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Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound-associated extracellular matrix: implications for cancer therapy.

McNitt DH, Choi SJ, Allen JL, Hames RA, Weed SA, Van De Water L, Berisio R, Lukomski S.

Mol Microbiol. 2019 May 30. doi: 10.1111/mmi.14317. [Epub ahead of print]


Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function, and Tumor Cell Invasion.

Markwell SM, Ammer AG, Interval ET, Allen JL, Papenberg BW, Hames RA, Castaño JE, Schafer DA, Weed SA.

Mol Cancer Res. 2019 Apr;17(4):987-1001. doi: 10.1158/1541-7786.MCR-18-0391. Epub 2019 Jan 4.


Beyond muscles: The untapped potential of creatine.

Riesberg LA, Weed SA, McDonald TL, Eckerson JM, Drescher KM.

Int Immunopharmacol. 2016 Aug;37:31-42. doi: 10.1016/j.intimp.2015.12.034. Epub 2016 Jan 8. Review.


High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes.

Walk EL, McLaughlin SL, Weed SA.

J Vis Exp. 2015 Jul 25;(101):e52718. doi: 10.3791/52718.


Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion.

Markwell SM, Weed SA.

Cancers (Basel). 2015 Feb 27;7(1):382-406. doi: 10.3390/cancers7010382. Review.


Use of high frequency ultrasound to monitor cervical lymph node alterations in mice.

Walk EL, McLaughlin S, Coad J, Weed SA.

PLoS One. 2014 Jun 23;9(6):e100185. doi: 10.1371/journal.pone.0100185. eCollection 2014.


NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.

Kozyreva VK, McLaughlin SL, Livengood RH, Calkins RA, Kelley LC, Rajulapati A, Ice RJ, Smolkin MB, Weed SA, Pugacheva EN.

Mol Cancer Res. 2014 May;12(5):681-93. doi: 10.1158/1541-7786.MCR-13-0654. Epub 2014 Feb 26.


NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

McLaughlin SL, Ice RJ, Rajulapati A, Kozyulina PY, Livengood RH, Kozyreva VK, Loskutov YV, Culp MV, Weed SA, Ivanov AV, Pugacheva EN.

Mol Cancer Res. 2014 Jan;12(1):69-81. doi: 10.1158/1541-7786.MCR-13-0300. Epub 2013 Nov 7.


Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa.

Novotny MJ, Bridge DR, Martin KH, Weed SA, Wysolmerski RB, Olson JC.

Biol Open. 2013 Jul 3;2(9):891-900. doi: 10.1242/bio.20133632. eCollection 2013.


SRChing for the substrates of Src.

Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT.

Oncogene. 2014 Sep 11;33(37):4537-47. doi: 10.1038/onc.2013.416. Epub 2013 Oct 14. Review.


Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion.

Liu Y, Conaway L, Rutherford Bethard J, Al-Ayoubi AM, Thompson Bradley A, Zheng H, Weed SA, Eblen ST.

Nucleic Acids Res. 2013 May;41(9):4949-62. doi: 10.1093/nar/gkt170. Epub 2013 Mar 21.


Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop.

Hayes KE, Walk EL, Ammer AG, Kelley LC, Martin KH, Weed SA.

Oncogene. 2013 Oct;32(40):4766-77. doi: 10.1038/onc.2012.513. Epub 2012 Nov 12.


Src binds cortactin through an SH2 domain cystine-mediated linkage.

Evans JV, Ammer AG, Jett JE, Bolcato CA, Breaux JC, Martin KH, Culp MV, Gannett PM, Weed SA.

J Cell Sci. 2012 Dec 15;125(Pt 24):6185-97. doi: 10.1242/jcs.121046. Epub 2012 Oct 24.


Effects of tobacco smoking and nicotine on cancer treatment.

Petros WP, Younis IR, Ford JN, Weed SA.

Pharmacotherapy. 2012 Oct;32(10):920-31. doi: 10.1002/j.1875-9114.2012.01117. Review.


Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.

Martin KH, Hayes KE, Walk EL, Ammer AG, Markwell SM, Weed SA.

J Vis Exp. 2012 Aug 27;(66):e4119. doi: 10.3791/4119.


Further insights into cortactin conformational regulation.

Evans JV, Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.

Bioarchitecture. 2011 Jan;1(1):21-23.


Multi-photon imaging of tumor cell invasion in an orthotopic mouse model of oral squamous cell carcinoma.

Gatesman Ammer A, Hayes KE, Martin KH, Zhang L, Spirou GA, Weed SA.

J Vis Exp. 2011 Jul 25;(53). pii: 2941. doi: 10.3791/2941.


Revisiting the ERK/Src cortactin switch.

Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.

Commun Integr Biol. 2011 Mar;4(2):205-7. doi: 10.4161/cib.4.2.14420.


Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.

Walk EL, Weed SA.

Cancers (Basel). 2011 Feb 22;3(1):747-72. doi: 10.3390/cancers3010747.


Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.

Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.

PLoS One. 2010 Nov 4;5(11):e13847. doi: 10.1371/journal.pone.0013847.


Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.

Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA.

J Cell Sci. 2010 Nov 15;123(Pt 22):3923-32. doi: 10.1242/jcs.075200. Epub 2010 Oct 27.


Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function.

Ammer AG, Kelley LC, Hayes KE, Evans JV, Lopez-Skinner LA, Martin KH, Frederick B, Rothschild BL, Raben D, Elvin P, Green TP, Weed SA.

J Cancer Sci Ther. 2009 Nov 30;1(2):52-61.


Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers.

Ren G, Helwani FM, Verma S, McLachlan RW, Weed SA, Yap AS.

J Biol Chem. 2009 Jul 10;284(28):18913-22. doi: 10.1074/jbc.M109.000307. Epub 2009 May 19.


Cortactin branches out: roles in regulating protrusive actin dynamics.

Ammer AG, Weed SA.

Cell Motil Cytoskeleton. 2008 Sep;65(9):687-707. doi: 10.1002/cm.20296. Review.


Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.

Dorfleutner A, Cho Y, Vincent D, Cunnick J, Lin H, Weed SA, Stehlik C, Flynn DC.

J Cell Sci. 2008 Jul 15;121(Pt 14):2394-405. doi: 10.1242/jcs.026187. Epub 2008 Jun 24.


Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer.

Kelley LC, Shahab S, Weed SA.

Clin Exp Metastasis. 2008;25(4):289-304. doi: 10.1007/s10585-008-9154-6. Epub 2008 Mar 7. Review.


PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.

Walker VG, Ammer A, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot H, Flynn DC.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C119-32. Epub 2007 Mar 14.


Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.

Greer RO Jr, Said S, Shroyer KR, Marileila VG, Weed SA.

Oral Oncol. 2007 Sep;43(8):735-41. Epub 2006 Nov 17.


Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.

Rothschild BL, Shim AH, Ammer AG, Kelley LC, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, Weed SA.

Cancer Res. 2006 Aug 15;66(16):8017-25.


Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.

Gatesman A, Walker VG, Baisden JM, Weed SA, Flynn DC.

Mol Cell Biol. 2004 Sep;24(17):7578-97.


Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.

Bougnères L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT.

J Cell Biol. 2004 Jul 19;166(2):225-35.


Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.

Fan L, Di Ciano-Oliveira C, Weed SA, Craig AW, Greer PA, Rotstein OD, Kapus A.

Biochem J. 2004 Jun 1;380(Pt 2):581-91.


Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization.

Helwani FM, Kovacs EM, Paterson AD, Verma S, Ali RG, Fanning AS, Weed SA, Yap AS.

J Cell Biol. 2004 Mar 15;164(6):899-910.


Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells.

McWilliams RR, Gidey E, Fouassier L, Weed SA, Doctor RB.

Biochem J. 2004 May 15;380(Pt 1):181-91.


Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages.

Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL.

J Cell Sci. 2004 Jan 15;117(Pt 2):243-55.


Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA.

Mol Biol Cell. 2003 Aug;14(8):3216-29. Epub 2003 Apr 17.


MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL.

EMBO J. 2003 Jul 1;22(13):3346-55.


Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion.

Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT.

Curr Biol. 2003 Mar 4;13(5):384-93.


Dynamin2 and cortactin regulate actin assembly and filament organization.

Schafer DA, Weed SA, Binns D, Karginov AV, Parsons JT, Cooper JA.

Curr Biol. 2002 Oct 29;12(21):1852-7.


Cortactin: coupling membrane dynamics to cortical actin assembly.

Weed SA, Parsons JT.

Oncogene. 2001 Oct 1;20(44):6418-34. Review.


Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain.

Zhang Z, Weed SA, Gallagher PG, Morrow JS.

Blood. 2001 Sep 15;98(6):1645-53.


Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.

Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, Cooper JA.

Curr Biol. 2001 Mar 6;11(5):370-4.


Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.

Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA.

Oncogene. 2000 Nov 20;19(49):5606-13. Review.


Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.

Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT.

J Cell Biol. 2000 Oct 2;151(1):29-40.


Regulation of c-SRC activity and function by the adapter protein CAS.

Burnham MR, Bruce-Staskal PJ, Harte MT, Weidow CL, Ma A, Weed SA, Bouton AH.

Mol Cell Biol. 2000 Aug;20(16):5865-78.


Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons.

Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT.

Mol Cell Biol. 1998 Oct;18(10):5838-51.


Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.

Weed SA, Du Y, Parsons JT.

J Cell Sci. 1998 Aug;111 ( Pt 16):2433-43.


Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.

Gallagher PG, Petruzzi MJ, Weed SA, Zhang Z, Marchesi SL, Mohandas N, Morrow JS, Forget BG.

J Clin Invest. 1997 Jan 15;99(2):267-77.


The lethal hemolytic mutation in beta I sigma 2 spectrin Providence yields a null phenotype in neonatal skeletal muscle.

Weed SA, Stabach PR, Oyer CE, Gallagher PG, Morrow JS.

Lab Invest. 1996 Jun;74(6):1117-29.


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