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Items: 1 to 50 of 154

1.

Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice.

Matundan HH, Mott KR, Allen SJ, Wang S, Bresee CJ, Ghiasi YN, Town T, Wechsler SL, Ghiasi H.

J Virol. 2016 Sep 29;90(20):9533-42. doi: 10.1128/JVI.01373-16. Print 2016 Oct 15.

2.

The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits.

Srivastava R, Dervillez X, Khan AA, Chentoufi AA, Chilukuri S, Shukr N, Fazli Y, Ong NN, Afifi RE, Osorio N, Geertsema R, Nesburn AB, Wechsler SL, BenMohamed L.

J Virol. 2016 Mar 28;90(8):3913-3928. doi: 10.1128/JVI.02450-15. Print 2016 Apr.

3.

Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis.

Jester JV, Morishige N, BenMohamed L, Brown DJ, Osorio N, Hsiang C, Perng GC, Jones C, Wechsler SL.

Cornea. 2016 Jan;35(1):81-8. doi: 10.1097/ICO.0000000000000666.

4.

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice.

BenMohamed L, Osorio N, Khan AA, Srivastava R, Huang L, Krochmal JJ, Garcia JM, Simpson JL, Wechsler SL.

Curr Eye Res. 2016 Jun;41(6):747-56. doi: 10.3109/02713683.2015.1061024. Epub 2015 Sep 23.

5.

A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a "Humanized" HLA Transgenic Rabbit Model.

Srivastava R, Khan AA, Huang J, Nesburn AB, Wechsler SL, BenMohamed L.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4013-28. doi: 10.1167/iovs.15-17074.

6.

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT).

Carpenter D, Hsiang C, Jiang X, Osorio N, BenMohamed L, Jones C, Wechsler SL.

J Neurovirol. 2015 Oct;21(5):568-75. doi: 10.1007/s13365-015-0361-z. Epub 2015 Jun 13.

7.

Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2.

Jiang X, Brown D, Osorio N, Hsiang C, BenMohamed L, Wechsler SL.

J Neurovirol. 2016 Feb;22(1):38-49. doi: 10.1007/s13365-015-0362-y. Epub 2015 Jun 12.

8.

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation.

BenMohamed L, Osorio N, Srivastava R, Khan AA, Simpson JL, Wechsler SL.

J Neurovirol. 2015 Oct;21(5):508-17. doi: 10.1007/s13365-015-0348-9. Epub 2015 May 22.

10.

Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus.

Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, BenMohamed L, Wechsler SL.

Curr Eye Res. 2016;41(3):284-91. doi: 10.3109/02713683.2015.1020172. Epub 2015 Apr 10.

11.

A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation.

Jiang X, Brown D, Osorio N, Hsiang C, Li L, Chan L, BenMohamed L, Wechsler SL.

J Neurovirol. 2015 Apr;21(2):199-209. doi: 10.1007/s13365-015-0319-1. Epub 2015 Feb 3.

12.

HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgenic mice against ocular herpes.

Srivastava R, Khan AA, Spencer D, Vahed H, Lopes PP, Thai NT, Wang C, Pham TT, Huang J, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L.

J Immunol. 2015 Mar 1;194(5):2232-48. doi: 10.4049/jimmunol.1402606. Epub 2015 Jan 23.

13.

Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes.

Khan AA, Srivastava R, Spencer D, Garg S, Fremgen D, Vahed H, Lopes PP, Pham TT, Hewett C, Kuang J, Ong N, Huang L, Scarfone VM, Nesburn AB, Wechsler SL, BenMohamed L.

J Virol. 2015 Apr;89(7):3776-92. doi: 10.1128/JVI.03419-14. Epub 2015 Jan 21.

14.

CD8α dendritic cells drive establishment of HSV-1 latency.

Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H.

PLoS One. 2014 Apr 2;9(4):e93444. doi: 10.1371/journal.pone.0093444. eCollection 2014.

15.

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H.

PLoS One. 2014 Jan 27;9(1):e87617. doi: 10.1371/journal.pone.0087617. eCollection 2014.

16.

Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency.

