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Items: 1 to 50 of 257

1.

One-fits-all pretreatment protocol facilitating Fluorescence In Situ Hybridization on formalin-fixed paraffin-embedded, fresh frozen and cytological slides.

Richardson SO, Huibers MMH, de Weger RA, de Leng WWJ, Hinrichs JWJ, Meijers RWJ, Willems SM, Peeters TLMG.

Mol Cytogenet. 2019 Jun 17;12:27. doi: 10.1186/s13039-019-0442-4. eCollection 2019.

2.

Modifying Graft-versus-Host Disease in a Humanized Mouse Model by Targeting Macrophages or B-Cells.

Hogenes MCH, van Dorp S, van Kuik J, Monteiro FRP, Ter Hoeve N, Guedes L, van Dijk MR, Martens AC, de Weger RA.

J Immunol Res. 2019 May 8;2019:3538963. doi: 10.1155/2019/3538963. eCollection 2019.

3.

The Translational Landscape of the Human Heart.

van Heesch S, Witte F, Schneider-Lunitz V, Schulz JF, Adami E, Faber AB, Kirchner M, Maatz H, Blachut S, Sandmann CL, Kanda M, Worth CL, Schafer S, Calviello L, Merriott R, Patone G, Hummel O, Wyler E, Obermayer B, Mücke MB, Lindberg EL, Trnka F, Memczak S, Schilling M, Felkin LE, Barton PJR, Quaife NM, Vanezis K, Diecke S, Mukai M, Mah N, Oh SJ, Kurtz A, Schramm C, Schwinge D, Sebode M, Harakalova M, Asselbergs FW, Vink A, de Weger RA, Viswanathan S, Widjaja AA, Gärtner-Rommel A, Milting H, Dos Remedios C, Knosalla C, Mertins P, Landthaler M, Vingron M, Linke WA, Seidman JG, Seidman CE, Rajewsky N, Ohler U, Cook SA, Hubner N.

Cell. 2019 Jun 27;178(1):242-260.e29. doi: 10.1016/j.cell.2019.05.010. Epub 2019 May 30.

PMID:
31155234
4.

High-beta/low-gamma frequency activity reflects top-down predictive coding during a spatial working memory test.

Zhang RV, Featherstone RE, Melynchenko O, Gifford R, Weger R, Liang Y, Siegel SJ.

Exp Brain Res. 2019 Jul;237(7):1881-1888. doi: 10.1007/s00221-019-05558-3. Epub 2019 May 15.

PMID:
31093716
5.

Clinical versus histological grading in the assessment of cutaneous graft versus host disease.

Hogenes MCH, Te Boome LCJ, van der Valk DC, van Dijk MR, de Weger RA, Kuball J, van Diest PJ.

Eur J Med Res. 2019 Apr 10;24(1):19. doi: 10.1186/s40001-019-0377-6.

6.

Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure.

Raso A, Dirkx E, Philippen LE, Fernandez-Celis A, De Majo F, Sampaio-Pinto V, Sansonetti M, Juni R, El Azzouzi H, Calore M, Bitsch N, Olieslagers S, Oerlemans MIFJ, Huibers MM, de Weger RA, Reckman YJ, Pinto YM, Zentilin L, Zacchigna S, Giacca M, da Costa Martins PA, López-Andrés N, De Windt LJ.

Mol Ther. 2019 Mar 6;27(3):584-599. doi: 10.1016/j.ymthe.2018.11.011. Epub 2018 Nov 17.

7.

Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study.

Antlanger M, Dust T, Reiter T, Böhm A, Lamm WW, Gornicec M, Willenbacher E, Nachbaur D, Weger R, Rabitsch W, Rasoul-Rockenschaub S, Worel N, Lechner D, Greinix H, Keil F, Gisslinger H, Agis H, Krauth MT.

BMC Cancer. 2018 Oct 20;18(1):1008. doi: 10.1186/s12885-018-4926-0.

8.

Potential Diagnosis of Vitreoretinal Lymphoma by Detection of MYD88 Mutation in Aqueous Humor With Ultrasensitive Droplet Digital Polymerase Chain Reaction.

Hiemcke-Jiwa LS, Ten Dam-van Loon NH, Leguit RJ, Nierkens S, Ossewaarde-van Norel J, de Boer JH, Roholl FF, de Weger RA, Huibers MMH, de Groot-Mijnes JDF, Kuiper JJW.

