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Items: 18

1.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.

2.

Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging.

Swales JG, Strittmatter N, Tucker JW, Clench MR, Webborn PJH, Goodwin RJA.

Sci Rep. 2016 Nov 24;6:37648. doi: 10.1038/srep37648.

3.

Future directions of imaging MS in pharmaceutical R&D.

Goodwin RJ, Webborn PJ.

Bioanalysis. 2015;7(20):2667-73. doi: 10.4155/bio.15.156. Epub 2015 Oct 29.

PMID:
26510897
4.

Mapping drug distribution in brain tissue using liquid extraction surface analysis mass spectrometry imaging.

Swales JG, Tucker JW, Spreadborough MJ, Iverson SL, Clench MR, Webborn PJ, Goodwin RJ.

Anal Chem. 2015 Oct 6;87(19):10146-52. doi: 10.1021/acs.analchem.5b02998. Epub 2015 Sep 30.

PMID:
26350423
5.

Mass spectrometry imaging in drug development.

Nilsson A, Goodwin RJ, Shariatgorji M, Vallianatou T, Webborn PJ, Andrén PE.

Anal Chem. 2015 Feb 3;87(3):1437-55. doi: 10.1021/ac504734s. Epub 2015 Jan 14. Review. No abstract available.

PMID:
25526173
6.

The role of pharmacokinetic studies in drug discovery: where are we now, how did we get here and where are we going?

Webborn PJ.

Future Med Chem. 2014 Jul;6(11):1233-5. doi: 10.4155/fmc.14.76. No abstract available.

7.

Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis.

Swales JG, Tucker JW, Strittmatter N, Nilsson A, Cobice D, Clench MR, Mackay CL, Andren PE, Takáts Z, Webborn PJ, Goodwin RJ.

Anal Chem. 2014 Aug 19;86(16):8473-80. doi: 10.1021/ac502217r. Epub 2014 Aug 8.

PMID:
25084360
8.

The right compound in the right assay at the right time: an integrated discovery DMPK strategy.

Ballard P, Brassil P, Bui KH, Dolgos H, Petersson C, Tunek A, Webborn PJ.

Drug Metab Rev. 2012 Aug;44(3):224-52. doi: 10.3109/03602532.2012.691099. Epub 2012 Jun 15. Review.

PMID:
22697420
9.

Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4.

Wilby AJ, Maeda K, Courtney PF, Debori Y, Webborn PJ, Kitamura Y, Kusuhara H, Riley RJ, Sugiyama Y.

Drug Metab Dispos. 2011 Dec;39(12):2361-9. doi: 10.1124/dmd.111.041814. Epub 2011 Sep 22.

PMID:
21940906
10.
11.

Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: a novel pro-drug approach to increase exposure.

Basarab GS, Hill PJ, Rastagar A, Webborn PJ.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4716-22. doi: 10.1016/j.bmcl.2008.06.092. Epub 2008 Jul 2.

PMID:
18640833
12.

Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.

Grime K, Webborn PJ, Riley RJ.

Drug Metab Dispos. 2008 Aug;36(8):1670-8. doi: 10.1124/dmd.108.021055. Epub 2008 May 12.

PMID:
18474678
13.

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.

Paine SW, Parker AJ, Gardiner P, Webborn PJ, Riley RJ.

Drug Metab Dispos. 2008 Jul;36(7):1365-74. doi: 10.1124/dmd.107.019455. Epub 2008 Apr 21.

PMID:
18426955
14.

In vitro-in vivo extrapolation of hepatic clearance involving active uptake: theoretical and experimental aspects.

Webborn PJ, Parker AJ, Denton RL, Riley RJ.

Xenobiotica. 2007 Oct-Nov;37(10-11):1090-109. Review.

PMID:
17968738
15.

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. Epub 2007 Aug 19.

PMID:
17827008
16.

Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.

Soars MG, Grime K, Sproston JL, Webborn PJ, Riley RJ.

Drug Metab Dispos. 2007 Jun;35(6):859-65. Epub 2007 Mar 7.

PMID:
17344337
18.

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