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Items: 1 to 50 of 93


Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.

Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC.

Alzheimers Res Ther. 2019 Jun 29;11(1):58. doi: 10.1186/s13195-019-0507-y.


The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling.

Blair LJ, Criado-Marrero M, Zheng D, Wang X, Kamath S, Nordhues BA, Weeber EJ, Dickey CA.

eNeuro. 2019 Mar 1;6(1). pii: ENEURO.0242-18.2019. doi: 10.1523/ENEURO.0242-18.2019. eCollection 2019 Jan-Feb.


Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice.

Grimmig B, Hudson C, Moss L, Peters M, Subbarayan M, Weeber EJ, Bickford PC.

Geroscience. 2019 Feb;41(1):77-87. doi: 10.1007/s11357-019-00051-9. Epub 2019 Feb 9.


Identification of spatiotemporal gait parameters and pressure-related characteristics in children with Angelman syndrome: A pilot study.

Grieco JC, Gouelle A, Weeber EJ.

J Appl Res Intellect Disabil. 2018 Nov;31(6):1219-1224. doi: 10.1111/jar.12462. Epub 2018 May 8.


A randomized controlled trial of levodopa in patients with Angelman syndrome.

Tan WH, Bird LM, Sadhwani A, Barbieri-Welge RL, Skinner SA, Horowitz LT, Bacino CA, Noll LM, Fu C, Hundley RJ, Wink LK, Erickson CA, Barnes GN, Slavotinek A, Jeremy R, Rotenberg A, Kothare SV, Olson HE, Poduri A, Nespeca MP, Chu HC, Willen JM, Haas KF, Weeber EJ, Rufo PA.

Am J Med Genet A. 2018 May;176(5):1099-1107. doi: 10.1002/ajmg.a.38457. Epub 2017 Sep 25.


Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice.

Born HA, Dao AT, Levine AT, Lee WL, Mehta NM, Mehra S, Weeber EJ, Anderson AE.

Sci Rep. 2017 Aug 16;7(1):8451. doi: 10.1038/s41598-017-08825-x.


Quantitative Measurement of Communication Ability in Children with Angelman Syndrome.

Grieco JC, Bahr RH, Schoenberg MR, Conover L, Mackie LN, Weeber EJ.

J Appl Res Intellect Disabil. 2018 Jan;31(1):e49-e58. doi: 10.1111/jar.12305. Epub 2016 Dec 19.


Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model.

Ciarlone SL, Wang X, Rogawski MA, Weeber EJ.

Neuropharmacology. 2017 Apr;116:142-150. doi: 10.1016/j.neuropharm.2016.12.009. Epub 2016 Dec 13.


Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model.

Ciarlone SL, Grieco JC, D'Agostino DP, Weeber EJ.

Neurobiol Dis. 2016 Dec;96:38-46. doi: 10.1016/j.nbd.2016.08.002. Epub 2016 Aug 18.


Reelin Proteolysis Affects Signaling Related to Normal Synapse Function and Neurodegeneration.

Lussier AL, Weeber EJ, Rebeck GW.

Front Cell Neurosci. 2016 Mar 29;10:75. doi: 10.3389/fncel.2016.00075. eCollection 2016. Review.


Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome.

Hethorn WR, Ciarlone SL, Filonova I, Rogers JT, Aguirre D, Ramirez RA, Grieco JC, Peters MM, Gulick D, Anderson AE, L Banko J, Lussier AL, Weeber EJ.

Eur J Neurosci. 2015 May;41(10):1372-80. doi: 10.1111/ejn.12893. Epub 2015 Apr 13.


An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome.

Grieco JC, Ciarlone SL, Gieron-Korthals M, Schoenberg MR, Smith AG, Philpot RM, Heussler HS, Banko JL, Weeber EJ.

BMC Neurol. 2014 Dec 10;14:232. doi: 10.1186/s12883-014-0232-x.


Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.

Burrell TC, Divekar SD, Weeber EJ, Rebeck GW.

PLoS One. 2014 Oct 23;9(10):e110845. doi: 10.1371/journal.pone.0110845. eCollection 2014.


Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.

Rueli RH, Parubrub AC, Dewing AS, Hashimoto AC, Bellinger MT, Weeber EJ, Uyehara-Lock JH, White LR, Berry MJ, Bellinger FP.

