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Items: 7

1.

The pharmacodynamic effects of combined administration of flibanserin and alcohol.

Stevens DM, Weems JM, Brown L, Barbour KA, Stahl SM.

J Clin Pharm Ther. 2017 Oct;42(5):598-606. doi: 10.1111/jcpt.12563. Epub 2017 Jun 13.

PMID:
28608926
2.

KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.

Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL.

Cancer Res. 2012 May 15;72(10):2554-64. doi: 10.1158/0008-5472.CAN-11-3552.

3.

Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.

Weems JM, Lamb JG, D'Agostino J, Ding X, Yost GS.

Chem Res Toxicol. 2010 Nov 15;23(11):1682-90. doi: 10.1021/tx100147z. Epub 2010 Aug 26.

4.

3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.

Weems JM, Yost GS.

Chem Res Toxicol. 2010 Mar 15;23(3):696-704. doi: 10.1021/tx9004506.

5.

3-Methylindole is mutagenic and a possible pulmonary carcinogen.

Weems JM, Cutler NS, Moore C, Nichols WK, Martin D, Makin E, Lamb JG, Yost GS.

Toxicol Sci. 2009 Nov;112(1):59-67. doi: 10.1093/toxsci/kfp201. Epub 2009 Aug 21.

6.

Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation.

Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM.

Biochem Biophys Res Commun. 2008 Jul 18;372(1):216-20. doi: 10.1016/j.bbrc.2008.05.013. Epub 2008 May 12.

7.

Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2.

Seasholtz TM, Radeff-Huang J, Sagi SA, Matteo R, Weems JM, Cohen AS, Feramisco JR, Brown JH.

J Neurochem. 2004 Oct;91(2):501-12.

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