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Impact of Microcystin-LR on Liver Function Varies by Dose and Sex in Mice.

Mrdjen I, Morse MA, Ruch RJ, Knobloch TJ, Choudhary S, Weghorst CM, Lee J.

Toxins (Basel). 2018 Oct 28;10(11). pii: E435. doi: 10.3390/toxins10110435.


Characterization of the Functional Changes in Mouse Gut Microbiome Associated with Increased Akkermansia muciniphila Population Modulated by Dietary Black Raspberries.

Tu P, Bian X, Chi L, Gao B, Ru H, Knobloch TJ, Weghorst CM, Lu K.

ACS Omega. 2018 Sep 30;3(9):10927-10937. doi: 10.1021/acsomega.8b00064. Epub 2018 Sep 10.


Storage conditions modulate the metabolomic profile of a black raspberry nectar with minimal impact on bioactivity.

Teegarden MD, Knobloch TJ, Weghorst CM, Cooperstone JL, Peterson DG.

Food Funct. 2018 Sep 19;9(9):4593-4601. doi: 10.1039/c8fo00639c.


Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries.

Oghumu S, Casto BC, Ahn-Jarvis J, Weghorst LC, Maloney J, Geuy P, Horvath KZ, Bollinger CE, Warner BM, Summersgill KF, Weghorst CM, Knobloch TJ.

Front Immunol. 2017 Oct 23;8:1325. doi: 10.3389/fimmu.2017.01325. eCollection 2017.


Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Oghumu S, Knobloch TJ, Terrazas C, Varikuti S, Ahn-Jarvis J, Bollinger CE, Iwenofu H, Weghorst CM, Satoskar AR.

Int J Cancer. 2016 Sep 15;139(6):1379-90. doi: 10.1002/ijc.30177. Epub 2016 Jun 16.


Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche.

Knobloch TJ, Uhrig LK, Pearl DK, Casto BC, Warner BM, Clinton SK, Sardo-Molmenti CL, Ferguson JM, Daly BT, Riedl K, Schwartz SJ, Vodovotz Y, Buchta AJ Sr, Schuller DE, Ozer E, Agrawal A, Weghorst CM.

Cancer Prev Res (Phila). 2016 Feb;9(2):159-71. doi: 10.1158/1940-6207.CAPR-15-0187. Epub 2015 Dec 23.


Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.

Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CM.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec;118(6):674-83. doi: 10.1016/j.oooo.2014.09.005. Epub 2014 Sep 16.


Comprehensive evaluation of caspase-14 in vulvar neoplasia: an opportunity for treatment with black raspberry extract.

Joehlin-Price AS, Elkins CT, Stephens JA, Cohn DE, Knobloch TJ, Weghorst CM, Suarez AA.

Gynecol Oncol. 2014 Dec;135(3):503-9. doi: 10.1016/j.ygyno.2014.09.012. Epub 2014 Sep 23.


Coordinated expression of cyclin-dependent kinase-4 and its regulators in human oral tumors.

Poi MJ, Knobloch TJ, Sears MT, Uhrig LK, Warner BM, Weghorst CM, Li J.

Anticancer Res. 2014 Jul;34(7):3285-92.


Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.

Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB.

Cancer Immunol Immunother. 2014 Sep;63(9):889-900. doi: 10.1007/s00262-014-1564-5. Epub 2014 Jun 4.


Alterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.

Poi MJ, Knobloch TJ, Sears MT, Warner BM, Uhrig LK, Weghorst CM, Li J.

Mol Carcinog. 2015 Jul;54(7):532-42. doi: 10.1002/mc.22119. Epub 2013 Dec 2.


The choice of reference gene affects statistical efficiency in quantitative PCR data analysis.

Guo Y, Pennell ML, Pearl DK, Knobloch TJ, Fernandez S, Weghorst CM.

Biotechniques. 2013 Oct;55(4):207-9. doi: 10.2144/000114090.


The study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin.

Yuan C, Guo Y, Zhu L, Guo W, Mahajan A, Weghorst CM, Li J.

Biochemistry. 2013 Jul 16;52(28):4848-57. doi: 10.1021/bi4005717. Epub 2013 Jul 8.


Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.

Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li J.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):217-22. doi: 10.1016/j.bbrc.2013.05.078. Epub 2013 May 29.


Genetic alterations of RD(INK4/ARF) enhancer in human cancer cells.

Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CM.

Mol Carcinog. 2014 Mar;53(3):211-8. doi: 10.1002/mc.21965. Epub 2012 Oct 12.


Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.

Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BC.

Int J Cancer. 2012 Sep 15;131(6):1277-86. doi: 10.1002/ijc.27395. Epub 2012 Jan 31.


Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.

Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE, Weghorst CM.

Anticancer Res. 2011 Sep;31(9):2683-92.


A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells.

Zhang Z, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CM.

Gynecol Oncol. 2011 Nov;123(2):401-6. doi: 10.1016/j.ygyno.2011.07.023. Epub 2011 Aug 9.


Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition.

Accurso BT, Warner BM, Knobloch TJ, Weghorst CM, Shumway BS, Allen CM, Kalmar JR.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):359-66. doi: 10.1016/j.tripleo.2011.03.042. Epub 2011 Jul 20.


Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.

Guo Y, Yuan C, Tian F, Huang K, Weghorst CM, Tsai MD, Li J.

J Mol Biol. 2010 May 28;399(1):168-81. doi: 10.1016/j.jmb.2010.04.010. Epub 2010 Apr 14.


IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16.

Guo Y, Yuan C, Weghorst CM, Li J.

Biochem Biophys Res Commun. 2010 Mar 12;393(3):504-8. doi: 10.1016/j.bbrc.2010.02.035. Epub 2010 Feb 10.


Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins.

Guo Y, Mahajan A, Yuan C, Joo SH, Weghorst CM, Tsai MD, Li J.

Biochemistry. 2009 May 19;48(19):4050-62. doi: 10.1021/bi802247p.


Oral cancer in Appalachia.

Casto BC, Sharma S, Fisher JL, Knobloch TJ, Agrawal A, Weghorst CM.

J Health Care Poor Underserved. 2009 Feb;20(1):274-85. doi: 10.1353/hpu.0.0097.


Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens.

Muscarella P, Bloomston M, Brewer AR, Mahajan A, Frankel WL, Ellison EC, Farrar WB, Weghorst CM, Li J.

Gene Expr. 2008;14(4):207-16.


Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia.

Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, Weghorst CM.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3179-87. doi: 10.1158/1055-9965.EPI-08-0574.


Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors.

Li J, Warner B, Casto BC, Knobloch TJ, Weghorst CM.

Mol Carcinog. 2008 Oct;47(10):733-8. doi: 10.1002/mc.20424.


Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.

Bian Y, Knobloch TJ, Sadim M, Kaklamani V, Raji A, Yang GY, Weghorst CM, Pasche B.

Hum Mol Genet. 2007 Dec 15;16(24):3128-35. Epub 2007 Sep 21.


Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.

Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J.

J Mol Biol. 2007 Nov 2;373(4):990-1005. Epub 2007 Aug 22.


Somatic acquisition and signaling of TGFBR1*6A in cancer.

Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM.

JAMA. 2005 Oct 5;294(13):1634-46.


Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).

Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD.

Biochemistry. 2005 Oct 11;44(40):13246-56.


Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors.

Li J, Weghorst CM, Tsutsumi M, Poi MJ, Knobloch TJ, Casto BC, Melvin WS, Tsai MD, Muscarella P.

Carcinogenesis. 2004 Feb;25(2):263-8. Epub 2003 Nov 6.


Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.

Li J, Qin D, Knobloch TJ, Tsai MD, Weghorst CM, Melvin WS, Muscarella P.

Biochem Biophys Res Commun. 2003 May 2;304(2):241-7.


Chemoprevention of oral cancer by black raspberries.

Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, Schut HA, Stoner GD, Mallery SR, Weghorst CM.

Anticancer Res. 2002 Nov-Dec;22(6C):4005-15.


Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia.

Kresty LA, Mallery SR, Knobloch TJ, Song H, Lloyd M, Casto BC, Weghorst CM.

Cancer Res. 2002 Sep 15;62(18):5295-300.


Mutational status of overexpressed p16 in head and neck cancer: evidence for germline mutation of p16/p14ARF.

