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Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma.

Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL.

Mol Cancer Res. 2019 Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.


G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling.

Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, Wedegaertner PB, Jiang X.

Exp Cell Res. 2017 Nov 15;360(2):273-280. doi: 10.1016/j.yexcr.2017.09.017. Epub 2017 Sep 11.


Functional selectivity of GPCR-directed drug action through location bias.

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M.

Nat Chem Biol. 2017 Jul;13(7):799-806. doi: 10.1038/nchembio.2389. Epub 2017 May 29.


Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.

Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE.

Mol Cancer Res. 2017 May;15(5):501-506. doi: 10.1158/1541-7786.MCR-17-0007. Epub 2017 Feb 21. Review.


Inducible Inhibition of Gβγ Reveals Localization-dependent Functions at the Plasma Membrane and Golgi.

Klayman LM, Wedegaertner PB.

J Biol Chem. 2017 Feb 3;292(5):1773-1784. doi: 10.1074/jbc.M116.750430. Epub 2016 Dec 19.


Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1.

Helms MC, Grabocka E, Martz MK, Fischer CC, Suzuki N, Wedegaertner PB.

Cell Signal. 2016 Jan;28(1):43-52. doi: 10.1016/j.cellsig.2015.10.004. Epub 2015 Oct 19.


PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway.

Hewavitharana T, Wedegaertner PB.

Cell Signal. 2015 Dec;27(12):2444-51. doi: 10.1016/j.cellsig.2015.08.017. Epub 2015 Aug 29.


G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.

Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV.

Mol Biol Cell. 2015 Mar 15;26(6):1188-98. doi: 10.1091/mbc.E14-10-1476. Epub 2015 Jan 21.


The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function.

Xu H, Jiang X, Shen K, Fischer CC, Wedegaertner PB.

Mol Biol Cell. 2014 Jul 1;25(13):2105-15. doi: 10.1091/mbc.E13-09-0547. Epub 2014 May 7.


Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.

Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB.

Mol Biol Cell. 2013 Sep;24(18):2785-94. doi: 10.1091/mbc.E12-07-0533. Epub 2013 Jul 24.


G protein trafficking.

Wedegaertner PB.

Subcell Biochem. 2012;63:193-223. doi: 10.1007/978-94-007-4765-4_11. Review.


Non-canonical signaling and localizations of heterotrimeric G proteins.

Hewavitharana T, Wedegaertner PB.

Cell Signal. 2012 Jan;24(1):25-34. doi: 10.1016/j.cellsig.2011.08.014. Epub 2011 Sep 1. Review.


Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.

Irannejad R, Wedegaertner PB.

J Biol Chem. 2010 Oct 15;285(42):32393-404. doi: 10.1074/jbc.M110.154963. Epub 2010 Aug 18.


An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution.

Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB.

Mol Pharmacol. 2010 Oct;78(4):767-77. doi: 10.1124/mol.110.066340. Epub 2010 Jul 27.


The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.

Banerjee J, Fischer CC, Wedegaertner PB.

Biochemistry. 2009 Aug 25;48(33):8032-43. doi: 10.1021/bi9010013.


Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF.

Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB.

Cell Signal. 2009 Jun;21(6):996-1006. doi: 10.1016/j.cellsig.2009.02.010. Epub 2009 Feb 25.


N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).

Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB.

Cell Signal. 2008 Oct;20(10):1900-10. doi: 10.1016/j.cellsig.2008.06.019. Epub 2008 Jul 2.


FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.

Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.

J Cell Sci. 2008 Mar 15;121(Pt 6):895-905. doi: 10.1242/jcs.020941. Epub 2008 Feb 26.


Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor.

Grabocka E, Wedegaertner PB.

Mol Pharmacol. 2007 Oct;72(4):993-1002. Epub 2007 Jul 3.


Assembly and trafficking of heterotrimeric G proteins.

Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB.

Biochemistry. 2007 Jul 3;46(26):7665-77. Epub 2007 Jun 9. Review.


Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.

Jiang X, Benovic JL, Wedegaertner PB.

Mol Biol Cell. 2007 Aug;18(8):2960-9. Epub 2007 May 30.


