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Items: 15


Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis.

Kwan R, Brady GF, Brzozowski M, Weerasinghe SV, Martin H, Park MJ, Brunt MJ, Menon RK, Tong X, Yin L, Stewart CL, Omary MB.

Cell Mol Gastroenterol Hepatol. 2017 Jul 6;4(3):365-383. doi: 10.1016/j.jcmgh.2017.06.005. eCollection 2017 Nov.


Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis.

Weerasinghe SV, Park MJ, Portney DA, Omary MB.

Mol Biol Cell. 2016 Oct 15;27(20):3005-3012. Epub 2016 Aug 17.


Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid.

Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK.

Arch Pharm (Weinheim). 2016 May;349(5):373-82. doi: 10.1002/ardp.201500472. Epub 2016 Apr 9.


PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.

Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB.

Hepatology. 2015 Dec;62(6):1858-69. doi: 10.1002/hep.27965. Epub 2015 Aug 25.


Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.

Weerasinghe SV, Jang YJ, Fontana RJ, Omary MB.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G355-64. doi: 10.1152/ajpgi.00303.2013. Epub 2014 Jun 12.


Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.

Weerasinghe SV, Ku NO, Altshuler PJ, Kwan R, Omary MB.

J Cell Sci. 2014 Apr 1;127(Pt 7):1464-75. doi: 10.1242/jcs.138479. Epub 2014 Jan 24.


CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation.

Snider NT, Griggs NW, Singla A, Moons DS, Weerasinghe SV, Lok AS, Ruan C, Burant CF, Conjeevaram HS, Omary MB.

Hepatology. 2013 Nov;58(5):1790-800. doi: 10.1002/hep.26525. Epub 2013 Aug 26.


Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation.

Snider NT, Weerasinghe SV, Singla A, Leonard JM, Hanada S, Andrews PC, Lok AS, Omary MB.

J Cell Biol. 2011 Oct 17;195(2):217-29. doi: 10.1083/jcb.201102142.


The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.

Choi SE, Weerasinghe SV, Pflum MK.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6139-42. doi: 10.1016/j.bmcl.2011.08.027. Epub 2011 Aug 12.


Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.

Weerasinghe SV, Moons DS, Altshuler PJ, Shah YM, Omary MB.

Hepatology. 2011 Apr;53(4):1323-32. doi: 10.1002/hep.24203.


Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB.

J Biol Chem. 2011 Jan 21;286(3):2273-84. doi: 10.1074/jbc.M110.171314. Epub 2010 Nov 9.


A histone deacetylase-dependent screen in yeast.

Weerasinghe SV, Wambua M, Pflum MK.

Bioorg Med Chem. 2010 Nov 1;18(21):7586-92. doi: 10.1016/j.bmc.2010.08.045. Epub 2010 Sep 20.


Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.

Weerasinghe SV, Estiu G, Wiest O, Pflum MK.

J Med Chem. 2008 Sep 25;51(18):5542-51. doi: 10.1021/jm800081j. Epub 2008 Aug 27.


Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.

Singh EK, Ravula S, Pan CM, Pan PS, Vasko RC, Lapera SA, Weerasinghe SV, Pflum MK, McAlpine SR.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2549-54. doi: 10.1016/j.bmcl.2008.03.047. Epub 2008 Mar 20.


Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

Bieliauskas AV, Weerasinghe SV, Pflum MK.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2216-9. Epub 2007 Feb 8.

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