J Alzheimers Dis. 2015;44(2):379-83. doi: 10.3233/JAD-141755.


Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation.

Trotter JH, Lussier AL, Psilos KE, Mahoney HL, Sponaugle AE, Hoe HS, Rebeck GW, Weeber EJ.

Neuroscience. 2014 Aug 22;274:299-307. doi: 10.1016/j.neuroscience.2014.05.046. Epub 2014 Jun 2.


Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2.

Divekar SD, Burrell TC, Lee JE, Weeber EJ, Rebeck GW.

J Biol Chem. 2014 Jun 6;289(23):15894-903. doi: 10.1074/jbc.M113.537548. Epub 2014 Apr 22.


In vivo administration of granulocyte colony-stimulating factor restores long-term depression in hippocampal slices prepared from transgenic APP/PS1 mice.

Song S, Wang X, Sava V, Weeber EJ, Sanchez-Ramos J.

J Neurosci Res. 2014 Aug;92(8):975-80. doi: 10.1002/jnr.23378. Epub 2014 Mar 24.


Activity-dependent changes in MAPK activation in the Angelman Syndrome mouse model.

Filonova I, Trotter JH, Banko JL, Weeber EJ.

Learn Mem. 2014 Jan 16;21(2):98-104. doi: 10.1101/lm.032375.113.


Dab1 is required for synaptic plasticity and associative learning.

Trotter J, Lee GH, Kazdoba TM, Crowell B, Domogauer J, Mahoney HM, Franco SJ, Müller U, Weeber EJ, D'Arcangelo G.

J Neurosci. 2013 Sep 25;33(39):15652-68. doi: 10.1523/JNEUROSCI.2010-13.2013.


Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA.

Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19.


Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex.

Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW.

Learn Mem. 2013 Apr 16;20(5):256-66. doi: 10.1101/lm.030031.112.


Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse.

Rogers JT, Zhao L, Trotter JH, Rusiana I, Peters MM, Li Q, Donaldson E, Banko JL, Keenoy KE, Rebeck GW, Hoe HS, D'Arcangelo G, Weeber EJ.

J Psychopharmacol. 2013 Apr;27(4):386-95. doi: 10.1177/0269881112463468. Epub 2012 Oct 26.


APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ.

J Biol Chem. 2012 Dec 7;287(50):41774-86. doi: 10.1074/jbc.M112.407957. Epub 2012 Oct 11.


Spatial and temporal silencing of the human maternal UBE3A gene.

Daily J, Smith AG, Weeber EJ.

Eur J Paediatr Neurol. 2012 Nov;16(6):587-91. doi: 10.1016/j.ejpn.2012.03.006. Epub 2012 May 3.


Single-crystal cubic silicon carbide: an in vivo biocompatible semiconductor for brain machine interface devices.

Frewin CL, Locke C, Saddow SE, Weeber EJ.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2957-60. doi: 10.1109/IEMBS.2011.6090582.


Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome.

Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ.

PLoS One. 2011;6(12):e27221. doi: 10.1371/journal.pone.0027221. Epub 2011 Dec 9.


Cotinine enhances the extinction of contextual fear memory and reduces anxiety after fear conditioning.

Zeitlin R, Patel S, Solomon R, Tran J, Weeber EJ, Echeverria V.

Behav Brain Res. 2012 Mar 17;228(2):284-93. doi: 10.1016/j.bbr.2011.11.023. Epub 2011 Nov 28.


CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.

Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM, Grimmig BA, Weeber EJ, Bickford PC, Gemma C.

J Neurosci. 2011 Nov 9;31(45):16241-50. doi: 10.1523/JNEUROSCI.3667-11.2011.


ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J.

J Neurosci. 2011 Oct 5;31(40):14413-23. doi: 10.1523/JNEUROSCI.3135-11.2011.


A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

O'Leary JC 3rd, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA.

PLoS One. 2011;6(9):e24840. doi: 10.1371/journal.pone.0024840. Epub 2011 Sep 15.


Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.

Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ.

Learn Mem. 2011 Aug 18;18(9):558-64. doi: 10.1101/lm.2153511. Print 2011 Sep.


Similarities and differences in structure, expression, and functions of VLDLR and ApoER2.

