.

Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.

Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC.

JCI Insight. 2017 May 4;2(9). pii: 92791. doi: 10.1172/jci.insight.92791. eCollection 2017 May 4.

6.

Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.

Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B.

Cancer Res. 2017 Jul 1;77(13):3632-3643. doi: 10.1158/0008-5472.CAN-16-2938. Epub 2017 Apr 26.

7.

Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.

Wang Y, Hedblom A, Koerner SK, Li M, Jernigan FE, Wegiel B, Sun L.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5703-5706. doi: 10.1016/j.bmcl.2016.10.063. Epub 2016 Oct 24.

8.

Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.

Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B.

Oncotarget. 2016 Apr 26;7(17):23919-32. doi: 10.18632/oncotarget.8081.

9.

Novel indolyl-chalcones target stathmin to induce cancer cell death.

Wegiel B, Wang Y, Li M, Jernigan F, Sun L.

Cell Cycle. 2016 May 2;15(9):1288-94. doi: 10.1080/15384101.2016.1160980. Epub 2016 Mar 17.

10.

"Nucleosome debris" provokes coagulation and inflammation.

Wegiel B, Ahmed A.

Thromb Res. 2016 Jan;137:1-2. doi: 10.1016/j.thromres.2015.11.022. Epub 2015 Nov 18. No abstract available.

PMID:
26603319
11.

Heme as a danger molecule in pathogen recognition.

Wegiel B, Hauser CJ, Otterbein LE.

Free Radic Biol Med. 2015 Dec;89:651-61. doi: 10.1016/j.freeradbiomed.2015.08.020. Epub 2015 Oct 9. Review.

PMID:
26456060
12.

Heme oxygenase-1 in macrophages controls prostate cancer progression.

Nemeth Z, Li M, Csizmadia E, Döme B, Johansson M, Persson JL, Seth P, Otterbein L, Wegiel B.

Oncotarget. 2015 Oct 20;6(32):33675-88. doi: 10.18632/oncotarget.5284.

13.

Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer.

Eguchi T, Prince T, Wegiel B, Calderwood SK.

J Cell Biochem. 2015 Oct;116(10):2146-54. doi: 10.1002/jcb.25203. Review.

14.

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.

Ahmad S, Hewett PW, Fujisawa T, Sissaoui S, Cai M, Gueron G, Al-Ani B, Cudmore M, Ahmed SF, Wong MK, Wegiel B, Otterbein LE, Vítek L, Ramma W, Wang K, Ahmed A.

Thromb Haemost. 2015 Feb;113(2):329-37. doi: 10.1160/TH14-01-0002. Epub 2014 Oct 30.

PMID:
25354586
15.

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE.

J Clin Invest. 2014 Nov;124(11):4926-40. doi: 10.1172/JCI72853. Epub 2014 Oct 8.

16.

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling.

Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC.

Biochem Biophys Res Commun. 2014 Jun 20;449(1):94-9. doi: 10.1016/j.bbrc.2014.04.150. Epub 2014 May 9.

17.

Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells.

Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE.

Cell Death Dis. 2014 Mar 20;5:e1139. doi: 10.1038/cddis.2014.97.

18.

Carbon monoxide induces chromatin remodelling to facilitate endothelial cell migration.

Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B.

Thromb Haemost. 2014 May 5;111(5):951-9. doi: 10.1160/TH13-09-0748. Epub 2014 Jan 30.

PMID:
24477332
19.

Heme oxygenase-1: a metabolic nike.

Wegiel B, Nemeth Z, Correa-Costa M, Bulmer AC, Otterbein LE.

Antioxid Redox Signal. 2014 Apr 10;20(11):1709-22. doi: 10.1089/ars.2013.5667. Epub 2014 Feb 27. Review.

20.

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth.

Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE.

Cancer Res. 2013 Dec 1;73(23):7009-21. doi: 10.1158/0008-5472.CAN-13-1075. Epub 2013 Oct 11.

21.

The social network of carbon monoxide in medicine.

Wegiel B, Hanto DW, Otterbein LE.

Trends Mol Med. 2013 Jan;19(1):3-11. doi: 10.1016/j.molmed.2012.10.001. Epub 2012 Nov 8. Review.

22.

Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules.

Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S.

J Biol Chem. 2012 Sep 14;287(38):32113-23. doi: 10.1074/jbc.M112.393140. Epub 2012 Jul 26.

23.

Go green: the anti-inflammatory effects of biliverdin reductase.

Wegiel B, Otterbein LE.

Front Pharmacol. 2012 Mar 16;3:47. doi: 10.3389/fphar.2012.00047. eCollection 2012.

24.

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase.

