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Items: 1 to 50 of 333

1.

A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: The ETHOS study protocol.

Rabe KF, Martinez FJ, Ferguson GT, Wang C, Singh D, Wedzicha JA, Trivedi R, St Rose E, Ballal S, McLaren J, Darken P, Reisner C, Dorinsky P.

Respir Med. 2019 Aug 22;158:59-66. doi: 10.1016/j.rmed.2019.08.010. [Epub ahead of print]

PMID:
31605923
2.

Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease.

Celli BR, Wedzicha JA.

N Engl J Med. 2019 Sep 26;381(13):1257-1266. doi: 10.1056/NEJMra1900500. Review. No abstract available.

PMID:
31553837
3.

Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease.

Singanayagam A, Glanville N, Cuthbertson L, Bartlett NW, Finney LJ, Turek E, Bakhsoliani E, Calderazzo MA, Trujillo-Torralbo MB, Footitt J, James PL, Fenwick P, Kemp SV, Clarke TB, Wedzicha JA, Edwards MR, Moffatt M, Cookson WO, Mallia P, Johnston SL.

Sci Transl Med. 2019 Aug 28;11(507). pii: eaav3879. doi: 10.1126/scitranslmed.aav3879.

PMID:
31462509
4.

Indacaterol/glycopyrronium versus tiotropium or glycopyrronium in long-acting bronchodilator-naïve COPD patients: A pooled analysis.

Muro S, Yoshisue H, Kostikas K, Olsson P, Gupta P, Wedzicha JA.

Respirology. 2019 Jul 24. doi: 10.1111/resp.13651. [Epub ahead of print]

5.

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.

Eur Respir J. 2019 Oct 10;54(4). pii: 1802244. doi: 10.1183/13993003.02244-2018. Print 2019 Oct.

PMID:
31320451
6.

Can Macrolide Antibiotics Prevent Hospital Readmissions?

Wedzicha JA, Ritchie AI, Martinez FJ.

Am J Respir Crit Care Med. 2019 Oct 1;200(7):796-798. doi: 10.1164/rccm.201905-0957ED. No abstract available.

7.

The Effect of Aclidinium on Symptoms Including Cough in Chronic Obstructive Pulmonary Disease: A Phase 4, Double-Blind, Placebo-controlled, Parallel-Group Study.

Smith JA, McGarvey L, Morice AH, Birring SS, Wedzicha JA, Notari M, Zapata A, Segarra R, Seoane B, Jarreta D.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):642-645. doi: 10.1164/rccm.201901-0048LE. No abstract available.

PMID:
30951372
8.

Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration.

Agusti A, Faner R, Donaldson G, Heuvelin E, Breyer-Kohansal R, Melén E, Maitland-van der Zee AH, Vestbo J, Allinson JP, Vanfleteren LEGW, van den Berge M, Adcock IM, Lahousse L, Brusselle G, Wedzicha JA; on behalf of the CADSET Clinical Research Collaboration; Current members of the CADSET Clinical Research Collaboration.

Eur Respir J. 2019 Mar 18;53(3). pii: 1900217. doi: 10.1183/13993003.00217-2019. Print 2019 Mar. No abstract available.

PMID:
30886026
9.

The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis.

Shi T, Arnott A, Semogas I, Falsey AR, Openshaw P, Wedzicha JA, Campbell H, Nair H; RESCEU Investigators .

J Infect Dis. 2019 Mar 8. pii: jiy662. doi: 10.1093/infdis/jiy662. [Epub ahead of print]

10.

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019.

Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Criner GJ, Frith P, Halpin DMG, Han M, López Varela MV, Martinez F, Montes de Oca M, Papi A, Pavord ID, Roche N, Sin DD, Stockley R, Vestbo J, Wedzicha JA, Vogelmeier C.

Eur Respir J. 2019 May 18;53(5). pii: 1900164. doi: 10.1183/13993003.00164-2019. Print 2019 May. Review.

PMID:
30846476
11.

ILD: Upcoming Themed Issue.

Martinez FJ, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):131. doi: 10.1164/rccm.1992ed1. No abstract available.

12.

Treatment response to indacaterol/glycopyrronium versus salmeterol/fluticasone in exacerbating COPD patients by gender: a post-hoc analysis in the FLAME study.