Reddy SS, Connor TE, Weeber EJ, Rebeck W.

Mol Neurodegener. 2011 May 9;6:30. doi: 10.1186/1750-1326-6-30.


The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.

Jinwal UK, Trotter JH, Abisambra JF, Koren J 3rd, Lawson LY, Vestal GD, O'Leary JC 3rd, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA.

J Biol Chem. 2011 May 13;286(19):16976-83. doi: 10.1074/jbc.M110.182493. Epub 2011 Mar 2.


ApoE receptor 2 regulates synapse and dendritic spine formation.

Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS.

PLoS One. 2011 Feb 15;6(2):e17203. doi: 10.1371/journal.pone.0017203.


Insights into synaptic function from mouse models of human cognitive disorders.

Banko JL, Trotter J, Weeber EJ.

Future Neurol. 2011 Jan;6(1):113-125.


Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.

Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G.

J Neurosci. 2010 Dec 15;30(50):17068-78. doi: 10.1523/JNEUROSCI.4067-10.2010.


Secretin deficiency causes impairment in survival of neural progenitor cells in mice.

Jukkola PI, Rogers JT, Kaspar BK, Weeber EJ, Nishijima I.

Hum Mol Genet. 2011 Mar 1;20(5):1000-7. doi: 10.1093/hmg/ddq545. Epub 2010 Dec 15.


Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J 3rd, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA.

J Neurosci. 2010 Nov 17;30(46):15374-82. doi: 10.1523/JNEUROSCI.3155-10.2010.


Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA.

Mol Neurodegener. 2010 Nov 1;5:45. doi: 10.1186/1750-1326-5-45.


Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome.

Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF.

Neurobiol Dis. 2010 Sep;39(3):283-91. doi: 10.1016/j.nbd.2010.04.012. Epub 2010 Apr 25.


Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit.

Qiu S, Champagne DL, Peters M, Catania EH, Weeber EJ, Levitt P, Pimenta AF.

Biol Psychiatry. 2010 Jul 15;68(2):197-204. doi: 10.1016/j.biopsych.2010.02.013. Epub 2010 Apr 10.


ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS.

J Neurosci. 2009 Dec 2;29(48):15317-22. doi: 10.1523/JNEUROSCI.4026-09.2009.


Chemical manipulation of hsp70 ATPase activity regulates tau stability.

Jinwal UK, Miyata Y, Koren J 3rd, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA.

J Neurosci. 2009 Sep 30;29(39):12079-88. doi: 10.1523/JNEUROSCI.3345-09.2009.


ApoE isoform-dependent changes in hippocampal synaptic function.

Korwek KM, Trotter JH, Ladu MJ, Sullivan PM, Weeber EJ.

Mol Neurodegener. 2009 May 27;4:21. doi: 10.1186/1750-1326-4-21.


Reelin and apoE actions on signal transduction, synaptic function and memory formation.

Rogers JT, Weeber EJ.

Neuron Glia Biol. 2008 Aug;4(3):259-70. doi: 10.1017/S1740925X09990184. Epub 2009 Aug 13. Review.


Impaired hippocampal synaptic function in secretin deficient mice.

Yamagata T, Urano H, Weeber EJ, Nelson DL, Nishijima I.

Neuroscience. 2008 Jul 17;154(4):1417-22. doi: 10.1016/j.neuroscience.2008.04.037. Epub 2008 May 2.


Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus.

Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ, Nguyen PV.

Learn Mem. 2008 May 28;15(6):403-11. doi: 10.1101/lm.830008. Print 2008 Jun.


Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.

Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI.

Hippocampus. 2008;18(8):814-23. doi: 10.1002/hipo.20442.


The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene.

Levenson JM, Qiu S, Weeber EJ.

Biochim Biophys Acta. 2008 Aug;1779(8):422-31. doi: 10.1016/j.bbagrm.2008.01.001. Epub 2008 Jan 12. Review.


Self-association of human PCSK9 correlates with its LDLR-degrading activity.

Fan D, Yancey PG, Qiu S, Ding L, Weeber EJ, Linton MF, Fazio S.

Biochemistry. 2008 Feb 12;47(6):1631-9. doi: 10.1021/bi7016359. Epub 2008 Jan 16.

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