Lipid-protein interactions in GPCR-associated signaling.

Escribá PV, Wedegaertner PB, Goñi FM, Vögler O.

Biochim Biophys Acta. 2007 Apr;1768(4):836-52. Epub 2006 Sep 16. Review.


Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth.

Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA Jr, Chan TO, Penn RB.

Biochemistry. 2005 Nov 8;44(44):14595-605.


Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling.

Evanko DS, Thiyagarajan MM, Takida S, Wedegaertner PB.

Cell Signal. 2005 Oct;17(10):1218-28. Epub 2005 Jan 22.


Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF.

Grabocka E, Wedegaertner PB.

Oncogene. 2005 Mar 24;24(13):2155-65.


Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o.

Takida S, Fischer CC, Wedegaertner PB.

Mol Pharmacol. 2005 Jan;67(1):132-9. Epub 2004 Oct 20.


Analysis of G-protein-coupled receptor kinase RGS homology domains.

Day PW, Wedegaertner PB, Benovic JL.

Methods Enzymol. 2004;390:295-310.


Characterization of the GRK2 binding site of Galphaq.

Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB.

J Biol Chem. 2004 Dec 17;279(51):53643-52. Epub 2004 Oct 7.


Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins.

Takida S, Wedegaertner PB.

FEBS Lett. 2004 Jun 4;567(2-3):209-13.


A predicted amphipathic helix mediates plasma membrane localization of GRK5.

Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB.

J Biol Chem. 2004 Apr 23;279(17):17989-95. Epub 2004 Feb 19.


Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.

Banerjee J, Wedegaertner PB.

Mol Biol Cell. 2004 Apr;15(4):1760-75. Epub 2004 Jan 23.


Differential interaction of GRK2 with members of the G alpha q family.

Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB.

Biochemistry. 2003 Aug 5;42(30):9176-84.


Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma.

Takida S, Wedegaertner PB.

J Biol Chem. 2003 May 9;278(19):17284-90. Epub 2003 Feb 27.


Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF.

Bhattacharyya R, Wedegaertner PB.

Biochem J. 2003 May 1;371(Pt 3):709-20.


G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits.

Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB.

J Biol Chem. 2003 Feb 21;278(8):6050-8. Epub 2002 Nov 8.


Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus.

Thiyagarajan MM, Bigras E, Van Tol HH, Hébert TE, Evanko DS, Wedegaertner PB.

Biochemistry. 2002 Jul 30;41(30):9470-84.


Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.

Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB.

J Biol Chem. 2001 Jun 29;276(26):23945-53. Epub 2001 Apr 9.


Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).

Evanko DS, Thiyagarajan MM, Wedegaertner PB.

J Biol Chem. 2000 Jan 14;275(2):1327-36.


Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T.

J Biol Chem. 1999 Nov 26;274(48):34483-92.


Lipid modifications and membrane targeting of G alpha.

Wedegaertner PB.

Biol Signals Recept. 1998 Mar-Apr;7(2):125-35. Review.


Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.

Iiri T, Backlund PS Jr, Jones TL, Wedegaertner PB, Bourne HR.

Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14592-7.


Activation-induced subcellular redistribution of Gs alpha.

Wedegaertner PB, Bourne HR, von Zastrow M.

Mol Biol Cell. 1996 Aug;7(8):1225-33.


Lipid modifications of trimeric G proteins.

Wedegaertner PB, Wilson PT, Bourne HR.

J Biol Chem. 1995 Jan 13;270(2):503-6. Review.


Activation and depalmitoylation of Gs alpha.

Wedegaertner PB, Bourne HR.

Cell. 1994 Jul 1;77(7):1063-70.


Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR.

J Biol Chem. 1993 Nov 25;268(33):25001-8.


Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor.

Wedegaertner PB, Gill GN.

Arch Biochem Biophys. 1992 Jan;292(1):273-80.


Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

Nishibe S, Wahl MI, Wedegaertner PB, Kim JW, Rhee SG, Carpenter G.

Proc Natl Acad Sci U S A. 1990 Jan;87(1):424-8. Erratum in: Proc Natl Acad Sci U S A 1990 Apr;87(8):3253. Kim JJ [corrected to Kim JW].

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