Wedzicha JA, Singh D, Tsiligianni I, Jenkins C, Fucile S, Fogel R, Shen S, Goyal P, Mezzi K, Kostikas K.

Respir Res. 2019 Jan 8;20(1):4. doi: 10.1186/s12931-019-0972-7.

13.

Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease.

Finney LJ, Belchamber KBR, Fenwick PS, Kemp SV, Edwards MR, Mallia P, Donaldson G, Johnston SL, Donnelly LE, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1496-1507. doi: 10.1164/rccm.201806-1095OC.

PMID:
30562053
14.

Current Controversies in Chronic Obstructive Pulmonary Disease. A Report from the Global Initiative for Chronic Obstructive Lung Disease Scientific Committee.

Criner GJ, Martinez FJ, Aaron S, Agusti A, Anzueto A, Bafadhel M, Barnes PJ, Bourbeau J, Chen R, Ewig J, Fabbri LM, Frith P, Halpin DMG, Han M, Montes de Oca M, Nishimura M, O'Donnell D, Papi A, Pavord I, Roche N, Rodriguez-Roisin R, Salvi S, Singh D, Sin DD, Stockley R, López Varela MV, Vestbo J, Vogelmeier CF, Washko G, Wedzicha JA, Celli BR.

Ann Am Thorac Soc. 2019 Jan;16(1):29-39. doi: 10.1513/AnnalsATS.201808-557PS. No abstract available.

PMID:
30427736
15.

Reply to Lan and Shi: Different Background, Short Duration, and Inappropriate Participants May Harm Your Conclusion.

Chapman KR, Hurst JR, Fogel RB, Pfister P, Kostikas K, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):390-392. doi: 10.1164/rccm.201809-1776LE. No abstract available.

16.

Asthma: Upcoming Themed Issue.

Wedzicha JA, Martinez FD.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):549. doi: 10.1164/rccm.1985ed1. No abstract available.

17.

Increased Chronic Obstructive Pulmonary Disease Exacerbations of Likely Viral Etiology Follow Elevated Ambient Nitrogen Oxides.

Pfeffer PE, Donaldson GC, Mackay AJ, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):581-591. doi: 10.1164/rccm.201712-2506OC.

18.

The Phillip Morris Foundation for a Smoke-Free World. A Cause for Concern.

Goldberg DS, Lederer DJ, MacKenzie EJ, Moss M, Samet JM, Schumacker PT, Wedzicha JA, Wynia MK.

Ann Am Thorac Soc. 2018 Nov;15(11):1269-1272. doi: 10.1513/AnnalsATS.201806-414GH. No abstract available.

19.

Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

Wedzicha JA, Banerji D, Kostikas K.

N Engl J Med. 2018 Aug 9;379(6):591. doi: 10.1056/NEJMc1807380. No abstract available.

20.

Childhood Exposures, Asthma, Smoking, Interactions, and the Catch-Up Hypothesis.

Allinson JP, Hardy R, Donaldson GC, Wedzicha JA.

Ann Am Thorac Soc. 2018 Oct;15(10):1241-1242. doi: 10.1513/AnnalsATS.201807-444LE. No abstract available.

21.

Capturing Exacerbations of Chronic Obstructive Pulmonary Disease with EXACT. A Subanalysis of FLAME.

Frent SM, Chapman KR, Larbig M, Mackay A, Fogel R, Gutzwiller FS, Shen S, Patalano F, Banerji D, Kostikas K, Wedzicha JA.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):43-51. doi: 10.1164/rccm.201801-0038OC.

22.

Indacaterol/glycopyrronium versus salmeterol/fluticasone in the prevention of clinically important deterioration in COPD: results from the FLAME study.

Anzueto AR, Kostikas K, Mezzi K, Shen S, Larbig M, Patalano F, Fogel R, Banerji D, Wedzicha JA.

Respir Res. 2018 Jun 20;19(1):121. doi: 10.1186/s12931-018-0830-z.

23.

Long-Term Triple Therapy De-escalation to Indacaterol/Glycopyrronium in Patients with Chronic Obstructive Pulmonary Disease (SUNSET): A Randomized, Double-Blind, Triple-Dummy Clinical Trial.

Chapman KR, Hurst JR, Frent SM, Larbig M, Fogel R, Guerin T, Banerji D, Patalano F, Goyal P, Pfister P, Kostikas K, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):329-339. doi: 10.1164/rccm.201803-0405OC.

24.

Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study.

Vogelmeier CF, Chapman KR, Miravitlles M, Roche N, Vestbo J, Thach C, Banerji D, Fogel R, Patalano F, Olsson P, Kostikas K, Wedzicha JA.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 10;13:1125-1134. doi: 10.2147/COPD.S160011. eCollection 2018.

25.

Patient-reported Outcomes for the Detection, Quantification, and Evaluation of Chronic Obstructive Pulmonary Disease Exacerbations.

Mackay AJ, Kostikas K, Murray L, Martinez FJ, Miravitlles M, Donaldson G, Banerji D, Patalano F, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):730-738. doi: 10.1164/rccm.201712-2482CI.

26.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.

27.

Is Peer Review Still Anonymous?

Ritchie AI, Polkey MI, Donaldson GC, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):278-280. doi: 10.1164/rccm.201711-2257LE. No abstract available.

28.

Intensifying Long-Acting β-Agonist/Corticosteroid Therapy at Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Wedzicha JA, Martinez FJ.

Am J Respir Crit Care Med. 2018 May 1;197(9):1096-1098. doi: 10.1164/rccm.201801-0202ED. No abstract available.

29.

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551. doi: 10.1164/rccm.201710-2028PP. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1463.

30.

Research Priorities in Pathophysiology for Sleep-disordered Breathing in Patients with Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Research Statement.

Malhotra A, Schwartz AR, Schneider H, Owens RL, DeYoung P, Han MK, Wedzicha JA, Hansel NN, Zeidler MR, Wilson KC, Badr MS; ATS Assembly on Sleep and Respiratory Neurobiology.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):289-299. doi: 10.1164/rccm.201712-2510ST. Review.

31.

Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future?

Wilson KC, Krishnan JA, Sliwinski P, Criner GJ, Miravitlles M, Hurst JR, Calverley PMA, Albert RK, Rigau D, Tonia T, Vestbo J, Papi A, Rabe KF, Anzueto A, Wedzicha JA.

Eur Respir J. 2018 Jan 11;51(1). pii: 1702577. doi: 10.1183/13993003.02577-2017. Print 2018 Jan. No abstract available.

32.

Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study.

Wang Z, Singh R, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR; COPDMAP.

Thorax. 2018 Apr;73(4):331-338. doi: 10.1136/thoraxjnl-2017-210741. Epub 2017 Dec 21.

33.

Reply to Cooper et al.: The Significance of Eosinophilic Inflammation in Chronic Obstructive Pulmonary Disease.

Roche N, Chapman KR, Vogelmeier CF, Herth FJF, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):968-969. doi: 10.1164/rccm.201710-2027LE. No abstract available.

PMID:
29140725
34.

Triple Therapy in COPD: What We Know and What We Don't.

Calverley PMA, Magnussen H, Miravitlles M, Wedzicha JA.

COPD. 2017 Dec;14(6):648-662. doi: 10.1080/15412555.2017.1389875. Epub 2017 Nov 9. Review.

PMID:
29120273
35.

Dual Bronchodilation Response by Exacerbation History and Eosinophilia in the FLAME Study.

Papi A, Kostikas K, Wedzicha JA, Vogelmeier CF, Roche N, Shen S, Banerji D, Fogel R, Patalano F, Chapman KR.

Am J Respir Crit Care Med. 2018 May 1;197(9):1223-1226. doi: 10.1164/rccm.201709-1822LE. No abstract available.

PMID:
29099609
36.

Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study.

Dal Negro RW, Wedzicha JA, Iversen M, Fontana G, Page C, Cicero AF, Pozzi E, Calverley PMA; RESTORE group; RESTORE study.

Eur Respir J. 2017 Oct 12;50(4). pii: 1700711. doi: 10.1183/13993003.00711-2017. Print 2017 Oct.

37.

Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline.

Wedzicha JA, Calverley PMA, Albert RK, Anzueto A, Criner GJ, Hurst JR, Miravitlles M, Papi A, Rabe KF, Rigau D, Sliwinski P, Tonia T, Vestbo J, Wilson KC, Krishnan JA.

Eur Respir J. 2017 Sep 9;50(3). pii: 1602265. doi: 10.1183/13993003.02265-2016. Print 2017 Sep.

38.

Airway Mucins in Chronic Obstructive Pulmonary Disease.

Wedzicha JA.