JAMA Ophthalmol. 2018 Oct 1;136(10):1098-1104. doi: 10.1001/jamaophthalmol.2018.2887.

9.

Molecular analysis in liquid biopsies for diagnostics of primary central nervous system lymphoma: Review of literature and future opportunities.

Hiemcke-Jiwa LS, Leguit RJ, Snijders TJ, Jiwa NM, Kuiper JJW, de Weger RA, Minnema MC, Huibers MMH.

Crit Rev Oncol Hematol. 2018 Jul;127:56-65. doi: 10.1016/j.critrevonc.2018.05.010. Epub 2018 May 17. Review.

PMID:
29891112
10.

The Interleukin-33/ST2 Pathway Is Expressed in the Failing Human Heart and Associated with Pro-fibrotic Remodeling of the Myocardium.

Tseng CCS, Huibers MMH, van Kuik J, de Weger RA, Vink A, de Jonge N.

J Cardiovasc Transl Res. 2018 Feb;11(1):15-21. doi: 10.1007/s12265-017-9775-8. Epub 2017 Dec 28.

11.

The use of droplet digital PCR in liquid biopsies: A highly sensitive technique for MYD88 p.(L265P) detection in cerebrospinal fluid.

Hiemcke-Jiwa LS, Minnema MC, Radersma-van Loon JH, Jiwa NM, de Boer M, Leguit RJ, de Weger RA, Huibers MMH.

Hematol Oncol. 2018 Apr;36(2):429-435. doi: 10.1002/hon.2489. Epub 2017 Dec 6.

PMID:
29210102
12.

Preanalytical blood sample workup for cell-free DNA analysis using Droplet Digital PCR for future molecular cancer diagnostics.

van Ginkel JH, van den Broek DA, van Kuik J, Linders D, de Weger R, Willems SM, Huibers MMH.

Cancer Med. 2017 Oct;6(10):2297-2307. doi: 10.1002/cam4.1184. Epub 2017 Sep 21.

13.

GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome.

Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ.

eNeuro. 2017 Mar 1;4(1). pii: ENEURO.0380-16.2017. doi: 10.1523/ENEURO.0380-16.2017. eCollection 2017 Jan-Feb.

14.

Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT).

Ubink I, Bloemendal HJ, Elias SG, Brink MA, Schwartz MP, Holierhoek YCW, Verheijen PM, Boerman AW, Mathijssen RHJ, de Leng WWJ, de Weger RA, van Grevenstein WMU, Koopman M, Lolkema MP, Kranenburg O, Borel Rinkes IHM.

BMC Cancer. 2017 Apr 19;17(1):282. doi: 10.1186/s12885-017-3264-y.

15.

Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies.

Sepehrkhouy S, Gho JMIH, van Es R, Harakalova M, de Jonge N, Dooijes D, van der Smagt JJ, Buijsrogge MP, Hauer RNW, Goldschmeding R, de Weger RA, Asselbergs FW, Vink A.

Heart Rhythm. 2017 Jul;14(7):1024-1032. doi: 10.1016/j.hrthm.2017.03.034. Epub 2017 Mar 30.

PMID:
28365402
16.

Lymphoblastic lymphoma with a triple-hit profile: a rare but distinct and relevant entity.

Hiemcke-Jiwa LS, Leguit RJ, van der Veken LT, Buijs A, Leeuwis JW, de Boer M, Jiwa NM, Bloem AC, Petersen EJ, de Weger RA, Huibers MMH.

Hum Pathol. 2017 May;63:171-176. doi: 10.1016/j.humpath.2016.11.002. Epub 2016 Nov 17.

PMID:
27867103
17.

Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons.

de Windt TS, Vonk LA, Slaper-Cortenbach IC, van den Broek MP, Nizak R, van Rijen MH, de Weger RA, Dhert WJ, Saris DB.

Stem Cells. 2017 Jan;35(1):256-264. doi: 10.1002/stem.2475. Epub 2016 Aug 29.

18.

Donor-Specific Antibodies Are Produced Locally in Ectopic Lymphoid Structures in Cardiac Allografts.

Huibers MM, Gareau AJ, Beerthuijzen JM, Siera-de Koning E, van Kuik J, Kamburova EG, Vink A, de Jonge N, Lee TD, Otten HG, de Weger RA.

