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Items: 1 to 50 of 62

1.

Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells.

El Maadidi S, Weber ANR, Motshwene P, Schüssler JM, Backes D, Dickhöfer S, Wang H, Liu X, Garcia MD, Taumer C, Soufi B, Wolz OO, Klimosch SN, Franz-Wachtel M, Macek B, Gay NJ.

Sci Rep. 2019 Sep 11;9(1):13168. doi: 10.1038/s41598-019-49017-z.

2.

Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.

Herster F, Bittner Z, Codrea MC, Archer NK, Heister M, Löffler MW, Heumos S, Wegner J, Businger R, Schindler M, Stegner D, Schäkel K, Grabbe S, Ghoreschi K, Miller LS, Weber ANR.

Front Immunol. 2019 Aug 16;10:1867. doi: 10.3389/fimmu.2019.01867. eCollection 2019.

3.

Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains.

Steimle A, Menz S, Bender A, Ball B, Weber ANR, Hagemann T, Lange A, Maerz JK, Parusel R, Michaelis L, Schäfer A, Yao H, Löw HC, Beier S, Tesfazgi Mebrhatu M, Gronbach K, Wagner S, Voehringer D, Schaller M, Fehrenbacher B, Autenrieth IB, Oelschlaeger TA, Frick JS.

PLoS Biol. 2019 Jun 17;17(6):e3000334. doi: 10.1371/journal.pbio.3000334. eCollection 2019 Jun.

4.

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo.

Hafner A, Kolbe U, Freund I, Castiglia V, Kovarik P, Poth T, Herster F, Weigand MA, Weber ANR, Dalpke AH, Eigenbrod T.

Front Immunol. 2019 Feb 21;10:198. doi: 10.3389/fimmu.2019.00198. eCollection 2019.

5.

The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.

Fuchs K, Cardona Gloria Y, Wolz OO, Herster F, Sharma L, Dillen CA, Täumer C, Dickhöfer S, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Roger T, Le Roy D, Schilling NA, Frauhammer F, Miller LS, Nürnberger T, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl D, Weber AN.

EMBO Rep. 2018 Dec;19(12). pii: e46065. doi: 10.15252/embr.201846065. Epub 2018 Oct 18.

PMID:
30337494
6.

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities.

Weber ANR, Cardona Gloria Y, Çınar Ö, Reinhardt HC, Pezzutto A, Wolz OO.

Cancer Immunol Immunother. 2018 Nov;67(11):1797-1807. doi: 10.1007/s00262-018-2242-9. Epub 2018 Sep 11. Review.

PMID:
30203262
7.

Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer.

Huhn S, da Silva Filho MI, Sanmuganantham T, Pichulik T, Catalano C, Pardini B, Naccarati A, Polakova-Vymetálkova V, Jiraskova K, Vodickova L, Vodicka P, Löffler MW, Courth L, Wehkamp J, Din FVN, Timofeeva M, Farrington SM, Jansen L, Hemminki K, Chang-Claude J, Brenner H, Hoffmeister M, Dunlop MG, Weber ANR, Försti A.

PLoS One. 2018 Jun 21;13(6):e0199350. doi: 10.1371/journal.pone.0199350. eCollection 2018.

8.

HSP110 sustains chronic NF-κB signaling in activated B-cell diffuse large B-cell lymphoma through MyD88 stabilization.

Boudesco C, Verhoeyen E, Martin L, Chassagne-Clement C, Salmi L, Mhaidly R, Pangault C, Fest T, Ramla S, Jardin F, Wolz OO, Weber ANR, Garrido C, Jego G.

Blood. 2018 Aug 2;132(5):510-520. doi: 10.1182/blood-2017-12-819706. Epub 2018 Jun 5.

9.

Short article: Influence of regulatory NLRC5 variants on colorectal cancer survival and 5-fluorouracil-based chemotherapy.

Catalano C, da Silva Filho MI, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A.

Eur J Gastroenterol Hepatol. 2018 Aug;30(8):838-842. doi: 10.1097/MEG.0000000000001154.

