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Items: 1 to 50 of 90

1.

A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation.

Hoffman KS, Vargas-Rodriguez O, Bak DW, Mukai T, Woodward LK, Weerapana E, Söll D, Reynolds NM.

J Biol Chem. 2019 Jul 11. pii: jbc.RA119.008219. doi: 10.1074/jbc.RA119.008219. [Epub ahead of print]

2.

Halogen Bonding Increases the Potency and Isozyme-selectivity of Protein Arginine Deiminase 1 Inhibitors.

Mondal S, Gong X, Zhang X, Salinger AJ, Zheng L, Sen S, Weerapana E, Zhang X, Thompson P.

Angew Chem Int Ed Engl. 2019 Jul 5. doi: 10.1002/anie.201906334. [Epub ahead of print]

PMID:
31276611
3.

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury.

Sorvillo N, Mizurini D, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson P, Wagner DD.

Circ Res. 2019 Jun 28. doi: 10.1161/CIRCRESAHA.118.314571. [Epub ahead of print]

PMID:
31248335
4.

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2.

Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR.

Biochemistry. 2019 Jul 9;58(27):3042-3056. doi: 10.1021/acs.biochem.9b00225. Epub 2019 Jun 27.

PMID:
31243954
5.

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.

Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon ER, Lyssiotis CA, Weerapana E, Banerjee R.

J Biol Chem. 2019 Jun 18. pii: jbc.RA119.009442. doi: 10.1074/jbc.RA119.009442. [Epub ahead of print]

6.

Triazine probes targeting ascorbate peroxidases in plants.

Morimoto K, Cole KS, Kourelis J, Witt CH, Brown D, Krahn D, Stegmann M, Kaschani F, Kaiser M, Burton J, Mohammed S, Yamaguchi-Shinozaki K, Weerapana E, van der Hoorn RAL.

Plant Physiol. 2019 May 28. pii: pp.00481.2019. doi: 10.1104/pp.19.00481. [Epub ahead of print]

PMID:
31138623
7.

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.

Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, Hergenrother PJ.

Nat Chem. 2019 Jun;11(6):521-532. doi: 10.1038/s41557-019-0261-6. Epub 2019 May 13.

PMID:
31086302
8.

Interrogation of Functional Mitochondrial Cysteine Residues by Quantitative Mass Spectrometry.

Bak DW, Weerapana E.

Methods Mol Biol. 2019;1967:211-227. doi: 10.1007/978-1-4939-9187-7_13.

PMID:
31069773
9.

Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase.

Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR.

ACS Chem Biol. 2019 Apr 19;14(4):613-618. doi: 10.1021/acschembio.9b00211. Epub 2019 Apr 5.

PMID:
30933557
10.

Mutually Orthogonal Nonsense-Suppression Systems and Conjugation Chemistries for Precise Protein Labeling at up to Three Distinct Sites.

Italia JS, Addy PS, Erickson SB, Peeler JC, Weerapana E, Chatterjee A.

J Am Chem Soc. 2019 Apr 17;141(15):6204-6212. doi: 10.1021/jacs.8b12954. Epub 2019 Apr 8.

PMID:
30909694
11.

Reactive-cysteine profiling for drug discovery.

Maurais AJ, Weerapana E.

Curr Opin Chem Biol. 2019 Jun;50:29-36. doi: 10.1016/j.cbpa.2019.02.010. Epub 2019 Mar 18. Review.

PMID:
30897495
12.

A chemoproteomic portrait of the oncometabolite fumarate.

Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, Levy M, Florens L, Washburn MP, Frizzell N, Dykhuizen EC, Weerapana E, Linehan WM, Meier JL.

Nat Chem Biol. 2019 Apr;15(4):391-400. doi: 10.1038/s41589-018-0217-y. Epub 2019 Feb 4.

PMID:
30718813
13.

Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.

Long MJC, Lawson AP, Baggio R, Qian Y, Rozhansky L, Fasci D, El Oualid F, Weerapana E, Hedstrom L.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):204-211. doi: 10.1016/j.bmcl.2018.11.055. Epub 2018 Nov 28.

PMID:
30528168
14.

Cysteine reactivity across the subcellular universe.

Bak DW, Bechtel TJ, Falco JA, Weerapana E.

Curr Opin Chem Biol. 2019 Feb;48:96-105. doi: 10.1016/j.cbpa.2018.11.002. Epub 2018 Nov 30. Review.

PMID:
30508703
15.

Selenium-Encoded Isotopic Signature Targeted Profiling.