Am J Transplant. 2017 Jan;17(1):246-254. doi: 10.1111/ajt.13969. Epub 2016 Aug 18.

19.

Comparison of intramedullary myeloma and corresponding extramedullary soft tissue plasmacytomas using genetic mutational panel analyses.

de Haart SJ, Willems SM, Mutis T, Koudijs MJ, van Blokland MT, Lokhorst HM, de Weger RA, Minnema MC.

Blood Cancer J. 2016 May 20;6:e426. doi: 10.1038/bcj.2016.35. No abstract available.

20.

Real-World Use of 3rd Line Therapy for Multiple Myeloma in Austria: An Austrian Myeloma Registry (AMR) Analysis of the Therapeutic Landscape and Clinical Outcomes prior to the Use of Next Generation Myeloma Therapeutics.

Willenbacher E, Weger R, Rochau U, Siebert U, Willenbacher W; Austrian Myeloma Registry (AMR).

PLoS One. 2016 Mar 3;11(3):e0147381. doi: 10.1371/journal.pone.0147381. eCollection 2016.

21.

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

de Leng WW, Gadellaa-van Hooijdonk CG, Barendregt-Smouter FA, Koudijs MJ, Nijman I, Hinrichs JW, Cuppen E, van Lieshout S, Loberg RD, de Jonge M, Voest EE, de Weger RA, Steeghs N, Langenberg MH, Sleijfer S, Willems SM, Lolkema MP.

PLoS One. 2016 Feb 26;11(2):e0149405. doi: 10.1371/journal.pone.0149405. eCollection 2016.

22.

Low Beclin-1 expression predicts improved overall survival in patients treated with immunomodulatory drugs for multiple myeloma and identifies autophagy inhibition as a promising potentially druggable new therapeutic target: an analysis from The Austrian Myeloma Registry (AMR).

Willenbacher W, Thangavadivel S, Greil R, Willenbacher E, Weger R, Manzl C, Jöhrer K, Brunner A.

Leuk Lymphoma. 2016 Oct;57(10):2330-41. doi: 10.3109/10428194.2016.1144880. Epub 2016 Feb 16.

PMID:
26880040
23.

Complete donor chimerism is a prerequisite for the effect of Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) on acute graft-versus-host disease.

Thus KA, de Weger RA, de Hoop TA, Boers Trilles VE, Kuball J, Spierings E.

Chimerism. 2014;5(3-4):94-8. doi: 10.1080/19381956.2015.1097025. Epub 2015 Dec 15.

24.

MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices.

Lok SI, de Jonge N, van Kuik J, van Geffen AJ, Huibers MM, van der Weide P, Siera E, Winkens B, Doevendans PA, de Weger RA, da Costa Martins PA.

PLoS One. 2015 Oct 2;10(10):e0136404. doi: 10.1371/journal.pone.0136404. eCollection 2015.

25.

Bone marrow microenvironmental CD4 + and CD8 + lymphocyte infiltration patterns define overall- and progression free survival in standard risk multiple myeloma--an analysis from the Austrian Myeloma Registry.

Willenbacher W, Willenbacher E, Zelle-Rieser C, Biedermann R, Weger R, Jöhrer K, Brunner A.

Leuk Lymphoma. 2016;57(6):1478-81. doi: 10.3109/10428194.2015.1099646. Epub 2015 Nov 16. No abstract available.

PMID:
26413883
26.

Predicted Indirectly ReCognizable HLA Epitopes Class I Promote Antileukemia Responses after Cord Blood Transplantation: Indications for a Potential Novel Donor Selection Tool.

Thus KA, de Hoop TA, de Weger RA, Bierings MB, Boelens JJ, Spierings E.

Biol Blood Marrow Transplant. 2016 Jan;22(1):170-3. doi: 10.1016/j.bbmt.2015.08.014. Epub 2015 Aug 28.

27.

Immunological and Fibrotic Mechanisms in Cardiac Allograft Vasculopathy.

Jansen MA, Otten HG, de Weger RA, Huibers MM.

Transplantation. 2015 Dec;99(12):2467-75. doi: 10.1097/TP.0000000000000848. Review.

PMID:
26285017
28.

Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis.

de Windt TS, Saris DB, Slaper-Cortenbach IC, van Rijen MH, Gawlitta D, Creemers LB, de Weger RA, Dhert WJ, Vonk LA.