Allen SJ, Rhode-Kurnow A, Mott KR, Jiang X, Carpenter D, Rodriguez-Barbosa JI, Jones C, Wechsler SL, Ware CF, Ghiasi H.

J Virol. 2014 Feb;88(4):1961-71. doi: 10.1128/JVI.02467-13. Epub 2013 Dec 4.

17.

Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes.

Dervillez X, Qureshi H, Chentoufi AA, Khan AA, Kritzer E, Yu DC, Diaz OR, Gottimukkala C, Kalantari M, Villacres MC, Scarfone VM, McKinney DM, Sidney J, Sette A, Nesburn AB, Wechsler SL, BenMohamed L.

J Immunol. 2013 Nov 15;191(10):5124-38. doi: 10.4049/jimmunol.1301415. Epub 2013 Oct 7.

18.

Sequence and comparative analysis of the genome of HSV-1 strain McKrae.

Watson G, Xu W, Reed A, Babra B, Putman T, Wick E, Wechsler SL, Rohrmann GF, Jin L.

Virology. 2012 Nov 25;433(2):528-37. doi: 10.1016/j.virol.2012.08.043. Epub 2012 Sep 25.

19.

Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine.

Dervillez X, Gottimukkala C, Kabbara KW, Nguyen C, Badakhshan T, Kim SM, Nesburn AB, Wechsler SL, Benmohamed L.

Future Virol. 2012 Apr 1;7(4):371-378.

20.

The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, Jiang X, Nesburn AB, Wechsler SL, Benmohamed L.

Viral Immunol. 2012 Jun;25(3):204-15. doi: 10.1089/vim.2011.0091. Epub 2012 Apr 18.

21.

Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.

Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H.

J Virol. 2011 Nov;85(21):11448-56. doi: 10.1128/JVI.00678-11. Epub 2011 Aug 31.

22.

CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection.

Allen SJ, Mott KR, Chentoufi AA, BenMohamed L, Wechsler SL, Ballantyne CM, Ghiasi H.

J Virol. 2011 Oct;85(19):9945-55. doi: 10.1128/JVI.05208-11. Epub 2011 Jul 20.

23.

The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism.

Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L.

J Virol. 2011 Sep;85(17):9127-38. doi: 10.1128/JVI.00587-11. Epub 2011 Jun 29.

24.

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.

Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H.

J Virol. 2011 May;85(9):4184-97. doi: 10.1128/JVI.02290-10. Epub 2011 Feb 9.

25.

The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.

Jiang X, Chentoufi AA, Hsiang C, Carpenter D, Osorio N, BenMohamed L, Fraser NW, Jones C, Wechsler SL.

J Virol. 2011 Mar;85(5):2325-32. doi: 10.1128/JVI.01791-10. Epub 2010 Dec 22.

27.

Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript.

Henderson G, Jaber T, Carpenter D, Wechsler SL, Jones C.

J Neurovirol. 2009 Sep;15(5-6):439-48. doi: 10.3109/13550280903296353.

PMID:
20175695
28.

A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes.

Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB, Wechsler SL, BenMohamed L.

J Immunol. 2010 Mar 1;184(5):2561-71. doi: 10.4049/jimmunol.0902322. Epub 2010 Feb 1.

29.

Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization.

Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, BenMohamed L.

Clin Vaccine Immunol. 2010 Mar;17(3):342-53. doi: 10.1128/CVI.00347-09. Epub 2010 Jan 20.

30.

Developing an asymptomatic mucosal herpes vaccine: the present and the future.

Dasgupta G, Nesburn AB, Wechsler SL, BenMohamed L.

Future Microbiol. 2010 Jan;5(1):1-4. doi: 10.2217/fmb.09.101. No abstract available.

31.
32.

New concepts in herpes simplex virus vaccine development: notes from the battlefield.

Dasgupta G, Chentoufi AA, Nesburn AB, Wechsler SL, BenMohamed L.

Expert Rev Vaccines. 2009 Aug;8(8):1023-35. doi: 10.1586/erv.09.60. Review.

33.

Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.

Jaber T, Henderson G, Li S, Perng GC, Carpenter D, Wechsler SL, Jones C.