Lang JC, Borchers J, Danahey D, Smith S, Stover DG, Agrawal A, Malone JP, Schuller DE, Weghorst CM, Holinga AJ, Lingam K, Patel CR, Esham B.

Int J Oncol. 2002 Aug;21(2):401-8.


Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells.

Muscarella P, Knobloch TJ, Ulrich AB, Casto BC, Moniaux N, Wittel UA, Melvin WS, Pour PM, Song H, Gold B, Batra SK, Weghorst CM.

Gene. 2001 Oct 31;278(1-2):235-43.


Identification of genetic alterations in the TGFbeta type II receptor gene promoter.

Seijo ER, Song H, Lynch MA, Jennings R, Qong X, Lazaridis E, Muro-Cacho C, Weghorst CM, Muñoz-Antonia T.

Mutat Res. 2001 Nov 1;483(1-2):19-26.


Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers.

Knobloch TJ, Lynch MA, Song H, DeGroff VL, Casto BC, Adams EM, Alam KY, Lang JC, Schuller DE, Weghorst CM.

Mutat Res. 2001 Aug 8;479(1-2):131-9.


Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.

Lynch MA, Petrel TA, Song H, Knobloch TJ, Casto BC, Ramljak D, Anderson LM, DeGroff V, Stoner GD, Brueggemeier RW, Weghorst CM.

Gene Expr. 2001;9(4-5):157-71.


Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.

Poi MJ, Yen T, Li J, Song H, Lang JC, Schuller DE, Pearl DK, Casto BC, Tsai MD, Weghorst CM.

Mol Carcinog. 2001 Jan;30(1):26-36.


Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).

Shirin H, Sordillo EM, Kolevska TK, Hibshoosh H, Kawabata Y, Oh SH, Kuebler JF, Delohery T, Weghorst CM, Weinstein IB, Moss SF.

Infect Immun. 2000 Sep;68(9):5321-8.


Genetic alterations in the transforming growth factor receptor complex in sporadic endometrial carcinoma.

Nakashima R, Song H, Enomoto T, Murata Y, McClaid MR, Casto BC, Weghorst CM.

Gene Expr. 1999;8(5-6):341-52.


Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia.

Hughes SJ, Morse MA, Weghorst CM, Kim H, Watkins PB, Guengerich FP, Orringer MB, Beer DG.

Neoplasia. 1999 Jun;1(2):145-53.


The p16/Cdkn2a/Ink4a gene is frequently deleted in nitrosourea-induced rat glial tumors.

Schlegel J, Piontek G, Kersting M, Schuermann M, Kappler R, Scherthan H, Weghorst C, Buzard G, Mennel H.

Pathobiology. 1999 Jul-Aug;67(4):202-6.


Expression of cytochrome P450 2A3 in rat esophagus: relevance to N-nitrosobenzylmethylamine.

Gopalakrishnan R, Morse MA, Lu J, Weghorst CM, Sabourin CL, Stoner GD, Murphy SE.

Carcinogenesis. 1999 May;20(5):885-91.


p16 mutation frequency and clinical correlation in head and neck cancer.

Danahey DG, Tobin EJ, Schuller DE, Bier-Laning CM, Weghorst CM, Lang JC.

Acta Otolaryngol. 1999 Mar;119(2):285-8.


Mutational analysis of the transforming growth factor beta receptor type II gene in human ovarian carcinoma.

Lynch MA, Nakashima R, Song H, DeGroff VL, Wang D, Enomoto T, Weghorst CM.

Cancer Res. 1998 Oct 1;58(19):4227-32.


Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors.

Sabourin CL, Wang QS, Ralston SL, Evans J, Coate J, Herzog CR, Jones SL, Weghorst CM, Kelloff GJ, Lubet RA, You M, Stoner GD.

Exp Lung Res. 1998 Jul-Aug;24(4):499-521.


Frequent mutation of p16 in squamous cell carcinoma of the head and neck.

Lang JC, Tobin EJ, Knobloch TJ, Schuller DE, Bartynski KJ, Mountain RE, Nicholson R, DeYoung BR, Weghorst CM.

Laryngoscope. 1998 Jun;108(6):923-8.


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