Gao J, Yang F, Che J, Han Y, Wang Y, Chen N, Bak DW, Lai S, Xie X, Weerapana E, Wang C.

ACS Cent Sci. 2018 Aug 22;4(8):960-970. doi: 10.1021/acscentsci.8b00112. Epub 2018 Jul 16.

16.

NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila.

Luo W, Guo F, McMahon A, Couvertier S, Jin H, Diaz M, Fieldsend A, Weerapana E, Rosbash M.

Neuron. 2018 Aug 22;99(4):768-780.e3. doi: 10.1016/j.neuron.2018.07.001. Epub 2018 Jul 26.

PMID:
30057203
17.

Citrullination Inactivates Nicotinamide- N-methyltransferase.

Nemmara VV, Tilvawala R, Salinger AJ, Miller L, Nguyen SH, Weerapana E, Thompson PR.

ACS Chem Biol. 2018 Sep 21;13(9):2663-2672. doi: 10.1021/acschembio.8b00578. Epub 2018 Aug 8.

PMID:
30044909
18.

A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome.

Bak DW, Gao J, Wang C, Weerapana E.

Cell Chem Biol. 2018 Sep 20;25(9):1157-1167.e4. doi: 10.1016/j.chembiol.2018.05.017. Epub 2018 Jul 5.

PMID:
29983274
19.

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP).

Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M.

Nat Chem Biol. 2018 Jun;14(6):609-617. doi: 10.1038/s41589-018-0060-1. Epub 2018 May 16.

20.

The Rheumatoid Arthritis-Associated Citrullinome.

Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR.

Cell Chem Biol. 2018 Jun 21;25(6):691-704.e6. doi: 10.1016/j.chembiol.2018.03.002. Epub 2018 Apr 5.

21.

Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.

Cole KS, Grandjean JMD, Chen K, Witt CH, O'Day J, Shoulders MD, Wiseman RL, Weerapana E.

Biochemistry. 2018 Apr 3;57(13):2035-2043. doi: 10.1021/acs.biochem.8b00178. Epub 2018 Mar 19.

22.

The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs).

Nemmara VV, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR.

ACS Chem Biol. 2018 Mar 16;13(3):712-722. doi: 10.1021/acschembio.7b00957. Epub 2018 Feb 1.

23.

Isotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.

Abo M, Li C, Weerapana E.

Mol Pharm. 2018 Mar 5;15(3):743-749. doi: 10.1021/acs.molpharmaceut.7b00832. Epub 2017 Dec 6.

24.

Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor.

Gorelenkova Miller O, Cole KS, Emerson CC, Allimuthu D, Golczak M, Stewart PL, Weerapana E, Adams DJ, Mieyal JJ.

PLoS One. 2017 Nov 20;12(11):e0187991. doi: 10.1371/journal.pone.0187991. eCollection 2017.

25.

Chemical Probes for Redox Signaling and Oxidative Stress.

Abo M, Weerapana E.

Antioxid Redox Signal. 2019 Apr 1;30(10):1369-1386. doi: 10.1089/ars.2017.7408. Epub 2017 Dec 22.

PMID:
29132214
26.

Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.

Lawson AP, Bak DW, Shannon DA, Long MJC, Vijaykumar T, Yu R, Oualid FE, Weerapana E, Hedstrom L.

Oncotarget. 2017 Apr 20;8(31):51296-51316. doi: 10.18632/oncotarget.17261. eCollection 2017 Aug 1.

27.

Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα.

Sun B, Dwivedi N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho IC.

Sci Immunol. 2017 Jun 9;2(12). pii: eaal3062. doi: 10.1126/sciimmunol.aal3062.

28.

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.

Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. doi: 10.1073/pnas.1614943114. Epub 2017 May 22.

29.

Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.

Casás-Selves M, Zhang AX, Dowling JE, Hallén S, Kawatkar A, Pace NJ, Denz CR, Pontz T, Garahdaghi F, Cao Q, Sabirsh A, Thakur K, O'Connell N, Hu J, Cornella-Taracido I, Weerapana E, Zinda M, Goodnow RA Jr, Castaldi MP.

ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26.

PMID:
28371485
30.

Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.

Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M.

MBio. 2017 Feb 28;8(1). pii: e02189-16. doi: 10.1128/mBio.02189-16.

31.

Identifying Functional Cysteine Residues in the Mitochondria.

Bak DW, Pizzagalli MD, Weerapana E.