J Gen Virol. 2009 Oct;90(Pt 10):2342-52. doi: 10.1099/vir.0.013318-0. Epub 2009 Jul 1.

34.

A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages.

Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H.

Virol J. 2009 May 13;6:56. doi: 10.1186/1743-422X-6-56.

35.

The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity.

Mott KR, Chentoufi AA, Carpenter D, BenMohamed L, Wechsler SL, Ghiasi H.

Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2903-12. doi: 10.1167/iovs.08-2957. Epub 2009 Jan 24.

PMID:
19168902
36.

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge.

Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L.

Mucosal Immunol. 2009 Mar;2(2):129-143. doi: 10.1038/mi.2008.81. Epub 2008 Dec 24.

37.

Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice.

Mott KR, Bresee CJ, Allen SJ, BenMohamed L, Wechsler SL, Ghiasi H.

J Virol. 2009 Mar;83(5):2246-54. doi: 10.1128/JVI.02234-08. Epub 2008 Dec 17.

38.

Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.

Jin L, Carpenter D, Moerdyk-Schauwecker M, Vanarsdall AL, Osorio N, Hsiang C, Jones C, Wechsler SL.

J Neurovirol. 2008 Oct;14(5):389-400. doi: 10.1080/13550280802216510. Epub 2008 Nov 12.

39.

A speculated ribozyme site in the herpes simplex virus type 1 latency-associated transcript gene is not essential for a wild-type reactivation phenotype.

Carpenter D, Singh S, Osorio N, Hsiang C, Jiang X, Jin L, Jones C, Wechsler SL.

J Neurovirol. 2008 Nov;14(6):558-62. doi: 10.1080/13550280802275912.

40.

Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency.

Mott KR, Underhill D, Wechsler SL, Ghiasi H.

J Virol. 2008 Oct;82(20):9870-9. doi: 10.1128/JVI.00566-08. Epub 2008 Jul 30.

41.

Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1-encoded latency-associated transcript.

Peng W, Vitvitskaia O, Carpenter D, Wechsler SL, Jones C.

J Neurovirol. 2008 Jan;14(1):41-52. doi: 10.1080/13550280701793957.

PMID:
18300074
42.

HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D.

Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, BenMohamed L.

J Immunol. 2008 Jan 1;180(1):426-37.

43.

Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity.

Carpenter D, Henderson G, Hsiang C, Osorio N, BenMohamed L, Jones C, Wechsler SL.

Microb Pathog. 2008 Feb;44(2):98-102. Epub 2007 Aug 12.

44.

Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines.

Bettahi I, Nesburn AB, Yoon S, Zhang X, Mohebbi A, Sue V, Vanderberg A, Wechsler SL, BenMohamed L.

Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4643-53.

PMID:
17898288
45.

Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis.

Carpenter D, Hsiang C, Brown DJ, Jin L, Osorio N, BenMohamed L, Jones C, Wechsler SL.

Virology. 2007 Dec 5;369(1):12-8. Epub 2007 Aug 28.

46.

Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.

Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, BenMohamed L.

J Virol. 2007 Jul;81(14):7647-61. Epub 2007 May 2.

47.

Reactivation phenotype in rabbits of a herpes simplex virus type 1 mutant containing an unrelated antiapoptosis gene in place of latency-associated transcript.

Jin L, Perng GC, Carpenter D, Mott KR, Osorio N, Naito J, Brick DJ, Jones C, Wechsler SL.

J Neurovirol. 2007;13(1):78-84.

PMID:
17454452
48.

Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system.

Nesburn AB, Bettahi I, Zhang X, Zhu X, Chamberlain W, Afifi RE, Wechsler SL, BenMohamed L.

Ocul Surf. 2006 Oct;4(4):178-87. Review.

PMID:
17146573
49.

Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.

Solbrig MV, Adrian R, Wechsler SL, Koob GF.

Eur J Pharmacol. 2007 Jan 19;555(1):23-9. Epub 2006 Oct 20.

50.

Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes.

Morishige N, Jester JV, Naito J, Osorio N, Wahlert A, Jones C, Everett RD, Wechsler SL, Perng GC.

J Gen Virol. 2006 Oct;87(Pt 10):2817-25.

PMID:
16963739

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