Wegiel B, Gallo D, Csizmadia E, Roger T, Kaczmarek E, Harris C, Zuckerbraun BS, Otterbein LE.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18849-54. doi: 10.1073/pnas.1108571108. Epub 2011 Oct 31.

25.

Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.

Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14491-6. doi: 10.1073/pnas.1102295108. Epub 2011 Aug 17.

26.

Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine.

Hanto DW, Maki T, Yoon MH, Csizmadia E, Chin BY, Gallo D, Konduru B, Kuramitsu K, Smith NR, Berssenbrugge A, Attanasio C, Thomas M, Wegiel B, Otterbein LE.

Am J Transplant. 2010 Nov;10(11):2421-30. doi: 10.1111/j.1600-6143.2010.03289.x.

27.

Molecular pathways in the progression of hormone-independent and metastatic prostate cancer.

Wegiel B, Evans S, Hellsten R, Otterbein LE, Bjartell A, Persson JL.

Curr Cancer Drug Targets. 2010 Jun;10(4):392-401.

PMID:
20384583
28.

Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury.

Wegiel B, Gallo DJ, Raman KG, Karlsson JM, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed A, Baty CJ, Otterbein LE.

Circulation. 2010 Feb 2;121(4):537-48. doi: 10.1161/CIRCULATIONAHA.109.887695. Epub 2010 Jan 18.

29.

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways.

Wegiel B, Jiborn T, Abrahamson M, Helczynski L, Otterbein L, Persson JL, Bjartell A.

PLoS One. 2009 Nov 23;4(11):e7953. doi: 10.1371/journal.pone.0007953.

30.

Effect of a novel botanical agent Drynol Cibotin on human osteoblast cells and implications for osteoporosis: promotion of cell growth, calcium uptake and collagen production.

Wegiel B, Persson JL.

Phytother Res. 2010 Jun;24 Suppl 2:S139-47. doi: 10.1002/ptr.3026. Erratum in: Phytother Res. 2010 Jun;24 Suppl 2:S233-4.

PMID:
19953582
31.

Photodynamic therapy-driven induction of suicide cytosine deaminase gene.

Bil J, Wlodarski P, Winiarska M, Kurzaj Z, Issat T, Jozkowicz A, Wegiel B, Dulak J, Golab J.

Cancer Lett. 2010 Apr 28;290(2):216-22. doi: 10.1016/j.canlet.2009.09.012. Epub 2009 Oct 12.

PMID:
19822393
32.

Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.

Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE.

J Biol Chem. 2009 Aug 7;284(32):21369-78. doi: 10.1074/jbc.M109.027433. Epub 2009 Jun 9.

33.

Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells.

da Silva CG, Specht A, Wegiel B, Ferran C, Kaczmarek E.

Circulation. 2009 Feb 17;119(6):871-9. doi: 10.1161/CIRCULATIONAHA.108.764571. Epub 2009 Feb 2.

34.

The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia.

Wegiel B, Ekberg J, Talasila KM, Jalili S, Persson JL.

Leukemia. 2009 Feb;23(2):251-61. doi: 10.1038/leu.2008.300. Epub 2008 Nov 6.

PMID:
18987662
35.

Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.

Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL.

J Natl Cancer Inst. 2008 Jul 16;100(14):1022-36. doi: 10.1093/jnci/djn214. Epub 2008 Jul 8.

36.

Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation.

Wegiel B, Chin BY, Otterbein LE.

Cell Cycle. 2008 May 15;7(10):1379-84. Epub 2008 Mar 11. Review.

PMID:
18418071
37.

Heme oxygenase and carbon monoxide initiate homeostatic signaling.

Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE.

J Mol Med (Berl). 2008 Mar;86(3):267-79. Epub 2007 Nov 22. Review.

PMID:
18034222
38.

Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival.

Wegiel B, Bjartell A, Culig Z, Persson JL.

Int J Cancer. 2008 Apr 1;122(7):1521-9.

39.

Therapeutic applications of bilirubin and biliverdin in transplantation.

Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH.

Antioxid Redox Signal. 2007 Dec;9(12):2175-85. Review.

PMID:
17919067
40.

Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages.

Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE.

J Immunol. 2007 May 1;178(9):5921-9.

41.

Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.

Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5109-14. Epub 2007 Mar 12.

42.

Carbon monoxide reverses established pulmonary hypertension.

Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE.

J Exp Med. 2006 Sep 4;203(9):2109-19. Epub 2006 Aug 14.

43.

New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes.

Dulak J, Zagorska A, Wegiel B, Loboda A, Jozkowicz A.

Cell Biochem Biophys. 2006;44(1):31-42. Review.

45.

A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer.

Wegiel B, Bjartell A, Ekberg J, Gadaleanu V, Brunhoff C, Persson JL.

Oncogene. 2005 Sep 22;24(42):6385-93.

PMID:
16007189

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