PMID:
29762254
10.

Toll-like receptor 9 (TLR-9) promotor polymorphisms and gene expression are associated with persistent Staphylococcus aureus nasal carriage.

Nurjadi D, Heeg K, Weber ANR, Zanger P.

Clin Microbiol Infect. 2018 Nov;24(11):1210.e7-1210.e12. doi: 10.1016/j.cmi.2018.02.014. Epub 2018 Feb 17.

PMID:
29458158
11.

Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer.

Catalano C, da Silva Filho MI, Frank C, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A.

PLoS One. 2018 Feb 6;13(2):e0192385. doi: 10.1371/journal.pone.0192385. eCollection 2018.

12.

The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling.

Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y, Weber ANR, Kufer TA.

J Biol Chem. 2018 Feb 23;293(8):2701-2710. doi: 10.1074/jbc.RA117.000152. Epub 2018 Jan 4.

13.

Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER).

Wolz OO, Koegl M, Weber ANR.

Methods Mol Biol. 2018;1714:119-130. doi: 10.1007/978-1-4939-7519-8_8.

PMID:
29177859
14.

Bruton's Tyrosine Kinase: An Emerging Key Player in Innate Immunity.

Weber ANR, Bittner Z, Liu X, Dang TM, Radsak MP, Brunner C.

Front Immunol. 2017 Nov 8;8:1454. doi: 10.3389/fimmu.2017.01454. eCollection 2017. Review.

15.

HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy.

Nelde A, Walz JS, Kowalewski DJ, Schuster H, Wolz OO, Peper JK, Cardona Gloria Y, Langerak AW, Muggen AF, Claus R, Bonzheim I, Fend F, Salih HR, Kanz L, Rammensee HG, Stevanović S, Weber AN.

Oncoimmunology. 2016 Dec 23;6(3):e1219825. doi: 10.1080/2162402X.2016.1219825. eCollection 2017.

16.

Psychiatric Emergencies: Assessing and Managing Suicidal Ideation.

Weber AN, Michail M, Thompson A, Fiedorowicz JG.

Med Clin North Am. 2017 May;101(3):553-571. doi: 10.1016/j.mcna.2016.12.006. Epub 2017 Mar 8. Review.

17.

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro.

Teofilović NK, Bihi M, Stojković MR, Tumir LM, Ester K, Kralj M, Majhen D, Oršolić N, Lepur A, Vrbanec D, Markotić A, Dembić Z, Weber AN, Piantanida I, Vugrek O, Diken M, Knežević J.

Bioorg Med Chem Lett. 2017 Apr 1;27(7):1530-1537. doi: 10.1016/j.bmcl.2017.02.048. Epub 2017 Feb 20.

PMID:
28254484
18.

Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.

Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR.

J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16.

PMID:
28216434
19.

The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation.

Stadler N, Hasibeder A, Lopez PA, Teschner D, Desuki A, Kriege O, Weber ANR, Schulz C, Michel C, Heβ G, Radsak MP.

Haematologica. 2017 May;102(5):e191-e194. doi: 10.3324/haematol.2016.152017. Epub 2017 Jan 25. No abstract available.

20.

The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation.

Murthy P, Durco F, Miller-Ocuin JL, Takedai T, Shankar S, Liang X, Liu X, Cui X, Sachdev U, Rath D, Lotze MT, Zeh HJ 3rd, Gawaz M, Weber AN, Vogel S.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):230-236. doi: 10.1016/j.bbrc.2016.12.161. Epub 2016 Dec 26.

PMID:
28034752
21.

The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.

Dossang AC, Motshwene PG, Yang Y, Symmons MF, Bryant CE, Borman S, George J, Weber AN, Gay NJ.

Sci Rep. 2016 Nov 23;6:37267. doi: 10.1038/srep37267.

22.

Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.

Fischer J, Weber ANR, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner C, O'Farrelly C, Berg T.