N Engl J Med. 2017 Sep 7;377(10):986-987. doi: 10.1056/NEJMe1707210. No abstract available.

39.

Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease.

Osadnik CR, Tee VS, Carson-Chahhoud KV, Picot J, Wedzicha JA, Smith BJ.

Cochrane Database Syst Rev. 2017 Jul 13;7:CD004104. doi: 10.1002/14651858.CD004104.pub4. Review.

40.

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.

Han MK, Quibrera PM, Carretta EE, Barr RG, Bleecker ER, Bowler RP, Cooper CB, Comellas A, Couper DJ, Curtis JL, Criner G, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Martinez CH, Pirozzi CB, O'Neal WK, Rennard S, Tashkin DP, Wedzicha JA, Woodruff P, Paine R 3rd, Martinez FJ; SPIROMICS investigators.

Lancet Respir Med. 2017 Aug;5(8):619-626. doi: 10.1016/S2213-2600(17)30207-2. Epub 2017 Jun 28.

41.

Erratum to "Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary" [Arch Bronconeumol. 2017;53:128-49].

Vogelmeier CF, Criner GJ, Martínez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DMG, Varela MVL, Nishimura M, Roche N, Rodríguez-Roisin R, Sin DD, Singh D, Stockley R, Vestbo J, Wedzicha JA, Agustí A.

Arch Bronconeumol. 2017 Jul;53(7):411-412. doi: 10.1016/j.arbres.2017.06.001. English, Spanish. No abstract available.

42.

Cardiovascular Disease Does Not Predict Exacerbation Rate or Mortality in Chronic Obstructive Pulmonary Disease.

Jones PW, Mullerova H, Agusti A, Decramer M, Adamek L, Raillard A, Zhu CQ, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):400-403. doi: 10.1164/rccm.201706-1066LE. No abstract available.

43.

Reply: What Should Be the Cutoff Value of Blood Eosinophilia as a Predictor of Inhaled Corticosteroid Responsiveness in Patients with Chronic Obstructive Pulmonary Disease?

Roche N, Chapman KR, Vogelmeier CF, Herth FJF, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1230-1231. doi: 10.1164/rccm.201706-1105LE. No abstract available.

44.

Update in Chronic Obstructive Pulmonary Disease 2016.

Allinson JP, Wedzicha JA.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):414-424. doi: 10.1164/rccm.201703-0588UP. Review. No abstract available.

45.

Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories.

Allinson JP, Hardy R, Donaldson GC, Shaheen SO, Kuh D, Wedzicha JA.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1021-1030. doi: 10.1164/rccm.201703-0506OC.

46.

Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.

Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N.

JAMA. 2017 Jun 6;317(21):2177-2186. doi: 10.1001/jama.2017.4451.

47.

Blood and sputum eosinophils in COPD; relationship with bacterial load.

Kolsum U, Donaldson GC, Singh R, Barker BL, Gupta V, George L, Webb AJ, Thurston S, Brookes AJ, McHugh TD, Wedzicha JA, Brightling CE, Singh D.

Respir Res. 2017 May 8;18(1):88. doi: 10.1186/s12931-017-0570-5.

48.

AJRCCM: 100-Year Anniversary. The Long View and the Fast Lane.

Wedzicha JA, Brochard LJ, Martinez FD, Martinez FJ, Donaldson G.

Am J Respir Crit Care Med. 2017 May 1;195(9):1081-1085. doi: 10.1164/rccm.201703-0525ED. No abstract available.

49.

Blood Eosinophils and Response to Maintenance Chronic Obstructive Pulmonary Disease Treatment. Data from the FLAME Trial.

Roche N, Chapman KR, Vogelmeier CF, Herth FJF, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA.

Am J Respir Crit Care Med. 2017 May 1;195(9):1189-1197. doi: 10.1164/rccm.201701-0193OC.

50.

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary.

Vogelmeier CF, Criner GJ, Martínez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, Frith P, Halpin DM, López Varela MV, Nishimura M, Roche N, Rodríguez-Roisin R, Sin DD, Singh D, Stockley R, Vestbo J, Wedzicha JA, Agustí A.

Arch Bronconeumol. 2017 Mar;53(3):128-149. doi: 10.1016/j.arbres.2017.02.001. Epub 2017 Mar 6. English, Spanish. Erratum in: Arch Bronconeumol. 2017 Jul;53(7):411-412.

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