ACS Chem Biol. 2017 Apr 21;12(4):947-957. doi: 10.1021/acschembio.6b01074. Epub 2017 Feb 15.

32.

Redox regulation: Taking AKTion on HNEs.

Weerapana E.

Nat Chem Biol. 2017 Mar;13(3):244-245. doi: 10.1038/nchembio.2311. Epub 2017 Jan 23. No abstract available.

PMID:
28114275
33.

From structure to redox: The diverse functional roles of disulfides and implications in disease.

Bechtel TJ, Weerapana E.

Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600391. Review.

34.

Optimization of Caged Electrophiles for Improved Monitoring of Cysteine Reactivity in Living Cells.

Abo M, Bak DW, Weerapana E.

Chembiochem. 2017 Jan 3;18(1):81-84. doi: 10.1002/cbic.201600524. Epub 2016 Dec 5.

35.
36.

Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity.

Martell J, Seo Y, Bak DW, Kingsley SF, Tissenbaum HA, Weerapana E.

Cell Chem Biol. 2016 Aug 18;23(8):955-66. doi: 10.1016/j.chembiol.2016.06.015. Epub 2016 Aug 4.

37.

Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2.

Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E.

Cell Chem Biol. 2016 Jun 23;23(6):727-37. doi: 10.1016/j.chembiol.2016.05.008. Epub 2016 Jun 9.

38.

A clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism.

Samarasinghe KT, Munkanatta Godage DN, Zhou Y, Ndombera FT, Weerapana E, Ahn YH.

Mol Biosyst. 2016 Jul 19;12(8):2471-80. doi: 10.1039/c6mb00175k.

39.

Protein labelling.

Jones LH, Weerapana E.

Mol Biosyst. 2016 May 24;12(6):1725-7. doi: 10.1039/c6mb90019d. No abstract available.

PMID:
27215194
40.

Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera.

Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK.

Nat Chem Biol. 2016 May 18;12(6):466. doi: 10.1038/nchembio0616-466. No abstract available.

PMID:
27191648
41.

GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.

Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK.

Cell Chem Biol. 2016 May 19;23(5):567-578. doi: 10.1016/j.chembiol.2016.03.017. Epub 2016 May 12.

42.

A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1).

Crawford LA, Weerapana E.

Mol Biosyst. 2016 May 24;12(6):1768-71. doi: 10.1039/c6mb00250a.

43.

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.

Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M.

Elife. 2016 Mar 24;5:e13663. doi: 10.7554/eLife.13663.

44.

Chemoproteomic profiling of host and pathogen enzymes active in cholera.

Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK.

Nat Chem Biol. 2016 Apr;12(4):268-274. doi: 10.1038/nchembio.2025. Epub 2016 Feb 22. Erratum in: Nat Chem Biol. 2016 May 18;12(6):466.

45.

Editorial overview: Omics: The maturation of chemical biology.

Saghatelian A, Nomura DK, Weerapana E.

Curr Opin Chem Biol. 2016 Feb;30:v-vi. doi: 10.1016/j.cbpa.2015.12.005. Epub 2015 Dec 28. No abstract available.

PMID:
26739665
46.

Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.

Lawson AP, Long MJC, Coffey RT, Qian Y, Weerapana E, El Oualid F, Hedstrom L.

Cancer Res. 2015 Dec 1;75(23):5130-5142. doi: 10.1158/0008-5472.CAN-15-1544. Epub 2015 Nov 5.

47.

Detection and identification of protein citrullination in complex biological systems.

Clancy KW, Weerapana E, Thompson PR.

Curr Opin Chem Biol. 2016 Feb;30:1-6. doi: 10.1016/j.cbpa.2015.10.014. Epub 2015 Oct 27. Review.

48.

Chemical Proteomic Platform To Identify Citrullinated Proteins.

Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR.

ACS Chem Biol. 2015 Nov 20;10(11):2520-8. doi: 10.1021/acschembio.5b00438. Epub 2015 Sep 23.

49.

A Caged Electrophilic Probe for Global Analysis of Cysteine Reactivity in Living Cells.

Abo M, Weerapana E.

J Am Chem Soc. 2015 Jun 10;137(22):7087-90. doi: 10.1021/jacs.5b04350. Epub 2015 Jun 1.

PMID:
26020833
50.

Cysteine-mediated redox signalling in the mitochondria.

Bak DW, Weerapana E.

Mol Biosyst. 2015 Mar;11(3):678-97. doi: 10.1039/c4mb00571f. Epub 2014 Dec 18. Review.

PMID:
25519845

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