Gut. 2017 Oct;66(10):1829-1837. doi: 10.1136/gutjnl-2015-310239. Epub 2016 Apr 21.

PMID:
27196570
23.

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L; German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC.

Blood. 2016 Jun 2;127(22):2732-41. doi: 10.1182/blood-2015-11-684183. Epub 2016 Apr 5.

24.

Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus.

Pichulik T, Khatamzas E, Liu X, Brain O, Delmiro Garcia M, Leslie A, Danis B, Mayer A, Baban D, Ragoussis J, Weber AN, Simmons A.

Eur J Immunol. 2016 Jan;46(1):167-77. doi: 10.1002/eji.201444970. Epub 2015 Oct 30.

25.

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.

Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups.

Hepatology. 2015 Nov;62(5):1375-87. doi: 10.1002/hep.28105. Epub 2015 Sep 28.

PMID:
26250868
26.

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D.

Cell Host Microbe. 2015 Apr 8;17(4):507-14. doi: 10.1016/j.chom.2015.02.007. Epub 2015 Mar 12.

27.

Neutrophils: Between host defence, immune modulation, and tissue injury.

Kruger P, Saffarzadeh M, Weber AN, Rieber N, Radsak M, von Bernuth H, Benarafa C, Roos D, Skokowa J, Hartl D.

PLoS Pathog. 2015 Mar 12;11(3):e1004651. doi: 10.1371/journal.ppat.1004651. eCollection 2015 Mar. Review.

28.

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization.

Avbelj M, Wolz OO, Fekonja O, Benčina M, Repič M, Mavri J, Krüger J, Schärfe C, Delmiro Garcia M, Panter G, Kohlbacher O, Weber AN, Jerala R.

Blood. 2014 Dec 18;124(26):3896-904. doi: 10.1182/blood-2014-05-573188. Epub 2014 Oct 30.

29.

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.

Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN.

J Biol Chem. 2014 Aug 15;289(33):23123-31. doi: 10.1074/jbc.M113.492934. Epub 2014 Jun 19.

30.

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.

Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AV, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN.

J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9.

31.

Toll-like receptor genetic variants and colorectal cancer.

Weber AN, Försti A.

Oncoimmunology. 2014 Jan 1;3(1):e27763. Epub 2014 Jan 10.

32.

Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis.

Novikova L, Czymmeck N, Deuretzbacher A, Buck F, Richter K, Weber AN, Aepfelbacher M, Ruckdeschel K.

J Immunol. 2014 Feb 1;192(3):1209-19. doi: 10.4049/jimmunol.1203464. Epub 2013 Dec 20.

33.

Functional TLR5 genetic variants affect human colorectal cancer survival.

Klimosch SN, Försti A, Eckert J, Knezevic J, Bevier M, von Schönfels W, Heits N, Walter J, Hinz S, Lascorz J, Hampe J, Hartl D, Frick JS, Hemminki K, Schafmayer C, Weber AN.

Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23.

34.

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.

Eckert JK, Kim YJ, Kim JI, Gürtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR.

Immunity. 2013 Oct 17;39(4):647-60. doi: 10.1016/j.immuni.2013.09.005. Epub 2013 Oct 10.

35.

IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B.

Over B, Ziegler S, Foermer S, Weber AN, Bode KA, Heeg K, Bekeredjian-Ding I.

Eur J Immunol. 2013 Jun;43(6):1630-42. doi: 10.1002/eji.201243217. Epub 2013 Apr 30.

36.

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.

Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5. doi: 10.1073/pnas.1008203109. Epub 2012 Jul 16.

37.

Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.

Knezević J, Pavlinić D, Rose WA 2nd, Leifer CA, Bendelja K, Gabrilovac J, Parcina M, Lauc G, Kubarenko AV, Petricevic B, Vrbanec D, Bulat-Kardum L, Bekeredjian-Ding I, Pavelić J, Dembić Z, Weber AN.

J Biol Chem. 2012 Jul 13;287(29):24544-53. doi: 10.1074/jbc.M111.337477. Epub 2012 May 21.