Tissue Eng Part A. 2015 Oct;21(19-20):2536-47. doi: 10.1089/ten.TEA.2014.0673. Epub 2015 Aug 12.

PMID:
26166387
29.

Comparison of next-generation sequencing and mutation-specific platforms in clinical practice.

Hinrichs JW, van Blokland WT, Moons MJ, Radersma RD, Radersma-van Loon JH, de Voijs CM, Rappel SB, Koudijs MJ, Besselink NJ, Willems SM, de Weger RA.

Am J Clin Pathol. 2015 Apr;143(4):573-8. doi: 10.1309/AJCP40XETVYAMJPY.

PMID:
25780010
30.

TP53 Y220C Is a Hotspot Mutation in Oropharyngeal Squamous Cell Carcinoma.

van Kempen PM, Verdam FJ, de Poel E, Braunius WW, de Weger RA, van Es RJ, Grolman W, Willems SM.

Pathobiology. 2015;82(1):21-27. Epub 2015 Feb 28.

31.

The composition of ectopic lymphoid structures suggests involvement of a local immune response in cardiac allograft vasculopathy.

Huibers MM, Gareau AJ, Vink A, Kruit R, Feringa H, Beerthuijzen JM, Siera-de Koning E, Peeters T, de Jonge N, de Weger RA, Lee TD.

J Heart Lung Transplant. 2015 May;34(5):734-45. doi: 10.1016/j.healun.2014.11.022. Epub 2014 Dec 8.

PMID:
25655346
32.

Cardiac allograft vasculopathy: a donor or recipient induced pathology?

van den Hoogen P, Huibers MM, Sluijter JP, de Weger RA.

J Cardiovasc Transl Res. 2015 Mar;8(2):106-16. doi: 10.1007/s12265-015-9612-x. Epub 2015 Feb 5. Review.

33.

Myocardial fibrosis and pro-fibrotic markers in end-stage heart failure patients during continuous-flow left ventricular assist device support.

Lok SI, Nous FM, van Kuik J, van der Weide P, Winkens B, Kemperman H, Huisman A, Lahpor JR, de Weger RA, de Jonge N.

Eur J Cardiothorac Surg. 2015 Sep;48(3):407-15. doi: 10.1093/ejcts/ezu539. Epub 2015 Jan 21.

PMID:
25609773
34.

Simultaneous detection of clinically relevant mutations and amplifications for routine cancer pathology.

Hoogstraat M, Hinrichs JW, Besselink NJ, Radersma-van Loon JH, de Voijs CM, Peeters T, Nijman IJ, de Weger RA, Voest EE, Willems SM, Cuppen E, Koudijs MJ.

J Mol Diagn. 2015 Jan;17(1):10-8. doi: 10.1016/j.jmoldx.2014.09.004. Epub 2014 Oct 24.

PMID:
25445215
35.

Plasma levels of alpha-1-antichymotrypsin are elevated in patients with chronic heart failure, but are of limited prognostic value.

Lok SI, Lok DJ, van der Weide P, Winkens B, Bruggink-André de la Porte PW, Doevendans PA, de Weger RA, van der Meer P, de Jonge N.

Neth Heart J. 2014 Sep;22(9):391-5. doi: 10.1007/s12471-014-0584-2.

36.

Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.

Vercoulen Y, Bellutti Enders F, Meerding J, Plantinga M, Elst EF, Varsani H, van Schieveen C, Bakker MH, Klein M, Scholman RC, Spliet W, Ricotti V, Koenen HJ, de Weger RA, Wedderburn LR, van Royen-Kerkhof A, Prakken BJ.

PLoS One. 2014 Aug 26;9(8):e105353. doi: 10.1371/journal.pone.0105353. eCollection 2014.

37.

Distinct phenotypes of cardiac allograft vasculopathy after heart transplantation: a histopathological study.

Huibers MM, Vink A, Kaldeway J, Huisman A, Timmermans K, Leenders M, Schipper ME, Lahpor JR, Kirkels HJ, Klöpping C, de Jonge N, de Weger RA.

Atherosclerosis. 2014 Oct;236(2):353-9. doi: 10.1016/j.atherosclerosis.2014.07.016. Epub 2014 Aug 2.

PMID:
25128973
38.

High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy.

Gho JM, van Es R, Stathonikos N, Harakalova M, te Rijdt WP, Suurmeijer AJ, van der Heijden JF, de Jonge N, Chamuleau SA, de Weger RA, Asselbergs FW, Vink A.