38.

Integrin genes and susceptibility to human melanoma.

Lenci RE, Rachakonda PS, Kubarenko AV, Weber AN, Brandt A, Gast A, Sucker A, Hemminki K, Schadendorf D, Kumar R.

Mutagenesis. 2012 May;27(3):367-73. doi: 10.1093/mutage/ger090. Epub 2011 Dec 20.

PMID:
22189006
39.

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation.

Shatnyeva OM, Kubarenko AV, Weber CE, Pappa A, Schwartz-Albiez R, Weber AN, Krammer PH, Lavrik IN.

PLoS One. 2011;6(5):e19927. doi: 10.1371/journal.pone.0019927. Epub 2011 May 18.

40.

A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.

Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A.

J Immunol. 2011 Apr 1;186(7):4213-22. doi: 10.4049/jimmunol.1003585. Epub 2011 Mar 7.

41.

Gadd45a is an RNA binding protein and is localized in nuclear speckles.

Sytnikova YA, Kubarenko AV, Schäfer A, Weber AN, Niehrs C.

PLoS One. 2011 Jan 7;6(1):e14500. doi: 10.1371/journal.pone.0014500.

42.

Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.

George J, Motshwene PG, Wang H, Kubarenko AV, Rautanen A, Mills TC, Hill AV, Gay NJ, Weber AN.

J Biol Chem. 2011 Jan 14;286(2):1341-53. doi: 10.1074/jbc.M110.159996. Epub 2010 Oct 21.

43.

Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.

Gdynia G, Keith M, Kopitz J, Bergmann M, Fassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, Schirmacher P, Roth W.

Cancer Res. 2010 Nov 1;70(21):8558-68. doi: 10.1158/0008-5472.CAN-10-0204. Epub 2010 Oct 19.

44.

A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

Kubarenko AV, Ranjan S, Rautanen A, Mills TC, Wong S, Vannberg F, Neumaier M, Bekeredjian-Ding I, Hill AV, Ahmad-Nejad P, Weber AN.

J Biol Chem. 2010 Nov 19;285(47):36486-94. doi: 10.1074/jbc.M110.117200. Epub 2010 Sep 14.

45.

MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.

George J, Kubarenko AV, Rautanen A, Mills TC, Colak E, Kempf T, Hill AV, Nieters A, Weber AN.

J Immunol. 2010 Mar 15;184(6):3025-32. doi: 10.4049/jimmunol.0901156. Epub 2010 Feb 17.

46.

Comprehensive modeling and functional analysis of Toll-like receptor ligand-recognition domains.

Kubarenko AV, Ranjan S, Colak E, George J, Frank M, Weber AN.

Protein Sci. 2010 Mar;19(3):558-69. doi: 10.1002/pro.333.

47.

Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes.

Shia AK, Glittenberg M, Thompson G, Weber AN, Reichhart JM, Ligoxygakis P.

J Cell Sci. 2009 Dec 15;122(Pt 24):4505-15. doi: 10.1242/jcs.049155. Epub 2009 Nov 24.

48.

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.

Pothlichet J, Burtey A, Kubarenko AV, Caignard G, Solhonne B, Tangy F, Ben-Ali M, Quintana-Murci L, Heinzmann A, Chiche JD, Vidalain PO, Weber AN, Chignard M, Si-Tahar M.

PLoS One. 2009 Oct 27;4(10):e7582. doi: 10.1371/journal.pone.0007582.

49.

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation.

Peter ME, Kubarenko AV, Weber AN, Dalpke AH.

J Immunol. 2009 Jun 15;182(12):7690-7. doi: 10.4049/jimmunol.0900819.

50.

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

Gangloff M, Murali A, Xiong J, Arnot CJ, Weber AN, Sandercock AM, Robinson CV, Sarisky R, Holzenburg A, Kao C, Gay NJ.

J Biol Chem. 2008 May 23;283(21):14629-35. doi: 10.1074/jbc.M800112200. Epub 2008 Mar 17.

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