PLoS One. 2014 Apr 14;9(4):e94820. doi: 10.1371/journal.pone.0094820. eCollection 2014.

39.

Humanized mouse models in transplantation research.

Hogenes M, Huibers M, Kroone C, de Weger R.

Transplant Rev (Orlando). 2014 Jul;28(3):103-10. doi: 10.1016/j.trre.2014.02.002. Epub 2014 Feb 14. Review.

PMID:
24636846
40.

[Granular cell tumors of the orbit: diagnostics and therapeutic aspects exemplified by a case report].

Emesz M, Arlt EM, Krall EM, Bauer FM, Weger R, Emberger M, Rasp M.

Ophthalmologe. 2014 Sep;111(9):866-70. doi: 10.1007/s00347-013-2972-1. German.

PMID:
24173669
41.

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.

Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ.

Nat Cell Biol. 2013 Nov;15(11):1282-93. doi: 10.1038/ncb2866. Epub 2013 Oct 27.

PMID:
24161931
42.

Immune regulators regulated to prevent transplant reactions.

de Weger RA.

J Am Coll Cardiol. 2014 Jan 7-14;63(1):30-2. doi: 10.1016/j.jacc.2013.07.073. Epub 2013 Aug 28. No abstract available.

43.

The estimation of tumor cell percentage for molecular testing by pathologists is not accurate.

Smits AJ, Kummer JA, de Bruin PC, Bol M, van den Tweel JG, Seldenrijk KA, Willems SM, Offerhaus GJ, de Weger RA, van Diest PJ, Vink A.

Mod Pathol. 2014 Feb;27(2):168-74. doi: 10.1038/modpathol.2013.134. Epub 2013 Jul 26.

44.

Single-centre experience of 85 patients with a continuous-flow left ventricular assist device: clinical practice and outcome after extended support.

Lok SI, Martina JR, Hesselink T, Rodermans BF, Hulstein N, Winkens B, Klöpping C, Kirkels JH, Doevendans PA, Ramjankhan F, de Weger RA, de Jonge N, Lahpor JR.

Eur J Cardiothorac Surg. 2013 Sep;44(3):e233-8. doi: 10.1093/ejcts/ezt347. Epub 2013 Jul 18.

PMID:
23868955
45.

Analysis of aortic valve commissural fusion after support with continuous-flow left ventricular assist device.

Martina JR, Schipper ME, de Jonge N, Ramjankhan F, de Weger RA, Lahpor JR, Vink A.

Interact Cardiovasc Thorac Surg. 2013 Oct;17(4):616-24. doi: 10.1093/icvts/ivt263. Epub 2013 Jun 24.

46.

Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA.

Cardiovasc Pathol. 2013 Sep-Oct;22(5):314-8. doi: 10.1016/j.carpath.2013.04.002. Epub 2013 May 17.

PMID:
23688911
47.

Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support.

Lok SI, van Mil A, Bovenschen N, van der Weide P, van Kuik J, van Wichen D, Peeters T, Siera E, Winkens B, Sluijter JP, Doevendans PA, da Costa Martins PA, de Jonge N, de Weger RA.

Circ Heart Fail. 2013 Jul;6(4):853-61. doi: 10.1161/CIRCHEARTFAILURE.112.000255. Epub 2013 May 2.

PMID:
23640964
48.

Congenital posterior pole cataract and adult onset dilating cardiomyopathy: expanding the phenotype of αB-crystallinopathies.

van der Smagt JJ, Vink A, Kirkels JH, Nelen M, ter Heide H, Molenschot MM, Weger RA, Schellekens PA, Hoogendijk J, Dooijes D.

Clin Genet. 2014 Apr;85(4):381-5. doi: 10.1111/cge.12169. Epub 2013 May 13.

PMID:
23590293
49.

A deep sequencing approach to uncover the miRNOME in the human heart.

Leptidis S, El Azzouzi H, Lok SI, de Weger R, Olieslagers S, Kisters N, Silva GJ, Heymans S, Cuppen E, Berezikov E, De Windt LJ, da Costa Martins P.

PLoS One. 2013;8(2):e57800. doi: 10.1371/journal.pone.0057800. Epub 2013 Feb 27. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/e33f9763-3385-42c7-b31e-d433dc8e499a. Olieslagers, Serv [corrected to Olieslagers, Servé].

50.

Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA.

Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.

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